Formulation and characterization of nanoemulsion intranasal adjuvants: Effects of surfactant composition on mucoadhesion and immunogenicity

Molecular Pharmaceutics

Volumn 11, Issue 2, 2014, Pages 531-544

  Wong, Pamela T ^a   Wang, Su He ^a   Ciotti, Susan ^b   Makidon, Paul E ^a   Smith, Douglas M ^a   Fan, Yongyi ^a   Schuler, Charles F ^a   Baker, James R ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b NanoBio Corporation   (United States)

Author keywords

adjuvant; intranasal vaccine; mucoadhesion; nanoemulsion; oil in water emulsion

Indexed keywords

ADJUVANT; ANTIGEN; MUCIN; NONIONIC SURFACTANT; OVALBUMIN; PROTEIN; VACCINE; EMULSION; IMMUNOLOGICAL ADJUVANT; SURFACTANT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LINE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; EMULSION; EPITHELIUM CELL; GEOMETRY; HYDROPHOBICITY; IMAGING; IMMUNE RESPONSE; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; INTRANASAL DELIVERY; LIGHT SCATTERING; MEASUREMENT; MOUSE; MUCOADHESION; MUCUS; NANOEMULSION; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SURFACE PLASMON RESONANCE; TISSUE SECTION; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; ANIMAL; CELL ADHESION; CHEMISTRY; DRUG EFFECTS; FEMALE; HUMAN; IMMUNOGENETICS; INTRANASAL DRUG ADMINISTRATION; MEDICINAL CHEMISTRY; NANOTECHNOLOGY; NOSE MUCOSA; PHARMACOLOGY;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRANASAL; ANIMALS; CELL ADHESION; CELL LINE; CHEMISTRY, PHARMACEUTICAL; EMULSIONS; FEMALE; HUMANS; IMMUNOGENETIC PHENOMENA; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; NANOTECHNOLOGY; NASAL MUCOSA; SURFACE-ACTIVE AGENTS;

EID: 84893272271     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp4005029     Document Type: Article

References (40)

1. Davis, S. S. Nasal vaccines Adv. Drug Delivery Rev. 2001, 51, 21-42 (Pubitemid 32763070)
2. Freytag, L. C.; Clements, J. D. Mucosal adjuvants Vaccine 2005, 23, 1804-13 (Pubitemid 40331849)
3. Holmgren, J.; Czerkinsky, C. Mucosal immunity and vaccines Nat. Med. 2005, 11, S45-53
4. Vajdy, M.; Singh, M. The role of adjuvants in the development of mucosal vaccines Expert Opin. Biol. Ther. 2005, 5, 953-65 (Pubitemid 41032851)
5. Neutra, M. R.; Kozlowski, P. A. Mucosal vaccines: the promise and the challenge Nat. Rev. Immunol. 2006, 6, 148-58 (Pubitemid 43361590)
6. Mestecky, J.; Moldoveanu, Z.; Russell, M. W. Immunologic uniqueness of the genital tract: challenge for vaccine development Am. J. Reprod. Immunol. 2005, 53, 208-14 (Pubitemid 40542802)
7. Wizel, B.; Persson, J.; Thorn, K.; Nagy, E.; Harandi, A. M. Nasal and skin delivery of IC31((R))-adjuvanted recombinant HSV-2 gD protein confers protection against genital herpes Vaccine 2012, 30, 4361-8
8. Costantino, H. R.; Illum, L.; Brandt, G.; Johnson, P. H.; Quay, S. C. Intranasal delivery: physicochemical and therapeutic aspects Int. J. Pharmaceutics 2007, 337, 1-24 (Pubitemid 46756063)
9. Kemble, G.; Greenberg, H. Novel generations of influenza vaccines Vaccine 2003, 21, 1789-95 (Pubitemid 36398375)
10. Van Kampen, K. R.; Shi, Z.; Gao, P.; Zhang, J.; Foster, K. W.; Chen, D. T.; Marks, D.; Elmets, C. A.; Tang, D. C. Safety and immunogenicity of adenovirus-vectored nasal and epicutaneous influenza vaccines in humans Vaccine 2005, 23, 1029-36 (Pubitemid 40037652)
11. Treanor, J. J.; Mattison, H. R.; Dumyati, G.; Yinnon, A.; Erb, S.; O'Brien, D.; Dolin, R.; Betts, R. F. Protective efficacy of combined live intranasal and inactivated influenza A virus vaccines in the elderly Ann. Intern. Med. 1992, 117, 625-33
12. Treanor, J.; Wu, H.; Liang, H.; Topham, D. J. Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults Vaccine 2006, 24, 6913-23 (Pubitemid 46107183)
13. Obrosova-Serova, N. P.; Slepushkin, A. N.; Kendal, A. P.; Harmon, M. W.; Burtseva, E. I.; Bebesheva, N. I.; Beljaev, A. L.; Lonskaja, N. I.; Medvedeva, T. E.; Egorov, A. Y. Evaluation in children of cold-adapted influenza B live attenuated intranasal vaccine prepared by reassortment between wild-type B/Ann Arbor/1/86 and cold-adapted B/Leningrad/14/55 viruses Vaccine 1990, 8, 57-60 (Pubitemid 20112884)
14. Haneberg, B.; Dalseg, R.; Wedege, E.; Hoiby, E. A.; Haugen, I. L.; Oftung, F.; Andersen, S. R.; Naess, L. M.; Aase, A.; Michaelsen, T. E.; Holst, J. Intranasal administration of a meningococcal outer membrane vesicle vaccine induces persistent local mucosal antibodies and serum antibodies with strong bactericidal activity in humans Infect. Immun. 1998, 66, 1334-41 (Pubitemid 128471487)
15. Zinkernagel, R. M.; Ehl, S.; Aichele, P.; Oehen, S.; Kundig, T.; Hengartner, H. Antigen localisation regulates immune responses in a dose- and time-dependent fashion: A geographical view of immune reactivity Immunol. Rev. 1997, 156, 199-209 (Pubitemid 27197203)
16. Storni, T.; Kundig, T. M.; Senti, G.; Johansen, P. Immunity in response to particulate antigen-delivery systems Adv. Drug Delivery Rev. 2005, 57, 333-355 (Pubitemid 39555501)
17. Makidon, P. E.; Bielinska, A. U.; Nigavekar, S. S.; Janczak, K. W.; Knowlton, J.; Scott, A. J.; Mank, N.; Cao, Z. Y.; Rathinavelu, S.; Beer, M. R.; Wilkinson, J. E.; Blanco, L. P.; Landers, J. J.; Baker, J. R. Pre-Clinical Evaluation of a Novel Nanoemulsion-Based Hepatitis B Mucosal Vaccine PLoS One 2008, 3, 2954
18. Makidon, P. E.; Belyakov, I. M.; Blanco, L. P.; Janczak, K. W.; Landers, J.; Bielinska, A. U.; Groom, J. V., 2nd; Baker, J. R., Jr. Nanoemulsion mucosal adjuvant uniquely activates cytokine production by nasal ciliated epithelium and induces dendritic cell trafficking Eur. J. Immunol. 2012, 42, 2073-2086
19. Stanberry, L. R.; Simon, J. K.; Johnson, C.; Robinson, P. L.; Morry, J.; Flack, M. R.; Gracon, S.; Myc, A.; Hamouda, T.; Baker, J. R. Safety and immunogenicity of a novel nanoemulsion mucosal adjuvant W(80)5EC combined with approved seasonal influenza antigens Vaccine 2012, 30, 307-316
20. Bielinska, A. U.; Chepurnov, A. A.; Landers, J. J.; Janczak, K. W.; Chepurnova, T. S.; Luker, G. D.; Baker, J. R. A novel, killed-virus nasal vaccinia virus vaccine Clin. Vaccine Immunol. 2008, 15, 348-358 (Pubitemid 352025538)
21. Bielinska, A. U.; Janczak, K. W.; Landers, J. J.; Makidon, P.; Sower, L. E.; Peterson, J. W.; Baker, J. R., Jr. Mucosal immunization with a novel nanoemulsion-based recombinant anthrax protective antigen vaccine protects against Bacillus anthracis spore challenge Infect. Immun. 2007, 75, 4020-4029 (Pubitemid 47206301)
22. Bielinska, A. U.; Janczak, K. W.; Landers, J. J.; Markovitz, D. M.; Montefiori, D. C.; Baker, J. R. Nasal immunization with a recombinant HIV gp120 and nanoemulsion adjuvant produces th1 polarized responses and neutralizing antibodies to primary HIV type 1 isolates AIDS Res. Hum. Retrovirus 2008, 24, 271-281 (Pubitemid 351282102)
23. Baos, S. C.; Phillips, D. B.; Wildling, L.; McMaster, T. J.; Berry, M. Distribution of sialic acids on mucins and gels: a defense mechanism Biophys. J. 2012, 102, 176-84
24. Lai, S. K.; Wang, Y. Y.; Hanes, J. Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues Adv. Drug Delivery Rev. 2009, 61, 158-71
25. Bansil, R.; Stanley, E.; LaMont, J. T. Mucin biophysics Annu. Rev. Physiol. 1995, 57, 635-57
26. Pawar, D.; Goyal, A. K.; Mangal, S.; Mishra, N.; Vaidya, B.; Tiwari, S.; Jain, A. K.; Vyas, S. P. Evaluation of mucoadhesive PLGA microparticles for nasal immunization AAPS J. 2010, 12, 130-7
27. Takeuchi, H.; Thongborisute, J.; Matsui, Y.; Sugihara, H.; Yamamoto, H.; Kawashima, Y. Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems Adv. Drug Delivery Rev. 2005, 57, 1583-94 (Pubitemid 41443471)
28. Thongborisute, J.; Takeuchi, H. Evaluation of mucoadhesiveness of polymers by BIACORE method and mucin-particle method Int. J. Pharmaceutics 2008, 354, 204-9
29. He, P.; Davis, S. S.; Illum, L. In vitro evaluation of the mucoadhesive properties of chitosan microspheres Int. J. Pharmaceutics 1998, 166, 75-88 (Pubitemid 28239741)
30. Choi, S. K.; Myc, A.; Silpe, J. E.; Sumit, M.; Wong, P. T.; McCarthy, K.; Desai, A. M.; Thomas, T. P.; Kotlyar, A.; Holl, M. M.; Orr, B. G.; Baker, J. R., Jr. Dendrimer-based multivalent vancomycin nanoplatform for targeting the drug-resistant bacterial surface ACS Nano 2013, 7, 214-28
31. Wengst, A.; Reichl, S. RPMI 2650 epithelial model and three-dimensional reconstructed human nasal mucosa as in vitro models for nasal permeation studies Eur. J. Pharm. Biopharm. 2010, 74, 290-7
32. Bai, S.; Yang, T.; Abbruscato, T. J.; Ahsan, F. Evaluation of human nasal RPMI 2650 cells grown at an air-liquid interface as a model for nasal drug transport studies J. Pharm. Sci. 2008, 97, 1165-78
33. Kissel, T.; Werner, U. Nasal delivery of peptides: an in vitro cell culture model for the investigation of transport and metabolism in human nasal epithelium J. Controlled Release 1998, 53, 195-203 (Pubitemid 28218702)
34. Harikarnpakdee, S.; Lipipun, V.; Sutanthavibul, N.; Ritthidej, G. C. Spray-dried mucoadhesive microspheres: preparation and transport through nasal cell monolayer AAPS PharmSciTech 2006, 7, E12
35. Bielinska, A. U.; Gerber, M.; Blanco, L. P.; Makidon, P. E.; Janczak, K. W.; Beer, M.; Swanson, B.; Baker, J. R., Jr. Induction of Th17 cellular immunity with a novel nanoemulsion adjuvant Crit. Rev. Immunol. 2010, 30, 189-99
36. Mangal, S.; Pawar, D.; Garg, N. K.; Jain, A. K.; Vyas, S. P.; Rao, D. S.; Jaganathan, K. S. Pharmaceutical and immunological evaluation of mucoadhesive nanoparticles based delivery system(s) administered intranasally Vaccine 2011, 29, 4953-62
37. Kang, M. L.; Cho, C. S.; Yoo, H. S. Application of chitosan microspheres for nasal delivery of vaccines Biotechnol. Adv. 2009, 27, 857-65
38. Slutter, B.; Bal, S.; Keijzer, C.; Mallants, R.; Hagenaars, N.; Que, I.; Kaijzel, E.; van Eden, W.; Augustijns, P.; Lowik, C.; Bouwstra, J.; Broere, F.; Jiskoot, W. Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen Vaccine 2010, 28, 6282-91
39. Myc, A.; Kukowska-Latallo, J. F.; Smith, D. M.; Passmore, C.; Pham, T.; Wong, P.; Bielinska, A. U.; Baker, J. R., Jr. Nanoemulsion nasal adjuvant W(8)(0)5EC induces dendritic cell engulfment of antigen-primed epithelial cells Vaccine 2013, 31, 1072-9
40. Tafaghodi, M.; Saluja, V.; Kersten, G. F.; Kraan, H.; Slutter, B.; Amorij, J. P.; Jiskoot, W. Hepatitis B surface antigen nanoparticles coated with chitosan and trimethyl chitosan: Impact of formulation on physicochemical and immunological characteristics Vaccine 2012, 30, 5341-8