-
1
-
-
0034910622
-
Molecular genetics of small cell lung carcinoma
-
Wistuba,I.I. et al. (2001) Molecular genetics of small cell lung carcinoma. Semin Oncol., 28(2 Suppl 4), 3-13.
-
(2001)
Semin Oncol.
, vol.28
, Issue.2 SUPPL. 4
, pp. 3-13
-
-
Wistuba, I.I.1
-
2
-
-
30044451287
-
Combined microarray analysis of small cell lung cancer reveals altered apoptotic balance and distinct expression signatures of MYC family gene amplification
-
Kim,Y.H. et al. (2006) Combined microarray analysis of small cell lung cancer reveals altered apoptotic balance and distinct expression signatures of MYC family gene amplification. Oncogene, 25, 130-138.
-
(2006)
Oncogene
, vol.25
, pp. 130-138
-
-
Kim, Y.H.1
-
3
-
-
0021261878
-
Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage
-
Brodeur,G.M. et al. (1984) Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science, 224, 1121-1124.
-
(1984)
Science
, vol.224
, pp. 1121-1124
-
-
Brodeur, G.M.1
-
4
-
-
0025979843
-
Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: a Pediatric Oncology Group study
-
Look,A.T. et al. (1991) Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: a Pediatric Oncology Group study. J. Clin. Oncol., 9, 581-591.
-
(1991)
J. Clin. Oncol.
, vol.9
, pp. 581-591
-
-
Look, A.T.1
-
5
-
-
63749118521
-
Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci
-
Pfister,S. et al. (2009) Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci. J. Clin. Oncol., 27, 1627-1636.
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 1627-1636
-
-
Pfister, S.1
-
6
-
-
14144250455
-
The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma
-
Slack,A. et al. (2005) The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma. Proc. Natl Acad. Sci. USA, 102, 731-736.
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 731-736
-
-
Slack, A.1
-
7
-
-
70249085177
-
N-Myc down regulation induced differentiation, early cell cycle exit, and apoptosis in human malignant neuroblastoma cells having wild type or mutant p53
-
Janardhanan,R. et al. (2009) N-Myc down regulation induced differentiation, early cell cycle exit, and apoptosis in human malignant neuroblastoma cells having wild type or mutant p53. Biochem. Pharmacol., 78, 1105-1114.
-
(2009)
Biochem. Pharmacol.
, vol.78
, pp. 1105-1114
-
-
Janardhanan, R.1
-
8
-
-
77952375097
-
Pleiotropic role for MYCN in medulloblastoma
-
Swartling,F.J. et al. (2010) Pleiotropic role for MYCN in medulloblastoma. Genes Dev., 24, 1059-1072.
-
(2010)
Genes Dev.
, vol.24
, pp. 1059-1072
-
-
Swartling, F.J.1
-
9
-
-
84861399134
-
Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC
-
Swartling,F.J. et al. (2012) Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC. Cancer Cell, 21, 601-613.
-
(2012)
Cancer Cell
, vol.21
, pp. 601-613
-
-
Swartling, F.J.1
-
10
-
-
20044391414
-
Relationship between MYCN copy number and expression in rhabdomyosarcomas and correlation with adverse prognosis in the alveolar subtype
-
Williamson,D. et al. (2005) Relationship between MYCN copy number and expression in rhabdomyosarcomas and correlation with adverse prognosis in the alveolar subtype. J. Clin. Oncol., 23, 880-888.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 880-888
-
-
Williamson, D.1
-
11
-
-
43049183354
-
Identification of PAX3-FKHR-regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcoma: focus on MYCN as a biologically relevant target
-
Mercado,G.E. et al. (2008) Identification of PAX3-FKHR-regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcoma: focus on MYCN as a biologically relevant target. Genes. Chromosomes Cancer, 47, 510-520.
-
(2008)
Genes. Chromosomes Cancer
, vol.47
, pp. 510-520
-
-
Mercado, G.E.1
-
12
-
-
57149093809
-
Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma
-
Naini,S. et al. (2008) Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma. Cancer Res., 68, 9583-9588.
-
(2008)
Cancer Res.
, vol.68
, pp. 9583-9588
-
-
Naini, S.1
-
13
-
-
34250643527
-
Expression of MYCN in pediatric synovial sarcoma
-
Somers,G.R. et al. (2007) Expression of MYCN in pediatric synovial sarcoma. Mod. Pathol., 20, 734-741.
-
(2007)
Mod. Pathol.
, vol.20
, pp. 734-741
-
-
Somers, G.R.1
-
14
-
-
0038444622
-
The requirement for evasion of programmed cell death in neuroblastomas with MYCN amplification
-
Hogarty,M.D. (2003) The requirement for evasion of programmed cell death in neuroblastomas with MYCN amplification. Cancer Lett., 197, 173-179.
-
(2003)
Cancer Lett.
, vol.197
, pp. 173-179
-
-
Hogarty, M.D.1
-
15
-
-
44449160893
-
N-myc augments death and attenuates protective effects of Bcl-2 in trophically stressed neuroblastoma cells
-
Ushmorov,A. et al. (2008) N-myc augments death and attenuates protective effects of Bcl-2 in trophically stressed neuroblastoma cells. Oncogene, 27, 3424-3434.
-
(2008)
Oncogene
, vol.27
, pp. 3424-3434
-
-
Ushmorov, A.1
-
16
-
-
0037267333
-
Validating survivin as a cancer therapeutic target
-
Altieri,D.C. (2003) Validating survivin as a cancer therapeutic target. Nat. Rev. Cancer, 3, 46-54.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 46-54
-
-
Altieri, D.C.1
-
17
-
-
52649172153
-
Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics
-
Mita,A.C. et al. (2008) Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics. Clin. Cancer Res., 14, 5000-5005.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 5000-5005
-
-
Mita, A.C.1
-
18
-
-
0033600283
-
Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma
-
Bown,N. et al. (1999) Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma. N. Engl. J. Med., 340, 1954-1961.
-
(1999)
N. Engl. J. Med.
, vol.340
, pp. 1954-1961
-
-
Bown, N.1
-
19
-
-
33746378618
-
Survivin mRNA levels are associated with biology of disease and patient survival in neuroblastoma: a report from the children's oncology group
-
Miller,M.A. et al. (2006) Survivin mRNA levels are associated with biology of disease and patient survival in neuroblastoma: a report from the children's oncology group. J. Pediatr. Hematol. Oncol., 28, 412-417.
-
(2006)
J. Pediatr. Hematol. Oncol.
, vol.28
, pp. 412-417
-
-
Miller, M.A.1
-
20
-
-
0034779647
-
Survivin inhibition induces human neural tumor cell death through caspase-independent and -dependent pathways
-
Shankar,S.L. et al. (2001) Survivin inhibition induces human neural tumor cell death through caspase-independent and -dependent pathways. J. Neurochem., 79, 426-436.
-
(2001)
J. Neurochem.
, vol.79
, pp. 426-436
-
-
Shankar, S.L.1
-
21
-
-
84855957229
-
Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe
-
Lamers,F. et al. (2011) Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe. Endocr. Relat. Cancer, 18, 657-668.
-
(2011)
Endocr. Relat. Cancer
, vol.18
, pp. 657-668
-
-
Lamers, F.1
-
22
-
-
23044445753
-
Survivin is a negative prognostic marker in medulloblastoma
-
Pizem,J. et al. (2005) Survivin is a negative prognostic marker in medulloblastoma. Neuropathol. Appl. Neurobiol., 31, 422-428.
-
(2005)
Neuropathol. Appl. Neurobiol.
, vol.31
, pp. 422-428
-
-
Pizem, J.1
-
23
-
-
33751042197
-
Histopathological prognostic factors in medulloblastoma: high expression of survivin is related to unfavourable outcome
-
Haberler,C. et al. (2006) Histopathological prognostic factors in medulloblastoma: high expression of survivin is related to unfavourable outcome. Eur. J. Cancer, 42, 2996-3003.
-
(2006)
Eur. J. Cancer
, vol.42
, pp. 2996-3003
-
-
Haberler, C.1
-
24
-
-
33144470613
-
Survivin-directed RNA interference cocktail is a potent suppressor of tumour growth in vivo
-
Caldas,H. et al. (2006) Survivin-directed RNA interference cocktail is a potent suppressor of tumour growth in vivo. J. Med. Genet., 43, 119-128.
-
(2006)
J. Med. Genet.
, vol.43
, pp. 119-128
-
-
Caldas, H.1
-
25
-
-
79952108411
-
Expression of survivin detected by immunohistochemistry in the cytoplasm and in the nucleus is associated with prognosis of leiomyosarcoma and synovial sarcoma patients
-
Taubert,H. et al. (2010) Expression of survivin detected by immunohistochemistry in the cytoplasm and in the nucleus is associated with prognosis of leiomyosarcoma and synovial sarcoma patients. BMC Cancer, 10, 65.
-
(2010)
BMC Cancer
, vol.10
, pp. 65
-
-
Taubert, H.1
-
26
-
-
85006768050
-
The metabolism of tumors in the body
-
Warburg,O. et al. (1927) The metabolism of tumors in the body. J. Gen. Physiol., 8, 519-530.
-
(1927)
J. Gen. Physiol.
, vol.8
, pp. 519-530
-
-
Warburg, O.1
-
27
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan,D. et al. (2011) Hallmarks of cancer: the next generation. Cell, 144, 646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
-
28
-
-
84866127673
-
Metabolic reprogramming of the tumor
-
Ferreira,L.M. et al. (2012) Metabolic reprogramming of the tumor. Oncogene, 31, 3999-4011.
-
(2012)
Oncogene
, vol.31
, pp. 3999-4011
-
-
Ferreira, L.M.1
-
29
-
-
78650403118
-
Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha
-
Qing,G. et al. (2010) Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha. Cancer Res., 70, 10351-10361.
-
(2010)
Cancer Res.
, vol.70
, pp. 10351-10361
-
-
Qing, G.1
-
30
-
-
84885178346
-
BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery
-
Hagenbuchner,J. et al. (2013) BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery. Oncogene, 32, 4748-4757.
-
(2013)
Oncogene
, vol.32
, pp. 4748-4757
-
-
Hagenbuchner, J.1
-
31
-
-
0029127219
-
Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors
-
Weidner,N. (1995) Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res. Treat., 36, 169-180.
-
(1995)
Breast Cancer Res. Treat.
, vol.36
, pp. 169-180
-
-
Weidner, N.1
-
32
-
-
0034652620
-
High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
-
Walenta,S. et al. (2000) High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res., 60, 916-921.
-
(2000)
Cancer Res.
, vol.60
, pp. 916-921
-
-
Walenta, S.1
-
33
-
-
0023148557
-
Neoplastic transformation by the human gene N-myc
-
Small,M.B. et al. (1987) Neoplastic transformation by the human gene N-myc. Mol. Cell. Biol., 7, 1638-1645.
-
(1987)
Mol. Cell. Biol.
, vol.7
, pp. 1638-1645
-
-
Small, M.B.1
-
34
-
-
0344156843
-
The chemical constitution of respiration ferment
-
Warburg,O. (1928) The chemical constitution of respiration ferment. Science, 68, 437-443.
-
(1928)
Science
, vol.68
, pp. 437-443
-
-
Warburg, O.1
-
35
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby,R.A. et al. (2004) Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer, 4, 891-899.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
-
36
-
-
33744783432
-
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
-
Fantin,V.R. et al. (2006) Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell, 9, 425-434.
-
(2006)
Cancer Cell
, vol.9
, pp. 425-434
-
-
Fantin, V.R.1
-
37
-
-
0033974001
-
The p21(WAF1/CIP1) promoter is methylated in Rat-1 cells: stable restoration of p53-dependent p21(WAF1/CIP1) expression after transfection of a genomic clone containing the p21(WAF1/CIP1) gene
-
Allan,L.A. et al. (2000) The p21(WAF1/CIP1) promoter is methylated in Rat-1 cells: stable restoration of p53-dependent p21(WAF1/CIP1) expression after transfection of a genomic clone containing the p21(WAF1/CIP1) gene. Mol. Cell. Biol., 20, 1291-1298.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 1291-1298
-
-
Allan, L.A.1
-
38
-
-
79960847016
-
Advances in sarcoma genomics and new therapeutic targets
-
Taylor,B.S. et al. (2011) Advances in sarcoma genomics and new therapeutic targets. Nat. Rev. Cancer, 11, 541-557.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 541-557
-
-
Taylor, B.S.1
-
39
-
-
84866047749
-
A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation
-
Piccinin,S. et al. (2012) A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation. Cancer Cell, 22, 404-415.
-
(2012)
Cancer Cell
, vol.22
, pp. 404-415
-
-
Piccinin, S.1
-
40
-
-
0033588883
-
Rhabdomyosarcoma-working out the pathways
-
Merlino,G. et al. (1999) Rhabdomyosarcoma-working out the pathways. Oncogene, 18, 5340-5348.
-
(1999)
Oncogene
, vol.18
, pp. 5340-5348
-
-
Merlino, G.1
-
41
-
-
2642528708
-
Altered expression and molecular abnormalities of cell-cycle-regulatory proteins in rhabdomyosarcoma
-
Takahashi,Y. et al. (2004) Altered expression and molecular abnormalities of cell-cycle-regulatory proteins in rhabdomyosarcoma. Mod. Pathol., 17, 660-669.
-
(2004)
Mod. Pathol.
, vol.17
, pp. 660-669
-
-
Takahashi, Y.1
-
42
-
-
33644552409
-
Increased frequency of aberrations in the p53/MDM2/p14(ARF) pathway in neuroblastoma cell lines established at relapse
-
Carr,J. et al. (2006) Increased frequency of aberrations in the p53/MDM2/p14(ARF) pathway in neuroblastoma cell lines established at relapse. Cancer Res., 66, 2138-2145.
-
(2006)
Cancer Res.
, vol.66
, pp. 2138-2145
-
-
Carr, J.1
-
43
-
-
76749166680
-
High Frequency of p53/MDM2/p14ARF Pathway Abnormalities in Relapsed Neuroblastoma
-
Carr-Wilkinson,J. et al. (2010) High Frequency of p53/MDM2/p14ARF Pathway Abnormalities in Relapsed Neuroblastoma. Clin. Cancer Res., 16, 1108-1118.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 1108-1118
-
-
Carr-Wilkinson, J.1
-
44
-
-
0028076921
-
Altered growth and phenotype in clonal mycN transfectants of the SK-N-SH neuroblastoma cell line
-
Gross,N. et al. (1994) Altered growth and phenotype in clonal mycN transfectants of the SK-N-SH neuroblastoma cell line. Int. J. Cancer, 59, 141-148.
-
(1994)
Int. J. Cancer
, vol.59
, pp. 141-148
-
-
Gross, N.1
-
45
-
-
0029743372
-
Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells
-
Lutz,W. et al. (1996) Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells. Oncogene, 13, 803-812.
-
(1996)
Oncogene
, vol.13
, pp. 803-812
-
-
Lutz, W.1
-
46
-
-
33750827351
-
The case for Survivin as mitotic regulator
-
Lens,S.M. et al. (2006) The case for Survivin as mitotic regulator. Curr. Opin. Cell Biol., 18, 616-622.
-
(2006)
Curr. Opin. Cell Biol.
, vol.18
, pp. 616-622
-
-
Lens, S.M.1
-
47
-
-
33750611276
-
The case for survivin as a regulator of microtubule dynamics and cell-death decisions
-
Altieri,D.C. (2006) The case for survivin as a regulator of microtubule dynamics and cell-death decisions. Curr. Opin. Cell Biol., 18, 609-615.
-
(2006)
Curr. Opin. Cell Biol.
, vol.18
, pp. 609-615
-
-
Altieri, D.C.1
-
48
-
-
0038376119
-
Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension
-
Lens,S.M. et al. (2003) Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J., 22, 2934-2947.
-
(2003)
EMBO J.
, vol.22
, pp. 2934-2947
-
-
Lens, S.M.1
-
49
-
-
73649095563
-
IAP regulation of metastasis
-
Mehrotra,S. et al. (2010) IAP regulation of metastasis. Cancer Cell, 17, 53-64.
-
(2010)
Cancer Cell
, vol.17
, pp. 53-64
-
-
Mehrotra, S.1
-
50
-
-
78049267203
-
Survivin enhances motility of melanoma cells by supporting Akt activation and {alpha}5 integrin upregulation
-
McKenzie,J.A. et al. (2010) Survivin enhances motility of melanoma cells by supporting Akt activation and {alpha}5 integrin upregulation. Cancer Res., 70, 7927-7937.
-
(2010)
Cancer Res.
, vol.70
, pp. 7927-7937
-
-
McKenzie, J.A.1
-
51
-
-
0023734130
-
Transfer of a functional human immune system to mice with severe combined immunodeficiency
-
Mosier,D.E. et al. (1988) Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature, 335, 256-259.
-
(1988)
Nature
, vol.335
, pp. 256-259
-
-
Mosier, D.E.1
-
52
-
-
0018905522
-
The polyoma virus 100K large T-antigen is not required for the maintenance of transformation
-
Lania,L. et al. (1980) The polyoma virus 100K large T-antigen is not required for the maintenance of transformation. Virology, 101, 217-232.
-
(1980)
Virology
, vol.101
, pp. 217-232
-
-
Lania, L.1
-
53
-
-
0035953308
-
IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity
-
Shankaran,V. et al. (2001) IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature, 410, 1107-1111.
-
(2001)
Nature
, vol.410
, pp. 1107-1111
-
-
Shankaran, V.1
-
54
-
-
84863753157
-
The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma
-
Berry,T. et al. (2012) The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma. Cancer Cell, 22, 117-130.
-
(2012)
Cancer Cell
, vol.22
, pp. 117-130
-
-
Berry, T.1
-
55
-
-
57849107571
-
Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma
-
Otto,T. et al. (2009) Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Cancer Cell, 15, 67-78.
-
(2009)
Cancer Cell
, vol.15
, pp. 67-78
-
-
Otto, T.1
|