Inhibiting the toll-like receptor 4 toll/interleukin-1 receptor domain protects against hepatic warm ischemia and reperfusion injury in mice

Critical Care Medicine

Volumn 42, Issue 2, 2014, Pages

  Meimei, He ^a   Dejin, Min ^a   Erzhen, Chen ^a   Minmin, Shi ^a   Songyao, Jiang ^a   Jianfang, Li ^a   Hao, Chen ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Apoptosis; Cytokine; Hepatic Protection; Ischemia Reperfusion; Toll Like Receptor 4; Toll Interleukin 1R Domain

Indexed keywords

INTERLEUKIN 1 RECEPTOR; TOLL LIKE RECEPTOR 4;

ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; ISCHEMIA; LIVER; MALE; MOUSE; REPERFUSION INJURY; SIGNAL TRANSDUCTION; VASCULARIZATION;

ANIMALS; LIVER; MALE; MICE; MICE, INBRED BALB C; RECEPTORS, INTERLEUKIN-1; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; WARM ISCHEMIA;

EID: 84893248265     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3182a647c1     Document Type: Article

References (34)

1. Selzner N, Rudiger H, Graf R, et al: Protective strategies against ischemic injury of the liver. Gastroenterology 2003; 125:917-936
2. Lentsch AB, Kato A, Yoshidome H, et al: Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury. Hepatology 2000; 32:169-173
3. Ren F, Duan Z, Cheng Q, et al: Inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury by way of an interleukin-10-mediated immune regulatory mechanism. Hepatology 2011; 54:687-696
4. Akira S, Takeda K: Toll-like receptor signalling. Nat Rev Immunol 2004; 4:499-511
5. Barton GM, Medzhitov R: Toll-like receptor signaling pathways. Science 2003; 300:1524-1525
6. Boros P, Bromberg JS: New cellular and molecular immune pathways in ischemia/reperfusion injury. Am J Transplant 2006; 6:652-658
7. Akira S, Uematsu S, Takeuchi O: Pathogen recognition and innate immunity. Cell 2006; 124:783-801
8. Brown J, Wang H, Hajishengallis GN, et al: TLR-signaling networks: An integration of adaptor molecules, kinases, and cross-talk. J Dent Res 2011; 90:417-427
9. Chang WJ, Toledo-Pereyra LH: Toll-like receptor signaling in liver ischemia and reperfusion. J Invest Surg 2012; 25:271-277
10. Zhang G, Budker V, Wolff JA: High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther 1999; 10:1735-1737
11. Clarke C, Kuboki S, Sakai N, et al: CXC chemokine receptor-1 is expressed by hepatocytes and regulates liver recovery after hepatic ischemia/reperfusion injury. Hepatology 2011; 53:261-271
12. Suzuki S, Toledo-Pereyra LH, Rodriguez FJ, et al: Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Modulating effects of FK506 and cyclosporine. Transplantation 1993; 55:1265-1272
13. Malhi H, Gores GJ, Lemasters JJ: Apoptosis and necrosis in the liver: A tale of two deaths Hepatology 2006; 43:S31-S44
14. Liu F, Song Y, Liu D: Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 1999; 6:1258-1266
15. Hodges BL, Scheule RK: Hydrodynamic delivery of DNA. Expert Opin Biol Ther 2003; 3:911-918
16. Condiotti R, Curran MA, Nolan GP, et al: Prolonged liver-specific transgene expression by a non-primate lentiviral vector. Biochem Biophys Res Commun 2004; 320:998-1006
17. Suda T, Gao X, Stolz DB, et al: Structural impact of hydrodynamic injection on mouse liver. Gene Ther 2007; 14:129-137
18. Kobayashi N, Nishikawa M, Hirata K, et al: Hydrodynamics-based procedure involves transient hyperpermeability in the hepatic cellular membrane: Implication of a nonspecific process in efficient intracellular gene delivery. J Gene Med 2004; 6:584-592
19. Maruyama H, Higuchi N, Nishikawa Y, et al: High-level expression of naked DNA delivered to rat liver via tail vein injection. J Gene Med 2002; 4:333-341
20. Shen XD, Ke B, Zhai Y, et al: Absence of Toll-like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model. Liver Transpl 2007; 13:1435-1443
21. Tsung A, Sahai R, Tanaka H, et al: The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med 2005; 201:1135-1143
22. Zhai Y, Qiao B, Shen XD, et al: Evidence for the pivotal role of endogenous Toll-like receptor 4 ligands in liver ischemia and reperfusion injury. Transplantation 2008; 85:1016-1022
23. Shen XD, Ke B, Zhai Y, et al: Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury. Am J Transplant 2005; 5:1793-1800
24. Jiang N, Zhang X, Zheng X, et al: Targeted gene silencing of TLR4 using liposomal nanoparticles for preventing liver ischemia reperfusion injury. Am J Transplant 2011; 11:1835-1844
25. Lysakova-Devine T, Keogh B, Harrington B, et al: Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIFrelated adaptor molecule. J Immunol 2010; 185:4261-4271
26. Zwacka RM, Zhang Y, Zhou W, et al: Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor kappaB independently of IkappaB degradation. Hepatology 1998; 28:1022-1030
27. Takeuchi O, Akira S: Pattern recognition receptors and inflammation. Cell 2010; 140:805-820
28. Bhoj VG, Chen ZJ: Ubiquitylation in innate and adaptive immunity. Nature 2009; 458:430-437
29. Yamamoto M, Sato S, Hemmi H, et al: Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 2002; 420:324-329
30. Fitzgerald KA, Palsson-McDermott EM, Bowie AG, et al: Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 2001; 413:78-83
31. Rüdiger HA, Graf R, Clavien PA: Liver ischemia: Apoptosis as a central mechanism of injury. J Invest Surg 2003; 16:149-159
32. Nakano H, Nakajima A, Sakon-Komazawa S, et al: Reactive oxygen species mediate crosstalk between NF-kappaB and JNK. Cell Death Differ 2006; 13:730-737
33. Evankovich J, Cho SW, Zhang R, et al: High mobility group box 1 release from hepatocytes during ischemia and reperfusion injury is mediated by decreased histone deacetylase activity. J Biol Chem 2010; 285:39888-39897
34. Cai D, Yuan M, Frantz DF, et al: Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 2005; 11:183-190