2-arachidonyl-glycerol stimulates nitric oxide release from human immune and vascular tissues and invertebrate immunocytes by cannabinoid receptor 1

Pharmacological Research

Volumn 42, Issue 4, 2000, Pages 317-322

  Stefano, George B ^a,b   Bilfinger, Thomas V ^a,b   Rialas, Christos M ^a   Deutsch, Dale G ^b  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

2 arachidonoyl glycerol; Endocannabinoid; Human; Nitric oxide; Vascular endothelia

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ANANDAMIDE; CANNABINOID; CANNABINOID RECEPTOR; CELL ADHESION MOLECULE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR;

ARTICLE; DRUG ACTIVITY; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INVERTEBRATE; LIGAND BINDING; LYMPHOCYTE; MONOCYTE; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RECEPTOR BINDING; VERTEBRATE;

EID: 0033801063     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.2000.0702     Document Type: Article

References (46)

1. Isolation and structure of a brain constituent that binds to the cannabinoid receptor
2. Search for endogenous ligands of the cannabinoid receptor
3. Biochemistry of the endogenous ligands of cannabinoid receptors
4. Anandamide (arachidonylethanolamide), a brain cannabinoid receptor agonist, reduces sperm fertilizing capacity in sea urchins by inhibiting the acrosome reaction
5. Identification and characterization of the leech CNS cannabinoid receptor: Coupling to nitric oxide release
6. Cannabinoid receptors are coupled to nitric oxide release in invertebrate immunocytes microglia, and human monocytes
7. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
8. 2-Arachidonoylglycerol: A possible endogenous cannabinoid receptor ligand in brain
9. An entourage effect: Inactive endogenous fatty acid glycerol esters enhance 2-arachidonoylglycerol cannbinoid activity
10. Release and degradation of the novel endogenous cannabimimetic metabolite 2-Arachidonoylglycerol in mouse neuroblastoma cells
11. A second endogenous cannabinoid that modulates long-term potentiation
12. Effects of putative cannabinoid receptor ligands, anandamide and 2-arachidonyl-glycerol, on immune function in B6C3F1 mouse splenocytes
13. 2-arachidonoyl-glycerol, putative endogenous cannabinoid, suppressed IL-2 expression by inhibition of NF-AT dependent transcription
14. 2+ transient in Ng108-15 cells
15. Inhibition by 2-Arachidonoylglycerol, a novel type of possible neuromodulator, of the depolarization-induced increase in intracellular free calcium in neuroblastoma x glioma hybrid Ng108-15 cells
16. Endocannabinoids
17. Morphine and anandamide stimulated nitric oxide production inhibits presynaptic dopamine release
18. Production and physiological actions of anandamide in the vasculature of the rat kidney
19. Pharmacological evidence for anandamide amidase in human cardiac and vascular tissues
20. Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor-Structure-activity relationship of 2-arachidonoylglycerolether-linked analogues, and related compounds
21. Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension
22. In vitro effects of electromagnetic fields on immunocytes
23. Stimulatory effects of opioid neuropeptides on locomotory activity and conformational changes in invertebrate and human immunocytes: Evidence for a subtype of delta receptor
24. Microscopic computer-assisted analysis of conformational state: Reference to neuroimmunology
25. (D-Ala2)-Deltorphin I binding and pharmacological evidence for a special subtype of delta opioid receptor on human and invertebrate immune cells
26. CD10 (CALLA)/neutral endopeptidase 24.11 modulates inflammatory peptide-induced changes in neutrophil morphology, migration, and adhesion proteins and is itself regulated by neutrophil activation
27. Opioid and opiate immunoregulatory processes
28. Antagonist of LPS and IFN-γ induction of iNOS in human saphenous vein endothelium by morphine and anandamide by nitric oxide inhibition of adenylate cyclase
29. Presence of the mu3 opiate receptor in endothelial cells: Coupling to nitric oxide production and vasodilation
30. Morphine-induced conformational changes in human monocytes, granulocytes, and endothelial cells and in invertebrate immunocytes and microglia are mediated by nitric oxide
31. Human vascular and cardiac endothelia express mu opiate receptor transcripts
32. Macrophage behavior associated with acute and chronic exposure to HIV GP120, morphine and anandamide: Endothelial implications
33. Suppressive effect of delta-9-tetrahydrocannabinol in vitro on phagocytosis by murine macrophages
34. Tetrahydrocannabinol-induced suppression of macrophage spreading and phagocytic activity in vitro
35. Suppression of human macrophage function in vitro by delta-9-tetrahydrocannabinol
36. Marijuana and immunity: Tetrahydrocannabinol-mediated inhibition of growth and phagocytic acitivity of the murine macrophage cell line, P388D1
37. Inhibition by delta-9-tetrahydrocannabinol of tumor necrosis factor alpha production by mouse and human macrophages
38. Inhibition of macrophage inducible protein expression by delta-9-tetrahydrocannabinol
39. Differential inhibition of RAW264.7 macrophage tumoricidal activity by delta 9tetrahydrocannabinol
40. Delta-9-tetrahydrocannabinol modulates antigen processing by macrophages
41. Autoimmunovascular regulation: Morphine and anandamide stimulated nitric oxide release
42. Mesenteric vasodilation mediated by endothelial anandamide receptor
43. Cardio vascular actions of cannabinoids and their generation during shock
44. Suppression of interleukin-2 by the putative endogenous cannabinoid 2-arachidonyl-glycerol is mediated through down-regulation of the nuclear factor of activated T cells
45. Morphine and anandamide stimulate intracellular calcium transients in human arterial endothelial cells: Coupling to nitric oxide release
46. Pharmacology of cannabinoid receptor ligands