Novel topoisomerase inhibitors: Microbiological characterisation and in vivo efficacy of pyrimidines

International Journal of Antimicrobial Agents

Volumn 41, Issue 4, 2013, Pages 363-371

  Uria Nickelsen, Maria ^a   Neckermann, Georg ^a   Sriram, Shubha ^a   Andrews, Beth ^a   Manchester, John I ^a   Carcanague, Dan ^a   Stokes, Suzanne ^a   Hull, Kenneth G ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

DNA topology; Mode of action; Topoisomerase inhibition

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING) B; PROTEIN PARE; PYRIMIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BACTERIAL COUNT; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG EXPOSURE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG RESISTANCE; DRUG STRUCTURE; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; FEMALE; HAEMOPHILUS INFLUENZAE; IC 50; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MORAXELLA CATARRHALIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES;

ANIMALS; ANTI-BACTERIAL AGENTS; DISEASE MODELS, ANIMAL; DNA GYRASE; DNA TOPOISOMERASE IV; FEMALE; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE COCCI; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PNEUMONIA, PNEUMOCOCCAL; STREPTOCOCCUS PNEUMONIAE; TOPOISOMERASE INHIBITORS; TREATMENT OUTCOME;

EID: 84875370612     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2012.12.001     Document Type: Article

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