Synergistic effects of PectaSol-C modified citrus pectin an inhibitor of galectin-3 and paclitaxel on apoptosis of human SKOV-3 ovarian cancer cells

Asian Pacific Journal of Cancer Prevention

Volumn 14, Issue 12, 2013, Pages 7561-7568

  Hossein, Ghamartaj ^a   Keshavarz, Maryam ^a   Ahmadi, Samira ^a   Naderi, Nima ^b  

^a UNIVERSITY OF TEHRAN   (Iran)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Apoptosis; Combination therapy; Galectin 3; Modified citrus pectin; Ovarian cancer; Paclitaxel

Indexed keywords

ANTINEOPLASTIC AGENT; GALECTIN 3; GALECTIN 3, HUMAN; GALECTIN-3, HUMAN; MESSENGER RNA; PACLITAXEL; PECTIN;

APOPTOSIS; ARTICLE; CELL ADHESION; CELL CYCLE; CELL MOTION; CELL PROLIFERATION; CHEMISTRY; CITRUS; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; FEMALE; GENETICS; HUMAN; METABOLISM; OVARY TUMOR; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE; UMBILICAL CORD; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BLOTTING, WESTERN; CELL ADHESION; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; CITRUS; DRUG SYNERGISM; FEMALE; GALECTIN 3; HUMANS; OVARIAN NEOPLASMS; PACLITAXEL; PECTINS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED; UMBILICAL CORD;

EID: 84893391677     PISSN: 15137368     EISSN: None     Source Type: Journal    
DOI: 10.7314/APJCP.2013.14.12.7561     Document Type: Article

References (39)

1. Ahn HJ, Kim YS, Kim JU, et al (2004). Mechanism of taxolinduced apoptosis in human SKOV3 ovarian carcinoma cells. J Cell Biochem, 91, 1043-52.
2. Bae J, Lim MC, Choi JH, et al (2009). Prognostic factors of secondary cytoreductive surgery for patients with recurrent epithelial ovarian cancer. J Gynecol Oncol, 20, 101-6.
3. Banerjee S, Gore M (2009). The future of targeted therapies in ovarian cancer. Oncologist, 14, 706-16.
4. Bankowski E, Sobolewski K, Romanowicz L, et al (1996). Collagen and glycosaminoglycans of Wharton's jelly and their alterations in EPH-gestosis. Eur J Obstet Gynecol Reprod Biol, 66, 109-17.
5. Choi JH, Chun KH, Raz A, et al (2004). Inhibition of N-(4-hydroxyphenyl) retinamide-induced apoptosis in breast cancer cells by galectin-3. Cancer Biol Ther, 3, 447-52.
6. Chumworathayi B (2013). Personalized cancer treatment for ovarian cancer. Asian Pac J Cancer Prev, 14, 1661-4.
7. Loeffler M, Daugas E, Susin SA, et al (2001). Dominant cell death induction by extramitochondrially targeted apoptosisinducing factor. FASEB J, 215, 758-67.
8. Elola MT, Wolfenstein-Todel C, Troncoso MF, et al (2007). Galectins: matricellular glycan-binding proteins linking celladhesion, migration, and survival. Cell Mol Life Sci, 64, 1679-700.
9. Glinsky VV, Kiriakova G, Glinskii OV, et al (2009). Synthetic galectin-3 inhibitor increases metastatic cancer cell sensitivity to taxol-induced apoptosis in vitro and in vivo. Neoplasia, 11, 901-9.
10. Goncalves A, Braguer D, Carles G, et al (2000). Caspase-8 activation independent of CD95/CD95-L interaction during paclitaxel-induced apoptosis in human colon cancer cells (HT29-D4). Biochem Pharmacol, 60, 1579-84.
11. Inohara H, Raz A (1994). Effects of natural complex carbohydrate (citrus pectin) on murine melanoma cell properties related to galectin-3 functions. Glycoconj J, 11, 527-32.
12. Inohara H, Akahani S, Raz A (1998). Galectin-3 stimulates cell proliferation. Exp Cell Res, 245, 294-302.
13. Iurisci I, Tinari N, Natoli C, et al (2000). Concentrations of galectin-3 in the sera of normal controls and cancer patients. Clin Cancer Res, 6, 1389-93.
14. Jemal A, Siegel R, Ward E, et al (2006). Cancer statistics. CA Cancer J Clin, 56, 106-30.
15. Kim HR, Lin HM, Biliran H, et al (1999). Cell cycle arrest and inhibition of anoikis by Galectin-3 in human breast epithelial cells. Cancer Res, 59, 4148-54.
16. Kim MK, Sung CO, Do IG, et al (2011). Overexpression of Galectin-3 and its clinical significance in ovarian carcinoma. Int J Clin Oncol, 16, 352-8.
17. Kiwaki K, Novak CM, Hsu DK (2007). Galectin-3 stimulates preadipocyte proliferation and is up-regulated in growing adipose tissue. Obesity, 15, 32-9.
18. Kuwabara I, Liu FT (1996). Galectin-3 promotes adhesion of human neutrophils to laminin. J Immunol, 156, 3939-44.
19. Lee JW, Juliano R (2004). Mitogenic signal transduction by integrin-and growth factor receptor-mediated pathways. Mol Cells, 17, 188-202.
20. Lin HM, Pestell RG, Raz A, et al (2002). Galectin-3 enhances cyclin D1 promoter activity through SP1 and a cAMPresponsive element in human breast epithelial cells. Oncogene, 21, 8001-10.
21. Nangia-Makker P, Nakahara S, Hogan V, et al (2007). Galectin-3 in apoptosis, a novel therapeutic target. J Bioenerg Biomembr, 39, 79-84.
22. Ochieng J, Leite-Browning ML, Warfield P (1998). Regulation of cellular adhesion to extracellular matrix proteins by galectin-3. Biochem Biophys Res Commun, 246, 788-91.
23. O'Driscoll L, Linehan R, Liang YH, et al (2002). Galectin-3 expression alters adhesion, motility and invasion in a lung cell line (DLKP), in vitro. Anticancer Res, 22, 3117-25.
24. Oka N, Nakahara S, Takenaka Y, Fukumori T, et al (2005). Galectin-3 inhibits tumor necrosis factor-related apoptosisinducing ligand-induced apoptosis by activating Akt in human bladder carcinoma cells. Cancer Res, 65, 7546-53.
25. Perkins C, Kim CN, Fang G, et al (1998). Overexpression of Apaf-1 promotes apoptosis of untreated and paclitaxel-or etoposide-treated HL-60 cells. Cancer Res, 8, 4561-6.
26. Pienta KJ, Naik H, Akhtar A, et al (1995). Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin. J Natl Cancer Inst, 87, 348-53.
27. Platt D, Raz A (1992). Modulation of the lung colonization of B16-F1 melanoma cells by citrus pectin. J Natl Cancer Inst, 84, 438-42.
28. Sher I, Adham SA, Petrik J, et al (2009). Autocrine VEGF-A/KDR loop protects epithelial ovarian carcinoma cells from anoikis. Int J Cancer, 124, 553-61.
29. Streetly MJ, Maharaj L, Joel S, et al (2010). GCS-100, a novel galectin-3 antagonist, modulates MCL-1, NOXA, and cell cycle to induce myeloma cell death. Blood, 115, 3939-48.
30. Tehranian N, Sepehri H, Mehdipour P, et al (2012). Combination effect of PectaSol and Doxorubicin on viability, cell cycle arrest and apoptosis in DU-145 and LNCaP prostate cancer cell lines. Cell Biol Int, 36, 601-10.
31. van den Brûle FA, Berchuck A, Bast RC, et al (1994). Differential expression of the 67-kD laminin receptor and 31-kD human laminin-binding protein in human ovarian carcinomas. Eur J Cancer, 30, 1096-9.
32. Wan SY, Zhang TF, Ding Y (2011). Galectin-3 enhances proliferation and angiogenes of endothelial cells differentiated from bone marrow mesenchymal stem cells. Transplant Proc, 43, 3933-8.
33. Wang Y, Nangia-Makker P, Balan V (2010). Calpain activation through galectin-3 inhibition sensitizes prostate cancer cells to cisplatin treatment. Cell Death Dis, 1, 101.
34. Wani MC, Taylor HL, Wall ME, et al (1971). The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc, 93, 2325-7.
35. Weigel TL, Lotze MT, Kim PK, et al (2000). Paclitaxel-induced apoptosis in nonsmall cell lung cancer cell lines is associated with increased caspase-3 activity. J Thorac Cardiovasc Surg, 119, 795-803.
36. Wongkham S, Junking M, Wongkham C, et al (2009). Suppression of galectin-3 expression enhances apoptosis and chemosensitivity in liver fluke-associated cholangiocarcinoma. Cancer Sci, 100, 2077-84.
37. Yan J, Katz A (2010). PectaSol-C Modified Citrus Pectin Induces Apoptosis and Inhibition of Proliferation in Human and Mouse Androgen Dependent and-Independent Prostate Cancer Cells. Integr Cancer Ther, 9, 197-203.
38. Zhao Q, Barclay M, Hilkens J, et al (2010). Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis. Molecular Cancer, 9, 154.
39. Zhu X, Ohtsubo M, Böhmer RM, et al (1996). Adhesiondependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein. J Cell Biol, 133, 391-403.