The Brain-Derived Neurotrophic Factor Val66Met Polymorphism Moderates an Effect of Physical Activity on Working Memory Performance

Psychological Science

Volumn 24, Issue 9, 2013, Pages 1770-1779

  Erickson, Kirk I ^a,b   Banducci, Sarah E ^c   Weinstein, Andrea M ^a,b   MacDonald III, Angus W ^d   Ferrell, Robert E ^b   Halder, Indrani ^a   Flory, Janine D ^e   Manuck, Stephen B ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

BDNF; episodic memory; executive function; genetics; physical activity; visual memory; working memory

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; METHIONINE; VALINE;

ADULT; ARTICLE; EPISODIC MEMORY; EXECUTIVE FUNCTION; FEMALE; GENETIC POLYMORPHISM; GENETICS; HUMAN; MALE; MOTOR ACTIVITY; NEUROPSYCHOLOGICAL TEST; PHYSICAL ACTIVITY; PHYSIOLOGY; QUESTIONNAIRE; SHORT TERM MEMORY; STATISTICS; VISUAL MEMORY; WORKING MEMORY;

BDNF; EPISODIC MEMORY; EXECUTIVE FUNCTION; GENETICS; PHYSICAL ACTIVITY; VISUAL MEMORY; WORKING MEMORY;

ADULT; BRAIN-DERIVED NEUROTROPHIC FACTOR; FEMALE; HUMANS; MALE; MEMORY, SHORT-TERM; METHIONINE; MOTOR ACTIVITY; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, GENETIC; QUESTIONNAIRES; VALINE;

EID: 84883771291     PISSN: 09567976     EISSN: 14679280     Source Type: Journal    
DOI: 10.1177/0956797613480367     Document Type: Article

References (40)

1. Ainsworth B. E.,Leon A. S.,Richardson M. T.,Jacobs D. R.,Paffenbarger R. S.Accuracy of the College Alumnus Physical Activity Questionnaire.Journal of Clinical Epidemiology. 1993;46:1403-1411.
2. Bleil M. E.,Gianaros P. J.,Jennings J. R.,Flory J. D.,Manuck S. B.Trait negative affect: Toward an integrated model of understanding psychological risk for impairment in cardiac autonomic function.Psychosomatic Medicine. 2008;70:328-337.
3. Chen X.,Levine L.,Kwok P.-Y.Fluorescence polarization in homogeneous nucleic acid analysis.Genome Research. 1999;9:492-498.
4. Chen Z. Y.,Bath K.,McEwen B.,Hempstead B.,Lee F.Novartis Foundation Symposium 289: Growth factors and psychiatric disorders. Chadwick D. J.Goode J., ed. Chichester, England: Wiley; 2008:180-192.
5. Cheng C. Y.,Hong C. F.,Yu Y. W.,Chen T. J.,Wu H. C.,Tsai S. D.Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males.Brain Research Molecular Brain Research. 2005;140:86-90.
6. Chomistek A. K.,Chiuve S. E.,Jensen M. K.,Cook N. R.,Rimm E. B.Vigorous physical activity, mediating biomarkers, and risk of myocardial infarction.Medicine & Science in Sports & Exercise. 2011;43:1884-1890.
7. Choo J.,Elci O. U.,Yang K.,Turk M. W.,Styn M. A.,Sereika S. M.,Burke L. E.Longitudinal relationship between physical activity and cardiometabolic factors in overweight and obese adults.European Journal of Applied Physiology. 2010;108:329-336.
8. Colcombe S.,Kramer A. F.Fitness effects on the cognitive function of older adults: A meta-analytic study.Psychological Science. 2003;14:125-130.
9. Egan M. F.,Kojima M.,Callicott J. H.,Goldberg T. E.,Kolachana B. S.,Bertolino A.,Weinberger D. R.The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.Cell. 2003;112:257-269.
10. Erickson K. I.,Kramer A. F.Aerobic exercise effects on cognitive and neural plasticity in older adults.British Journal of Sports Medicine. 2009;43:22-24.
11. Erickson K. I.,Miller D. L.,Roecklein K. A.The aging hippocampus: Interactions between exercise, depression, and BDNF.Neuroscientist. 2012;18:82-97.
12. Erickson K. I.,Voss M. W.,Prakash R. S.,Basak C.,Szabo A.,Chaddock L.,Kramer A. F.Exercise training increases size of hippocampus and improves memory.Proceedings of the National Academy of Sciences, USA. 2011;108:3017-3022.
13. Etnier J. L.,Nowell P. M.,Landers D. M.,Sibley B. A.A meta-regression to examine the relationship between aerobic fitness and cognitive performance.Brain Research Reviews. 2006;52:119-130.
14. Falush D.,Stephens M.,Pritchard J. K.Inference of population structure using multilocus genotype data: Linked loci and correlated allele frequencies.Genetics. 2003;164:1567-1587.
15. Gapin J. I.,Labban J. D.,Etnier J. L.The effects of physical activity on attention deficit hyperactivity disorder symptoms: The evidence.Preventive Medicine. 2011;52:S70-S74.
16. Harris S. E.,Fox H.,Wright A. F.,Hayward C.,Starr J. M.,Whalley L. J.,Deary I. J.The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills.Molecular Psychiatry. 2006;11:505-513.
17. Head D.,Bugg J. M.,Goate A. M.,Fagan A. M.,Mintun M. A.,Benzinger T.,Morris J. C.Exercise engagement as a moderator of the effects of APOE genotype on amyloid deposition.Archives of Neurology. 2012;69:636-643.
18. Hillman C. H.,Erickson K. I.,Kramer A. F.Be smart, exercise your heart: Exercise effects on brain and cognition.Nature Reviews Neuroscience. 2008;9:58-65.
19. Knaepen K.,Goekint M.,Heyman E. M.,Meeusen R.Neuroplasticity-exercise-induced response of peripheral brain-derived neurotrophic factor: A systematic review of experimental studies in human subjects.Sports Medicine. 2010;40:765-801.
20. Kramer A. F.,Erickson K. I.Capitalizing on cortical plasticity: Influence of physical activity on cognition and brain function.Trends in Cognitive Sciences. 2007;11:342-348.
21. Krueger F.,Pardini M.,Huey E. D.,Raymont V.,Solomon J.,Lipsky R. H.,Grafman J.The role of the Met66 brain-derived neurotrophic factor allele in the recovery of executive functioning after combat-related traumatic brain injury.Journal of Neuroscience. 2011;31:598-606.
22. Li Y.,Luikart B. W.,Birnbaum S.,Chen J.,Kwon C. H.,Kernie S. G.,Parada L. F.TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment.Neuron. 2008;59:399-412.
23. Liang K. Y.,Mintun M. A.,Fagan A. M.,Goate A. M.,Bugg J. M.,Holtzman D. M.,Head D.Exercise and Alzheimer's disease biomarkers in cognitively normal older adults.Annals of Neurology. 2010;68:311-318.
24. Mandelman S. D.,Grigorenko E. L.BDNF Val66Met and cognition: All, none, or some? A meta-analysis of the genetic association.Genes, Brain and Behavior. 2012;11:127-136.
25. Manuck S. B.,Phillips J. E.,Gianaros P. J.,Flory J. D.,Muldoon M. F.Subjective socioeconomic status and presence of the metabolic syndrome in midlife community volunteers.Psychosomatic Medicine. 2010;72:35-45.
26. Mata J.,Thompson R. J.,Gotlib I. H.BDNF genotype moderates the relation between physical activity and depressive symptoms.Health Psychology. 2010;29:130-133.
27. McFarlin B. K.,Flynn M. G.,Campbell W. W.,Craig B. A.,Robinson J. P.,Stewart L. K.,Coen P. M.Physical activity status, but not age, influences inflammatory biomarkers and toll-like receptor 4.Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2006;61:388-393.
28. Neeper S. A.,Gomez-Pinilla F.,Choi J.,Cotman C.Exercise and brain neurotrophins.Nature. 1995;373 (6510): 109.
29. Nowak Z.,Plewa M.,Skowron M.,Markiewicz A.,Kucio C.,Osiadlo G.Paffenbarger Physical Activity Questionnaire as an additional tool in clinical assessment of patients with coronary artery disease treated with angioplasty.Kardiologia Polska. 2010;68:32-39.
30. Paffenbarger R. S.,Wing A. L.,Hyde R. T.Physical activity as an index of heart attack risk in college alumni.American Journal of Epidemiology. 1978;108:161-175.
31. Pajonk F. G.,Wobrock T.,Gruber O.,Scherk H.,Berner D.,Kaizl I.,Falkai P.Hippocampal plasticity in response to exercise in schizophrenia.Archives of General Psychiatry. 2010;67:133-143.
32. Reitan R. M.Trail Making Test: Manual for administration and scoring. Tucson, AZ: Reitan Neuropsychological Laboratory; 1992:.
33. Rockwood K.,Middleton L.Physical activity and the maintenance of cognitive function.Alzheimer's & Dementia. 2007;3:S38-S44.
34. Sattler J. M.,Ryan J. J.Assessment with the WAIS-IV. San Diego, CA: Jerome M. Sattler; 2009:.
35. Schuit A. J.,Feskens E. J.,Launer L. J.,Kromhout D.Physical activity and cognitive decline, the role of the apolipoprotein e4 allele.Medicine & Science in Sports & Exercise. 2001;33:772-777.
36. Shedd K. M.,Hanson K. B.,Alekel D. L.,Schiferl D. J.,Hanson L. N.,Van Loan M. D.Quantifying leisure physical activity and its relation to bone density and strength.Medicine & Science in Sports & Exercise. 2007;39:2189-2198.
37. Smith J. C.,Nielson K. A.,Woodard J. L.,Seidenberg M.,Durgerian S.,Antuono P.,Rao S. M.Interactive effects of physical activity and APOE-epsilon4 on BOLD semantic memory activation in healthy elders.NeuroImage. 2011;54:635-644.
38. Smith P. J.,Blumenthal J. A.,Hoffman B. M.,Cooper H.,Strauman T. A.,Welsh-Bohmer K.,Sherwood A.Aerobic exercise and neurocognitive performance: A meta-analytic review of randomized controlled trials.Psychosomatic Medicine. 2010;72:239-252.
39. Vaynman S.,Ying Z.,Gomez-Pinilla F.Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition.European Journal of Neuroscience. 2004;20:2580-2590.
40. Wechsler D.Wechsler Memory Scale-Third edition. San Antonio, TX: The Psychological Corp; 1997:.