1DUMMY Regulation of c-Fos gene expression by NF-κB: A p65 homodimer binding site in mouse embryonic fibroblasts but not human HEK293 cells

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Tu, Yu Cheng ^a   Huang, Duen Yi ^a   Shiah, Shine Gwo ^b   Wang, Jang Shiun ^a   Lin, Wan Wan ^a,c  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ELK1 PROTEIN, MOUSE; I KAPPA B KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN C FOS; TRANSCRIPTION FACTOR ELK 1; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; BINDING SITE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; ENZYME ACTIVATION; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; PROMOTER REGION; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; SIGNAL TRANSDUCTION;

ANIMALS; BASE SEQUENCE; BINDING SITES; ENZYME ACTIVATION; ETS-DOMAIN PROTEIN ELK-1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; I-KAPPA B KINASE; MICE; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTO-ONCOGENE PROTEINS C-FOS; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84893560379     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084062     Document Type: Article

References (50)

1. Wang Y, Prywes R (2000) Activation of the c-fos enhancer by the erk MAP kinase pathway through two sequence elements: the c-fos AP-1 and p62TCF sites. Oncogene 19: 1379-1385. (Pubitemid 30171168)
2. Delghandi MP, Johannessen M, Moens U (2005) The cAMP signalling pathway activates CREB through PKA, p38 and MSK1 in NIH 3T3 cells. Cell Signal 17: 1343-1351. (Pubitemid 41206644)
3. Wagner EF (2010) Bone development and inflammatory disease is regulated by AP-1 (Fos/Jun). Ann Rheum Dis 69 Suppl 1: i86-88.
4. Durchdewald M, Angel P, Hess J (2009) The transcription factor Fos: a Janus-type regulator in health and disease. Histol Histopathol 24: 1451-1461.
5. Ishihara Y, Ito F, Shimamoto N (2011) Increased expression of c-Fos by extracellular signal-regulated kinase activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosis. FEBS J 278: 1873-1881.
6. Johnson RS, Spiegelman BM, Papaioannou V (1992) Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell 71: 577-586.
7. Hazzalin CA, Mahadevan LC (2002) MAPK-regulated transcription: a continuously variable gene switch? Nat Rev Mol Cell Biol 3: 30-40. (Pubitemid 135709916)
8. Gille H, Kortenjann M, Thomae O, Moomaw C, Slaughter C, et al. (1995) ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J 14: 951-962.
9. Whitmarsh AJ, Shore P, Sharrocks AD, Davis RJ (1995) Integration of MAP kinase signal transduction pathways at the serum response element. Science 269: 403-407.
10. Whitmarsh AJ, Yang SH, Su MS, Sharrocks AD, Davis RJ (1997) Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors. Mol Cell Biol 17: 2360-2371. (Pubitemid 27175117)
11. Duan R, Xie W, Li X, McDougal A, Safe S (2002) Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum response factor in MCF-7 breast cancer cells. Biochem Biophys Res Commun 294: 384-394. (Pubitemid 34694107)
12. Ely HA, Mellon PL, Coss D (2011) GnRH induces the c-Fos gene via phosphorylation of SRF by the calcium/calmodulin kinase II pathway. Mol Endocrinol 25: 669-680.
13. Eto K, Hommyo A, Yonemitsu R, Abe S (2010) ErbB4 signals Neuregulin 1- stimulated cell proliferation and c-fos gene expression through phosphorylation of serum response factor by mitogen-activated protein kinase cascade. Mol Cell Biochem 339: 119-125.
14. Cen B, Selvaraj A, Burgess RC, Hitzler JK, Ma Z, et al. (2003) Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. Mol Cell Biol 23: 6597-6608. (Pubitemid 37075770)
15. Mayr B, Montminy M (2001) Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2: 599-609. (Pubitemid 33674011)
16. Zhang HM, Li L, Papadopoulou N, Hodgson G, Evans E, et al. (2008) Mitogen-induced recruitment of ERK and MSK to SRE promoter complexes by ternary complex factor Elk-1. Nucleic Acids Res 36: 2594-2607. (Pubitemid 351659574)
17. Oeckinghaus A, Hayden MS, Ghosh S (2011) Crosstalk in NF-kappaB signaling pathways. Nat Immunol 12: 695-708.
18. Vallabhapurapu S, Karin M (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 27: 693-733.
19. Fujioka S, Niu J, Schmidt C, Sclabas GM, Peng B, et al. (2004) NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity. Mol Cell Biol 24: 7806-7819. (Pubitemid 39121503)
20. Anest V, Cogswell PC, Baldwin AS Jr (2004) IkappaB kinase alpha and p65/RelA contribute to optimal epidermal growth factor-induced c-fos gene expression independent of IkappaBalpha degradation. J Biol Chem 279: 31183-31189. (Pubitemid 39037782)
21. Lancaster GI, Skiba B, Yang C, Nicholls HT, Langley KG, et al. (2012) IkappaB kinase beta (IKKbeta) does not mediate feedback inhibition of the insulin signalling cascade. Biochem J 442: 723-732.
22. Lawrence T, Bebien M, Liu GY, Nizet V, Karin M (2005) IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature 434: 1138-1143. (Pubitemid 40663493)
23. Makris C, Roberts JL, Karin M (2002) The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation. Mol Cell Biol 22: 6573-6581.
24. Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D (1995) Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 376: 167-170.
25. Dignam JD, Lebovitz RM, Roeder RG (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11: 1475-1489.
26. Remels AH, Langen RC, Gosker HR, Russell AP, Spaapen F, et al. (2009) PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle. Am J Physiol Endocrinol Metab 297: E174-183.
27. Liu Z, Garrard WT (2005) Long-range interactions between three transcriptional enhancers, active Vkappa gene promoters, and a 39 boundary sequence spanning 46 kilobases. Mol Cell Biol 25: 3220-3231. (Pubitemid 40464323)
28. Perkins ND (2007) Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 8: 49-62.
29. Yoboua F, Martel A, Duval A, Mukawera E, Grandvaux N (2010) Respiratory syncytial virus-mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK beta. J Virol 84: 7267-7277.
30. Geng H, Wittwer T, Dittrich-Breiholz O, Kracht M, Schmitz ML (2009) Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination. EMBO Rep 10: 381-386.
31. Shan B, Hagood JS, Zhuo Y, Nguyen HT, MacEwen M, et al. (2010) Thy-1 attenuates TNF-alpha-activated gene expression in mouse embryonic fibroblasts via Src family kinase. PLoS One 5: e11662.
32. Adli M, Baldwin AS (2006) IKK-i/IKKepsilon controls constitutive, cancer cell-associated NF-kappaB activity via regulation of Ser-536 p65/RelA phosphorylation. J Biol Chem 281: 26976-26984. (Pubitemid 44401726)
33. Bohuslav J, Chen LF, Kwon H, Mu Y, Greene WC (2004) p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1. J Biol Chem 279: 26115-26125. (Pubitemid 38798756)
34. Buss H, Dorrie A, Schmitz ML, Hoffmann E, Resch K, et al. (2004) Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including IkappaB kinase (IKK)-alpha, IKKbeta, IKKepsilon, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription. J Biol Chem 279: 55633-55643. (Pubitemid 40068850)
35. Madrid LV, Mayo MW, Reuther JY, Baldwin AS, Jr. (2001) Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38. J Biol Chem 276: 18934-18940.
36. Mandrekar P, Jeliazkova V, Catalano D, Szabo G (2007) Acute alcohol exposure exerts anti-inflammatory effects by inhibiting IkappaB kinase activity and p65 phosphorylation in human monocytes. J Immunol 178: 7686-7693. (Pubitemid 46898039)
37. Sakurai H, Chiba H, Miyoshi H, Sugita T, Toriumi W (1999) IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain. J Biol Chem 274: 30353-30356.
38. Hoberg JE, Popko AE, Ramsey CS, Mayo MW (2006) IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300. Mol Cell Biol 26: 457-471. (Pubitemid 43090920)
39. Shore P, Sharrocks AD (1994) The transcription factors Elk-1 and serum response factor interact by direct protein-protein contacts mediated by a short region of Elk-1. Mol Cell Biol 14: 3283-3291. (Pubitemid 24132741)
40. Yang SH, Shore P, Willingham N, Lakey JH, Sharrocks AD (1999) The mechanism of phosphorylation-inducible activation of the ETS-domain transcription factor Elk-1. EMBO J 18: 5666-5674. (Pubitemid 29486384)
41. Chen YQ, Ghosh S, Ghosh G (1998) A novel DNA recognition mode by the NF-kappa B p65 homodimer. Nat Struct Biol 5: 67-73. (Pubitemid 28048979)
42. Malek S, Huang DB, Huxford T, Ghosh S, Ghosh G (2003) X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex. J Biol Chem 278: 23094-23100. (Pubitemid 36830375)
43. Ganchi PA, Sun SC, Greene WC, Ballard DW (1993) A novel NF-kappa B complex containing p65 homodimers: implications for transcriptional control at the level of subunit dimerization. Mol Cell Biol 13: 7826-7835.
44. Kunsch C, Rosen CA (1993) NF-kappa B subunit-specific regulation of the interleukin-8 promoter. Mol Cell Biol 13: 6137-6146. (Pubitemid 23292608)
45. Sandersen C, Bureau F, Turlej R, Fievez L, Dogne S, et al. (2001) p65 Homodimer activity in distal airway cells determines lung dysfunction in equine heaves. Vet Immunol Immunopathol 80: 315-326. (Pubitemid 32655457)
46. Rahman A, Anwar KN, True AL, Malik AB (1999) Thrombin-induced p65 homodimer binding to downstream NF-kappa B site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion. J Immunol 162: 5466-5476. (Pubitemid 29307157)
47. Charital YM, van Haasteren G, Massiha A, Schlegel W, Fujita T (2009) A functional NF-kappaB enhancer element in the first intron contributes to the control of c-fos transcription. Gene 430: 116-122.
48. O'Donnell A, Yang SH, Sharrocks AD (2008) MAP kinase-mediated c-fos regulation relies on a histone acetylation relay switch. Mol Cell 29: 780-785. (Pubitemid 351400926)
49. Murray AJ (2008) Pharmacological PKA inhibition: all may not be what it seems. Sci Signal 1: re4.
50. Davies SP, Reddy H, Caivano M, Cohen P (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351: 95-105.