Biomarkers of chemotherapy-induced diarrhoea: A clinical study of intestinal microbiome alterations, inflammation and circulating matrix metalloproteinases

Supportive Care in Cancer

Volumn 21, Issue 7, 2013, Pages 1843-1852

  Stringer, Andrea M ^a,b   Al Dasooqi, Noor ^b   Bowen, Joanne M ^b   Tan, Thean H ^c   Radzuan, Maryam ^a   Logan, Richard M ^b   Mayo, Bronwen ^b   Keefe, Dorothy M K ^b,c   Gibson, Rachel J ^b  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

Biomarkers; Matrix metalloproteinases; Microbiome; Mucositis

Indexed keywords

ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; CALGRANULIN; CAPECITABINE; CARBOPLATIN; CISPLATIN; FLUOROURACIL; FOLINIC ACID; GELATINASE A; GELATINASE B; GEMCITABINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; IRINOTECAN; MATRIX METALLOPROTEINASE; OXALIPLATIN; PACLITAXEL; STROMELYSIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ABDOMINAL CRAMP; ABDOMINAL PAIN; ADULT; ARTICLE; BACTERIUM CULTURE; BACTEROIDES; BIFIDOBACTERIUM; BLOATING; BLOOD SAMPLING; BREAST CANCER; CANCER PATIENT; CLINICAL ARTICLE; COLORECTAL CANCER; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; DNA EXTRACTION; ENTERITIS; ENTEROCOCCUS; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; ESOPHAGUS CANCER; FECES ANALYSIS; FEMALE; HUMAN; LACTOBACILLUS; LARYNX CANCER; MALE; MALIGNANT NEOPLASTIC DISEASE; MELANOMA; METHANOGENIC ARCHAEON; MICROBIOME; MUCOSA INFLAMMATION; NAUSEA AND VOMITING; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAPHYLOCOCCUS; STOMATITIS; UNSPECIFIED SIDE EFFECT; VOMITING;

AGED; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BIOLOGICAL MARKERS; COHORT STUDIES; DIARRHEA; FECES; FEMALE; HUMANS; INTERLEUKIN-1BETA; INTESTINES; MALE; MATRIX METALLOPROTEINASES; MICROBIOTA; MIDDLE AGED; MUCOSITIS; NEOPLASMS; NF-KAPPA B; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84878707113     PISSN: 09414355     EISSN: 14337339     Source Type: Journal    
DOI: 10.1007/s00520-013-1741-7     Document Type: Article

References (44)

1. Keefe DM, Schubert MM, Elting LS, Sonis ST, Epstein JB, Raber-Durlacher JE, Migliorati CA, McGuire DB, Hutchins RD, Peterson DE (2007) Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer 109(5):820-831
2. Gibson RJ, Bowen JM, Cummins AG, Keefe DM (2005) Relationship between dose of methotrexate, apoptosis, p53/p21 expression and intestinal crypt proliferation in the rat. Clin Exp Med 4(4):188-195
3. Logan RM, Gibson RJ, Bowen JM, Stringer AM, Sonis ST, Keefe DM (2008) Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis. Cancer Chemother Pharmacol 62(1):33-41
4. Bowen JM, Gibson RJ, Cummins AG, Tyskin A, Keefe DM (2007) Irinotecan changes gene expression in the small intestine of the rat with breast cancer. Cancer Chemother Pharmacol 59(3):337-348
5. Paris F, Fuks Z, Kang A, Capodieci P, Juan G, Ehleiter D, Haimovitz-Friedman A, Cordon-Cardo C, Kolesnick R (2001) Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 293:293-297
6. Gibson RJ, Bowen JM, Inglis MR, Cummins AG, Keefe DM (2003) Irinotecan causes severe small intestinal damage, as well as colonic damage, in the rat with implanted breast cancer. J Gastroenterol Hepatol 18(9):1095-1100
7. Stringer AM, Gibson RJ, Logan RM, Bowen JM, Yeoh AS, Burns J, Keefe DM (2007) Chemotherapy-induced diarrhea is associated with changes in the luminal environment in the DA rat. Exp Biol Med (Maywood) 232(1):96-106
8. Stringer AM, Gibson RJ, Logan RM, Bowen JM, Yeoh AS, Hamilton J, Keefe DM (2009) Gastrointestinal microflora and mucins may play a critical role in the development of 5-fluorouracil-induced gastrointestinal mucositis. Exp Biol Med (Maywood) 234(4):430-441
9. Al-Dasooqi N, Gibson RJ, Bowen JM, Logan RM, Stringer AM, Keefe DM (2010) Matrix metalloproteinases are possible mediators for the development of alimentary tract mucositis in the dark agouti rat. Exp Biol Med (Maywood) 235(10):1244-1256
10. Gibson RJ, Keefe DM (2006) Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies. Support Care Cancer 14(9):890-900
11. Elting LS, Cooksley C, Chambers M, Cantor SB, Manzullo E, Rubenstein EB (2003) The burdens of cancer therapy. Clinical and economic outcomes of chemotherapy-induced mucositis. Cancer 98(7):1531-1539
12. Savarese DM, Hsieh C, Stewart FM (1997) Clinical impact of chemotherapy dose escalation in patients with hematologic malignancies and solid tumors. J Clin Oncol 15(8):2981-2995
13. Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, Bekele BN, Raber-Durlacher J, Donnelly JP, Rubenstein EB (2004) Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100(9 Suppl):1995-2025
14. Costa F, Mumolo MG, Ceccarelli L, Bellini M, Romano MR, Sterpi C, Ricchiuti A, Marchi S, Bottai M (2005) Calprotectin is a stronger predictive marker of relapse in ulcerative colitis than in Crohn's disease. Gut 54(3):364-368
15. Foell D, Wittkowski H, Ren Z, Turton J, Pang G, Daebritz J, Ehrchen J, Heidemann J, Borody T, Roth J, Clancy R (2008) Phagocyte-specific S100 proteins are released from affected mucosa and promote immune responses during inflammatory bowel disease. J Pathol 216(2):183-192
16. Roseth AG (2003) Determination of faecal calprotectin, a novel marker of organic gastrointestinal disorders. Dig Liver Dis 35(9):607-609
17. Wedlake L, McGough C, Hackett C, Thomas K, Blake P, Harrington K, Tait D, Khoo V, Dearnaley D, Andreyev HJ (2008) Can biological markers act as non-invasive, sensitive indicators of radiation-induced effects in the gastrointestinal mucosa? Aliment Pharmacol Ther 27(10):980-987
18. van Vliet MJ, Tissing WJ, Rings EH, Koetse HA, Stellaard F, Kamps WA, de Bont ES (2009) Citrulline as a marker for chemotherapy induced mucosal barrier injury in pediatric patients. Pediatr Blood Cancer 53(7):1188-1194
19. Page-McCaw A, Ewald AJ, Werb Z (2007) Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol 8(3):221-233
20. Stankovic S, Konjevic G, Gopcevic K, Jovic V, Inic M, Jurisic V (2010) Activity of MMP-2 and MMP-9 in sera of breast cancer patients. Pathol Res Pract 206(4):241-247
21. Edwards KJ, Kaufmann ME, Saunders NA (2001) Rapid and accurate identification of coagulase-negative staphylococci by real-time PCR. J Clin Microbiol 39(9):3047-3051
22. Layton A, McKay L, Williams D, Garrett V, Gentry R, Sayler G (2006) Development of Bacteroides 16S rRNA gene TaqMan-based real-time PCR assays for estimation of total, human, and bovine fecal pollution in water. Appl Environ Microbiol 72(6):4214-4224
23. Matsuki T, Watanabe K, Fujimoto J, Takada T, Tanaka R (2004) Use of 16S rRNA gene-targeted group-specific primers for real-time PCR analysis of predominant bacteria in human feces. Appl Environ Microbiol 70(12):7220-7228
24. Penders J, Vink C, Driessen C, London N, Thijs C, Stobberingh EE (2005) Quantification of Bifidobacterium spp., Escherichia coli and Clostridium difficile in faecal samples of breast-fed and formula-fed infants by real-time PCR. FEMS Microbiol Lett 243(1):141-147
25. Rinttila T, Kassinen A, Malinen E, Krogius L, Palva A (2004) Development of an extensive set of 16S rDNA-targeted primers for quantification of pathogenic and indigenous bacteria in faecal samples by real-time PCR. J Appl Microbiol 97(6):1166-1177
26. Loitsch SM, Shastri Y, Stein J (2008) Stool test for colorectal cancer screening - it's time to move! Clin Lab 54(11-12):473-484
27. Stringer AM, Gibson RJ, Bowen JM, Logan RM, Yeoh AS, Keefe DM (2007) Chemotherapy-induced mucositis: the role of gastrointestinal microflora and mucins in the luminal environment. J Support Oncol 5(6):259-267
28. Lutgens LC, Blijlevens NM, Deutz NE, Donnelly JP, Lambin P, de Pauw BE (2005) Monitoring myeloablative therapy-induced small bowel toxicity by serum citrulline concentration: a comparison with sugar permeability tests. Cancer 103(1):191-199
29. Logan RM, Stringer AM, Bowen JM, Yeoh AS, Gibson RJ, Sonis ST, Keefe DM (2007) The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs. Cancer Treat Rev 33(5):448-460
30. Heller F, Duchmann R (2003) Intestinal flora and mucosal immune responses. Int J Med Microbiol 293(1):77-86
31. Smith NF, Figg WD, Sparreboom A (2006) Pharmacogenetics of irinotecan metabolism and transport: an update. Toxicol In Vitro 20(2):163-175
32. Wexler HM (2007) Bacteroides: the good, the bad, and the nitty-gritty. Clin Microbiol Rev 20(4):593-621
33. Neish AS (2002) The gut microflora and intestinal epithelial cells: a continuing dialogue. Microbes Infect 4(3):309-317
34. Cassel SL, Sutterwala FS, Flavell RA (2008) The tiny conductor: immune regulation via commensal organisms. Cell Host Microbe 3(6):340-341
35. McCartney AL, Wenzhi W, Tannock GW (1996) Molecular analysis of the composition of the bifidobacterial and lactobacillus microflora of humans. Appl Environ Microbiol 62(12):4608-4613
36. Masco L, Van Hoorde K, De Brandt E, Swings J, Huys G (2006) Antimicrobial sensitivity of Bifidobacterium strains from humans, animals and probiotic products. J Antimicrob Chemother 58:85-94
37. Gibson GR, Cummings JH, Macfarlane GT (1988) Competition for hydrogen between sulphate-reducing bacteria and methanogenic bacteria from the human large intestine. J Appl Bacteriol 65(3):241-247
38. Pimentel M, Kong Y, Park S (2004) BS subjects with methane on lactulose breath test have lower postprandial serotonin levels than subjects with hydrogen. Dig Dis Sci 49(1):84-87
39. Scanlan PD, Shanahan F, Marchesi JR (2008) Human methanogen diversity and incidence in healthy and diseased colonic groups using mcrA gene analysis. BMC Microbiol 8:79
40. Samuel BS, Shaito A, Motoike T, Rey FE, Backhed F, Manchester JK, Hammer RE, Williams SC, Crowley J, Yanagisawa M, Gordon JI (2008) Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci U S A 105(43):16767-16772
41. Kumar A, Wu H, Collier-Hyams LS, Hansen JM, Li T, Yamoah K, Pan ZQ, Jones DP, Neish AS (2007) Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species. EMBO J 26(21):4457-4466
42. Sonis ST (2004) The pathobiology of mucositis. Nat Rev Cancer 4(4):277-284
43. Al-Dasooqi N, Gibson RJ, Bowen JM, Keefe DM (2009) Matrix metalloproteinases: key regulators in the pathogenesis of chemotherapy-induced mucositis? Cancer Chemother Pharmacol 64(1):1-9
44. Gibson RJ, Bowen JM (2011) Biomarkers of regimen-related mucosal injury. Cancer Treat Rev 37(6):487-493