AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats

Biochemical and Biophysical Research Communications

Volumn 443, Issue 3, 2014, Pages 852-857

  Igarashi, Maki ^a,b   Hippo, Yoshitaka ^a   Ochiai, Masako ^a   Fukuda, Hirokazu ^a   Nakagama, Hitoshi ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

AKT; Colon cancer; Obesity; PhIP; Rat; Susceptibility

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; BIOLOGICAL MARKER; CARCINOGEN; CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TRANSCRIPTOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COLON CANCER; COLON CARCINOGENESIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LOW FAT DIET; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; WNT SIGNALING PATHWAY;

RATTUS;

ABERRANT CRYPT FOCI; ACF; AKT; AMINO-1-METHYL-6-PHENYLIMIDAZO [4,5-B] PYRIDINE; COLON CANCER; GENE SET ENRICHMENT ANALYSIS; GSEA; HCA; HETEROCYCLIC AMINE; OBESITY; PHIP; RAT; SUSCEPTIBILITY;

ABERRANT CRYPT FOCI; ANIMALS; APOPTOSIS; CARCINOGENESIS; CARCINOGENS; CELL LINE; COLON; COLONIC NEOPLASMS; DIET; DIET, HIGH-FAT; DISEASE SUSCEPTIBILITY; ENZYME ACTIVATION; HUMANS; IMIDAZOLES; MALE; OBESITY; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, INBRED F344; WNT SIGNALING PATHWAY;

EID: 84893664426     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.12.059     Document Type: Article

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