Enhancement of the encapsulation and transmembrane permeation of isoflavone-containing red clover extracts in phospholipid-based microemulsions using different extraction processes

Journal of Agricultural and Food Chemistry

Volumn 57, Issue 20, 2009, Pages 9489-9495

  Lee, Mei Hwa ^a   Yu, Ming Wen ^b   Kao, Li ^c   Lin, Chuan Chuan ^b  

^a I SHOU UNIVERSITY   (Taiwan)

^b CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Encapsulation; Extraction; Isoflavones; Microemulsion; Red clover extract; Transmembrane permeation

Indexed keywords

ISOFLAVONE DERIVATIVE; PHOSPHOLIPID; PLANT EXTRACT; EMULSION;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CELL MEMBRANE PERMEABILITY; CHEMISTRY; CLOVER; DRUG EFFECT; DRUG FORMULATION; EMULSION; FRACTIONATION; IN VITRO STUDY; ISOLATION AND PURIFICATION; METABOLISM; MOUSE; SKIN; SOLID PHASE EXTRACTION; DRUG EFFECTS;

ANIMALS; CELL MEMBRANE PERMEABILITY; CHEMICAL FRACTIONATION; DRUG COMPOUNDING; EMULSIONS; ISOFLAVONES; MICE; MICE, INBRED BALB C; PHOSPHOLIPIDS; PLANT EXTRACTS; SKIN; SOLID PHASE EXTRACTION; TRIFOLIUM; IN VITRO TECHNIQUES;

TRIFOLIUM PRATENSE;

EID: 70350333883     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf902066g     Document Type: Article

References (29)

1. Magee, P. J,; Rowland, I. R. Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer. Br. J. Nutr. 2004. 91. 513-531.
2. Cornwell, T.; Cohich, W.; Raskin, I. Dietary phytoestrogens and health. Phvtochemistrv 2004, 65, 995-1016.
3. Albertazzi, P.; Purdie, D. W. The nature and utility of the phytoestrogens: a review of the evidence. Maturitas 2002, 42, 173-185.
4. Adlercreutz, H. (1995) Phytoestrogens: epidemiology and a possible role in cancer protection. Environ. Health Persnect. 1995, 103 (Suppl. 7), 103-112.
5. (5) Beck, V.; Rohr, U.; Jungbauer, A. Phytoestrogens derived from red clover: an alternative to estrogen replacement therapy? .7. Steroid Bioehem. Mol. Biol. 2005, 94, 499-518. (Pubitemid 40616410)
6. (6) Van De Weijer, P. H. M.; Barentsen, R. Isoflavones from, red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas 2002, 42, 187-193. (Pubitemid 34876810)
7. Jungbauer, A.; Beck, V. Yeast reporter system for rapid determination of estrogenic activity. J. Chromatoer. B: Anal. Technol. Blamed. Life Sci. 2002, 777, 167-178.
8. (8) Kreilgaard, M. Influence of microemulsions on cutaneous drug delivery. Adv. Drug Delivery Rev. 2002, 54 (Suppl. 1), S77-S98. (Pubitemid 35379956)
9. (9) Lundberg, B. Preparation of drug-earner emulsions stabilized with phosphatidylcholine-surfactant mixtures. J. Pharm. Sci. 1994, 83, 72-75. (Pubitemid 24233734)
10. Magdassi, S.; Siman-Tov, A. Formation and stabilization of perfluorocarbon emulsions. Int. J. Pharm. 1990, 59, 69-72.
11. Acosta, E. Bioavailability of nanoparticles in nutrient and nutraceutical delivery. Curr. Onin. Colloid Interface Sci. 2009, 14, 3-15.
12. Flanagan, J.; Singh, H. Microemulsions: a potential delivery system for bioactives in food. Crit Rev. Food Sci. Nutr.2006, 46, 221-237.
13. Garti, N.; Yaghmur, A.; Leser, M. E.; Clement, V.; Watzke, H. J. Improved oil solubilization in oil/water food grade microemulsions in the presence of polyols and ethanol. J. Agric Food Chem. 2001,49, 2552-2562.
14. Amar, I.; Aserin, A.; Garti, N. Solubilization patterns of lutein and lutein esters in food grade nonionic microemulsions. J. Agric. Food Chem. 2003. 51. 4775-4781.
15. Patel, N.; Schmid, U.; Lawrence, M. J. Phospholipid-based microemulsions suitable for use in foods. J. Agric. Food Chem. 2006, 54, 7817-7824.
16. (16) Spernath, A.; Aserin, A.; Sintov, A. C.; Garti, N. Phosphatidylcholine embedded micellar systems: enhanced permeability through rat skin. J. Colloid Interface Sci. Stí- 2008, 318, 421-429. (Pubitemid 350299374)
17. (17) Spernath, A.; Aserin, A.; Ziserman, L.; Danino, D.; Garti, N. Phosphatidylcholine embedded microemulsions: physical properties and improved Caco-2 cell, permeability. J. Contolled Release 2007, 119, 279-290. (Pubitemid 46770876)
18. Lin, C. C.; Lin, H. Y.; Chen, H. C.; Yu, M. W.; Lee, M. H. Stability and characterisation of phospholipid-based curcumin-encapsulated microemulsions. Food Chem. 2009, 116, 923-928.
19. Lee, S. H.; Kim, Y. H.; Yu, H. J.; Cho, N. S.; Kim, T. H.; Kim, D. C.; Chung, C. B.; Hwang, Y. I.; Kim, K. H. Enhanced bioavailability of soy isoflavones by complexation with β-cyclodextrin in rats. Biosci., Biotechnol., Biochem. 2007, 71, 2927-2933.
20. Quan, D. Q.; Xu, G. X.; Wu, X. G. Studies on preparation and absolute bioavailability of a self-emulsifying system, containing puerarin. Chem. Pharm. Bull. 2007, 55, 800-803.
21. (21) Balmelli-Gallacchi, P.; Schoumacher, F.; Liu, J. W.; Epenberger, U.; Mueller, H.; Picard, D. A yeast-based bioassay for the determination of functional and non-functional estrogen receptors. Nucleic Acids Res. 1999, 27, 1875-1881. (Pubitemid 29209630)
22. (22) Metzger, D.; White, J. H.; Chambon, P. The human oestrogen receptor functions in yeast. Nature 1988, 334, 31-36. (Pubitemid 18160548)
23. Guthrie, C.; Fink, G. R. Guide to Yeast Genetics and Molecular and Cell Biology, Methods in Enzymology; Academic Press: New York. 1991; Vol. 194.
24. Tomas-Barberan, F. A.; Blazquez, M. A.; Garcia-Viguera, C.; Ferreres, F.; Tomas-Lorente, F. A comparative study of different Amberlite XAD resins in flavonoid analysis. Phvtochem. Anal. 1992, 3, 178-181.
25. 2-ER-ERE-dependent gene expression in recombinant yeast and MCF-7 human breast cancer cells. Food Chem. 2008, 108, 719-726.
26. (26) Chen, H.; Chang, X.; Weng, T.; Zhao, X.; Gao, Z.; Yang, Y.; Xu, H.; Yang, X. A study of microemulsion systems for transdermal delivery of triptolide. J. Controlled Release 2004, 98, 427-436. (Pubitemid 39093953)
27. (27) Escribano, E.; Calpena, A. C.; Queralt, J.; Obach, R.; Domenech, J. Assessment of diclofenac permeation with, different formulations: anti-inflammatory study of a selected formula. Ew, J. Pharm. Sci. 2003, 19, 203-210. (Pubitemid 36918412)
28. Peltola, S.; Saarinen-Savolainen, P.; Kiesvaara, J.; Suhonen, T. M.; Urtti, A. Microemulsions for topical delivery of estradiol. Int. J. Pharm. 2003, 254, 99-107.
29. (29) Sintov, A. C.; Shapiro, L. New microemulsion vehicle facilitates percutaneous penetration in vitro and cutaneous drug bioavailability in vivo. J. Controlled Release 2004, 95, 173-183. (Pubitemid 38230033)