Fasting-induced oxidative stress in very long chain acyl-CoA dehydrogenase-deficient mice

FEBS Journal

Volumn 277, Issue 22, 2010, Pages 4699-4708

  Tucci, Sara ^a   Primassin, Sonja ^a   Spiekerkoetter, Ute ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

Fatty acid oxidation; Hepatopathy; Medium chain triglyceride (MCT); Oxidative stress; Very long chain acyl CoA dehydrogenase (VLCAD) deficiency

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; CATALASE; GLUTATHIONE PEROXIDASE; LIPID; LONG CHAIN TRIACYLGLYCEROL; MEDIUM CHAIN TRIACYLGLYCEROL; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET; DIET RESTRICTION; ENZYME ACTIVITY; ENZYME INDUCTION; FATTY ACID OXIDATION; GENE EXPRESSION; LIPID BLOOD LEVEL; LIPID LIVER LEVEL; LIVER DISEASE; LIVER FUNCTION; MOUSE; MULTIPLE ACYL COA DEHYDROGENASE DEFICIENCY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ACYL-COA DEHYDROGENASE, LONG-CHAIN; ANIMALS; CATALASE; DIET; DIETARY FATS; FASTING; FATTY ACIDS; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HUMANS; LIVER; METABOLISM, INBORN ERRORS; MICE; MICE, KNOCKOUT; OXIDATION-REDUCTION; OXIDATIVE STRESS; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TRIGLYCERIDES;

MUS;

EID: 78049267233     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07876.x     Document Type: Article

References (44)

1. Spiekerkoetter U, Sun B, Zytkovicz T, Wanders R, Strauss AW & Wendel U (2003) MS/MS-based newborn and family screening detects asymptomatic patients with very-long-chain acyl-CoA dehydrogenase deficiency. J Pediatr 143, 335-342.
2. Kompare M & Rizzo WB (2008) Mitochondrial fatty-acid oxidation disorders. Semin Pediatr Neurol 15, 140-149.
3. Gregersen N, Andresen BS, Corydon MJ, Corydon TJ, Olsen RK, Bolund L & Bross P (2001) Mutation analysis in mitochondrial fatty acid oxidation defects: exemplified by acyl-CoA dehydrogenase deficiencies, with special focus on genotype-phenotype relationship. Hum Mutat 18, 169-189.
4. Spiekerkoetter U, Ruiter J, Tokunaga C, Wendel U, Mayatepek E, Wijburg FA, Strauss AW & Wanders RJ (2006) Evidence for impaired gluconeogenesis in very long-chain acyl-CoA dehydrogenase-deficient mice. Horm Metab Res 38, 625-630.
5. Spiekerkoetter U, Tokunaga C, Wendel U, Mayatepek E, Exil V, Duran M, Wijburg FA, Wanders RJ & Strauss AW (2004) Changes in blood carnitine and acylcarnitine profiles of very long-chain acyl-CoA dehydrogenase-deficient mice subjected to stress. Eur J Clin Invest 34, 191-196.
6. Bach AC & Babayan VK (1982) Medium-chain triglycerides: an update. Am J Clin Nutr 36, 950-962.
7. Spiekerkoetter U, Lindner M, Santer R, Grotzke M, Baumgartner MR, Boehles H, Das A, Haase C, Hennermann JB, Karall D et al. (2009) Treatment recommendations in long-chain fatty acid oxidation defects: consensus from a workshop. J Inherit Metab Dis 34, 498-505.
8. Arnold GL, Van HJ, Freedenberg D, Strauss A, Longo N, Burton B, Garganta C, Ficicioglu C, Cederbaum S, Harding C et al. (2009) A Delphi clinical practice protocol for the management of very long chain acyl-CoA dehydrogenase deficiency. Mol Genet Metab 96, 85-90.
9. Spiekerkoetter U, Lindner M, Santer R, Grotzke M, Baumgartner MR, Boehles H, Das A, Haase C, Hennermann JB, Karall D et al. (2009) Management and outcome in 75 individuals with long-chain fatty acid oxidation defects: results from a workshop. J Inherit Metab Dis 32, 488-497.
10. Roe CR, Sweetman L, Roe DS, David F & Brunengraber H (2002) Treatment of cardiomyopathy and rhabdomyolysis in long-chain fat oxidation disorders using an anaplerotic odd-chain triglyceride. J Clin Invest 110, 259-269.
11. Hardwick JP (2008) Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases. Biochem Pharmacol 75, 2263-2275.
12. Thomas H, Schladt L, Knehr M & Oesch F (1989) Effect of diabetes and starvation on the activity of rat liver epoxide hydrolases, glutathione S-transferases and peroxisomal beta-oxidation. Biochem Pharmacol 38, 4291-4297.
13. Tucci S, Primassin S, Ter Veld F & Spiekerkoetter U (2010) Medium-chain triglycerides impair lipid metabolism and induce hepatic steatosis in very long-chain acyl-CoA dehydrogenase (VLCAD)-deficient mice. Mol Genet Metab 101, 40-47.
14. Fainaru M & Schafer Z (2000) Effect of prolonged fasting on plasma lipids, lipoproteins and apolipoprotein B in 12 physicians participating in a hunger strike: an observational study. Isr Med Assoc J 2, 215-219.
15. Savendahl L & Underwood LE (1999) Fasting increases serum total cholesterol, LDL cholesterol and apolipoprotein B in healthy, nonobese humans. J Nutr 129, 2005-2008.
16. Aoyama T, Peters JM, Iritani N, Nakajima T, Furihata K, Hashimoto T & Gonzalez FJ (1998) Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha). J Biol Chem 273, 5678-5684.
17. Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B & Wahli W (1999) Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest 103, 1489-1498.
18. Peters JM, Hennuyer N, Staels B, Fruchart JC, Fievet C, Gonzalez FJ & Auwerx J (1997) Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice. J Biol Chem 272, 27307-27312.
19. Goetzman ES, Tian L & Wood PA (2005) Differential induction of genes in liver and brown adipose tissue regulated by peroxisome proliferator-activated receptor-alpha during fasting and cold exposure in acyl-CoA dehydrogenase-deficient mice. Mol Genet Metab 84, 39-47.
20. Wanders RJ & Komen JC (2007) Peroxisomes, Refsum's disease and the alpha- and omega-oxidation of phytanic acid. Biochem Soc Trans 35, 865-869.
21. Westin MA, Hunt MC & Alexson SE (2005) The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes. J Biol Chem 280, 38125-38132.
22. Hardwick JP, Osei-Hyiaman D, Wiland H, Abdelmegeed MA & Song BJ (2009) PPAR/RXR regulation of fatty acid metabolism and fatty acid omega-hydroxylase (CYP4) isozymes: implications for prevention of lipotoxicity in fatty liver disease. PPAR Res 2009 (952734), 1-20.
23. Rao MS & Reddy JK (2004) PPARalpha in the pathogenesis of fatty liver disease. Hepatology 40, 783-786.
24. Day CP & James OF (1998) Steatohepatitis: a tale of two 'hits'? Gastroenterology 114, 842-845.
25. Martinez-Chantar ML, Corrales FJ, Martinez-Cruz LA, Garcia-Trevijano ER, Huang ZZ, Chen L, Kanel G, Avila MA, Mato JM & Lu SC (2002) Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A. FASEB J 16, 1292-1294.
26. Robertson G, Leclercq I & Farrell GC (2001) Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress. Am J Physiol Gastrointest Liver Physiol 281, G1135-G1139.
27. Blankenberg S, Rupprecht HJ, Bickel C, Torzewski M, Hafner G, Tiret L, Smieja M, Cambien F, Meyer J & Lackner KJ (2003) Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease. N Engl J Med 349, 1605-1613.
28. Nemoto M, Nishimura R, Sasaki T, Hiki Y, Miyashita Y, Nishioka M, Fujimoto K, Sakuma T, Ohashi T, Fukuda K et al. (2007) Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography. Cardiovasc Diabetol 6:23, 1-7.
29. Redon J, Oliva MR, Tormos C, Giner V, Chaves J, Iradi A & Saez GT (2003) Antioxidant activities and oxidative stress byproducts in human hypertension. Hypertension 41, 1096-1101.
30. Sommerburg O, Grune T, Ehrich JH & Siems WG (2002) Adaptation of glutathione-peroxidase activity to oxidative stress occurs in children but not in adult patients with end-stage renal failure undergoing hemodialysis. Clin Nephrol 58(Suppl 1), S31-S36.
31. Pessayre D, Mansouri A & Fromenty B (2002) Nonalcoholic steatosis and steatohepatitis. V. Mitochondrial dysfunction in steatohepatitis. Am J Physiol Gastrointest Liver Physiol 282, G193-G199.
32. Jones PM, Butt Y, Messmer B, Boriak R & Bennett MJ (2006) Medium-chain fatty acids undergo elongation before beta-oxidation in fibroblasts. Biochem Biophys Res Commun 346, 193-197.
33. Hill JO, Peters JC, Swift LL, Yang D, Sharp T, Abumrad N & Greene HL (1990) Changes in blood lipids during six days of overfeeding with medium or long chain triglycerides. J Lipid Res 31, 407-416.
34. Tholstrup T, Ehnholm C, Jauhiainen M, Petersen M, Hoy CE, Lund P & Sandstrom B (2004) Effects of medium-chain fatty acids and oleic acid on blood lipids, lipoproteins, glucose, insulin, and lipid transfer protein activities. Am J Clin Nutr 79, 564-569.
35. Jaeschke H, Gores GJ, Cederbaum AI, Hinson JA, Pessayre D & Lemasters JJ (2002) Mechanisms of hepatotoxicity. Toxicol Sci 65, 166-176.
36. Exil VJ, Roberts RL, Sims H, McLaughlin JE, Malkin RA, Gardner CD, Ni G, Rottman JN & Strauss AW (2003) Very-long-chain acyl-coenzyme a dehydrogenase deficiency in mice. Circ Res 93, 448-455.
37. Folch J, Lees M & Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226, 497-509.
38. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72, 248-254.
39. Mohanty JG, Jaffe JS, Schulman ES & Raible DG (1997) A highly sensitive fluorescent micro-assay of H2O2 release from activated human leukocytes using a dihydroxyphenoxazine derivative. J Immunol Methods 202, 133-141.
40. Zhou M, Diwu Z, Panchuk-Voloshina N & Haugland RP (1997) A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: applications in detecting the activity of phagocyte NADPH oxidase and other oxidases. Anal Biochem 253, 162-168.
41. Lawrence RA & Burk RF (1976) Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun 71, 952-958.
42. Mantha SV, Prasad M, Kalra J & Prasad K (1993) Antioxidant enzymes in hypercholesterolemia and effects of vitamin E in rabbits. Atherosclerosis 101, 135-144.
43. Yagi K (1976) A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med 15, 212-216.
44. Schafer C, Hoffmann L, Heldt K, Lornejad-Schafer MR, Brauers G, Gehrmann T, Garrow TA, Haussinger D, Mayatepek E, Schwahn BC et al. (2007) Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells. Am J Physiol Gastrointest Liver Physiol 292, G1089-G1098.