-
1
-
-
69749124925
-
Concerning the modifications which particular organic materials undergo in their transition to the urine
-
Wöhler F, Frerichs FT. Concerning the modifications which particular organic materials undergo in their transition to the urine. Ann. Chem. Pharm. 63, 335 (1848
-
(1848)
Ann. Chem. Pharm
, vol.63
, pp. 335
-
-
Wöhler, F.1
Frerichs, F.T.2
-
2
-
-
84887816252
-
On gouty concretions; With a new method of treatment
-
Ure A. On gouty concretions; with a new method of treatment. Med. Chir. Trans. 24, 30-35 (1841
-
(1841)
Med. Chir. Trans
, vol.24
, pp. 30-35
-
-
Ure, A.1
-
3
-
-
84977248846
-
On the conversion of benzoic acid into hippuric acid
-
Keller W. On the conversion of benzoic acid into hippuric acid. Ann. Chem. Pharm. 43, 108 (1842
-
(1842)
Ann. Chem. Pharm
, vol.43
, pp. 108
-
-
Keller, W.1
-
4
-
-
69749123673
-
Metabolism of cinnamic acid to hippuric acid in animals
-
Marchand RF. Metabolism of cinnamic acid to hippuric acid in animals. Ann. Chem. Pharm. 44, 344 (1842
-
(1842)
Ann. Chem. Pharm
, vol.44
, pp. 344
-
-
Marchand, R.F.1
-
5
-
-
84893362887
-
The behaviour of benzene-derived hydrocarbons in the animal organism
-
Schultzen O, Naunyn B. The behaviour of benzene-derived hydrocarbons in the animal organism. Arch. Anat. Physiol. 349 (1867
-
(1867)
Arch. Anat. Physiol
, vol.349
-
-
Schultzen, O.1
Naunyn, B.2
-
6
-
-
77954697530
-
Development of bioanalysis: A short history
-
Hill H. Development of bioanalysis: A short history. Bioanalysis 1(1), 3-7 (2009
-
(2009)
Bioanalysis
, vol.1
, Issue.1
, pp. 3-7
-
-
Hill, H.1
-
7
-
-
53549097600
-
-
US Department of Health and Human Services Food and Drug Administration, US FDA, Center for Drug Evaluation and Research, Pharmacology and Toxicology. US FDA, Rockville, MD, USA
-
US Department of Health and Human Services Food and Drug Administration, US FDA, Center for Drug Evaluation and Research, Pharmacology and Toxicology. Guidance for Industry, Safety Testing of Drug Metabolites. US FDA, Rockville, MD, USA (2008
-
(2008)
Guidance for Industry, Safety Testing of Drug Metabolites
-
-
-
10
-
-
24944563781
-
Seeing through the MIST: Abundance versus percentage Commentary on metabolites in safety testing
-
Smith D, Obach RS. Seeing through the MIST: Abundance versus percentage. Commentary on metabolites in safety testing. Drug Metab. Dispos. 33, 1409-1417 (2005
-
(2005)
Drug Metab. Dispos
, vol.33
, pp. 1409-1417
-
-
Smith, D.1
Obach, R.S.2
-
11
-
-
77953777481
-
Use of the ole-Tozer model in understanding mechanisms and determinants of drug distribution
-
Waters NJ, Lombardo F. Use of the ole-Tozer model in understanding mechanisms and determinants of drug distribution. Drug Metab. Dispos. 38, 1159-1165 (2010
-
(2010)
Drug Metab. Dispos
, vol.38
, pp. 1159-1165
-
-
Waters, N.J.1
Lombardo, F.2
-
12
-
-
77649216536
-
Membrane transporters in drug development
-
International Transporter Consortium March
-
International Transporter Consortium, Giacomini KM, Huang SM et al. Membrane Transporters in Drug Development. Nat. Rev. Drug Discov. 9, 215-236 (March 2010
-
(2010)
Nat. Rev. Drug Discov
, vol.9
, pp. 215-236
-
-
Giacomini, K.M.1
Huang, S.M.2
-
13
-
-
34047157087
-
The prediction of drug metabolism, tissue distribution and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools
-
De Buck SS, Sinha VK, Fenu LA, Gilissen RA, Mackie CE, Nijsen MJ. The prediction of drug metabolism, tissue distribution and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools. Drug Metab. Dispos. 35, 649-659 (2007
-
(2007)
Drug Metab. Dispos
, vol.35
, pp. 649-659
-
-
De Buck, S.S.1
Sinha, V.K.2
Fenu, L.A.3
Gilissen, R.A.4
MacKie, C.E.5
Nijsen, M.J.6
-
14
-
-
77049195108
-
Studies on the distribution and fate of 35S-labelled benzylpenicillin in the body
-
Ullberg S. Studies on the distribution and fate of 35S-labelled benzylpenicillin in the body. Acta Radiologica Suppl. 118, 1-110 (1954
-
(1954)
Acta Radiologica Suppl
, vol.118
, pp. 1-110
-
-
Ullberg, S.1
-
15
-
-
0002250291
-
The technique of whole body autoradiography cryosectioning of large specimens. Science Tools
-
Ullberg S. The technique of whole body autoradiography cryosectioning of large specimens. Science Tools, The LKB Instrument Journal 1-29 (1977
-
(1977)
The LKB Instrument Journal
, pp. 1-29
-
-
Ullberg, S.1
-
17
-
-
1642281756
-
Drug-protein adducts: An industry perspective on minimising the potential for drug bioactivation in drug discovery and development
-
Evans DC, Watt AP, Nicoll-Griffith DA, Baillie TA. Drug-protein adducts: An industry perspective on minimising the potential for drug bioactivation in drug discovery and development. Chem. Res. Toxicol. 17, 3-16 (2004
-
(2004)
Chem. Res. Toxicol
, vol.17
, pp. 3-16
-
-
Evans, D.C.1
Watt, A.P.2
Nicoll-Griffith, D.A.3
Baillie, T.A.4
-
18
-
-
18844373318
-
Role of metabolism in drug-induced idiosynchratic hepatotoxicity
-
Walgren JL, Mitchell MD, Thompson DC. Role of metabolism in drug-induced idiosynchratic hepatotoxicity. Crit. Rev. Toxicol. 35, 325-361(2005
-
(2005)
Crit. Rev. Toxicol
, vol.35
, pp. 325-361
-
-
Walgren, J.L.1
Mitchell, M.D.2
Thompson, D.C.3
-
19
-
-
13844319935
-
Drug bioactivation, covalent binding to target proteins and toxicity relevance
-
Zhou S, Chan E, Duan W, Huang M, Chen YZ. Drug bioactivation, covalent binding to target proteins and toxicity relevance. Drug Metab. Rev. 37, 41-213 (2005
-
(2005)
Drug Metab. Rev
, vol.37
, pp. 41-213
-
-
Zhou, S.1
Chan, E.2
Duan, W.3
Huang, M.4
Chen, Y.Z.5
-
20
-
-
0027205012
-
Mass spectrometry in the analysis of glutathione conjugates
-
Baillie TA, Davis MR. Mass spectrometry in the analysis of glutathione conjugates. Biol. Mass Spectrom. 22, 319-325 (1993
-
(1993)
Biol. Mass Spectrom
, vol.22
, pp. 319-325
-
-
Baillie, T.A.1
Davis, M.R.2
-
21
-
-
34047275727
-
Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediates and in vitro glutathione conjugate formation in rats and humans
-
Masabuchi N, Makino C, Murayama N. Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediates and in vitro glutathione conjugate formation in rats and humans. Chem. Res. Toxicol. 20, 455-464 (2007
-
(2007)
Chem. Res. Toxicol
, vol.20
, pp. 455-464
-
-
Masabuchi, N.1
Makino, C.2
Murayama, N.3
-
22
-
-
18944396519
-
Dansyl glutathione as a trapping agent for quantitative estimation and identification of reactive metabolites
-
Gan J, Harper TW, Hsueh MM, Qu Q, Humphreys WG. Dansyl glutathione as a trapping agent for quantitative estimation and identification of reactive metabolites. Chem. Res. Toxicol. 18, 896-903 (2005
-
(2005)
Chem. Res. Toxicol
, vol.18
, pp. 896-903
-
-
Gan, J.1
Harper, T.W.2
Hsueh, M.M.3
Qu, Q.4
Humphreys, W.G.5
-
23
-
-
50049084336
-
Covalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity
-
Takakusa H, Masamuto H, Yukinaga H et al. Covalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity. Drug Metab. Dispos. 36, 1770-1779 (2008
-
(2008)
Drug Metab. Dispos
, vol.36
, pp. 1770-1779
-
-
Takakusa, H.1
Masamuto, H.2
Yukinaga, H.3
-
24
-
-
84893416969
-
Pharmacokinetics, tissue distribution and oral bioavailability evaluation of isoimperotorin by high performance liquid chromatography coupled with mass spectrometry
-
Zhang J, Tao F, Li Y et al. Pharmacokinetics, tissue distribution and oral bioavailability evaluation of isoimperotorin by high performance liquid chromatography coupled with mass spectrometry. J. Med. Plant Res. 6, 1721-1729 (2011
-
(2011)
J. Med. Plant Res
, vol.6
, pp. 1721-1729
-
-
Zhang, J.1
Tao, F.2
Li, Y.3
-
25
-
-
33947268472
-
Utility of imaging mass spectrometry (IMS) by matrix-Assisted laser desorption ionisation (MALDI) on an ion trap mass spectrometer in the ana¬lysis of drugs and metabolites in biological tissues
-
Drexler DM, Garrett TJ, Cantone JL et al. Utility of imaging mass spectrometry (IMS) by matrix-Assisted laser desorption ionisation (MALDI) on an ion trap mass spectrometer in the ana¬lysis of drugs and metabolites in biological tissues. J. Pharmaol. Toxicol. Methods 55(3), 279-288 (2007
-
(2007)
J. Pharmaol. Toxicol. Methods
, vol.55
, Issue.3
, pp. 279-288
-
-
Drexler, D.M.1
Garrett, T.J.2
Cantone, J.L.3
-
26
-
-
84893353021
-
-
American Society for Mass Spectrometry CO USA
-
Barroso ML, King KW, Tran C, Shen A, Zhang X. Case studies of accurate measurement of small molecule drugs in various tissues: Knowledge versus assumption. American Society for Mass Spectrometry, CO, USA (2008
-
(2008)
Case Studies of Accurate Measurement of Small Molecule Drugs in Various Tissues: Knowledge Versus Assumption
-
-
Barroso, M.L.1
King, K.W.2
Tran, C.3
Shen, A.4
Zhang, X.5
-
27
-
-
84870170181
-
Bioanalysis of drug in tissue: Current status and challenges
-
Xue Y-J, Gao H, Li QC et al. Bioanalysis of drug in tissue: Current status and challenges. Bioanalysis 4(21), 2637-2653 (2012
-
(2012)
Bioanalysis
, vol.4
, Issue.21
, pp. 2637-2653
-
-
Xue -. Y, J.1
Gao, H.2
Li, Q.C.3
-
28
-
-
84857417908
-
Investigation of figopitant and its metabolites in rat tissue by combining whole-body autoradiography with liquid extraction surface analysis mass spectrometry
-
Schadt S, Kallbach S, Almeida R, Sandel J. Investigation of figopitant and its metabolites in rat tissue by combining whole-body autoradiography with liquid extraction surface analysis mass spectrometry. Drug Metab. Dispos. 40, 419-425 (2012
-
(2012)
Drug Metab. Dispos
, vol.40
, pp. 419-425
-
-
Schadt, S.1
Kallbach, S.2
Almeida, R.3
Sandel, J.4
-
29
-
-
8844242556
-
Methods to assess tissue-specific distribution and metabolism of drugs
-
Langer O, Muller M. Methods to assess tissue-specific distribution and metabolism of drugs. Curr. Drug Metab. 5(6), 463-481(2004
-
(2004)
Curr. Drug Metab
, vol.5
, Issue.6
, pp. 463-481
-
-
Langer, O.1
Muller, M.2
-
30
-
-
84872039962
-
Global metabolic profiling of animal and human tissues via UPLC-MS
-
Want EJ, Masson P, Michopolous F et al Global metabolic profiling of animal and human tissues via UPLC-MS. Nature Protoc. 8(1), 17-32 (2013
-
(2013)
Nature Protoc
, vol.8
, Issue.1
, pp. 17-32
-
-
Want, E.J.1
Masson, P.2
Michopolous, F.3
-
31
-
-
33845379876
-
Influence of the wavelength in high-irradiance ultraviolet laser desorption mass spectrometry of organic molecules
-
Karas M, Bachmann D, Hillenkamp F. Influence of the wavelength in high-irradiance ultraviolet laser desorption mass spectrometry of organic molecules. Anal. Chem. 57(14), 2935-2939 (1985
-
(1985)
Anal. Chem
, vol.57
, Issue.14
, pp. 2935-2939
-
-
Karas, M.1
Bachmann, D.2
Hillenkamp, F.3
-
32
-
-
0033407306
-
Detection of pharmaceutical compounds in tissue by matrix-Assisted laser desorption/ionisation tandem mass spectrometry with a quadropole ion trap
-
Troendle FJ, Reddick CD, Yost RA. Detection of pharmaceutical compounds in tissue by matrix-Assisted laser desorption/ionisation tandem mass spectrometry with a quadropole ion trap. J. Am. Soc. Mass Spectrom. 10, 1315-1321 (1999
-
(1999)
J. Am. Soc. Mass Spectrom
, vol.10
, pp. 1315-1321
-
-
Troendle, F.J.1
Reddick, C.D.2
Yost, R.A.3
-
33
-
-
10944222054
-
MALDI mass spectrometric imaging of biological tissue sections
-
Rohner TC, Staab D, Stoeckli M. MALDI mass spectrometric imaging of biological tissue sections. Mech. Ageing Dev. 126, 177-185 (2005
-
(2005)
Mech. Ageing Dev
, vol.126
, pp. 177-185
-
-
Rohner, T.C.1
Staab, D.2
Stoeckli, M.3
-
34
-
-
33846012228
-
Compound and metabolite distribution measured by MALDI mass spectrometric imaging in whole body tissue sections
-
Stoeckli M, Staab D, Schweizer A. Compound and metabolite distribution measured by MALDI mass spectrometric imaging in whole body tissue sections. J. Mass Spectrom. 260, 195-202 (2007
-
(2007)
J. Mass Spectrom
, vol.260
, pp. 195-202
-
-
Stoeckli, M.1
Staab, D.2
Schweizer, A.3
-
35
-
-
33748865022
-
Direct molecular ana¬lysis of whole-body animal tissue sections by imaging MALDI mass spectrometry
-
Khatib-Shahidi S, Andersson M, Herman JL, Gillespie TA, Caprioli RM. Direct molecular ana¬lysis of whole-body animal tissue sections by imaging MALDI mass spectrometry. Anal. Chem. 78(18) 6448-6456 (2006).
-
(2006)
Anal. Chem
, vol.78
, Issue.18
, pp. 6448-6456
-
-
Khatib-Shahidi, S.1
Andersson, M.2
Herman, J.L.3
Gillespie, T.A.4
Caprioli, R.M.5
-
36
-
-
81055144381
-
Maldi imaging mass spectrometry: Bridging biology and chemistry in drug development
-
Castellino S, Groseclose MR, Wagner D. MALDI imaging mass spectrometry: Bridging biology and chemistry in drug development. Bioanalysis 3(21), 2427-2441 (2011
-
(2011)
Bioanalysis
, vol.3
, Issue.21
, pp. 2427-2441
-
-
Castellino, S.1
Groseclose, M.R.2
Wagner, D.3
-
37
-
-
0038574979
-
Ion suppression in mass spectrometry
-
Annesly T. Ion suppression in mass spectrometry. Clin. Chem. 49(7), 1041-1044 (2003
-
(2003)
Clin. Chem
, vol.49
, Issue.7
, pp. 1041-1044
-
-
Annesly, T.1
-
38
-
-
57449106862
-
Molecular imaging of proteins in tissues by mass spectrometry
-
Seeley EH, Caprioli RM. Molecular imaging of proteins in tissues by mass spectrometry. Proc. Natl Acad. Sci. USA 105(47), 18126-18131 (2008
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, Issue.47
, pp. 18126-18131
-
-
Seeley, E.H.1
Caprioli, R.M.2
-
39
-
-
56349116855
-
Suppression of matrix-related ions using cyclodextrin in maldi mass spectrometry
-
Yamaguchi S, Fujita T, Fujino T, Korenaga T. Suppression of matrix-related ions using cyclodextrin in MALDI mass spectrometry. Anal. Sci. 24, 1497-1500 (2008
-
(2008)
Anal. Sci
, vol.24
, pp. 1497-1500
-
-
Yamaguchi, S.1
Fujita, T.2
Fujino, T.3
Korenaga, T.4
-
40
-
-
77955372862
-
Fine mapping the spatial distribution and concentration of unlabeled drugs within tissue micro-compartments using imaging mass spectrometry
-
Nillson A, Fehniger TE, Gustavsson L et al. Fine mapping the spatial distribution and concentration of unlabeled drugs within tissue micro-compartments using imaging mass spectrometry. PloS ONE 5(7), e11411 (2010
-
(2010)
PloS ONE
, vol.5
, Issue.7
-
-
Nillson, A.1
Fehniger, T.E.2
Gustavsson, L.3
-
42
-
-
0023180539
-
A simple method for the quantitation of 14C-whole-body autoradiograms
-
Schweitzer A, Fahr A, Neideberger W. A simple method for the quantitation of 14C-whole-body autoradiograms. Int. J. Rad. Appl. Instrum. 38(5), 329-333 (1987
-
(1987)
Int. J. Rad. Appl. Instrum
, vol.38
, Issue.5
, pp. 329-333
-
-
Schweitzer, A.1
Fahr, A.2
Neideberger, W.3
-
43
-
-
56449126797
-
Matrix-Assisted laser desorption/ionisation-ion mobility separation-mass spectrometry imaging of vinblastine in whole body tissue sections
-
Trim PJ, Henson CM, Avery JL et al. Matrix-Assisted laser desorption/ionisation-ion mobility separation-mass spectrometry imaging of vinblastine in whole body tissue sections. Anal. Chem. 80, 8628-8634 (2008
-
(2008)
Anal. Chem
, vol.80
, pp. 8628-8634
-
-
Trim, P.J.1
Henson, C.M.2
Avery, J.L.3
-
44
-
-
70350675595
-
Application of a liquid extraction based sealing surface sampling probe for mass spectrometric ana¬lysis of dried blood spots and mouse whole-body thin tissue sections
-
Van Berkel GJ, Kertesz V. Application of a liquid extraction based sealing surface sampling probe for mass spectrometric ana¬lysis of dried blood spots and mouse whole-body thin tissue sections. Anal. Chem. 81(21), 9146-9152 (2009
-
(2009)
Anal. Chem
, vol.81
, Issue.21
, pp. 9146-9152
-
-
Van Berkel, G.J.1
Kertesz, V.2
-
45
-
-
81555215472
-
Liquid extraction surface ana¬lysis mass spectrometry (lesa-ms) as a novel profiling tool for drug distribution and metabolism ana¬lysis: The terfenadine example
-
Eikel D, Vavrek M, Smith S et al. Liquid extraction surface ana¬lysis mass spectrometry (LESA-MS) as a novel profiling tool for drug distribution and metabolism ana¬lysis: The terfenadine example. Rapid Commun. Mass Spectrom. 25, 3587-3596 (2011
-
(2011)
Rapid Commun. Mass Spectrom
, vol.25
, pp. 3587-3596
-
-
Eikel, D.1
Vavrek, M.2
Smith, S.3
-
46
-
-
84869009503
-
Analysis of chloroquine and metabolites directly from whole-body animal tissue sections by liquid extraction surface analysis (LESA) and tandem mass spectrometry
-
Parson WB, Koeniger SL, Johnson RW et al. Analysis of chloroquine and metabolites directly from whole-body animal tissue sections by liquid extraction surface analysis (LESA) and tandem mass spectrometry. J. Mass Spectrom. 47, 1420-1428 (2012
-
(2012)
J. Mass Spectrom
, vol.47
, pp. 1420-1428
-
-
Parson, W.B.1
Koeniger, S.L.2
Johnson, R.W.3
-
47
-
-
84863786541
-
Novel physiologically based pharmacokinetic modelling of patupilone for human pharmacokinetic predictions
-
Xia B, Heimbach T, Lin T, He H, Wang Y, Tan E. Novel physiologically based pharmacokinetic modelling of patupilone for human pharmacokinetic predictions. Cancer Chemother. Pharmacol. 69(6), 1567-1582 (2012).
-
(2012)
Cancer Chemother. Pharmacol
, vol.69
, Issue.6
, pp. 1567-1582
-
-
Xia, B.1
Heimbach, T.2
Lin, T.3
He, H.4
Wang, Y.5
Tan, E.6
|