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Volumn 11, Issue 7, 2013, Pages 877-885

The multifaceted nature of myelodysplastic syndromes: Clinical, molecular, and biological prognostic features

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; BONE MARROW CELL; CLINICAL FEATURE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE MUTATION; HUMAN; INTERNATIONAL PROGNOSTIC SCORING SYSTEM; MYELODYSPLASTIC SYNDROME; PATHOGENESIS; PHENOTYPE; PROGNOSIS; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84882953089     PISSN: 15401405     EISSN: 15401413     Source Type: Journal    
DOI: 10.6004/jnccn.2013.0105     Document Type: Review
Times cited : (31)

References (66)
  • 1
    • 0030897009 scopus 로고    scopus 로고
    • International scoring system for evaluating prognosis in myelodysplastic syndromes
    • Greenberg P, Cox C, LeBeau MM, et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997;89:2079-2088.
    • (1997) Blood , vol.89 , pp. 2079-2088
    • Greenberg, P.1    Cox, C.2    Lebeau, M.M.3
  • 2
    • 32144431895 scopus 로고    scopus 로고
    • Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria, a basis for clinical decision making
    • Malcovati L, Porta M, Pascutto C, et al. Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria, a basis for clinical decision making. J Clin Oncol 2005;23:7594-7603.
    • (2005) J Clin Oncol , vol.23 , pp. 7594-7603
    • Malcovati, L.1    Porta, M.2    Pascutto, C.3
  • 3
    • 34548219420 scopus 로고    scopus 로고
    • Time-dependent prognostic scoringsystem for predicting survival and leukemic evolution in myelodysplastic syndromes
    • Malcovati L, Germing U, Kuendgen A, et al. Time-dependent prognostic scoringsystem for predicting survival and leukemic evolution in myelodysplastic syndromes. J Clin Oncol 2007;25:3503-3510.
    • (2007) J Clin Oncol , vol.25 , pp. 3503-3510
    • Malcovati, L.1    Germing, U.2    Kuendgen, A.3
  • 4
    • 53149113768 scopus 로고    scopus 로고
    • Proposal for a new risk model inmyelodysplastic syndrome that accounts for events not considered in the original International Prognostic Scoring System
    • Kantarjian H, O'Brien S, Ravandi F, et al. Proposal for a new risk model inmyelodysplastic syndrome that accounts for events not considered in the original International Prognostic Scoring System. Cancer 2008;113:1351-1361.
    • (2008) Cancer , vol.113 , pp. 1351-1361
    • Kantarjian, H.1    O'brien, S.2    Ravandi, F.3
  • 5
    • 79952346792 scopus 로고    scopus 로고
    • Risk stratification based on bothdisease status and extra-hematologic comorbidities in patients with myelodysplastic syndrome
    • Della Porta MG, Luca Malcovati L, Strupp C, et al. Risk stratification based on bothdisease status and extra-hematologic comorbidities in patients with myelodysplastic syndrome. Haematologica 2011;96:441-449.
    • (2011) Haematologica , vol.96 , pp. 441-449
    • Della Porta, M.G.1    Luca Malcovati, L.2    Strupp, C.3
  • 6
    • 70349256226 scopus 로고    scopus 로고
    • The 2008 revision of the WHO classificationof myeloid neoplasms and acute leukemia, rationale and important changes
    • Vardiman JW, Thiele J, Arber DA, et al. The 2008 revision of the WHO classificationof myeloid neoplasms and acute leukemia, rationale and important changes. Blood 2009;114:937-951.
    • (2009) Blood , vol.114 , pp. 937-951
    • Vardiman, J.W.1    Thiele, J.2    Arber, D.A.3
  • 7
    • 0019952276 scopus 로고
    • Proposals for the classification of themyelodysplastic syndromes
    • Bennett JM, Catovsky D, Daniel MT, et al. Proposals for the classification of themyelodysplastic syndromes. Br J Haematol 1982;51:189-199.
    • (1982) Br J Haematol , vol.51 , pp. 189-199
    • Bennett, J.M.1    Catovsky, D.2    Daniel, M.T.3
  • 8
    • 84858830672 scopus 로고    scopus 로고
    • New comprehensive cytogenetic scoring system forprimary myelodysplastic syndromes and oligoblastic AML following MDS derived froman international database merge
    • Schanz J, Tüchler H, Solé F, et al. New comprehensive cytogenetic scoring system forprimary myelodysplastic syndromes and oligoblastic AML following MDS derived froman international database merge. J Clin Oncol 2012;30:820-829.
    • (2012) J Clin Oncol , vol.30 , pp. 820-829
    • Schanz, J.1    Tüchler, H.2    Solé, F.3
  • 9
    • 84866621729 scopus 로고    scopus 로고
    • Revised international prognostic scoring system for myelodysplastic syndromes
    • Greenberg P, Tuechler H, Schanz J, et al. Revised International Prognostic Scoring System for Myelodysplastic Syndromes. Blood 2012;120:2454-2465.
    • (2012) Blood , vol.120 , pp. 2454-2465
    • Greenberg, P.1    Tuechler, H.2    Schanz, J.3
  • 10
    • 53549108334 scopus 로고    scopus 로고
    • International MDS risk analysis workshop (IMRAW)/IPSS re-analyzed: Impact of cytopenias on clinical outcomes inmyelodysplastic syndromes
    • Kao JM, McMillan A, Greenberg PL. International MDS risk analysis workshop (IMRAW)/IPSS re-analyzed: impact of cytopenias on clinical outcomes inmyelodysplastic syndromes. Am J Hematol 2008;83:765-770.
    • (2008) Am J Hematol , vol.83 , pp. 765-770
    • Kao, J.M.1    McMillan, A.2    Greenberg, P.L.3
  • 11
    • 80053186861 scopus 로고    scopus 로고
    • Impact of the degree of anemia on theoutcome of patients with myelodysplastic syndrome and its integration into the WHO classification-based Prognostic Scoring System (WPSS)
    • Malcovati L, Della Porta MG, Strupp C, et al. Impact of the degree of anemia on theoutcome of patients with myelodysplastic syndrome and its integration into the WHO classification-based Prognostic Scoring System (WPSS). Haematologica 2011;96:1433-1440.
    • (2011) Haematologica , vol.96 , pp. 1433-1440
    • Malcovati, L.1    Della Porta, M.G.2    Strupp, C.3
  • 12
    • 0024402407 scopus 로고
    • Two regression models and a scoring system for predicting survival and planning treatment in myelodysplastic syndromes: A multivariate analysis of prognostic factors in 370 patients
    • Sanz GF, Sanz MA, Vallespi T, et al. Two regression models and a scoring system for predicting survival and planning treatment in myelodysplastic syndromes: a multivariate analysis of prognostic factors in 370 patients. Blood 1989;74:395-408.
    • (1989) Blood , vol.74 , pp. 395-408
    • Sanz, G.F.1    Sanz, M.A.2    Vallespi, T.3
  • 13
    • 84855960902 scopus 로고    scopus 로고
    • The degree of neutropenia has aprognostic impact in low risk myelodysplastic syndrome
    • Cordoba I, Gonzalez-Porras JR, Such E, et al. The degree of neutropenia has aprognostic impact in low risk myelodysplastic syndrome. Leuk Res 2012;36:287-292.
    • (2012) Leuk Res , vol.36 , pp. 287-292
    • Cordoba, I.1    Gonzalez-Porras, J.R.2    Such, E.3
  • 14
    • 34247646400 scopus 로고    scopus 로고
    • The incidence and impact of thrombocytopenia in myelodysplastic syndromes
    • Kantarjian H, Giles F, List A, et al. The incidence and impact of thrombocytopenia in myelodysplastic syndromes. Cancer 2007;109:1705-1714.
    • (2007) Cancer , vol.109 , pp. 1705-1714
    • Kantarjian, H.1    Giles, F.2    List, A.3
  • 15
    • 0026504855 scopus 로고
    • Primary myelodysplastic syndromes: Analysis of prognostic factors in 235 patients and proposals for an improved scoring system
    • Aul C, Gattermann N, Heyll A, et al. Primary myelodysplastic syndromes: analysis of prognostic factors in 235 patients and proposals for an improved scoring system. Leukemia 1992;6:52-59.
    • (1992) Leukemia , vol.6 , pp. 52-59
    • Aul, C.1    Gattermann, N.2    Heyll, A.3
  • 16
    • 82955249043 scopus 로고    scopus 로고
    • Prognostic impact of severe thrombocytopenia in low-risk myelodysplastic syndrome
    • Gonzalez-Porras JR, Cordoba I, Such E, et al. Prognostic impact of severe thrombocytopenia in low-risk myelodysplastic syndrome. Cancer 2011;117:5529-5537.
    • (2011) Cancer , vol.117 , pp. 5529-5537
    • Gonzalez-Porras, J.R.1    Cordoba, I.2    Such, E.3
  • 17
    • 0030056556 scopus 로고    scopus 로고
    • Prognostic factors in myelodysplasticsyndromes: Critical analysis of the impact of age and gender and failure to identify a very-low-risk group using standard mortality ratio techniques
    • Morel P, Declercq C, Hebbar M, et al. Prognostic factors in myelodysplasticsyndromes: critical analysis of the impact of age and gender and failure to identify a very-low-risk group using standard mortality ratio techniques. Br J Haematol 1996;94:116-119.
    • (1996) Br J Haematol , vol.94 , pp. 116-119
    • Morel, P.1    Declercq, C.2    Hebbar, M.3
  • 18
    • 33846953453 scopus 로고    scopus 로고
    • Myelodysplastic syndromes in patientsyounger than age 50
    • Kuendgen A, Strupp C, Aivado M, et al. Myelodysplastic syndromes in patientsyounger than age 50. J Clin Oncol 2006;24:5358-5365.
    • (2006) J Clin Oncol , vol.24 , pp. 5358-5365
    • Kuendgen, A.1    Strupp, C.2    Aivado, M.3
  • 19
    • 77949327961 scopus 로고    scopus 로고
    • Prognostic impact of age and gender in 897 untreated patients with primary myelodysplastic syndromes
    • Nösslinger T, Tüchler H, Germing U, et al. Prognostic impact of age and gender in 897 untreated patients with primary myelodysplastic syndromes. Ann Oncol 2010;21:120-125.
    • (2010) Ann Oncol , vol.21 , pp. 120-125
    • Nösslinger, T.1    Tüchler, H.2    Germing, U.3
  • 21
    • 84871063591 scopus 로고    scopus 로고
    • IPSS-r is a powerful tool to evaluate the outcome of MDS patient treated with azacitidine: The GFM experience [abstract]
    • Abstract 422
    • Ades L, Lamarque M, Raynaud S, et al. IPSS-r is a powerful tool to evaluate the outcome of MDS patient treated with azacitidine: the GFM experience [abstract]. Blood 2012;120:Abstract 422.
    • (2012) Blood , vol.120
    • Ades, L.1    Lamarque, M.2    Raynaud, S.3
  • 22
    • 84882960974 scopus 로고    scopus 로고
    • The prognostic impact of the IPSS-R cytogenetic scoring system for patients with MDS allows a risk-stratification for patients with MDS-derived AML [abstract]
    • Abstract 1715
    • Stölzel F, Kramer M, Mohr B, et al. The prognostic impact of the IPSS-R cytogenetic scoring system for patients with MDS allows a risk-stratification for patients with MDS-derived AML [abstract]. Blood 2012;120:Abstract 1715.
    • (2012) Blood , vol.120
    • Stölzel, F.1    Kramer, M.2    Mohr, B.3
  • 23
    • 84887316915 scopus 로고    scopus 로고
    • High predictive value of the IPSS-R: An external analysis of 646 patients from a multiregional Italian MDS registry [abstract]
    • Abstract 1702
    • Messa E, Gioia D, Evangelista A, et al. High predictive value of the IPSS-R: an external analysis of 646 patients from a multiregional Italian MDS registry [abstract]. Blood 2012;120:Abstract 1702.
    • (2012) Blood , vol.120
    • Messa, E.1    Gioia, D.2    Evangelista, A.3
  • 24
    • 84883011594 scopus 로고    scopus 로고
    • Validation of the R-IPSS for patients with MDS: Therapeutic implications [abstract]
    • Abstract 2816
    • Mishra A, Al Ali NH, Corrales-Yepez M, et al. Validation of the R-IPSS for patients with MDS: therapeutic implications [abstract]. Blood 2012;120:Abstract 2816.
    • (2012) Blood , vol.120
    • Mishra, A.1    Al Ali, N.H.2    Corrales-Yepez, M.3
  • 25
    • 84863785114 scopus 로고    scopus 로고
    • Standardization of flow cytometry in myelodysplastic syndromes: A report from an international consortium and the European LeukemiaNet Working Group
    • Westers TM, Ireland R, Wolfgang Kern W, et al. Standardization of flow cytometry in myelodysplastic syndromes: a report from an international consortium and the European LeukemiaNet Working Group. Leukemia 2012;26:1730-1741.
    • (2012) Leukemia , vol.26 , pp. 1730-1741
    • Westers, T.M.1    Ireland, R.2    Wolfgang Kern, W.3
  • 26
    • 84928639100 scopus 로고    scopus 로고
    • Pathogenetic mechanisms underlying myelodysplastic syndrome
    • Greenberg PL, ed. Cambridge, England: Cambridge University Press
    • Greenberg PL. Pathogenetic mechanisms underlying myelodysplastic syndrome. In: Greenberg PL, ed. Myelodysplastic Syndromes: Clinical and Biological Advances. Cambridge, England: Cambridge University Press; 2006:63-94.
    • (2006) Myelodysplastic Syndromes: Clinical and Biological Advances , pp. 63-94
    • Greenberg, P.L.1
  • 27
    • 0029957664 scopus 로고    scopus 로고
    • Altered oncogene expression and apoptosis in myelodysplastic syndrome marrow cells
    • Rajapaksa R, Ginzton N, Rott L, Greenberg PL. Altered oncogene expression and apoptosis in myelodysplastic syndrome marrow cells. Blood 1996;88:4275-4287.
    • (1996) Blood , vol.88 , pp. 4275-4287
    • Rajapaksa, R.1    Ginzton, N.2    Rott, L.3    Greenberg, P.L.4
  • 28
    • 0028930939 scopus 로고
    • Simultaneous assessment of cell kinetics and programmed cell death in bone marrow biopsies of myelodysplastics reveals extensive apoptosis as the probable basis for ineffective hematopoiesis
    • Raza A, Mundle S, Iftikhar A, et al. Simultaneous assessment of cell kinetics and programmed cell death in bone marrow biopsies of myelodysplastics reveals extensive apoptosis as the probable basis for ineffective hematopoiesis. Am J Hematol 1995;48:143-154.
    • (1995) Am J Hematol , vol.48 , pp. 143-154
    • Raza, A.1    Mundle, S.2    Iftikhar, A.3
  • 29
    • 0034551738 scopus 로고    scopus 로고
    • The role of apoptosis, proliferation and the Bcl2-related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS
    • Parker J, Mufti G, Rasool F, et al. The role of apoptosis, proliferation and the Bcl2-related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS. Blood 2000;96:3932-3938.
    • (2000) Blood , vol.96 , pp. 3932-3938
    • Parker, J.1    Mufti, G.2    Rasool, F.3
  • 30
    • 84874235360 scopus 로고    scopus 로고
    • On hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes
    • Pang WW, Pluvinage JV, Price EA, et al. On hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes. Proc Natl Acad Sci (USA) 2013;110:3011-3016.
    • (2013) Proc Natl Acad Sci (USA) , vol.110 , pp. 3011-3016
    • Pang, W.W.1    Pluvinage, J.V.2    Price, E.A.3
  • 31
    • 0036659925 scopus 로고    scopus 로고
    • Involvement and functional impairment of the CD34(+)CD38(-)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8
    • Nilsson L, Astrand-Grundström I, Anderson K, et al. Involvement and functional impairment of the CD34(+)CD38(-)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8. Blood 2002;100:259-267.
    • (2002) Blood , vol.100 , pp. 259-267
    • Nilsson, L.1    Astrand-Grundström, I.2    Anderson, K.3
  • 32
    • 35548954717 scopus 로고    scopus 로고
    • The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes
    • Nilsson L, Edén P, Olsson E, et al. The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes. Blood 2007;110:3005-3014.
    • (2007) Blood , vol.110 , pp. 3005-3014
    • Nilsson, L.1    Edén, P.2    Olsson, E.3
  • 33
    • 77956516658 scopus 로고    scopus 로고
    • Persistent malignant stem cells in del(5q) myelodysplasia in remission
    • Tehranchi R, Woll PS, Anderson K, et al. Persistent malignant stem cells in del(5q) myelodysplasia in remission. N Engl J Med 2010;363:1025-1037.
    • (2010) N Engl J Med , vol.363 , pp. 1025-1037
    • Tehranchi, R.1    Woll, P.S.2    Anderson, K.3
  • 34
    • 84866180518 scopus 로고    scopus 로고
    • Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations
    • Will B, Zhou L, Vogler TO, et al. Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations. Blood 2012;120:2076-2086.
    • (2012) Blood , vol.120 , pp. 2076-2086
    • Will, B.1    Zhou, L.2    Vogler, T.O.3
  • 35
    • 79952164235 scopus 로고    scopus 로고
    • Unraveling the molecular pathophysiology of myelodysplastic syndromes
    • Bejar R, Levine R, Ebert BL. Unraveling the molecular pathophysiology of myelodysplastic syndromes. J Clin Oncol 2011;29:504-515.
    • (2011) J Clin Oncol , vol.29 , pp. 504-515
    • Bejar, R.1    Levine, R.2    Ebert, B.L.3
  • 36
    • 77955081371 scopus 로고    scopus 로고
    • Combined mutations of ASXL1, CBL, FLT3, IDH1,IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias
    • Rocquain J, Carbuccia N, Trouplin V, et al. Combined mutations of ASXL1, CBL, FLT3, IDH1,IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias. Biomed Central Cancer 2010;10:401-408.
    • (2010) Biomed Central Cancer , vol.10 , pp. 401-408
    • Rocquain, J.1    Carbuccia, N.2    Trouplin, V.3
  • 37
    • 74049098354 scopus 로고    scopus 로고
    • Relationship of differential gene expression profiles in CD34+ myelodysplastic syndrome marrow cells to disease subtype and progression
    • Sridhar K, Ross D, Tibshirani R, et al. Relationship of differential gene expression profiles in CD34+ myelodysplastic syndrome marrow cells to disease subtype and progression. Blood 2009;114:4847-4858.
    • (2009) Blood , vol.114 , pp. 4847-4858
    • Sridhar, K.1    Ross, D.2    Tibshirani, R.3
  • 38
    • 70349249936 scopus 로고    scopus 로고
    • Microarray-based classifiers and prognosis models identify subgroups with distinct clinical outcomes and high risk of AML transformation of myelodysplastic syndrome
    • Mills K, Kohlmann A, Williams PM, et al. Microarray-based classifiers and prognosis models identify subgroups with distinct clinical outcomes and high risk of AML transformation of myelodysplastic syndrome. Blood 2009;114:1063-1072.
    • (2009) Blood , vol.114 , pp. 1063-1072
    • Mills, K.1    Kohlmann, A.2    Williams, P.M.3
  • 39
    • 79959794787 scopus 로고    scopus 로고
    • Clinical effect of point mutations in myelodysplastic syndromes
    • Bejar R, Stevenson K, Abdel-Wahab O, et al. Clinical effect of point mutations in myelodysplastic syndromes. N Engl J Med 2011;364:2496-2506.
    • (2011) N Engl J Med , vol.364 , pp. 2496-2506
    • Bejar, R.1    Stevenson, K.2    Abdel-Wahab, O.3
  • 40
    • 67650588639 scopus 로고    scopus 로고
    • Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/ myeloproliferative neoplasms
    • Jankowska AM, Szpurka H, Tiu RV, et al. Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/ myeloproliferative neoplasms. Blood 2009;113:6403-6410.
    • (2009) Blood , vol.113 , pp. 6403-6410
    • Jankowska, A.M.1    Szpurka, H.2    Tiu, R.V.3
  • 41
    • 70350438115 scopus 로고    scopus 로고
    • TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes
    • Kosmider, O, Gelsi-Boyer V, Cheok M, et al. TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes. Blood 2009;114:3285-3291.
    • (2009) Blood , vol.114 , pp. 3285-3291
    • Kosmider, O.1    Gelsi-Boyer, V.2    Cheok, M.3
  • 42
    • 84882938549 scopus 로고    scopus 로고
    • High throughput targeted gene sequencing in 738 myelodysplastic syndromes patients reveals novel oncogenic genes, rare driver mutations and complex molecular signatures with potential impact for patient diagnosis and prognosis in the clinic [abstract]
    • Abstract LBA-5
    • Papaemmanuil E, Gerstung M, Malcovati, et al. High throughput targeted gene sequencing in 738 myelodysplastic syndromes patients reveals novel oncogenic genes, rare driver mutations and complex molecular signatures with potential impact for patient diagnosis and prognosis in the clinic [abstract]. Blood 2012;120:Abstract LBA-5.
    • (2012) Blood , vol.120
    • Papaemmanuil, E.1    Malcovati, G.M.2
  • 43
    • 84867253750 scopus 로고    scopus 로고
    • SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)
    • Meggendorfer M, Roller A, Haferlach T, et al. SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML). Blood 2012;120:3080-3088.
    • (2012) Blood , vol.120 , pp. 3080-3088
    • Meggendorfer, M.1    Roller, A.2    Haferlach, T.3
  • 44
    • 84872085802 scopus 로고    scopus 로고
    • Spliceosomal gene mutations are frequent events in the diverse mutational spectrum of chronic myelomonocytic leukemia but largely absent in juvenile myelomonocytic leukemia
    • Abu Kar S, Jankowska A, Makishima H, et al. Spliceosomal gene mutations are frequent events in the diverse mutational spectrum of chronic myelomonocytic leukemia but largely absent in juvenile myelomonocytic leukemia. Haematologica 2013;98:107-113.
    • (2013) Haematologica , vol.98 , pp. 107-113
    • Abu Kar, S.1    Jankowska, A.2    Makishima, H.3
  • 45
    • 84878913163 scopus 로고    scopus 로고
    • Somatic mutations in Schinzel-Giedion syndrome gene SETBP1 determine progression in myeloid malignancies [abstract]
    • Abstract 3
    • Makishima H, Yoshida K, Nguyen N, et al. Somatic mutations in Schinzel-Giedion syndrome gene SETBP1 determine progression in myeloid malignancies [abstract]. Blood 2012;120:Abstract 3.
    • (2012) Blood , vol.120
    • Makishima, H.1    Yoshida, K.2    Nguyen, N.3
  • 46
    • 77449131060 scopus 로고    scopus 로고
    • SETBP1 overexpression is a novel leukemogenic mechanism that predicts adverse outcome in elderly patients with acute myeloid leukemia
    • Cristóbal I, Blanco FJ, Garcia-Orti L, et al. SETBP1 overexpression is a novel leukemogenic mechanism that predicts adverse outcome in elderly patients with acute myeloid leukemia. Blood 2010;115:615-625.
    • (2010) Blood , vol.115 , pp. 615-625
    • Cristóbal, I.1    Blanco, F.J.2    Garcia-Orti, L.3
  • 47
    • 78651307662 scopus 로고    scopus 로고
    • Impact of adjunct cytogenetic abnormalities for prognostic stratification in patients with myelodysplastic syndrome and deletion 5q
    • Mallo M, Cervera J, Schanz J, et al. Impact of adjunct cytogenetic abnormalities for prognostic stratification in patients with myelodysplastic syndrome and deletion 5q. Leukemia 2011;25:110-120.
    • (2011) Leukemia , vol.25 , pp. 110-120
    • Mallo, M.1    Cervera, J.2    Schanz, J.3
  • 48
    • 79956291339 scopus 로고    scopus 로고
    • TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression
    • Jädersten M, Saft L, Smith A, et al. TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression. J Clin Oncol 2011;29:1971-1979.
    • (2011) J Clin Oncol , vol.29 , pp. 1971-1979
    • Jädersten, M.1    Saft, L.2    Smith, A.3
  • 49
    • 80053900941 scopus 로고    scopus 로고
    • Frequent pathway mutations of splicing machinery in myelodysplasia
    • Yoshida K, Sanada M, Shiraishi Y, et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature 2011;478:64-69.
    • (2011) Nature , vol.478 , pp. 64-69
    • Yoshida, K.1    Sanada, M.2    Shiraishi, Y.3
  • 50
    • 80054010617 scopus 로고    scopus 로고
    • Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts
    • Papaemmanuil E, Cazzola M, Boultwood J, et al. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med 2011;365:1384-1395.
    • (2011) N Engl J Med , vol.365 , pp. 1384-1395
    • Papaemmanuil, E.1    Cazzola, M.2    Boultwood, J.3
  • 51
    • 84555192302 scopus 로고    scopus 로고
    • Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes
    • 2012
    • Graubert TA, Shen D, Ding L, et al. 2012. Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nat Genet 2012;44:53-57.
    • (2012) Nat Genet , vol.44 , pp. 53-57
    • Graubert, T.A.1    Shen, D.2    Ding, L.3
  • 52
    • 84859595800 scopus 로고    scopus 로고
    • Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes
    • Damm F, Kosmider O, Gelsi-Boyer V, et al. Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes. Blood 2012;119:3211-3218.
    • (2012) Blood , vol.119 , pp. 3211-3218
    • Damm, F.1    Kosmider, O.2    Gelsi-Boyer, V.3
  • 53
    • 38949123096 scopus 로고    scopus 로고
    • Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML
    • Gondek LP, Tiu R, O'Keefe CL, et al. Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML. Blood 2008;111:1534-1542.
    • (2008) Blood , vol.111 , pp. 1534-1542
    • Gondek, L.P.1    Tiu, R.2    O'keefe, C.L.3
  • 54
    • 79959525954 scopus 로고    scopus 로고
    • SNP array-based karyotyping: Differences and similarities between aplastic anemia and hypocellular myelodysplastic syndromes
    • Afable MG, Wlodarski M, Makishima H, et al. SNP array-based karyotyping: differences and similarities between aplastic anemia and hypocellular myelodysplastic syndromes. Blood 2011;117:6876-6884.
    • (2011) Blood , vol.117 , pp. 6876-6884
    • Afable, M.G.1    Wlodarski, M.2    Makishima, H.3
  • 55
    • 38349088899 scopus 로고    scopus 로고
    • Identification of RPS14 as a 5q-syndrome gene by RNA interference screen
    • Ebert BL, Pretz J, Bosco J, et al. Identification of RPS14 as a 5q-syndrome gene by RNA interference screen. Nature 2008;451:335-339.
    • (2008) Nature , vol.451 , pp. 335-339
    • Ebert, B.L.1    Pretz, J.2    Bosco, J.3
  • 56
    • 77950988337 scopus 로고    scopus 로고
    • Induction of p53 and up-regulation of the p53 pathway in the human 5q- syndrome
    • Pellagatti A, Marafioti T, Paterson JC, et al. Induction of p53 and up-regulation of the p53 pathway in the human 5q- syndrome. Blood 2010;115:2721-2723.
    • (2010) Blood , vol.115 , pp. 2721-2723
    • Pellagatti, A.1    Marafioti, T.2    Paterson, J.C.3
  • 57
    • 70349643737 scopus 로고    scopus 로고
    • Low RPS14 expression is common in myelodysplastic syndromes without 5q- aberration and defines a subgroup of patients with prolonged survival
    • Czibere A, Burns I, Junge B. Low RPS14 expression is common in myelodysplastic syndromes without 5q- aberration and defines a subgroup of patients with prolonged survival. Haematologica 2009;94:1453-1455.
    • (2009) Haematologica , vol.94 , pp. 1453-1455
    • Czibere, A.1    Burns, I.2    Junge, B.3
  • 58
    • 73849121794 scopus 로고    scopus 로고
    • Identification of miR-145 and miR-146a as mediators of the 5q-syndrome phenotype
    • Starczynowski DT, Kuchenbauer F, Argiropoulos B, et al. Identification of miR-145 and miR-146a as mediators of the 5q-syndrome phenotype. Nature Med 2010;16:49-58.
    • (2010) Nature Med , vol.16 , pp. 49-58
    • Starczynowski, D.T.1    Kuchenbauer, F.2    Argiropoulos, B.3
  • 59
    • 79952587193 scopus 로고    scopus 로고
    • Identification of a risk dependent microRNA expression signature in myelodysplastic syndromes
    • Sokol L, Caceres G, Volinia S, et al. Identification of a risk dependent microRNA expression signature in myelodysplastic syndromes. Br J Haematol 2011;153:24-32.
    • (2011) Br J Haematol , vol.153 , pp. 24-32
    • Sokol, L.1    Caceres, G.2    Volinia, S.3
  • 60
    • 77950943405 scopus 로고    scopus 로고
    • Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells
    • Pellagatti A, Cazzola M, Giagounidis A, et al. Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells. Leukemia 2010;24:756-764.
    • (2010) Leukemia , vol.24 , pp. 756-764
    • Pellagatti, A.1    Cazzola, M.2    Giagounidis, A.3
  • 61
    • 77950529126 scopus 로고    scopus 로고
    • Epigenetic changes in the myelodysplastic syndrome
    • Issa P. Epigenetic changes in the myelodysplastic syndrome. Hematol Oncol Clin North Am 2010;24:317-330.
    • (2010) Hematol Oncol Clin North Am , vol.24 , pp. 317-330
    • Issa, P.1
  • 62
    • 70350720044 scopus 로고    scopus 로고
    • MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation
    • Figueroa ME, Skrabanek L, Li Y, et al. MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation. Blood 2009;114:3448-3458.
    • (2009) Blood , vol.114 , pp. 3448-3458
    • Figueroa, M.E.1    Skrabanek, L.2    Li, Y.3
  • 63
    • 79960255863 scopus 로고    scopus 로고
    • Recurrent DNMT3A mutations in patients with myelodysplastic syndromes
    • Walter MJ, Ding L, Shen D, et al. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia 2011;25:1153-1158.
    • (2011) Leukemia , vol.25 , pp. 1153-1158
    • Walter, M.J.1    Ding, L.2    Shen, D.3
  • 64
    • 0032902504 scopus 로고    scopus 로고
    • Telomere stability is frequently impaired in high-risk groups of patients with myelodysplastic syndromes
    • Ohyashiki JH, Iwama H, Yahata N, et al. Telomere stability is frequently impaired in high-risk groups of patients with myelodysplastic syndromes. Clin Cancer Res 1999;5:1155-1160.
    • (1999) Clin Cancer Res , vol.5 , pp. 1155-1160
    • Ohyashiki, J.H.1    Iwama, H.2    Yahata, N.3
  • 65
    • 76649089645 scopus 로고    scopus 로고
    • Telomere shortening and chromosomal instability in myelodysplastic syndromes
    • Lange K, Holm L, Vang Nielsen K, et al. Telomere shortening and chromosomal instability in myelodysplastic syndromes. Genes Chromosomes Cancer 2010;49:260-269.
    • (2010) Genes Chromosomes Cancer , vol.49 , pp. 260-269
    • Lange, K.1    Holm, L.2    Vang Nielsen, K.3
  • 66
    • 68049129840 scopus 로고    scopus 로고
    • Increase of telomerase activity and hTERT expression in myelodysplastic syndromes
    • Briatore F, Barrera G, Pizzimenti S, et al. Increase of telomerase activity and hTERT expression in myelodysplastic syndromes. Cancer Biol Ther 2009;8:883-889.
    • (2009) Cancer Biol Ther , vol.8 , pp. 883-889
    • Briatore, F.1    Barrera, G.2    Pizzimenti, S.3


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