Cardiac-specific VLCAD deficiency induces dilated cardiomyopathy and cold intolerance

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 306, Issue 3, 2014, Pages

  Xiong, Dingding ^a   He, Huamei ^b   James, Jeanne ^a   Tokunaga, Chonan ^a   Powers, Corey ^a   Huang, Yan ^a   Osinska, Hanna ^a   Towbin, Jeffrey A ^a   Purevjav, Enkhsaikhan ^a   Balschi, James A ^c   Javadov, Sabzali ^d   McGowan Jr , Francis X ^b   Strauss, Arnold W ^a   Khuchua, Zaza ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

Author keywords

Cardiac metabolism; Cardiomyopathy; Cold intolerance; Fatty acid oxidation; Mitochondria; Mouse; VLCAD

Indexed keywords

ADENINE NUCLEOTIDE; DOBUTAMINE; LONG CHAIN ACYL COENZYME A DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG; VERY LONG CHAIN ACYL COENZYME A DEHYDROGENASE; ADENOSINE TRIPHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE DISORDER; BODY WEIGHT; BRADYCARDIA; COLD EXPOSURE; COLD INTOLERANCE; COMPARATIVE STUDY; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; CORE TEMPERATURE; DIASTOLIC DYSFUNCTION; DIET RESTRICTION; ELECTROCARDIOGRAM; ENERGY METABOLISM; ENZYME ACTIVITY; FATTY ACID METABOLISM; FATTY ACID OXIDATION; HEART CONTRACTION; HEART FUNCTION; HEART MUSCLE CELL; HEART RATE; HEART WEIGHT; HYPOTHERMIA; M MODE ECHOCARDIOGRAPHY; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PHENOTYPE; PRIORITY JOURNAL; RESPIRATION CONTROL; RESTING METABOLIC RATE; ANIMAL; C57BL MOUSE; CARDIOMYOPATHY, DILATED; COLD; DEFICIENCY; DISEASE MODEL; DISORDERS OF LIPID AND LIPOPROTEIN METABOLISM; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYMOLOGY; KNOCKOUT MOUSE; METABOLISM; MUSCLE DISEASE; OXIDATION REDUCTION REACTION; PHYSIOLOGICAL STRESS;

ACYL-COA DEHYDROGENASE, LONG-CHAIN; ADENOSINE TRIPHOSPHATE; ANIMALS; CARDIOMYOPATHY, DILATED; COLD TEMPERATURE; DISEASE MODELS, ANIMAL; HYPOTHERMIA; LIPID METABOLISM, INBORN ERRORS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIAL DISEASES; MUSCULAR DISEASES; OXIDATION-REDUCTION; STRESS, PHYSIOLOGICAL;

EID: 84893407026     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00931.2012     Document Type: Article

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