Preparation of curcumin microemulsions with food-grade soybean oil/lecithin and their cytotoxicity on the HepG2 cell line

Food Chemistry

Volumn 154, Issue , 2014, Pages 282-290

  Lin, Chuan Chuan ^a   Lin, Hung Yin ^b   Chi, Ming Hung ^b   Shen, Chin Min ^c   Chen, Hwan Wen ^b   Yang, Wen Jen ^b   Lee, Mei Hwa ^c  

^a CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^b NATIONAL UNIVERSITY OF KAOHSIUNG   (Taiwan)

^c I SHOU UNIVERSITY   (Taiwan)

Author keywords

Curcumin; Cytotoxicity; Lecithin; Microemulsions; Soybean oil

Indexed keywords

CELL CULTURE; CYTOTOXICITY; FLUORESCENCE MICROSCOPY; LECITHIN; OILS AND FATS; PARTICLE SIZE; SOYBEAN OIL;

CURCUMIN; CYTOTOXIC EFFECTS; DIFFERENT PARTICLE SIZES; DIFFERENTIAL EFFECT; FOOD-GRADE SOYBEAN OIL; FUNCTIONAL FOODS; HEPG2 CELL LINE; SOYBEAN LECITHINS;

MICROEMULSIONS;

CURCUMIN; OLEIC ACID ETHYL ESTER; PHOSPHATIDYLCHOLINE; SOYBEAN OIL;

ARTICLE; CELL STRAIN HEK293; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; CYTOTOXICITY TEST; DOSE RESPONSE; DRUG STABILITY; EMBRYO; ENCAPSULATION; EVALUATION STUDY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; MICROEMULSION; PARTICLE SIZE;

CURCUMIN; CYTOTOXICITY; LECITHIN; MICROEMULSIONS; SOYBEAN OIL;

CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; CURCUMIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; EMULSIONS; HEK293 CELLS; HEP G2 CELLS; HUMANS; LECITHINS; PARTICLE SIZE; SOLUBILITY; SOYBEAN OIL; SURFACE-ACTIVE AGENTS;

EID: 84893483593     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2014.01.012     Document Type: Article

References (35)

1. B.B. Aggarwal, and K.B. Harikumar Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases Journal of Biochemistry & Cell Biology 41 1 2009 40 59
2. D. Attwood, C. Mallon, and C.J. Taylor Phase studies on oil-in-water phospholipid microemulsions International Journal of Pharmaceutics 84 2 1992 R5 R8
3. G. Bhatia, Y. Zhou, and A.K. Banga Adapalene microemulsion for transfollicular drug delivery Journal of Pharmaceutical Sciences 102 8 2013 2622 2631
4. A.L. Cheng, C.H. Hsu, J.K. Lin, M.M. Hsu, Y.F. Ho, and T.S. Shen et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions Anticancer Research 21 4B 2001 2895 2900
5. P.P. Constantinides Lipid microemulsions for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects Pharmaceutical Research 12 11 1995 1561 1572 (Pubitemid 26005509)
6. M. Fanun Microemulsions as delivery systems Current Opinion in Colloid & Interface Science 17 5 2012 306 313
7. T.P. Formariz, V.H.V. Sarmento, A.A. Silva-Junior, M.V. Scarpa, C.V. Santilli, and A.G. Oliveira Doxorubicin biocompatible O/W microemulsion stabilized by mixed surfactant containing soya phosphatidylcholine Colloids and Surfaces B: Biointerfaces 51 1 2006 54 61 (Pubitemid 44094026)
8. A.G. Gaonkar, and R.P. Bagwe Microemulsions in foods: Challenges and applications Surfactant Science Series 109 2003 407 430
9. N. Garti, A. Aserin, E. Wachtel, O. Gans, and Y. Shaul Water solubilization in nonionic microemulsions stabilized by grafted siliconic emulsifiers Journal of Colloid and Interface Science 233 2 2001 286 294
10. M. Ghosh, A.T.K. Singh, W. Xu, T. Sulchek, L.I. Gordon, and R.O. Ryan Curcumin nanodisks: Formulation and characterization Nanomedicine: Nanotechnology, Biology, and Medicine 7 2 2011 162 167
11. C.H. Hsu, Z. Cui, R.J. Mumper, and M. Jay Preparation and characterization of novel coenzyme Q10 nanoparticles engineered from microemulsion precursors AAPS PharmSciTech. 4 3 2003 24 35
12. S.R. Hwang, S.J. Lim, J.S. Park, and C.K. Kim Phospholipid-based microemulsion formulation of all-trans-retinoic acid for parenteral administration International Journal of Pharmaceutics 276 1-2 2004 175 183 (Pubitemid 38542997)
13. A. Kogan, and N. Garti Microemulsions as transdermal drug delivery vehicles Advances in Colloid and Interface Science 123-126 2006 369 385 (Pubitemid 44665819)
14. Y.S.R. Krishnaiah Pharmaceutical technologies for enhancing oral bioavailability of poorly soluble drugs Journal of Bioequivalence & Bioavailability 2 2 2010 28 36
15. C. Lao, M. Ruffin, D. Normolle, D. Heath, S. Murray, and J. Bailey et al. Dose escalation of a curcuminoid formulation BMC Complementary and Alternative Medicine 6 10 2006 1 4
16. M.H. Lee, L. Kao, and C.C. Lin Comparison of the antioxidant and transmembrane permeative activities of the different polygonum cuspidatum extracts in phospholipid-based microemulsions Journal of Agricultural and Food Chemistry 59 17 2011 9135 9141
17. M.H. Lee, H.Y. Lin, H.C. Chen, and J.L. Thomas Ultrasound mediates the release of curcumin from microemulsions Langmuir 24 5 2008 1707 1713 (Pubitemid 351500922)
18. M.H. Lee, M.W. Yu, L. Kao, and C.C. Lin Enhancement of the encapsulation and transmembrane permeation of isoflavone-containing red clover extracts in phospholipid-based microemulsions using different extraction processes Journal of Agricultural and Food Chemistry 57 20 2009 9489 9495
19. L. Li, F.S. Braiteh, and R. Kurzrock Liposome-encapsulated curcumin Cancer 104 6 2005 1322 1331
20. C.C. Lin, H.Y. Lin, H.C. Chen, M.W. Yu, and M.H. Lee Stability and characterisation of phospholipid-based curcumin-encapsulated microemulsions Food Chemistry 116 4 2009 923 928
21. H.Y. Lin, J.L. Thomas, H.W. Chen, C.M. Shen, W.J. Yang, and M.H. Lee In vitro suppression of oral squamous cell carcinoma growth by ultrasound-mediated delivery of curcumin microemulsions International Journal of Nanomedicine 7 2012 941 951
22. D. Mou, H. Chen, D. Du, C. Mao, J. Wan, and H. Xu et al. Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs International Journal of Pharmaceutics 353 1-2 2008 270 276
23. N. Patel, U. Schmid, and M.J. Lawrence Phospholipid-based microemulsions suitable for use in foods Journal of Agricultural and Food Chemistry 54 20 2006 7817 7824 (Pubitemid 44645807)
24. M.A. Polizelli, V.R.N. Telis, L.Q. Amaral, and E. Feitosa Formation and characterization of soy bean oil/surfactant/water microemulsions Colloids and Surfaces A: Physicochemical and Engineering Aspects 281 1-3 2006 230 236
25. V. Ravindranath, and N. Chandrasekhara Metabolism of curcumin-studies with [3H] curcumin Toxicology 22 4 1981 337 344
26. F.F. Sahle, H. Metz, J. Wohlrab, and R.H.H. Neubert Polyglycerol fatty acid ester surfactant-based microemulsions for targeted delivery of ceramide AP into the stratum corneum: Formulation, characterisation, in vitro release and penetration investigation European Journal of Pharmaceutics and Biopharmaceutics 82 1 2012 139 150
27. J. Shaikh, D.D. Ankola, V. Beniwal, D. Singh, and M.N.V.R. Kumar Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer European Journal of Pharmaceutical Sciences 37 3-4 2009 223 230
28. I.M. Shaikh, K.R. Jadhav, P.S. Gide, V.J. Kadam, and S.S. Pisal Topical delivery of aceclofenac from lecithin organogels: Preformulation study Current Drug Delivery 3 4 2006 417 427 (Pubitemid 44534054)
29. G. Shoba, D. Joy, T. Joseph, M. Majeed, R. Rajendran, and P.S.S.R. Srinivas Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers Planta Medica 64 04 1998 353 356 (Pubitemid 28234275)
30. S.S. Solanki, B. Sarkar, and R.K. Dhanwani Microemulsion drug delivery system: For bioavailability enhancement of ampelopsin ISRN Pharmaceutics 2012 2012 4
31. K. Thanki, R.P. Gangwal, A.T. Sangamwar, and S. Jain Oral delivery of anticancer drugs: Challenges and opportunities Journal of Controlled Release 170 1 2013 15 40
32. 2+ concentration European Journal of Pharmacology 650 1 2011 41 47
33. Y. Wang, K.C. Wu, B.X. Zhao, X. Zhao, X. Wang, and S. Chen et al. A novel paclitaxel microemulsion containing a reduced amount of cremophor el: Pharmacokinetics, biodistribution, and in vivo antitumor efficacy and safety Journal of Biomedicine and Biotechnology 2011 2011 1 10
34. M.M. Yallapu, M. Jaggi, and S.C. Chauhan Curcumin nanoformulations: A future nanomedicine for cancer Drug Discovery Today 17 1-2 2012 71 80
35. F.L. Yen, T.H. Wu, C.W. Tzeng, L.T. Lin, and C.C. Lin Curcumin nanoparticles improve the physicochemical properties of curcumin and effectively enhance its antioxidant and antihepatoma activities Journal of Agricultural and Food Chemistry 58 12 2010 7376 7382