Thiazolopyridone ureas as DNA gyrase B inhibitors: Optimization of antitubercular activity and efficacy

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 3, 2014, Pages 870-879

  Kale, Ramesh R ^a   Kale, Manoj G ^a   Waterson, David ^a,b   Raichurkar, Anandkumar ^a   Hameed, Shahul P ^a   Manjunatha, M R ^a   Kishore Reddy, B K ^a   Malolanarasimhan, Krishnan ^a,c   Shinde, Vikas ^a   Koushik, Krishna ^a   Jena, Lalit Kumar ^a   Menasinakai, Sreenivasaiah ^a   Humnabadkar, Vaishali ^a   Madhavapeddi, Prashanti ^a   Basavarajappa, Halesha ^a   Sharma, Sreevalli ^a   Nandishaiah, Radha ^a   Kumar, K N Mahesh ^a,d   Ganguly, Samit ^a   Ahuja, Vijaykamal ^a,e   Gaonkar, Sheshagiri ^a,f   Naveen Kumar, C N ^a   Ogg, Derek ^a   Boriack Sjodin, P Ann ^a,g   Sambandamurthy, Vasan K ^a   De Sousa, Sunita M ^a   Ghorpade, Sandeep R ^a   more..

^a ASTRAZENECA   (United Kingdom)

^b AstraZeneca ^*  (Switzerland)

^c Dr Reddys Laboratories   (India)

^d IQVIA   (United States)

^e Agilent Technologies   (India)

^f Vipragen   (India)

^g EPIZYME INC   (United States)

Author keywords

DNA gyrase; GyrB; Thiazolopyridone ureas; Tuberculosis

Indexed keywords

ADENOSINE TRIPHOSPHATE; ARGININE; DNA TOPOISOMERASE (ATP HYDROLYSING) B; DNA TOPOISOMERASE INHIBITOR; ISONIAZID; THIAZOLOPYRIDONE UREA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; COLONY FORMING UNIT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; GROWTH INHIBITION; HYDROGEN BOND; IC 50; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; TUBERCULOSIS;

MYCOBACTERIUM TUBERCULOSIS;

DNA GYRASE; GYRB; THIAZOLOPYRIDONE UREAS; TUBERCULOSIS;

ADMINISTRATION, ORAL; ANIMALS; ANTITUBERCULAR AGENTS; DISEASE MODELS, ANIMAL; INHIBITORY CONCENTRATION 50; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PYRIDONES; THIAZOLES; TOPOISOMERASE II INHIBITORS; UREA;

EID: 84893648853     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.12.080     Document Type: Article

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