Development and validation of high-throughput screening assays for poly(ADP-ribose) polymerase-2 inhibitors

Analytical Biochemistry

Volumn 449, Issue 1, 2014, Pages 188-194

  Zhu, Zhixiang ^a   Jin, Jing ^a   Xue, Nina ^a   Song, Xiuyun ^a   Chen, Xiaoguang ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Chemical quantification; ELISA; High throughput screening; Inhibitor; PARP2

Indexed keywords

COST EFFECTIVENESS; DISEASES; T-CELLS;

CEREBRAL ISCHEMIA; ELISA; HIGH THROUGHPUT SCREENING; INHIBITOR; PARP2; POLY(ADP RIBOSE) POLYMERASE 1; SPECIFIC INHIBITORS; THERAPEUTIC EFFECTS;

DIAGNOSIS;

3 AMINOBENZAMIDE; ANTINEOPLASTIC AGENT; BIOTIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 2 INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; VELIPARIB;

ADIPOGENESIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA REPAIR; DRUG DETERMINATION; DRUG SCREENING; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENOME; HELA CELL; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; LIMIT OF QUANTITATION; PRIORITY JOURNAL; SIGNAL NOISE RATIO; SPERMATOGENESIS;

BIOTINYLATED NAD(+); CHEMICAL QUANTIFICATION; ELISA; HIGH-THROUGHPUT SCREENING; INHIBITOR; PARP2;

BIOTINYLATION; DRUG EVALUATION, PRECLINICAL; ENZYME ASSAYS; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HELA CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; NAD; POLY(ADP-RIBOSE) POLYMERASES;

EID: 84893333115     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2013.12.028     Document Type: Article

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