-
1
-
-
57049089995
-
-
doi:10.1016/j.devcel.2008.11.010
-
Jiang, J.; Hui, C.-c. Dev. Cell 2008, 15, 801-812. doi:10.1016/j.devcel. 2008.11.010
-
(2008)
Dev. Cell
, vol.15
, pp. 801-812
-
-
Jiang, J.1
Hui, C.-C.2
-
2
-
-
34247857432
-
Pathways of signal transduction employed by vertebrate Hedgehogs
-
DOI 10.1042/BJ20061723
-
Riobo, N. A.; Manning, D. R. Biochem. J. 2007, 403, 369-379. doi:10.1042/BJ20061723 (Pubitemid 46706966)
-
(2007)
Biochemical Journal
, vol.403
, Issue.3
, pp. 369-379
-
-
Riobo, N.A.1
Manning, D.R.2
-
4
-
-
0027423758
-
-
doi:10.1126/science.8378770 See for the X-ray structure of GLI-DNA complex.
-
Pavletich, N. P.; Pabo, C. O. Science 1993, 261, 1701-1707. doi:10.1126/science.8378770 See for the X-ray structure of GLI-DNA complex.
-
(1993)
Science
, vol.261
, pp. 1701-1707
-
-
Pavletich, N.P.1
Pabo, C.O.2
-
6
-
-
33751549095
-
Targeting the Hedgehog pathway in cancer
-
DOI 10.1038/nrd2086, PII NRD2086
-
Rubin, L. L.; de Sauvage, F. J. Nat. Rev. Drug Discovery 2006, 5, 1026-1033. doi:10.1038/nrd2086 (Pubitemid 44835129)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.12
, pp. 1026-1033
-
-
Rubin, L.L.1
De Sauvage, F.J.2
-
8
-
-
0036829397
-
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
-
DOI 10.1101/gad.1025302
-
Chen, J. K.; Taipale, J.; Cooper, M. K.; Beachy, P. A. Genes Dev. 2002, 16, 2743-2748. doi:10.1101/gad.1025302 (Pubitemid 35253140)
-
(2002)
Genes and Development
, vol.16
, Issue.21
, pp. 2743-2748
-
-
Chen, J.K.1
Taipale, J.2
Cooper, M.K.3
Beachy, P.A.4
-
9
-
-
0031723219
-
-
Incardona, J. P.; Gaffield, W.; Kapur, R. P.; Roelink, H. Development 1998, 125, 3553-3562.
-
(1998)
Development
, vol.125
, pp. 3553-3562
-
-
Incardona, J.P.1
Gaffield, W.2
Kapur, R.P.3
Roelink, H.4
-
10
-
-
0037447269
-
Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions
-
DOI 10.1073/pnas.0732813100
-
Williams, J. A.; Guicherit, O. M.; Zaharian, B. I.; Xu, Y.; Chai, L.; Wichterle, H.; Kon, C.; Gatchalian, C.; Porter, J. A.; Rubin, L. L.; Wang, F. Y. Proc. Natl. Acad. Sci. U. S. A. 2003, 100, 4616-4621. doi:10.1073/pnas. 0732813100 (Pubitemid 36457779)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.8
, pp. 4616-4621
-
-
Williams, J.A.1
Guicherit, O.M.2
Zaharian, B.I.3
Xu, Y.4
Chai, L.5
Wichterle, H.6
Kon, C.7
Gatchalian, C.8
Porter, J.A.9
Rubin, L.L.10
Wang, F.Y.11
-
11
-
-
0037195074
-
Small molecule modulation of smoothened activity
-
DOI 10.1073/pnas.182542899
-
Chen, J. K.; Taipale, J.; Young, K. E.; Maiti, T.; Beachy, P. A. Proc. Natl. Acad. Sci. U. S. A. 2002, 99, 14071-14076. doi:10.1073/pnas.182542899 (Pubitemid 35257626)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.22
, pp. 14071-14076
-
-
Chen, J.K.1
Taipale, J.2
Young, K.E.3
Maiti, T.4
Beachy, P.A.5
-
12
-
-
60249088794
-
-
doi:10.1038/nchembio.142
-
Stanton, B. Z.; Peng, L. F.; Maloof, N.; Nakai, K.; Wang, X.; Duffner, J. L.; Taveras, K. M.; Hyman, J. L.; Lee, S. W.; Koehler, A. N.; Chen, J. K.; Fox, J. L.; Mandinova, A.; Schreiber, S. L. Nat. Chem. Biol. 2009, 5, 154-156. doi:10.1038/nchembio.142
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 154-156
-
-
Stanton, B.Z.1
Peng, L.F.2
Maloof, N.3
Nakai, K.4
Wang, X.5
Duffner, J.L.6
Taveras, K.M.7
Hyman, J.L.8
Lee, S.W.9
Koehler, A.N.10
Chen, J.K.11
Fox, J.L.12
Mandinova, A.13
Schreiber, S.L.14
-
13
-
-
37549047672
-
-
doi:10.1002/cbic.200700403
-
Lee, J.; Wu, X.; Pasca di Magliano, M.; Peters, E. C.; Wang, Y.; Hong, J.; Hebrok, M.; Ding, S.; Cho, C. Y.; Schultz, P. G. ChemBioChem 2007, 8, 1916-1919. doi:10.1002/cbic.200700403
-
(2007)
ChemBioChem
, vol.8
, pp. 1916-1919
-
-
Lee, J.1
Wu, X.2
Pasca Di Magliano, M.3
Peters, E.C.4
Wang, Y.5
Hong, J.6
Hebrok, M.7
Ding, S.8
Cho, C.Y.9
Schultz, P.G.10
-
14
-
-
34249867843
-
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
-
DOI 10.1073/pnas.0609699104
-
Lauth, M.; Bergström, Å.; Shimokawa, T.; Toftgård, R. Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 8455-8460. doi:10.1073/pnas. 0609699104 (Pubitemid 47175509)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.20
, pp. 8455-8460
-
-
Lauth, M.1
Bergstrom, A.2
Shimokawa, T.3
Toftgard, R.4
-
15
-
-
69549138464
-
-
doi:10.1073/pnas.0907134106
-
Hyman, J. M.; Firestone, A. J.; Heine, V. M.; Zhao, Y.; Ocasio, C. A.; Han, K.; Sun, M.; Rack, P. G.; Sinha, S.; Wu, J. J.; Solow-Cordero, D. E.; Jiang, J.; Rowitch, D. H.; Chen, J. K. Proc. Natl. Acad. Sci. U. S. A. 2009, 106, 14132-14137. doi:10.1073/pnas.0907134106
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 14132-14137
-
-
Hyman, J.M.1
Firestone, A.J.2
Heine, V.M.3
Zhao, Y.4
Ocasio, C.A.5
Han, K.6
Sun, M.7
Rack, P.G.8
Sinha, S.9
Wu, J.J.10
Solow-Cordero, D.E.11
Jiang, J.12
Rowitch, D.H.13
Chen, J.K.14
-
16
-
-
84862814996
-
-
doi:10.1038/nature10936
-
Firestone, A. J.; Weinger, J. S.; Maldonado, M.; Barlan, K.; Langston, L. D.; O'Donnell, M.; Gelfand, V. I.; Kapoor, T. M.; Chen, J. K. Nature 2012, 484, 125-129. doi:10.1038/nature10936
-
(2012)
Nature
, vol.484
, pp. 125-129
-
-
Firestone, A.J.1
Weinger, J.S.2
Maldonado, M.3
Barlan, K.4
Langston, L.D.5
O'donnell, M.6
Gelfand, V.I.7
Kapoor, T.M.8
Chen, J.K.9
-
17
-
-
46649095470
-
-
doi:10.1002/cbic.200700511
-
Hosoya, T.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. ChemBioChem 2008, 9, 1082-1092. doi:10.1002/cbic.200700511
-
(2008)
ChemBioChem
, vol.9
, pp. 1082-1092
-
-
Hosoya, T.1
Arai, M.A.2
Koyano, T.3
Kowithayakorn, T.4
Ishibashi, M.5
-
18
-
-
53749085689
-
-
doi:10.1016/j.bmc.2008.09.053
-
Arai, M. A.; Tateno, C.; Hosoya, T.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. Bioorg. Med. Chem. 2008, 16, 9420-9424. doi:10.1016/j.bmc.2008.09. 053
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 9420-9424
-
-
Arai, M.A.1
Tateno, C.2
Hosoya, T.3
Koyano, T.4
Kowithayakorn, T.5
Ishibashi, M.6
-
19
-
-
79551661875
-
-
doi:10.1039/c0ob00677g
-
Arai, M. A.; Tateno, C.; Koyano, T.; Kowithayakorn, T.; Kawabe, S.; Ishibashi, M. Org. Biomol. Chem. 2011, 9, 1133-1139. doi:10.1039/c0ob00677g
-
(2011)
Org. Biomol. Chem.
, vol.9
, pp. 1133-1139
-
-
Arai, M.A.1
Tateno, C.2
Koyano, T.3
Kowithayakorn, T.4
Kawabe, S.5
Ishibashi, M.6
-
20
-
-
77952970051
-
-
doi:10.1021/np1000818
-
Rifai, Y.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. J. Nat. Prod. 2010, 73, 995-997. doi:10.1021/np1000818
-
(2010)
J. Nat. Prod.
, vol.73
, pp. 995-997
-
-
Rifai, Y.1
Arai, M.A.2
Koyano, T.3
Kowithayakorn, T.4
Ishibashi, M.5
-
21
-
-
78651225643
-
-
doi:10.1016/j.bmcl.2010.11.126
-
Rifai, Y.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. Bioorg. Med. Chem. Lett. 2011, 21, 718-722. doi:10.1016/j.bmcl.2010.11.126
-
(2011)
Bioorg. Med. Chem. Lett.
, vol.21
, pp. 718-722
-
-
Rifai, Y.1
Arai, M.A.2
Sadhu, S.K.3
Ahmed, F.4
Ishibashi, M.5
-
22
-
-
84875866140
-
-
doi:10.1039/c3mb25567k
-
Arai, M. A.; Fujimatsu, T.; Uchida, K.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. Mol. BioSyst. 2013, 9, 1012-1018. doi:10.1039/c3mb25567k
-
(2013)
Mol. BioSyst.
, vol.9
, pp. 1012-1018
-
-
Arai, M.A.1
Fujimatsu, T.2
Uchida, K.3
Sadhu, S.K.4
Ahmed, F.5
Ishibashi, M.6
-
23
-
-
0029609561
-
Structural revision of physalin H isolated from Physalis angulata
-
DOI 10.1021/np50125a004
-
Makino, B.; Kawai, M.; Ogura, T.; Nakanishi, M.; Yamamura, H.; Butsugan, Y. J. Nat. Prod. 1995, 58, 1668-1674. doi:10.1021/np50125a004 (Pubitemid 26051588)
-
(1995)
Journal of Natural Products
, vol.58
, Issue.11
, pp. 1668-1674
-
-
Makino, B.1
Kawai, M.2
Ogura, T.3
Nakanishi, M.4
Yamamura, H.5
Butsugan, Y.6
-
24
-
-
15444363860
-
-
doi:10.1016/0031-9422(80)83078-0
-
Row, L. R.; Reddy, K. S.; Sarma, N. S.; Matsuura, T.; Nakashima, R. Phytochemistry 1980, 19, 1175-1181. doi:10.1016/0031-9422(80)83078-0
-
(1980)
Phytochemistry
, vol.19
, pp. 1175-1181
-
-
Row, L.R.1
Reddy, K.S.2
Sarma, N.S.3
Matsuura, T.4
Nakashima, R.5
-
25
-
-
0029030919
-
-
doi:10.1246/bcsj.68.219
-
Makino, B.; Kawai, M.; Iwata, Y.; Yamaura, H.; Butsugan, Y.; Ogawa, K.; Hayashi, M. Bull. Chem. Soc. Jpn. 1995, 68, 219-226. doi:10.1246/bcsj.68.219
-
(1995)
Bull. Chem. Soc. Jpn.
, vol.68
, pp. 219-226
-
-
Makino, B.1
Kawai, M.2
Iwata, Y.3
Yamaura, H.4
Butsugan, Y.5
Ogawa, K.6
Hayashi, M.7
-
26
-
-
0001649791
-
-
doi:10.1016/0031-9422(93)80040-Y
-
Sunayama, R.; Kuroyanagi, M.; Umehara, K.; Ueno, A. Phytochemistry 1992, 34, 529-533. doi:10.1016/0031-9422(93)80040-Y
-
(1992)
Phytochemistry
, vol.34
, pp. 529-533
-
-
Sunayama, R.1
Kuroyanagi, M.2
Umehara, K.3
Ueno, A.4
-
27
-
-
49349136512
-
-
doi:10.1016/S0031-9422(00)94660-0
-
Row, L. R.; Sarma, N. S.; Reddy, K. S.; Matsuura, T.; Nakashima, R. Phytochemistry 1978, 17, 1647-1650. doi:10.1016/S0031-9422(00)94660-0
-
(1978)
Phytochemistry
, vol.17
, pp. 1647-1650
-
-
Row, L.R.1
Sarma, N.S.2
Reddy, K.S.3
Matsuura, T.4
Nakashima, R.5
-
28
-
-
0028264958
-
-
doi:10.1246/bcsj.67.222
-
Kawai, M.; Makino, B.; Taga, T.; Miwa, Y.; Yamamoto, T.; Furuta, T.; Yamamura, H.; Butsugan, Y.; Ogawa, K.; Hayashi, M. Bull. Chem. Soc. Jpn. 1994, 67, 222-226. doi:10.1246/bcsj.67.222
-
(1994)
Bull. Chem. Soc. Jpn.
, vol.67
, pp. 222-226
-
-
Kawai, M.1
Makino, B.2
Taga, T.3
Miwa, Y.4
Yamamoto, T.5
Furuta, T.6
Yamamura, H.7
Butsugan, Y.8
Ogawa, K.9
Hayashi, M.10
-
29
-
-
0000064713
-
-
doi:10.1016/S0040-4020(01)93024-8
-
Kawai, M.; Matsuura, T. Tetrahedron 1970, 26, 1743-1745. doi:10.1016/S0040-4020(01)93024-8
-
(1970)
Tetrahedron
, vol.26
, pp. 1743-1745
-
-
Kawai, M.1
Matsuura, T.2
-
30
-
-
38649132910
-
An integrated approach identifies Nhlh1 and Insm1 as sonic hedgehog-regulated genes in developing cerebellum and medulloblastoma
-
DOI 10.1593/neo.07891
-
De Smaele, E.; Fragomeli, C.; Ferretti, E.; Pelloni, M.; Po, A.; Canettieri, G.; Coni, S.; Di Marcotullio, L.; Greco, A.; Moretti, M.; Di Rocco, C.; Pazzaglia, S.; Maroder, M.; Screpanti, I.; Giannini, G.; Gulino, A. Neoplasia 2008, 10, 89-98. doi:10.1593/neo.07891 (Pubitemid 351170716)
-
(2008)
Neoplasia
, vol.10
, Issue.1
, pp. 89-98
-
-
De Smaele, E.1
Fragomeli, C.2
Ferretti, E.3
Pelloni, M.4
Po, A.5
Canettieri, G.6
Coni, S.7
Di Marcotullio, L.8
Greco, A.9
Moretti, M.10
Di Rocco, C.11
Pazzaglia, S.12
Maroder, M.13
Screpanti, I.14
Giannini, G.15
Gulino, A.16
-
31
-
-
1842839986
-
Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site
-
DOI 10.1016/j.gene.2004.01.010, PII S0378111904000368
-
Ågren, M.; Kogerman, P.; Kleman, M. I.; Wessling, M.; Toftgård, R. Gene 2004, 330, 101-114. doi:10.1016/j.gene.2004.01.010 (Pubitemid 38490423)
-
(2004)
Gene
, vol.330
, Issue.1-2
, pp. 101-114
-
-
Agren, M.1
Kogerman, P.2
Kleman, M.I.3
Wessling, M.4
Toftgard, R.5
-
32
-
-
0030891148
-
-
Sasaki, H.; Hui, C.; Nakafuku, M.; Kondoh, H. Development 1997, 124, 1313-1322.
-
(1997)
Development
, vol.124
, pp. 1313-1322
-
-
Sasaki, H.1
Hui, C.2
Nakafuku, M.3
Kondoh, H.4
|