Therapeutic hypercapnia prevents inhaled nitric oxide-induced right-ventricular systolic dysfunction in juvenile rats

Free Radical Biology and Medicine

Volumn 69, Issue , 2014, Pages 35-49

  Dunlop, Kristyn ^a   Gosal, Kiranjot ^a,b   Kantores, Crystal ^a   Ivanovska, Julijana ^a   Dhaliwal, Rupinder ^a   Desjardins, Jean François ^c   Connelly, Kim A ^c,d   Jain, Amish ^a,b   McNamara, Patrick J ^a,b   Jankov, Robert P ^a,b,d  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Free radicals; iNOS; Interleukin 1; Pulmonary hypertension; Reactive nitrogen species; Right ventricle

Indexed keywords

CARBON DIOXIDE; ETANERCEPT; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1ALPHA; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYGEN; PEROXYNITRITE; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HEART RIGHT VENTRICLE FAILURE; HEART RIGHT VENTRICLE HYPERTROPHY; HYPERCAPNIA; INHALATION; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RIGHT VENTRICULAR SYSTOLIC DYSFUNCTION; SYSTOLIC DYSFUNCTION; THERAPEUTIC HYPERCAPNIA; UPREGULATION;

FREE RADICALS; INOS; INTERLEUKIN-1; PULMONARY HYPERTENSION; REACTIVE NITROGEN SPECIES; RIGHT VENTRICLE;

ANIMALS; CARBON DIOXIDE; HUMANS; HYPERCAPNIA; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; INTERLEUKIN-1; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RATS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84893513016     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.01.008     Document Type: Article

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