Chronic hypercapnia downregulates arginase expression and activity and increases pulmonary arterial smooth muscle relaxation in the newborn rat

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 297, Issue 4, 2009, Pages

  Belik, Jaques ^a,b,c,e   Stevens, Danielle ^d   Pan, Jingyi ^a   Shehnaz, Darakhshanda ^a   Ibrahim, Christine ^b   Kantores, Crystal ^b   Ivanovska, Julijana ^b   Grasemann, Hartmut ^a,b   Jankov, Robert P ^b,c  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d MAASTRICHT UNIVERSITY   (Netherlands)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Hypoxia; Nitric oxide; Pulmonary vascular resistance

Indexed keywords

ARGINASE; ARGINASE 1; CARBON DIOXIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTERY MUSCLE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; HYPERCAPNIA; HYPOXIA; LONG TERM EXPOSURE; LUNG VASCULAR RESISTANCE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; SMOOTH MUSCLE RELAXATION; SPRAGUE DAWLEY RAT; VASODILATATION;

ANIMALS; ANIMALS, NEWBORN; ANOXIA; ARGINASE; CARBON DIOXIDE; CHRONIC DISEASE; DOWN-REGULATION; FEMALE; HYPERCAPNIA; IMMUNOBLOTTING; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; VASODILATION;

EID: 70349770790     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00047.2009     Document Type: Article

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