What do we know about the genetics of aspirin intolerance?

Journal of Clinical Pharmacy and Therapeutics

Volumn 33, Issue 5, 2008, Pages 465-472

  Palikhe, N S ^a   Kim, S H ^a   Park, H S ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

Aspirin intolerant asthma; Aspirin intolerant urticaria; Genetic marker; Polymorphism

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONATE 5 LIPOXYGENASE; HISTAMINE METHYLTRANSFERASE; LEUKOTRIENE C4 SYNTHASE; PEPTIDOLEUKOTRIENE; PROSTAGLANDIN E2; THROMBOXANE A2 RECEPTOR; TRANSCRIPTION FACTOR T BET;

ANAPHYLAXIS; ARACHIDONIC ACID METABOLISM; ASPIRIN INTOLERANT ASTHMA; ASPIRIN INTOLERANT URTICARIA; ASTHMA; CLINICAL FEATURE; DRUG ERUPTION; DRUG TOLERANCE; GENETIC MARKER; HUMAN; HYPERSENSITIVITY REACTION; ICOSANOID METABOLISM; PATHOGENESIS; PHARMACOGENETICS; REVIEW; RHINITIS;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; ASTHMA; DRUG HYPERSENSITIVITY; GENETIC MARKERS; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; URTICARIA;

EID: 52049103374     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/j.1365-2710.2008.00961.x     Document Type: Review

References (45)

1. Hedman J, Kaprio J, Poussa T, Nieminen MM (1999) Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study. International Journal of Epidemiology, 28, 717 722.
2. Valley H, Taylor ML, Thompson PJ (2002) The prevalence of aspirin intolerant asthma (AIA) in Australian asthmatic patients. Thorax, 57, 569 574.
3. Kasper L, Sladek K, Duplaga M et al. (2003) Prevalence of asthma with aspirin hypersensitivity in the adult population of Poland. Allergy, 58, 1064 1066.
4. Cebeci F, Tanrikut A, Topcu E, Onsun N, Kurtulmus N, Uras AR (2006) Association between chronic urticaria and thyroid autoimmunity. European Journal of Dermatology, 16, 402 405.
5. Lee JY, Kim HM, Ye YM et al. (2006) Role of staphylococcal superantigen-specifc IgE antibodies in aspirin intolerant asthma. Allergy Asthma Proceedings, 27, 341 346.
6. Ye YM, Kim JE, Nahm DI, Kim SH, Suh CH, Nahm DH, Park HS (2005) Comparsion of clinical characteristics and prognosis of chronic urticaria according to the aspirin sensitivity. Korean Journal of Asthma Allergy and Clinical Immunology, 25, 194 199.
7. Choi JH, Park HS, Oh HB, Lee JH, Suh YJ, Park CS, Shin HD (2004) Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase. Human Genetics, 114, 337 344.
8. Kowalski ML, Ptasinska A, Jedrzejczak M et al. (2005) Aspirin-triggered 15-HETE generation in peripheral blood leukocytes is a specific and sensitive Aspirin Sensitive Patients Identification Test (ASPITest). Allergy, 60, 1139 1145.
9. Rudolf M, Milavec-Puretic V, Lipozencic J, Malenica B (2005) Clinical usefulness of cellular antigen stimulation test in detection of aspirin allergy. Acta Dermatovenerologica Croatica, 13, 93 96.
10. Chavis C, Vachier I, Godard P, Bousquet J, Chanez P (2000) Lipoxins and other arachidonate derived mediators in bronchial asthma. Thorax, 55 (Suppl. 2 S38 S41.
11. Pierzchalska M, Szabo Z, Sanak M, Soja J, Szczeklik A (2003) Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma. Journal of Allergy and Clinical Immunology, 111, 1041 1048.
12. Sanak M, Levy BD, Clish CB et al. (2000) Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics. European Respiratory Journal, 16, 44 49.
13. Hui Y, Funk CD (2002) Cysteinyl leukotriene receptors. Biochemical Pharmacology, 64, 1549 1557.
14. Capra V (2004) Molecular and functional aspects of human cysteinyl leukotriene receptors. Pharmacological Research, 50, 1 11.
15. Ciana P, Fumagalli M, Trincavelli ML et al. (2006) The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO Journal, 25, 4615 4627.
16. Sousa AR, Parikh A, Scadding G, Corrigan CJ, Lee TH (2002) Leukotriene receptor expression on nasal mucosal inflammatory cells in aspirin-sensitive rhinosinusitis. The New England Journal of Medicine, 347, 1493 1499.
17. Hamad AM, Sutcliffe AM, Knox AJ (2004) Aspirin-induced asthma: clinical aspects, pathogenesis and management. Drugs, 64, 2417 2432.
18. Szczeklik A, Nizankowska E, Bochenek G, Nagraba K, Mejza F, Swierczynska M (2001) Safety of a specific COX-2 inhibitor in aspirin-induced asthma. Clinical and Experimental Allergy, 31, 179 181.
19. Picado C, Fernandez-Morata JC, Juan M, Roca-Ferrer J, Fuentes M, Xaubet A, Mullol J (1999) Cyclooxygenase-2 mRNA is downexpressed in nasal polyps from aspirin-sensitive asthmatics. American Journal of Respiratory and Critical Care Medicine, 160, 291 296.
20. Kowalski ML, Pawliczak R, Wozniak J et al. (2000) Differential metabolism of arachidonic acid in nasal polyp epithelial cells cultured from aspirin-sensitive and aspirin tolerant patients. American Journal of Respiratory and Critical Care Medicine, 161, 391 398.
21. Pierzchalska M, Szabo Z, Sanak M, Soja J, Szczeklik A (2003) Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients with special reference to aspirin-induced asthma. The Journal of Allergy and Clinical Immunology, 111, 1041 1048.
22. Chambers LS, Black JL, Ge Q et al. (2003) PAR-2 activation, PGE2 and COX-2 in human asthmatics and nonasthmatic airway smooth muscles cells. American Journal of Physiology, 285, L619 L627.
23. Nasser S, Christie PE, Pfister R, Sousa AR, Walls A, Schmitz-Schumann M, Lee TH (1996) Effect of endobronchial aspirin challenge on inflammatory cells in bronchial biopsy samples from aspirin-sensitive asthmatics subjects. Thorax, 51, 64 70.
24. Nasser SM, Pfister R, Christie PE, Sousa AR, Barker J, Schmitz-Schumann M, Lee TH (1996) Inflammatory cell populations in bronchial biopsies from aspirin-sensitive asthmatic subjects. American Journal of Respiratory and Critical Care Medicine, 153, 90 96.
25. Min JW, Jang AS, Park SM, Lee SH, Lee JH, Park SW, Park CS (2005) Comparison of plasma eotaxin family level in aspirin-induced and aspirin-tolerant asthma patients. Chest, 128, 3127 3132.
26. Choi JH, Lee KW, Oh HB, Lee KJ, Suh YJ, Park CS, Park HS (2004) HLA association in aspirin-intolerant asthma: DPB1*0301 as a strong marker in a Korean population. The Journal of Allergy and Clinical Immunology, 113, 562 564.
27. Park HS, Kim SH, Sampson AP, Lee KW, Park CS (2004) The HLA-DPB1*0301 marker might predict the requirement for leukotriene receptor antagonist in patients with aspirin-tolerant asthma. The Journal of Allergy and Clinical Immunology, 114, 688 689.
28. Kim SH, Choi JH, Lee KW et al. (2005) The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria. Clinical and Experimental Allergy, 35, 339 344.
29. Sanak M, Simon HU, Szczeklik A (1997) Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma. Lancet, 350, 1599 1600.
30. Sanak M, Pierzchalska M, Bazan-Socha S, Szczeklik A (2000) Enhanced expression of the leukotriene C(4) synthase due to overactive transcription of an allelic variant associated with aspirin-intolerant asthma. American Journal of Respiratory Cell and Molec Biology, 23, 290 296.
31. Van Sambeek R, Stevenson DD, Baldasaro M et al. (2000) 5′ flanking region polymorphism of the gene encoding leukotriene C4 synthase does not correlate with the aspirin intolerant asthma phenotype in the United States. The Journal of Allergy and Clinical Immunology, 106, 72 76.
32. Kawagishi Y, Mita H, Taniguchi M et al. (2002) Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin-induced asthma. The Journal of Allergy and Clinical Immunology, 109, 936 942.
33. Kim SH, Bae JS, Suh CH, Nahm DH, Holloway JW, Park HS (2005) Polymorphism of tandem repeat in promoter of 5-lipoxygenase in ASA-intolerant asthma: a positive association with airway hyperresponsiveness. Allergy, 60, 760 765.
34. Kim SH, Choi JH, Holloway JW et al. (2005) Leukotriene-related gene polymorphisms in patients with aspirin-intolerant urticaria and aspirin-intolerant asthma: differing contributions of ALOX5 polymorphism in Korean population. Journal of Korean Medical Science, 20, 926 931.
35. Kim SH, Oh JM, Kim YS, Palmer LJ, Suh CH, Nahm DH, Park HS (2006) Cysteinyl leukotriene receptor 1 promoter polymorphism is associated with aspirin-intolerant asthma in males. Clinical and Experimental Allergy, 36, 433 439.
36. Kim SH, Ye YM, Hur GY et al. (2007) CysLTR1 promoter polymorphism and requirement of leukotriene receptor antagonist in aspirin-intolerant asthma patients. Pharmacogenomics, 8, 1143 1150.
37. Bae JS, Kim SH, Ye YM, Yoon HJ, Suh CH, Nahm DH, Park HS (2007) Significant association of FcepsilonRIalpha promoter polymorphisms with aspirin-intolerant chronic urticaria. The Journal of Allergy and Clinical Immunology, 119, 449 456.
38. Palikhe NS, Kim SH, Yang EM, Kang YM, Ye YM, Hur GY, Park HS (2008) Analysis of high-affinity IgE receptor (FcepsilonRI) polymorphisms in patients with aspirin intolerant chronic urticaria. Allergy and Asthma Proceeding, 29, 250 257.
39. Palikhe NS, Kim SH, Cho BY, Ye YM, Hur GY, Park HS (2008) Association of three sets of high-affinity IgE receptor (FcepsilonRI) polymorphisms with aspirin-intolerant asthma. Respiratory Medicine, 102, 1132 1139.
40. Kim SH, Kang YM, Kim SH, Cho BY, Ye YM, Hur GY, Park HS (2008) Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria. Allergy, accepted.
41. Jinnai N, Sakagami T, Sekigawa T et al. (2004) Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach. Human Molecular Genetics, 13, 3202 3217.
42. Kim SH, Choi JH, Park HS, Holloway JW, Lee SK, Park CS, Shin HD (2005) Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma. Clinical and Experimental Allergy, 35, 585 590.
43. Akahoshi M, Obara K, Hirota T et al. (2005) Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. Human Genetics, 117, 16 26.
44. Park JS, Chang HS, Park CS et al. (2005) Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics. Pharmacogenetics and Genomics, 15, 483 492.
45. Kim SH, Jeong HH, Cho BY et al. (2008) Association of four-locus gene interaction with aspirin-intolerant asthma in Korean asthmatics. Journal of Clinical Immunology, 28, 336 342.