A novel paclitaxel microemulsion containing a reduced amount of cremophor EL: Pharmacokinetics, biodistribution, and in vivo antitumor efficacy and safety

Journal of Biomedicine and Biotechnology

Volumn 2011, Issue , 2011, Pages

  Zhang, Xuan ^a   Wang, Ying ^a,b   Wu, Ke Chun ^a   Zhao, Bing Xiang ^a   Zhao, Xin ^a   Wang, Xin ^a   Chen, Su ^a   Nie, Shu Fang ^b   Pan, Wei San ^b   Zhang, Qiang ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CREMOPHOR; PACLITAXEL; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; DRUG VEHICLE; GLYCEROL;

ANGIONEUROTIC EDEMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD CLOTTING; CONTINUOUS INFUSION; CONTROLLED STUDY; DROWSINESS; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG ERUPTION; DRUG FATALITY; DRUG FORMULATION; DRUG HYPERSENSITIVITY; DRUG RESPONSE; DRUG SAFETY; DYSPNEA; FEMALE; HEMOLYSIS; HYPEREMIA; LICKING; MANIA; MICROEMULSION; NONHUMAN; RAT; TISSUE DISTRIBUTION; TUMOR VOLUME; VOMITING; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DOG; DRUG SCREENING; EMULSION; EXPERIMENTAL NEOPLASM; HUMAN; MALE; METABOLISM; MOUSE; PARTICLE SIZE; PATHOLOGY; RABBIT; SPRAGUE DAWLEY RAT;

ANIMALIA;

ANIMALS; ANTINEOPLASTIC AGENTS; DOGS; EMULSIONS; FEMALE; GLYCEROL; HUMANS; MALE; MICE; MICE, INBRED BALB C; NEOPLASMS, EXPERIMENTAL; PACLITAXEL; PARTICLE SIZE; PHARMACEUTICAL VEHICLES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79952209187     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/854872     Document Type: Article

References (29)

1. Rowinsky E. K., Cazenave L. A., Donehower R. C., Taxol: a novel investigational antimicrotubule agent Jo (Pubitemid 20239995)
2. Gelderblom H., Verweij J., Nooter K., Sparreboom A., Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation European Journal of Cancer 2001 37 13 1590 1598 (Pubitemid 32778603)
3. Szebeni J., Alving C. R., Savay S., Barenholz Y., Priev A., Danino D., Talmon Y., Formation of complement-activating particles in aqueous solutions of Taxol: possible role in hypersensitivity reactions International Immunopharmacology 2001 1 4 721 735 (Pubitemid 32206533)
4. Rowinsky E. K., Eisenhauer E. A., Chaudhry V., Arbuck S. G., Donehower R. C., Clinical toxicities encountered with paclitaxel (TAXOL) Seminars in Oncology 1993 20 4 1 15 (Pubitemid 23239390)
5. Weiss R. B., Donehower R. C., Wiernik P. H., Ohnuma T., Gralla R. J., Trump D. L., Baker J. R., Van Echo D., Von Hoff D. D., Leyland-Jones B., Hypersensitivity reactions from taxol Journal of Clinical Oncology 1990 8 7 1263 1268 (Pubitemid 20195638)
6. Eisenhauer E. A., ten Bokkel Huinink W. W., Swenerton K. D., Gianni L., Myles J., Van Der Burg M. E. L., Kerr I., Vermorken J. B., Buser K., Colombo N., Bacon M., Santabrbara P., Onetto N., Winograd B., Canetta R., European-Canadian randomized trial of paclitaxel in relapsed ovarian cancer: high-dose versus low-dose and long versus short infusion Journal of Clinical Oncology 1994 12 12 2654 2666 (Pubitemid 24379653)
7. Singh S., Dash A. K., Paclitaxel in cancer treatment: perspectives and prospects of its delivery challenges Critical Reviews in Therapeutic Drug Carrier Systems 2009 26 4 333 372
8. Kim T. Y., Kim D. W., Chung J. Y., Shin S. G., Kim S. C., Heo D. S., Kim N. K., Bang Y. J., Phase I and pharmacokinetic study of Genexol-PM, a Cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies Clinical Cancer Research 2004 10 11 3708 3716 (Pubitemid 38697604)
9. Kim D. W., Kim S. Y., Kim H. K., Kim S. W., Shin S. W., Kim J. S., Park K., Lee M. Y., Heo D. S., Multicenter phase II trial of Genexol-PM, a novel Cremophor-free, polymeric micelle formulation of paclitaxel, with cisplatin in patients with advanced non-small-cell lung cancer Annals of Oncology 2007 18 12 2009 2014 (Pubitemid 350286241)
10. Mita A. C., Olszanski A. J., Walovitch R. C., Perez R. P., MacKay K., Tuck D. P., Simmons C., Hammond S., Mita M. M., Beeram M., Stone A. J., Rowinsky E. K., Lewis L. D., Phase I and pharmacokinetic study of AI-850, a novel microparticle hydrophobic drug delivery system for paclitaxel Clinical Cancer Research 2007 13 11 3293 3301 (Pubitemid 46944915)
11. Chao T. C., Chu Z., Tseng L. M., Chiou T. J., Hsieh R. K., Wang W. S., Yen C. C., Yang M. H., Hsiao L. T., Liu J. H., Chen PO. M., Paclitaxel in a novel formulation containing less Cremophor EL as first-line therapy for advanced breast cancer: a phase II trial Investigational New Drugs 2005 23 2 171 177 (Pubitemid 40386235)
12. Stinchcombe T. E., Nanoparticle albumin-bound paclitaxel: a novel Cremphor-EL-free formulation of paclitaxel Nanomedicine 2007 2 4 415 423 (Pubitemid 47365124)
13. Talegaonkar S., Azeem A., Ahmad F. J., Khar R. K., Pathan S. A., Khan Z. I., Microemulsions: a novel approach to enhanced drug delivery Recent Patents on Drug Delivery and Formulation 2008 2 3 238 257
14. Bagwe R. P., Kanicky J. R., Palla B. J., Patanjali P. K., Shah D. O., Improved drug delivery using microemulsions: rationale, recent progress, and new horizons Critical Reviews in Therapeutic Drug Carrier Systems 2001 18 1 77 140 (Pubitemid 32319398)
15. Lawrence M. J., Rees G. D., Microemulsion-based media as novel drug delivery systems Advanced Drug Delivery Reviews 2000 45 1 89 121
16. Malina I., Radomska-Soukharev A., Microemulsions with timolol as potential eye drops Pharmazie 2006 61 7 650 651 (Pubitemid 44098037)
17. Nornoo A. O., Osborne D. W., Chow D. S. L., Cremophor-free intravenous microemulsions for paclitaxel. I: formulation, cytotoxicity and hemolysis International Journal of Pharmaceutics 2008 349 1-2 108 116 (Pubitemid 350299695)
18. Nornoo A. O., Chow D. S. L., Cremophor-free intravenous microemulsions for paclitaxel. II. Stability, in vitro release and pharmacokinetics International Journal of Pharmaceutics 2008 349 1-2 117 123 (Pubitemid 350299696)
19. Hennenfent K. L., Govindan R., Novel formulations of taxanes: a review. Old wine in a new bottle? Annals of Oncology 2006 17 5 735 749
20. He L., Wang G. L., Zhang Q., An alternative paclitaxel microemulsion formulation: hypersensitivity evaluation and pharmacokinetic profile International Journal of Pharmaceutics 2003 250 1 45 50 (Pubitemid 35447936)
21. Poirier V. J., Hershey A. E., Burgess K. E., Phillips B., Turek M. M., Forrest L. J., Beaver L., Vail D. M., Efficacy and toxicity of paclitaxel (Taxol) for the treatment of canine malignant tumors Journal of Veterinary Internal Medicine 2004 18 2 219 222 (Pubitemid 38393633)
22. Liu X. R., Wu KE. C., Huang Y., Sun J. B., Ke XI. Y., Wang J. C., Lu W. L., Zhang X., Zhang Q., In vitro and in vivo studies on plasma-to-blood ratio of paclitaxel in human, rabbit and rat blood fractions Biological and Pharmaceutical Bulletin 2008 31 6 1215 1220 (Pubitemid 351871182)
23. Gelderblom H., Mross K., ten Tije A. J., Behringer D., Mielke S., Van Zomeren D. M., Verweij J., Sparreboom A., Comparative pharmacokinetics of unbound paclitaxel during 1- and 3-hour infusions Journal of Clinical Oncology 2002 20 2 574 581 (Pubitemid 34072542)
24. Crown J., O'Leary M., The taxanes: an update The Lancet 2000 355 9210 1176 1178 (Pubitemid 30172946)
25. Szebeni J., Muggia F. M., Alving C. R., Complement activation by Cremophor EL as a possible contributor to hypersensitivity to paclitaxel: an in vitro study Journal of the National Cancer Institute 1998 90 4 300 306 (Pubitemid 28182386)
26. Szebeni J., Alving C. R., Rosivall L., Bnger R., Baranyi L., Bedcs P., Tth M., Barenholz Y., Animal models of complement-mediated hypersensitivity reactions to liposomes and other lipid-based nanoparticles Journal of Liposome Research 2007 17 2 107 117 (Pubitemid 47026981)
27. Ennis M., Lorenz W., Kapp B., Comparison of the histamine-releasing activity of cremophor E1 and some of its derivatives in two experimental models: the in vivo anaesthetized dog and in vitro rat peritoneal mast cells Agents and Actions 1985 16 3-4 265 268 (Pubitemid 15116711)
28. Howrie D. L., Ptachcinski R. J., Griffith B. P., Anaphylactoid reactions associated with parenteral cyclosporine use: possible role of Cremophor EL Drug Intelligence and Clinical Pharmacy 1985 19 6 425 427 (Pubitemid 15056453)
29. O'Dwyer P. J., King S. A., Fortner C. L., Leyland-Jones B., Hypersensitivity reactions to teniposide (VM-26): an analysis Journal of Clinical Oncology 1986 4 8 1262 1269 (Pubitemid 16043878