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Volumn 6, Issue 3, 2014, Pages 272-283

The meta-genome of sepsis: Host genetics, pathogens and the acute immune response

Author keywords

Gene expression; Genetics; Meta genome; Microbiome; Sepsis

Indexed keywords

ALPHA2 INTERFERON; CD135 ANTIGEN; CXCL1 CHEMOKINE; EOTAXIN; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; FRACTALKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; INTERLEUKIN 9; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3;

EID: 84893649138     PISSN: 1662811X     EISSN: 16628128     Source Type: Journal    
DOI: 10.1159/000358835     Document Type: Review
Times cited : (39)

References (65)
  • 2
    • 33750047495 scopus 로고    scopus 로고
    • Management of sepsis
    • Russell JA: Management of sepsis. N Engl J Med 2006; 355: 1699-1713.
    • (2006) N Engl J Med , vol.355 , pp. 1699-1713
    • Russell, J.A.1
  • 11
    • 34547652674 scopus 로고    scopus 로고
    • National estimates of severe sepsis in United States emergency departments
    • Wang HE, Shapiro NI, Angus DC, Yealy DM: National estimates of severe sepsis in United States emergency departments. Crit Care Med 2007; 35: 1928-1936.
    • (2007) Crit Care Med , vol.35 , pp. 1928-1936
    • Wang, H.E.1    Shapiro, N.I.2    Angus, D.C.3    Yealy, D.M.4
  • 17
    • 0028957549 scopus 로고
    • Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome.0 A randomized, controlled, doubleblind, multicenter clinical trial
    • TNF-alpha MAb Sepsis Study Group
    • Abraham E, Wunderink R, Silverman H, Perl TM, Nasraway S, Levy H, Bone R, Wenzel RP, Balk R, Allred R, et al: Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, doubleblind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group. JAMA 1995; 273: 934-941.
    • (1995) JAMA , vol.273 , pp. 934-941
    • Abraham, E.1    Wunderink, R.2    Silverman, H.3    Perl, T.M.4    Nasraway, S.5    Levy, H.6    Bone, R.7    Wenzel, R.P.8    Balk, R.9    Allred, R.10
  • 18
    • 0029835023 scopus 로고    scopus 로고
    • INTERSEPT: An international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis
    • International Sepsis Trial Study Group
    • Cohen J, Carlet J: INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group. Crit Care Med 1996; 24: 1431-1440.
    • (1996) Crit Care Med , vol.24 , pp. 1431-1440
    • Cohen, J.1    Carlet, J.2
  • 21
    • 0023239471 scopus 로고
    • Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis
    • The Veterans Administration Systemic Sepsis Cooperative Study Group
    • Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. The Veterans Administration Systemic Sepsis Cooperative Study Group. N Engl J Med 1987; 317: 659-665.
    • (1987) N Engl J Med , vol.317 , pp. 659-665
  • 22
    • 0023252009 scopus 로고
    • A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock
    • Bone RC, Fisher CJ Jr, Clemmer TP, Slotman GJ, Metz CA, Balk RA: A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med 1987; 317: 653-658.
    • (1987) N Engl J Med , vol.317 , pp. 653-658
    • Bone, R.C.1    Fisher Jr., C.J.2    Clemmer, T.P.3    Slotman, G.J.4    Metz, C.A.5    Balk, R.A.6
  • 27
    • 77954959272 scopus 로고    scopus 로고
    • A survival benefit of combination antibiotic therapy for serious infections associated with sepsis and septic shock is contingent only on the risk of death: A meta-analytic/meta-regression study
    • Kumar A, Safdar N, Kethireddy S, Chateau D: A survival benefit of combination antibiotic therapy for serious infections associated with sepsis and septic shock is contingent only on the risk of death: a meta-analytic/meta- regression study. Crit Care Med 2010; 38: 1651-1664.
    • (2010) Crit Care Med , vol.38 , pp. 1651-1664
    • Kumar, A.1    Safdar, N.2    Kethireddy, S.3    Chateau, D.4
  • 28
    • 77956264846 scopus 로고    scopus 로고
    • Early antimicrobial therapy in severe sepsis and septic shock
    • Kumar A: Early antimicrobial therapy in severe sepsis and septic shock. Curr Infect Dis Rep 2010; 12: 336-344.
    • (2010) Curr Infect Dis Rep , vol.12 , pp. 336-344
    • Kumar, A.1
  • 29
    • 70350594710 scopus 로고    scopus 로고
    • Optimizing antimicrobial therapy in sepsis and septic shock
    • viii
    • Kumar A: Optimizing antimicrobial therapy in sepsis and septic shock. Crit Care Clin 2009; 25: 733-751, viii.
    • (2009) Crit Care Clin , vol.25 , pp. 733-751
    • Kumar, A.1
  • 30
    • 54049089677 scopus 로고    scopus 로고
    • Antimicrobial management of sepsis and septic shock
    • ix
    • Sharma S, Kumar A: Antimicrobial management of sepsis and septic shock. Clin Chest Med 2008; 29: 677-687, ix.
    • (2008) Clin Chest Med , vol.29 , pp. 677-687
    • Sharma, S.1    Kumar, A.2
  • 33
    • 84861362934 scopus 로고    scopus 로고
    • Microbiome: The critters within
    • Gravitz L: Microbiome: the critters within. Nature 2012; 485:S12-S13.
    • (2012) Nature , vol.485
    • Gravitz, L.1
  • 34
    • 14944375926 scopus 로고    scopus 로고
    • Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults
    • Sutherland AM, Walley KR, Russell JA: Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults. Crit Care Med 2005; 33: 638-644.
    • (2005) Crit Care Med , vol.33 , pp. 638-644
    • Sutherland, A.M.1    Walley, K.R.2    Russell, J.A.3
  • 35
    • 80054868277 scopus 로고    scopus 로고
    • Il17a genetic variation is associated with altered susceptibility to gram-positive infection and mortality of severe sepsis
    • Nakada TA, Russell JA, Boyd JH, Walley KR: Il17a genetic variation is associated with altered susceptibility to gram-positive infection and mortality of severe sepsis. Crit Care 2011; 15:R254.
    • (2011) Crit Care , vol.15
    • Nakada, T.A.1    Russell, J.A.2    Boyd, J.H.3    Walley, K.R.4
  • 36
    • 80052060185 scopus 로고    scopus 로고
    • A nonsynonymous polymorphism of IRAK4 associated with increased prevalence of Gram-positive infection and decreased response to Toll-like receptor ligands
    • Sutherland AM, Walley KR, Nakada TA, Sham AH, Wurfel MM, Russell JA: A nonsynonymous polymorphism of IRAK4 associated with increased prevalence of Gram-positive infection and decreased response to Toll-like receptor ligands. J Innate Immun 2011; 3: 447-458.
    • (2011) J Innate Immun , vol.3 , pp. 447-458
    • Sutherland, A.M.1    Walley, K.R.2    Nakada, T.A.3    Sham, A.H.4    Wurfel, M.M.5    Russell, J.A.6
  • 37
    • 84873888611 scopus 로고    scopus 로고
    • Genetic susceptibility to meningococcal infection
    • Dale AP, Read RC: Genetic susceptibility to meningococcal infection. Expert Rev Anti Infect Ther 2013; 11: 187-199.
    • (2013) Expert Rev Anti Infect Ther , vol.11 , pp. 187-199
    • Dale, A.P.1    Read, R.C.2
  • 39
    • 11844292713 scopus 로고    scopus 로고
    • The association of interleukin 6 haplotype clades with mortality in critically ill adults
    • Sutherland AM, Walley KR, Manocha S, Russell JA: The association of interleukin 6 haplotype clades with mortality in critically ill adults. Arch Intern Med 2005; 165: 75-82.
    • (2005) Arch Intern Med , vol.165 , pp. 75-82
    • Sutherland, A.M.1    Walley, K.R.2    Manocha, S.3    Russell, J.A.4
  • 40
    • 33845954994 scopus 로고    scopus 로고
    • Protein c-1641 AA is associated with decreased survival and more organ dysfunction in severe sepsis
    • Walley KR, Russell JA: Protein c-1641 AA is associated with decreased survival and more organ dysfunction in severe sepsis. Crit Care Med 2007; 35: 12-17.
    • (2007) Crit Care Med , vol.35 , pp. 12-17
    • Walley, K.R.1    Russell, J.A.2
  • 41
    • 45049085042 scopus 로고    scopus 로고
    • Protein C rs2069912 C allele is associated with increased mortality from severe sepsis in North Americans of East Asian ancestry
    • Russell JA, Wellman H, Walley KR: Protein C rs2069912 C allele is associated with increased mortality from severe sepsis in North Americans of East Asian ancestry. Hum Genet 2008; 123: 661-663.
    • (2008) Hum Genet , vol.123 , pp. 661-663
    • Russell, J.A.1    Wellman, H.2    Walley, K.R.3
  • 42
    • 79951836784 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in NFkappaB inducing kinase is associated with mortality in septic shock
    • Thair SA, Walley KR, Nakada TA, McConechy MK, Boyd JH, Wellman H, Russell JA: A single nucleotide polymorphism in NFkappaB inducing kinase is associated with mortality in septic shock. J Immunol 2011; 186: 2321-2328.
    • (2011) J Immunol , vol.186 , pp. 2321-2328
    • Thair, S.A.1    Walley, K.R.2    Nakada, T.A.3    McConechy, M.K.4    Boyd, J.H.5    Wellman, H.6    Russell, J.A.7
  • 43
    • 84867961219 scopus 로고    scopus 로고
    • AA genotype of IL-8 -251A/T is associated with low PaO(2)/FiO(2) in critically ill patients and with increased IL-8 expression
    • Wacharasint P, Nakada TA, Boyd JH, Russell JA, Walley KR: AA genotype of IL-8 -251A/T is associated with low PaO(2)/FiO(2) in critically ill patients and with increased IL-8 expression. Respirology 2012; 17: 1253-1260.
    • (2012) Respirology , vol.17 , pp. 1253-1260
    • Wacharasint, P.1    Nakada, T.A.2    Boyd, J.H.3    Russell, J.A.4    Walley, K.R.5
  • 48
    • 78650227047 scopus 로고    scopus 로고
    • Conventional and molecular techniques for the early diagnosis of bacteraemia
    • Paolucci M, Landini MP, Sambri V: Conventional and molecular techniques for the early diagnosis of bacteraemia. Int J Antimicrob Agents 2010; 36(suppl 2):S6-S16.
    • (2010) Int J Antimicrob Agents , vol.36 , Issue.SUPPL. 2
    • Paolucci, M.1    Landini, M.P.2    Sambri, V.3
  • 50
    • 66149087199 scopus 로고    scopus 로고
    • High levels of mecA DNA detected by a quantitative real-time PCR assay are associated with mortality in patients with methicillin-resistant Staphylococcus aureus bacteremia
    • Ho YC, Chang SC, Lin SR, Wang WK: High levels of mecA DNA detected by a quantitative real-time PCR assay are associated with mortality in patients with methicillin-resistant Staphylococcus aureus bacteremia. J Clin Microbiol 2009; 47: 1443-1451.
    • (2009) J Clin Microbiol , vol.47 , pp. 1443-1451
    • Ho, Y.C.1    Chang, S.C.2    Lin, S.R.3    Wang, W.K.4
  • 54
    • 78651466515 scopus 로고    scopus 로고
    • Diagnostic accuracy of a 16s ribosomal DNA gene-based molecular technique (rt-PCR, microarray, and sequencing) for bacterial meningitis, early- onset neonatal sepsis, and spontaneous bacterial peritonitis
    • Esparcia O, Montemayor M, Ginovart G, Pomar V, Soriano G, Pericas R, Gurgui M, Sulleiro E, Prats G, Navarro F, Coll P: Diagnostic accuracy of a 16s ribosomal DNA gene-based molecular technique (rt-PCR, microarray, and sequencing) for bacterial meningitis, early- onset neonatal sepsis, and spontaneous bacterial peritonitis. Diagn Microbiol Infect Dis 2011; 69: 153-160.
    • (2011) Diagn Microbiol Infect Dis , vol.69 , pp. 153-160
    • Esparcia, O.1    Montemayor, M.2    Ginovart, G.3    Pomar, V.4    Soriano, G.5    Pericas, R.6    Gurgui, M.7    Sulleiro, E.8    Prats, G.9    Navarro, F.10    Coll, P.11
  • 56
    • 84864235202 scopus 로고    scopus 로고
    • Using the rate of bacterial clearance determined by realtime polymerase chain reaction as a timely surrogate marker to evaluate the appropriateness of antibiotic usage in critical patients with Acinetobacter baumannii bacteremia
    • Chuang YC, Chang SC, Wang WK: Using the rate of bacterial clearance determined by realtime polymerase chain reaction as a timely surrogate marker to evaluate the appropriateness of antibiotic usage in critical patients with Acinetobacter baumannii bacteremia. Crit Care Med 2012; 40: 2273-2280.
    • (2012) Crit Care Med , vol.40 , pp. 2273-2280
    • Chuang, Y.C.1    Chang, S.C.2    Wang, W.K.3
  • 57
    • 72049096370 scopus 로고    scopus 로고
    • Detecting sepsis-associated bloodstream infection acquired in intensive care using multi-pathogen real-time PCR
    • Dark P, Chadwick P, Warhurst G: Detecting sepsis-associated bloodstream infection acquired in intensive care using multi-pathogen real-time PCR. J Infect 2009; 59: 296-298.
    • (2009) J Infect , vol.59 , pp. 296-298
    • Dark, P.1    Chadwick, P.2    Warhurst, G.3
  • 58
    • 70349779856 scopus 로고    scopus 로고
    • Clinical impact of a commercially available multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis
    • Dierkes C, Ehrenstein B, Siebig S, Linde HJ, Reischl U, Salzberger B: Clinical impact of a commercially available multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis. BMC Infect Dis 2009; 9: 126.
    • (2009) BMC Infect Dis , vol.9 , pp. 126
    • Dierkes, C.1    Ehrenstein, B.2    Siebig, S.3    Linde, H.J.4    Reischl, U.5    Salzberger, B.6
  • 60
    • 81155139734 scopus 로고    scopus 로고
    • Multiplex PCR pathogen detection in two severely burned patients with suspected septicemia
    • Tran NK, Greenhalgh DG, Palmieri TL, Kost GJ: Multiplex PCR pathogen detection in two severely burned patients with suspected septicemia. J Burn Care Res 2011; 32:e172-e177.
    • (2011) J Burn Care Res , vol.32
    • Tran, N.K.1    Greenhalgh, D.G.2    Palmieri, T.L.3    Kost, G.J.4
  • 63
    • 84878707113 scopus 로고    scopus 로고
    • Biomarkers of chemotherapy- induced diarrhoea: A clinical study of intestinal microbiome alterations, inflammation and circulating matrix metalloproteinases
    • Stringer AM, Al-Dasooqi N, Bowen JM, Tan TH, Radzuan M, Logan RM, Mayo B, Keefe DM, Gibson RJ: Biomarkers of chemotherapy- induced diarrhoea: a clinical study of intestinal microbiome alterations, inflammation and circulating matrix metalloproteinases. Support Care Cancer 2013; 21: 1843-1852.
    • (2013) Support Care Cancer , vol.21 , pp. 1843-1852
    • Stringer, A.M.1    Al-Dasooqi, N.2    Bowen, J.M.3    Tan, T.H.4    Radzuan, M.5    Logan, R.M.6    Mayo, B.7    Keefe, D.M.8    Gibson, R.J.9
  • 64
    • 0036146824 scopus 로고    scopus 로고
    • Determination of bacterial load by realtime PCR using a broad-range (universal) probe and primers set
    • Nadkarni MA, Martin FE, Jacques NA, Hunter N: Determination of bacterial load by realtime PCR using a broad-range (universal) probe and primers set. Microbiology 2002; 148: 257-266.
    • (2002) Microbiology , vol.148 , pp. 257-266
    • Nadkarni, M.A.1    Martin, F.E.2    Jacques, N.A.3    Hunter, N.4


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