Exercise as a way of capitalizing on neuroplasticity in late adulthood

Topics in Geriatric Rehabilitation

Volumn 30, Issue 1, 2014, Pages 8-14

  Erickson, Kirk I ^a,b   Oberlin, Lauren ^a,b   Gujral, Swathi ^a,b   Leckie, Regina L ^a,b   Weinstein, Andrea M ^a,b   Hodzic, Jennifer C ^a   Dabbagh, Asmaa ^a   Whitmoyer, Patrick R ^a   Wollam, Mariegold E ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

brain; cognition; cortex; exercise; fitness; neuroplasticity; physical activity

Indexed keywords

ADULTHOOD; AGING; ARTICLE; BRAIN FUNCTION; CARDIOPULMONARY HEMODYNAMICS; COGNITION; COGNITIVE DEFECT; CROSS-SECTIONAL STUDY; EXERCISE; FUNCTIONAL NEUROIMAGING; HUMAN; LIFESPAN; MENTAL DETERIORATION; MOOD; NERVE CELL PLASTICITY; PHYSICAL ACTIVITY;

EID: 84893246869     PISSN: 08827524     EISSN: None     Source Type: Journal    
DOI: 10.1097/TGR.0000000000000008     Document Type: Article

References (74)

1. United States Census Bureau. The Older Population, 2010. The US Census Bureau Web site: http://www.census.gov/prod/cen2010/briefs/c2010br-09.pdf. Accessed June 12, 2013.
2. Colcombe S, Kramer AF. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci. 2003; 14 (2): 125-130. (Pubitemid 37283096)
3. Smith PJ, Blumenthal JA, Hoffman BM, et al. Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosom Med. 2010; 72 (3): 239-252.
4. Sofi F, Valecchi D, Bacci D, et al. Physical activity and risk of cognitive decline: a meta-analysis of prospective studies. J Intern Med. 2011; 269 (1): 107-117.
5. Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol. 2011; 10 (9): 819-828.
6. Lautenschlager NT, Cox KL, Flicker L, et al. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA. 2008; 300 (9): 1027-1037.
7. Baker LD, Frank LL, Foster-Schubert K, et al. Effects of aerobic exercise on mild cognitive impairment: a controlled trial. Arch Neurol. 2010; 67 (1): 71-79.
8. Nagamatsu LS, Chan A, Davis JC, et al. Physical activity improves verbal and spatial memory in older adults with probable mild cognitive impairment: a 6-month randomized controlled trial. J Aging Res. 2013; 2013: 861893.
9. Galper DI, Trivedi MH, Barlow CE, Dunn AL, Kampert JB. Inverse association between physical inactivity and mental health in men and women. Med Sci Sports Exerc. 2006; 38 (1): 173-178. (Pubitemid 43062974)
10. Goodwin RD. Association between physical activity and mental disorders among adults in the United States. Prev Med. 2003; 36 (6): 698-703. (Pubitemid 36555550)
11. Hassmen P, Koivula N, Uutela A. Physical exercise and psychological well-being: a population study in Finland. Prev Med. 2000; 30 (1): 17-25. (Pubitemid 30090113)
12. Paffenbarger RS, Jr Lee IM, Leung R. Physical activity and personal characteristics associated with depression and suicide in American college men. Acta Psychiatr Scand Suppl. 1994; 377: 16-22. (Pubitemid 24147799)
13. Teychenne M, Ball K, Salmon J. Physical activity and likelihood of depression in adults: a review. Prev Med. 2008; 46 (5): 397-411.
14. Barbour KA, Edenfi eld TM, Blumenthal JA. Exercise as a treatment for depression and other psychiatric disorders: a review. J Cardiopulm Rehabil Prev. 2007; 27 (6): 359-367.
15. Blumenthal JA, Babyak MA, Doraiswamy PM, et al. Exercise and pharmacotherapy in the treatment of major depressive disorder . Psychosom Med. 2007; 69 (7): 587-596. (Pubitemid 47469807)
16. Bridle C, Spanjers K, Patel S, Atherton NM, Lamb SE. Effect of exercise on depression severity in older people: systematic review and meta-analysis of randomised controlled trials. Br J Psychiatry. 2012; 201 (3): 180-185.
17. DiLorenzo TM, Bargman EP, Stucky-Ropp R, Brassington GS, Frensch PA, LaFontaine T. Long-term effects of aerobic exercise on psychological outcomes. Prev Med. 1999; 28 (1): 75-85. (Pubitemid 29372092)
18. Bailey M, McLaren S. Physical activity alone and with others as predictors of sense of belonging and mental health in retirees. Aging Ment Health. 2005; 9 (1): 82-90. (Pubitemid 40129120)
19. Brown DR, Wang Y, Ward A, et al. Chronic psychological effects of exercise and exercise plus cognitive strategies. Med Sci Sports Exerc. 1995; 27 (5): 765-775.
20. Cramer SR, Nieman DC, Lee JW. The effects of moderate exercise training on psychological well-being and mood state in women. J Psychosom Res. 1991; 35 (4-5): 437-449.
21. Vanhanen M, Koivisto K, Moilanen L, et al. Association of metabolic syndrome with Alzheimer disease: a population-based study. Neurology. 2006; 67 (5): 843-847. (Pubitemid 44394200)
22. Kivipelto M, Ngandu T, Fratiglioni L, et al. Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch Neurol. 2005; 62 (10): 1556-1560. (Pubitemid 41434560)
23. Whitmer RA, Gustafson DR, Barrett-Connor E, Haan MN, Gunderson EP, Yaffe K. Central obesity and increased risk of dementia more than three decades later. Neurology. 2008; 71 (14): 1057-1064.
24. Xu WL, Atti AR, Gatz M, Pedersen NL, Johansson B, Fratiglioni L. Midlife overweight and obesity increase late-life dementia risk: a population-based twin study. Neurology. 2011; 76 (18): 1568-1574.
25. Whitmer RA, Gunderson EP, Barrett-Connor E, Quesenberry CP, Jr Yaffe K. Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study. BMJ. 2005; 330 (7504): 1360.
26. Launer LJ, Ross GW, Petrovitch H, et al. Midlife blood pressure and dementia: the Honolulu-Asia aging study. Neurobiol Aging. 2000; 21 (1): 49-55. (Pubitemid 30224785)
27. Raffaitin C, Gin H, Empana JP, et al. Metabolic syndrome and risk for incident Alzheimer's disease or vascular dementia: the Three-City Study. Diabetes Care. 2009; 32 (1): 169-174.
28. Solomon A, Kivipelto M, Wolozin B, Zhou J, Whitmer RA. Midlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades later. Dement Geriatr Cogn Disord. 2009; 28 (1): 75-80.
29. Elias MF, Elias PK, Sullivan LM, Wolf PA, D'Agostino RB. Lower cognitive function in the presence of obesity and hypertension: the Framingham Heart Study. Int J Obes Relat Metab Disord. 2003; 27 (2): 260-268. (Pubitemid 36255810)
30. Launer LJ, Masaki K, Petrovitch H, Foley D, Havlik RJ. The association between midlife blood pressure levels and late-life cognitive function. The Honolulu-Asia Aging Study. JAMA. 1995; 274 (23): 1846-1851. (Pubitemid 26001260)
31. Tzourio C, Dufouil C, Ducimetiere P, Alperovitch A. Cognitive decline in individuals with high blood pressure: a longitudinal study in the elderly. EVA Study Group. Epidemiology of Vascular Aging. Neurology. 1999; 53 (9): 1948-1952.
32. Komulainen P, Lakka TA, Kivipelto M, et al. Metabolic syndrome and cognitive function: a population-based follow-up study in elderly women. Dement Geriatr Cogn Disord. 2007; 23 (1): 29-34. (Pubitemid 46005788)
33. Dik MG, Jonker C, Comijs HC, et al. Contribution of metabolic syndrome components to cognition in older individuals. Diabetes Care. 2007; 30 (10): 2655-2660. (Pubitemid 47547816)
34. Yaffe K, Weston AL, Blackwell T, Krueger KA. The metabolic syndrome and development of cognitive impairment among older women. Arch Neurol. 2009; 66 (3): 324-328.
35. Dunn AL, Marcus BH, Kampert JB, Garcia ME, Kohl HW, III Blair SN. Comparison of lifestyle and structured interventions to increase physical activity and cardiorespiratory fi tness: a randomized trial. JAMA. 1999; 281 (4): 327-334. (Pubitemid 29061036)
36. Ross R, Dagnone D, Jones PJ, et al. Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial. Ann Intern Med. 2000; 133 (2): 92-103. (Pubitemid 30490409)
37. Healy GN, Wijndaele K, Dunstan DW, et al. Objectively measured sedentary time, physical activity, and metabolic risk: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab). Diabetes Care. 2008; 31 (2): 369-371. (Pubitemid 351213354)
38. Rennie KL, McCarthy N, Yazdgerdi S, Marmot M, Brunner E. Association of the metabolic syndrome with both vigorous and moderate physical activity. Int J Epidemiol. 2003; 32 (4): 600-606. (Pubitemid 37039015)
39. Laaksonen DE, Lakka HM, Salonen JT, Niskanen LK, Rauramaa R, Lakka TA. Low levels of leisure-time physical activity and cardiorespiratory fi tness predict development of the metabolic syndrome. Diabetes Care. 2002; 25 (9): 1612-1618. (Pubitemid 41071120)
40. Abramson JL, Vaccarino V. Relationship between physical activity and infl ammation among apparently healthy middle-aged and older US adults. Arch Intern Med. 2002; 162 (11): 1286-1292. (Pubitemid 34595035)
41. Ford ES. Does exercise reduce infl ammation? Physical activity and C-reactive protein among U.S. adults. Epidemiology. 2002; 13 (5): 561-568.
42. Brown BM, Peiffer JJ, Taddei K, et al. Physical activity and amyloid-beta plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Mol Psychiatry. 2013; 18 (8): 875-881.
43. Raz N, Lindenberger U, Rodrigue KM, et al. Regional brain changes in aging healthy adults: general trends, individual differences and modifi ers. Cereb Cortex. 2005; 15 (11): 1676-1689. (Pubitemid 41447032)
44. Erickson KI, Prakash RS, Voss MW, et al. Aerobic fi tness is associated with hippocampal volume in elderly humans. Hippocampus. 2009; 19 (10): 1030-1039.
45. Honea RA, Thomas GP, Harsha A, et al. Cardiorespiratory fi tness and preserved medial temporal lobe volume in Alzheimer disease. Alzheimer Dis Assoc Disord. 2009; 23 (3): 188-197.
46. Bugg JM, Shah K, Villareal DT, Head D. Cognitive and neural correlates of aerobic fi tness in obese older adults. Exp Aging Res. 2012; 38 (2): 131-145.
47. Herting MM, Nagel BJ. Aerobic fi tness relates to learning on a virtual Morris Water Task and hippocampal volume in adolescents . Behav Brain Res. 2012; 233 (2): 517-525.
48. Chaddock L, Erickson KI, Prakash RS, et al. A neuroimaging investigation of the association between aerobic fi tness, hippocampal volume, and memory performance in preadolescent children. Brain Res. 2010; 1358: 172-183.
49. Weinstein AM, Voss MW, Prakash RS, et al. The association between aerobic fi tness and executive function is mediated by prefrontal cortex volume. Brain Behav Immun. 2012; 26 (5): 811-819.
50. Verstynen TD, Lynch B, Miller DL, et al. Caudate nucleus volume mediates the link between cardiorespiratory fi tness and cognitive fl exibility in older adults. J Aging Res. 2012; 2012: 939285.
51. Johnson NF, Kim C, Clasey JL, Bailey A, Gold BT. Cardiorespiratory fi tness is positively correlated with cerebral white matter integrity in healthy seniors. NeuroImage. 2012; 59 (2): 1514-1523.
52. Marks BL, Madden DJ, Bucur B, et al. Role of aerobic fi tness and aging on cerebral white matter integrity. Ann N Y Acad Sci. 2007; 1097: 171-174. (Pubitemid 47084897)
53. Marks BL, Katz LM, Styner M, Smith JK. Aerobic fi tness and obesity: relationship to cerebral white matter integrity in the brain of active and sedentary older adults. Br J Sports Med. 2011; 45 (15): 1208-1215.
54. Voss MW, Heo S, Prakash RS, et al. The infl uence of aerobic fi tness on cerebral white matter integrity and cognitive function in older adults: results of a one-year exercise intervention. Hum Brain Mapp. 2013; 34 (11): 2972-2985.
55. Tseng BY, Gundapuneedi T, Khan MA, et al. White matter integrity in physically fi t older adults. NeuroImage. 2013; 82: 510-516.
56. Sen A, Gider P, Cavalieri M, et al. Association of cardiorespiratory fi tness and morphological brain changes in the elderly: results of the Austrian Stroke Prevention Study. Neurodegener Dis. 2012; 10 (1-4): 135-137.
57. Colcombe SJ, Erickson KI, Scalf PE, et al. Aerobic exercise training increases brain volume in aging humans. J Gerontol A Biol Sci Med Sci. 2006; 61 (11): 1166-1170. (Pubitemid 46034467)
58. Ruscheweyh R, Willemer C, Kruger K, et al. Physical activity and memory functions: an interventional study. Neurobiol Aging. 2011; 32 (7): 1304-1319.
59. Bugg JM, Head D. Exercise moderates age-related atrophy of the medial temporal lobe. Neurobiol Aging. 2011; 32 (3): 506-514.
60. Erickson KI, Voss MW, Prakash RS, et al. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci USA. 2011; 108 (7): 3017-3022.
61. Erickson KI, Raji CA, Lopez OL, et al. Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study. Neurology. 2010; 75 (16): 1415-1422.
62. Rovio S, Spulber G, Nieminen LJ, et al. The effect of midlife physical activity on structural brain changes in the elderly. Neurobiol Aging. 2010; 31 (11): 1927-1936.
63. Colcombe SJ, Kramer AF, McAuley E, Erickson KI, Scalf P. Neurocognitive aging and cardiovascular fi tness: recent fi ndings and future directions. J Mol Neurosci. 2004; 24 (1): 9-14. (Pubitemid 41359162)
64. Prakash RS, Voss MW, Erickson KI, et al. Cardiorespiratory fi tness and attentional control in the aging brain. Front Hum Neurosci. 2011; 4: 229.
65. Rosano C, Venkatraman VK, Guralnik J, et al. Psychomotor speed and functional brain MRI 2 years after completing a physical activity treatment. J Gerontol A Biol Sci Med Sci. 2010; 65 (6): 639-647.
66. Liu-Ambrose T, Nagamatsu LS, Voss MW, Khan KM, Handy TC. Resistance training and functional plasticity of the aging brain: a 12-month randomized controlled trial. Neurobiol Aging. 2012; 33 (8): 1690-1698.
67. Voelcker-Rehage C, Godde B, Staudinger UM. Physical and motor fi tness are both related to cognition in old age. Eur J Neurosci. 2010; 31 (1): 167-176.
68. Voelcker-Rehage C, Godde B, Staudinger UM. Cardiovascular and coordination training differentially improve cognitive performance and neural processing in older adults. Front Hum Neurosci. 2011; 5: 26.
69. Nagamatsu LS, Handy TC, Hsu CL, Voss M, Liu-Ambrose T. Resistance training promotes cognitive and functional brain plasticity in seniors with probable mild cognitive impairment. Arch Intern Med. 2012; 172 (8): 666-668.
70. Smith JC, Nielson KA, Woodard JL, et al. Does physical activity infl uence semantic memory activation in amnestic mild cognitive impairment ? Psychiatry Res. 2011; 193 (1): 60-62.
71. Liang KY, Mintun MA, Fagan AM, et al. Exercise and Alzheimer's disease biomarkers in cognitively normal older adults. Ann Neurol. 2010; 68 (3): 311-318.
72. Head D, Bugg JM, Goate AM, et al. Exercise Engagement as a moderator of the effects of APOE genotype on amyloid deposition . Arch Neurol. 2012; 69 (5): 636-643.
73. Erickson KI, Banducci S, Weinstein A, et al. The BDNF val66met polymorphism moderates an effect of physical activity on working memory performance. Psychol Sci. 2013; 24 (9): 1770-1779.
74. Leckie RL, Weinstein AM, Hodzic JC, Erickson KI. Potential moderators of physical activity on brain health. J Aging Res. 2012; 2012: 948981.