Cannabinoid type-1 receptors in the paraventricular nucleus of the hypothalamus inhibit stimulated food intake

Neuroscience

Volumn 263, Issue , 2014, Pages 46-53

  Soria Gomez E ^a,c   Massa, F ^a,c   Bellocchio, L ^a,c,d   Rueda Orozco, P E ^b,e   Ciofi, P ^a,c   Cota, D ^a,c   Oliet, S H R ^a,c   Prospero Garcia O ^b   Marsicano, G ^a,c  

^a INSTITUT FRANÇOIS MAGENDIE   (France)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c UNIVERSITÉ DE BORDEAUX   (France)

^d UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^e Turing Center for Living Systems CENTURI Aix Marseille University   (France)

Author keywords

CB1; Fasting; Food intake; Ghrelin; Hypothalamus; Rats

Indexed keywords

CB1; FASTING; FOOD INTAKE; GHRELIN; HYPOTHALAMUS; RATS;

ANIMALS; CANNABINOID RECEPTOR ANTAGONISTS; GHRELIN; HYPERPHAGIA; MALE; MEMBRANE POTENTIALS; NEURONS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PIPERIDINES; PYRAZOLES; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1;

EID: 84893663638     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.01.005     Document Type: Article

References (36)

1. Alen F., Crespo I., Ramirez-Lopez M.T., Jagerovic N., Goya P., de Fonseca F.R., de Heras R.G., Orio L. Ghrelin-induced orexigenic effect in rats depends on the metabolic status and is counteracted by peripheral CB1 receptor antagonism. PLoS One 2013, 8:e60918.
2. Bellocchio L., Lafenetre P., Cannich A., Cota D., Puente N., Grandes P., Chaouloff F., Piazza P.V., Marsicano G. Bimodal control of stimulated food intake by the endocannabinoid system. Nat Neurosci 2010, 13:281-283.
3. Carlini V.P., Perez M.F., Salde E., Schioth H.B., Ramirez O.A., de Barioglio S.R. Ghrelin induced memory facilitation implicates nitric oxide synthase activation and decrease in the threshold to promote LTP in hippocampal dentate gyrus. Physiol Behav 2010, 101:117-123.
4. Chapman C.D., Dono L.M., French M.C., Weinberg Z.Y., Schuette L.M., Currie P.J. Paraventricular nucleus anandamide signaling alters eating and substrate oxidation. Neuroreport 2012, 23:425-429.
5. Cota D., Marsicano G., Lutz B., Vicennati V., Stalla G.K., Pasquali R., Pagotto U. Endogenous cannabinoid system as a modulator of food intake. Int J Obes Relat Metab Disord 2003, 27:289-301.
6. Cowley M.A., Smith R.G., Diano S., Tschop M., Pronchuk N., Grove K.L., Strasburger C.J., Bidlingmaier M., Esterman M., Heiman M.L., Garcia-Segura L.M., Nillni E.A., Mendez P., Low M.J., Sotonyi P., Friedman J.M., Liu H., Pinto S., Colmers W.F., Cone R.D., Horvath T.L. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 2003, 37:649-661.
7. Crosby K.M., Inoue W., Pittman Q.J., Bains J.S. Endocannabinoids gate state-dependent plasticity of synaptic inhibition in feeding circuits. Neuron 2011, 71:529-541.
8. Daigle T.L., Kearn C.S., Mackie K. Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling. Neuropharmacology 2008, 54:36-44.
9. Di Marzo V., Matias I. Endocannabinoid control of food intake and energy balance. Nat Neurosci 2005, 8:585-589.
10. Egecioglu E., Jerlhag E., Salome N., Skibicka K.P., Haage D., Bohlooly Y.M., Andersson D., Bjursell M., Perrissoud D., Engel J.A., Dickson S.L. Ghrelin increases intake of rewarding food in rodents. Addict Biology 2010, 15:304-311.
11. Glass M., Felder C.C. Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor. J Neurosci 1997, 17:5327-5333.
12. Grill H.J., Kaplan J.M. The neuroanatomical axis for control of energy balance. Front Neuroendocrinol 2002, 23:2-40.
13. Jo Y.H., Chen Y.J., Chua S.C., Talmage D.A., Role L.W. Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit. Neuron 2005, 48:1055-1066.
14. Kano M., Ohno-Shosaku T., Hashimotodani Y., Uchigashima M., Watanabe M. Endocannabinoid-mediated control of synaptic transmission. Physiol Rev 2009, 89:309-380.
15. Kirkham T.C., Williams C.M., Fezza F., Di Marzo V. Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. Br J Pharmacol 2002, 136:550-557.
16. Kola B., Farkas I., Christ-Crain M., Wittmann G., Lolli F., Amin F., Harvey-White J., Liposits Z., Kunos G., Grossman A.B., Fekete C., Korbonits M. The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. PLoS One 2008, 3:e1797.
17. Lauckner J.E., Hille B., Mackie K. The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins. Proc Natl Acad Sci U S A 2005, 102:19144-19149.
18. Leibowitz S.F., Hammer N.J., Chang K. Hypothalamic paraventricular nucleus lesions produce overeating and obesity in the rat. Physiol Behav 1981, 27:1031-1040.
19. Luther J.A., Tasker J.G. Voltage-gated currents distinguish parvocellular from magnocellular neurones in the rat hypothalamic paraventricular nucleus. J Physiol 2000, 523(Pt 1):193-209.
20. Malcher-Lopes R., Di S., Marcheselli V.S., Weng F.J., Stuart C.T., Bazan N.G., Tasker J.G. Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release. J Neurosci 2006, 26:6643-6650.
21. Morton G.J., Cummings D.E., Baskin D.G., Barsh G.S., Schwartz M.W. Central nervous system control of food intake and body weight. Nature 2006, 443:289-295.
22. Murakami N., Hayashida T., Kuroiwa T., Nakahara K., Ida T., Mondal M.S., Nakazato M., Kojima M., Kangawa K. Role for central ghrelin in food intake and secretion profile of stomach ghrelin in rats. J Endocrinol 2002, 174:283-288.
23. Nunes E.J., Randall P.A., Podurgiel S., Correa M., Salamone J.D. Nucleus accumbens neurotransmission and effort-related choice behavior in food motivation: Effects of drugs acting on dopamine, adenosine, and muscarinic acetylcholine receptors. Neurosci Biobehav Rev 2013, 37:2015-2025.
24. Pagotto U., Marsicano G., Cota D., Lutz B., Pasquali R. The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocr Rev 2006, 27:73-100.
25. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1986, Academic Press, S. Diego, CA, USA.
26. Piomelli D. The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 2003, 4:873-884.
27. Schlosburg J.E., Blankman J.L., Long J.Z., Nomura D.K., Pan B., Kinsey S.G., Nguyen P.T., Ramesh D., Booker L., Burston J.J., Thomas E.A., Selley D.E., Sim-Selley L.J., Liu Q.S., Lichtman A.H., Cravatt B.F. Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Nat Neurosci 2010, 13:1113-1119.
28. Shin A.C., Zheng H., Berthoud H.R. An expanded view of energy homeostasis: neural integration of metabolic, cognitive, and emotional drives to eat. Physiol Behav 2009, 97:572-580.
29. Simmons D.M., Swanson L.W. Comparison of the spatial distribution of seven types of neuroendocrine neurons in the rat paraventricular nucleus: toward a global 3D model. J Comp Neurol 2009, 516:423-441.
30. Small C.J., Bloom S.R. Gut hormones and the control of appetite. Trends Endocrinol Metab 2004, 15:259-263.
31. Soria-Gomez E., Matias I., Rueda-Orozco P.E., Cisneros M., Petrosino S., Navarro L., Di Marzo V., Prospero-Garcia O. Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. Br J Pharmacol 2007, 151:1109-1116.
32. Stefano G.B., Bilfinger T.V., Rialas C.M., Deutsch D.G. 2-arachidonyl-glycerol stimulates nitric oxide release from human immune and vascular tissues and invertebrate immunocytes by cannabinoid receptor 1. Pharmacol Res 2000, 42:317-322.
33. Tamura H., Kamegai J., Shimizu T., Ishii S., Sugihara H., Oikawa S. Ghrelin stimulates GH but not food intake in arcuate nucleus ablated rats. Endocrinology 2002, 143:3268-3275.
34. Tschop M., Smiley D.L., Heiman M.L. Ghrelin induces adiposity in rodents. Nature 2000, 407:908-913.
35. Tucci S.A., Rogers E.K., Korbonits M., Kirkham T.C. The cannabinoid CB1 receptor antagonist SR141716 blocks the orexigenic effects of intrahypothalamic ghrelin. Br J Pharmacol 2004, 143:520-523.
36. Verty A.N., McGregor I.S., Mallet P.E. Paraventricular hypothalamic CB(1) cannabinoid receptors are involved in the feeding stimulatory effects of Delta(9)-tetrahydrocannabinol. Neuropharmacology 2005, 49:1101-1109.