Microneedle delivery of an M2e-TLR5 ligand fusion protein to skin confers broadly cross-protective influenza immunity

Journal of Controlled Release

Volumn 178, Issue 1, 2014, Pages 1-7

  Wang, Bao Zhong ^a   Gill, Harvinder S ^a,b   He, Cheng ^c   Ou, Changbo ^c   Wang, Li ^a   Wang, Ying Chun ^a   Feng, Hao ^a   Zhang, Han ^a   Prausnitz, Mark R ^d   Compans, Richard W ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Electrical and Computer Engineering   (United States)

^c CHINA AGRICULTURAL UNIVERSITY   (China)

^d Georgia Institute of Technology   (United States)

Author keywords

Cross protection; Influenza M2e; Microneedle array; TLR5 ligand; Universal influenza vaccine

Indexed keywords

IMMUNIZATION; LIGANDS; NEEDLES; VACCINES; VIRUSES;

CROSS-PROTECTION; EXTRACELLULAR DOMAINS; INFLUENZA M2E; INFLUENZA VACCINES; INTRAMUSCULAR INJECTIONS; INTRANASAL IMMUNIZATIONS; MICRONEEDLE ARRAYS; PROTECTIVE EFFICACY;

PROTEINS;

4 M2E FLAGELLIN FUSION PROTEIN; HYBRID PROTEIN; INFLUENZA VACCINE; UNCLASSIFIED DRUG; VIRUS ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; CROSS PROTECTION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SAFETY; DRUG STORAGE; INFLUENZA; INFLUENZA VACCINATION; MICRONEEDLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS LOAD;

CROSS-PROTECTION; INFLUENZA M2E; MICRONEEDLE ARRAY; TLR5 LIGAND; UNIVERSAL INFLUENZA VACCINE;

ADMINISTRATION, CUTANEOUS; ANIMALS; CELL LINE; DOGS; FLAGELLIN; IMMUNITY; IMMUNOGLOBULIN G; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA VACCINES; LIGANDS; MADIN DARBY CANINE KIDNEY CELLS; MICE; MICROINJECTIONS; NEEDLES; ORTHOMYXOVIRIDAE INFECTIONS; RECOMBINANT FUSION PROTEINS; TOLL-LIKE RECEPTOR 5; VIRAL MATRIX PROTEINS;

EID: 84893360955     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.01.002     Document Type: Article

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