STAT4 is critical for immunity but not for antileishmanial activity of antimonials in experimental visceral leishmaniasis

European Journal of Immunology

Volumn 44, Issue 2, 2014, Pages 450-459

  Oghumu, Steve ^a,b   Gupta, Gaurav ^a   Snider, Heidi M ^a,b   Varikuti, Sanjay ^a   Terrazas, César A ^a   Papenfuss, Tracey L ^a   Kaplan, Mark H ^c   Satoskar, Abhay R ^a  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

IFN ; IL 12; Leishmania donovani; Sodium stibogluconate; STAT4 chemotherapy

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P35; INTERLEUKIN 12P70; INTERLEUKIN 4; MACROPHAGE DERIVED CHEMOKINE; MESSENGER RNA; PARASITE ANTIGEN; SSG; STAT4 PROTEIN; STIBOGLUCONATE SODIUM; UNCLASSIFIED DRUG;

AMASTIGOTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIPROTOZOAL ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; IMMUNOPATHOLOGY; IN VITRO STUDY; KNOCKOUT MOUSE; LEISHMANIA DONOVANI; LIVER GRANULOMA; LYMPHOCYTE SUBPOPULATION; MACROPHAGE; MOUSE; NONHUMAN; PARASITE CLEARANCE; PARASITE IMMUNITY; PARASITE LOAD; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN CELL; TH1 CELL; VISCERAL LEISHMANIASIS;

IFN-Γ; IL-12; LEISHMANIA DONOVANI; SODIUM STIBOGLUCONATE; STAT4 CHEMOTHERAPY;

ANIMALS; INTERLEUKIN-10; INTERLEUKIN-4; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; LIVER; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; SPLEEN; STAT4 TRANSCRIPTION FACTOR; TH1 CELLS;

EID: 84893585795     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201343477     Document Type: Article

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