Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo

Journal of Pharmaceutical Sciences

Volumn 100, Issue 9, 2011, Pages 3912-3923

  Sadiq, Muhammad Waqas ^a   Borgs, Annika ^a   Okura, Takashi ^b   Shimomura, Keita ^b   Kato, Sayaka ^b   Deguchi, Yoshiharu ^b   Jansson, Britt ^a   Björkman, Sven ^a   Terasaki, Tetsuya ^c   Hammarlund udenaes, Margareta ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b TEIKYO UNIVERSITY   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

Active transport; Blood brain barrier; Drug interactions; HPLC (high performance pressure liquid chromatography); Mass spectrometry; Organic cation transporters (OCTs); Pharmacokinetics

Indexed keywords

DIPHENHYDRAMINE; OXYCODONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG HALF LIFE; DRUG INHIBITION; DRUG TRANSPORT; DRUG UPTAKE; ENDOTHELIUM CELL; IN VITRO STUDY; IN VIVO STUDY; INTERSTITIAL FLUID; MALE; MICRODIALYSIS; NONHUMAN; RAT;

EID: 79960112074     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22567     Document Type: Article

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