Morphine and metastasis: From bench to bedside

Morphine and Metastasis

Volumn , Issue , 2013, Pages 1-13

  Parat, Marie Odile ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Cancer; Endogenous morphine; Immunosuppression; Methylnaltrexone; MicroRNA; Morphine glucuronides; Opioid antagonists; Opioid receptor; Pain management; Polymorphism; Surgery; Tolerance; Tumor microenvironment; Withdrawal

Indexed keywords

EID: 84893240274     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-94-007-5678-6_1     Document Type: Chapter

References (84)

1. Afsharimani B, Cabot PJ, Parat MO (2011a) Morphine and tumor growth and metastasis. Cancer Metastasis Rev 30:225-238
2. Afsharimani B, Cabot PJ, Parat MO (2011b) Morphine use in cancer surgery. Front Pharmacol 2:46
3. Bar-Yosef S, Melamed R, Page GG, Shakhar G, Shakhar K, Ben-Eliyahu S (2001) Attenuation of the tumor-promoting effect of surgery by spinal blockade in rats. Anesthesiology 94:1066-1073
4. Biki B, Mascha E, Moriarty DC, Fitzpatrick JM, Sessler DI, Buggy DJ (2008) Anesthetic technique for radical prostatectomy surgery affects cancer recurrence: a retrospective analysis. Anesthesiology 109:180-187
5. Boettcher C, Fellermeier M, Boettcher C, Drager B, Zenk MH (2005) How human neuroblastoma cells make morphine. Proc Natl Acad Sci USA 102:8495-8500
6. Bortsov AV, Millikan RC, Belfer I, Boortz-Marx RL, Arora H, McLean SA (2012) Mu-opioid receptor gene A118G polymorphism predicts survival in patients with breast cancer. Anesthesiology 116:896-902
7. Bortsov AV, Millikan RC, Belfer I, Boortz-Marx RL, Arora H, McLean SL (2013) Genetic polymorphisms in the p-opioid receptor gene and breast cancer survival. In: Parat MO (ed) Morphine and metastasis. Springer, Dordrecht
8. Boyerinas B, Park SM, Hau A, Murmann AE, Peter ME (2010) The role of let-7 in cell differentiation and cancer. Endocr Relat Cancer 17:F19-F36
9. Brix-Christensen V, Tonnesen E, Sanchez RG, Bilfinger TV, Stefano B (1997) Endogenous morphine levels increase following cardiac surgery as part of the antiinflammatory response? Int J Cardiol 62:191-197
10. Brix-Christensen V, Goumon Y, Tonnesen E, Chew M, Bilfinger T, Stefano GB (2000) Endogenous morphine is produced in response to cardiopulmonary bypass in neonatal pigs. Acta Anaesthesiol Scand 44:1204-1208
11. Cabot PJ, Carter L, Gaiddon C, Zhang Q, Schafer M, Loeffler JP, Stein C (1997) Immune cell-derived beta-endorphin: production, release, and control of inflammatory pain in rats. J Clin Invest 100:142-148
12. Cadet P, Rasmussen M, Zhu W, Tonnesen E, Mantione KJ, Stefano GB (2004) Endogenous mor-phinergic signaling and tumor growth. Front Biosci 9:3176-3186
13. Campa D, Gioia A, Tomei A, Poli P, Barale R (2007) Association of ABCB1//MDR1 and OPRM1 Gene Polymorphisms with Morphine Pain Relief. Clin Pharmacol Ther 83:559-566
14. Carrigan KA, Lysle DT (2001) Morphine-6-beta-glucuronide induces potent immunomodulation. Int Immunopharmacol 1:821-831
15. Chen C, Farooqui M, Gupta K (2006) Morphine stimulates vascular endothelial growth factor-like signaling in mouse retinal endothelial cells. Curr Neurovasc Res 3:171-180
16. Chou WY, Wang CH, Liu PH, Liu CC, Tseng CC, Jawan B (2006) Human opioid receptor A118G polymorphism affects intravenous patient-controlled analgesia morphine consumption after total abdominal hysterectomy. Anesthesiology 105:334-337
17. Cummings KC III, Xu F, Cummings LC, Cooper GS (2012) A comparison of epidural analgesia and traditional pain management effects on survival and cancer recurrence after colectomy: a population-based study. Anesthesiology 116:797-806
18. Dave RS, Khalili K (2010) Morphine treatment of human monocyte-derived macrophages induces differential miRNA and protein expression: impact on inflammation and oxidative stress in the central nervous system. J Cell Biochem 110:834-845
19. Day A, Smith R, Jourdan I, Fawcett W, Scott M, Rockall T (2012) Retrospective analysis of the effect of postoperative analgesia on survival in patients after laparoscopic resection of colorectal cancer. Br J Anaesth 109:185-190
20. De Oliveira G, Jr AS, Schink JC, Singh DK, Fitzgerald PC, McCarthy RJ (2011) Intraoperative neuraxial anesthesia but not postoperative neuraxial analgesia is associated with increased relapse-free survival in ovarian cancer patients after primary cytoreductive surgery. Reg Anesth Pain Med 36:271-277
21. Eisenstein TK, Rogers TJ, Meissler JJ Jr, Adler MW, Hilburger ME (1998) Morphine depresses macrophage numbers and function in mouse spleens. Adv Exp Med Biol 437:33-41
22. Eisenstein TK, Rahim R, Feng P, Thingalaya N, Meissler J (2006) Effects of opioid tolerance and withdrawal on the immune system. J Neuroimmune Pharmacol 1:237-249
23. Exadaktylos AK, Buggy DJ, Moriarty DC, Mascha E, Sessler DI (2006) Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis? Anesthesiology 105:660-664
24. Farooqui M, Geng ZH, Stephenson EJ, Zaveri N, Yee D, Gupta K (2006) Naloxone acts as an antagonist of estrogen receptor activity in MCF-7 cells. Mol Cancer Ther 5:611-620
25. Fimiani C, Arcuri E, Santoni A, Rialas CM, Bilfinger TV, Peter D, Salzet B, Stefano GB (1999) Mu3 Opiate receptor expression in lung and lung carcinoma: ligand binding and coupling to nitric oxide release. Cancer Lett 146:45-51
26. Forget P, Tombal B, Scholtes JL, Nzimbala J, Meulders C, Legrand C, Van Cangh P, Cosyns JP, De Kock M (2011) Do intraoperative analgesics influence oncological outcomes after radical prostatectomy for prostate cancer? Eur J Anaesthesiol 28:830-835
27. Fuggetta MP, Di Francesco P, Falchetti R, Cottarelli A, Rossi L, Tricarico M, Lanzilli G (2005) Effect of morphine on cell-mediated immune responses of human lymphocytes against allogeneic malignant cells. J Exp Clin Cancer Res 24:255-263
28. Fujioka N, Nguyen J, Chen C, Li Y, Pasrija T, Niehans G, Johnson KN, Gupta V, Kratzke RA, Gupta K (2011) Morphine-induced epidermal growth factor pathway activation in non-small cell lung cancer. Anesth Analg 113:1353-1364
29. Glattard E, Welters ID, Lavaux T, Muller AH, Laux A, Zhang D, Schmidt AR, Delalande F, Laventie BJ, Dirrig-Grosch S, Colin DA, Van Dorsselaer A, Aunis D, Metz-Boutigue MH, Schneider F, Goumon Y (2010) Endogenous morphine levels are increased in sepsis: a partial implication of neutrophils. PLoS One 5:e8791
30. Gupta K (2013) Iatrogenic angiogenesis. In: Parat MO (ed) Morphine and metastasis. Springer, Dordrecht
31. Gupta K, Kshirsagar S, Chang L, Schwartz R, Law PY, Yee D, Hebbel RP (2002) Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth. Cancer Res 62:4491-4498
32. Hashiguchi S, Morisaki H, Kotake Y, Takeda J (2005) Effects of morphine and its metabolites on immune function in advanced cancer patients. J Clin Anesth 17:575-580
33. Hassan F, Islam S, Tumurkhuu G, Naiki Y, Koide N, Mori I, Yoshida T, Yokochi T (2006) Intracellular expression of toll-like receptor 4 in neuroblastoma cells and their unresponsiveness to lipopolysaccharide. BMC Cancer 6:281
34. He Y, Wang ZJ (2012) Let-7 microRNAs and opioid tolerance. Front Genet 3:110
35. He Y, Yang C, Kirkmire CM, Wang ZJ (2010) Regulation of opioid tolerance by let-7 family microRNA targeting the mu opioid receptor. J Neurosci 30:10251-10258
36. Hoskin PJ, Hanks GW, Aherne GW, Chapman D, Littleton P, Filshie J (1989) The bioavailability and pharmacokinetics of morphine after intravenous, oral and buccal administration in healthy volunteers. Br J Clin Pharmacol 27:499-505
37. Ishikawa M, Tanno K, Kamo A, Takayanagi Y, Sasaki K (1993) Enhancement of tumor growth by morphine and its possible mechanism in mice. Biol Pharm Bull 16:762-766
38. Johnson KN, Zaveri N, Gupta K (2013) Interaction of naloxone and estrogen receptor in breast cancer. In: Parat MO (ed) Morphine and metastasis. Springer, Dordrecht
39. Kasai S, Ikeda K (2011) Pharmacogenomics of the human mu opioid receptor. Pharmacogenomics 12:1305-1320
40. Klepstad P, Rakvag TT, Kaasa S, Holthe M, Dale O, Borchgrevink PC, Baar C, Vikan T, Krokan HE, Skorpen F (2004) The 118 A > G polymorphism in the human mu opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease. Acta Anaesthesiol Scand 48:1232-1239
41. Koodie L, Roy S (2013) Morphine and immunosuppression in the context of tumor growth and metastasis. In: Parat MO (ed) Morphine and metastasis. Springer, Dordrecht
42. Koodie L, Ramakrishnan S, Roy S (2010) Morphine suppresses tumor angiogenesis through a HIF-1alpha/p38MAPK pathway. Am J Pathol 177:984-997
43. Kuo CK, Hanioka N, Hoshikawa Y, Oguri K, Yoshimura H (1991) Species difference of site-selective glucuronidation of morphine. J Pharmacobiodyn 14:187-193
44. Lennon FE, Singleton PA (2013) Opioid regulation of vascular integrity. In: Parat MO (ed) Morphine and metastasis. Springer, Dordrecht
45. Madbouly KM, Senagore AJ, Delaney CP (2010) Endogenous morphine levels after laparoscopic versus open colectomy. Br J Surg 97:759-764
46. Martini L, Whistler JL (2007) The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence. Curr Opin Neurobiol 17:556-564
47. Mathew B, Lennon FE, Siegler J, Mirzapoiazova T, Mambetsariev N, Sammani S, Gerhold LM, LaRiviere PJ, Chen CT, Garcia JGN, Salgia R, Moss J, Singleton PA (2011) The novel role of the mu opioid receptor in lung cancer progression: a laboratory investigation. Anesth Analg112:558-567
48. Molteni M, Marabella D, Orlandi C, Rossetti C (2006) Melanoma cell lines are responsive in vitro to lipopolysaccharide and express TLR-4. Cancer Lett 235:75-83
49. Muller A, Glattard E, Taleb O, Kemmel V, Laux A, Miehe M, Delalande F, Roussel G, Van Dorsselaer A, Metz-Boutigue MH, Aunis D, Goumon Y (2008) Endogenous morphine in SH-SY5Y cells and the mouse cerebellum. PLoS One 3:e1641
50. Munjal ID, Minna JD, Manneckjee R, Bieck P, Spector S (1995) Possible role of endogenous morphine and codeine on growth regulation of lung tissue. Life Sci 57:517-521
51. Myles PS, Peyton P, Silbert B, Hunt J, Rigg JR, Sessler DI (2011) Perioperative epidural analgesia for major abdominal surgery for cancer and recurrence-free survival: randomised trial. BMJ 342:d1491
52. Nagano E, Yamada H, Oguri K (2000) Characteristic glucuronidation pattern of physiologic concentration of morphine in rat brain. Life Sci 67:2453-2464
53. Osborne R, Joel S, Trew D, Slevin M (1988) Analgesic activity of morphine-6-glucuronide. Lancet 331:828
54. Osborne R, Joel S, Trew D, Slevin M (1990) Morphine and metabolite behavior after different routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide. Clin Pharmacol Ther 47:12-19
55. Page GG, Ben-Eliyahu S, Yirmiya R, Liebeskind JC (1993) Morphine attenuates surgery-induced enhancement of metastatic colonization in rats. Pain 54:21-28
56. Page GG, Ben-Eliyahu S, Liebeskind JC (1994) The role of LGL/NK cells in surgery-induced promotion of metastasis and its attenuation by morphine. Brain Behav Immun 8:241-250
57. Page GG, McDonald JS, Ben-Eliyahu S (1998) Pre-operative versus postoperative administration of morphine: impact on the neuroendocrine, behavioural, and metastatic-enhancing effects of surgery. Br J Anaesth 81:216-223
58. Page GG, Blakely WP, Ben-Eliyahu S (2001) Evidence that postoperative pain is a mediator of the tumor-promoting effects of surgery in rats. Pain 90:191-199
59. Poeaknapo C, Schmidt J, Brandsch M, Drager B, Zenk MH (2004) Endogenous formation of morphine in human cells. Proc Natl Acad Sci USA 101:14091-14096
60. Popping DM, Wenk M, Schug SA (2013) Anaesthetic and pain management technique in long term cancer outcome - benefits of regional anaesthesia and analgesia in the context of cancer surgery. In: Parat MO (ed) Morphine and metastasis. Springer, Dordrecht
61. Sasamura T, Nakamura S, Iida Y, Fujii H, Murata J, Saiki I, Nojima H, Kuraishi Y (2002) Morphine analgesia suppresses tumor growth and metastasis in a mouse model of cancer pain produced by orthotopic tumor inoculation. Eur J Pharmacol 441:185-191
62. Schoof CR, Botelho EL, Izzotti A, Vasques LR (2012) MicroRNAs in cancer treatment and prognosis. Am J Cancer Res 2:414-433
63. Sessler DI, Ben-Eliyahu S, Mascha EJ, Parat MO, Buggy DJ (2008) Can regional analgesia reduce the risk of recurrence after breast cancer? Methodology of a multicenter randomized trial. Contemp Clin Trials 29:517-526
64. Shanahan H, Parat MO, Buggy DJ (2013) Could opioids affect cancer recurrence or metastases? Current experimental and translational evidence. In: Parat MO (ed) Morphine and metastasis. Springer, Dordrecht
65. Shigeta Y, Kasai S, Han W, Hata H, Nishi A, Takamatsu Y, Hagino Y, Yamamoto H, Koide T, Shiroishi T, Kasai K, Tsunashima K, Kato N, Ikeda K (2008) Association of morphine-induced antinociception with variations in the 5' flanking and 3' untranslated regions of the mu opioid receptor gene in 10 inbred mouse strains. Pharmacogenet Genomics 18:927-936
66. Shilling AM, Tiouririne M (2013) Perioperative morphine and cancer recurrence. In: Parat MO (ed) Morphine and metastasis. Springer, Dordrecht
67. Shimomura K, Kamata O, Ueki S, Ida S, Oguri K, Yoshimura H, Tsukamoto H (1971) Analgesic effect of morphine glucuronides. Tohoku J Exp Med 105:45-52
68. Sia AT, Lim Y, Lim EC, Goh RW, Law HY, Landau R, Teo YY, Tan EC (2008) A118G single nucleotide polymorphism of human mu-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia. Anesthesiology 109:520-526
69. Singleton PA, Lingen MW, Fekete MJ, Garcia JGN, Moss J (2006) Methylnaltrexone inhibits opiate and VEGF-induced angiogenesis: role of receptor transactivation. Microvasc Res 72:3-11
70. Stefano GB, Hartman A, Bilfinger TV, Magazine HI, Liu Y, Casares F, Goligorsky MS (1995) Presence of the mu3 opiate receptor in endothelial cells: coupling to nitric oxide production and vasodilation. J Biol Chem 270:30290-30293
71. Stefano GB, Ptacek R, Kuzelova H, Kream RM (2012) Endogenous morphine: up-to-date review (2011). Folia Biol (Praha) 58:49-56
72. Tang XY, Zhu YQ, Wei B, Wang H (2010) Expression and functional research of TLR4 in human colon carcinoma. Am J Med Sci 339:319-326
73. Thornton JE, Gregory RI (2012) How does Lin28 let-7 control development and disease? Trends Cell Biol. doi:10.1016/j.tcb.2012.06.001
74. Tsui BC, Rashiq S, Schopflocher D, Murtha A, Broemling S, Pillay J, Finucane BT (2010) Epidural anesthesia and cancer recurrence rates after radical prostatectomy. Can J Anaesth 57:107-112
75. Wang S, Li Y, Liu XD, Zhao CX, Yang KQ (2012a) Polymorphism of A118G in mu-opioid receptor gene is associated with risk of esophageal squamous cell carcinoma in a Chinese population. Int J Clin Oncol. doi:10.1007/s10147-012-0441-5
76. Wang X, Cao L, Wang Y, Wang X, Liu N, You Y (2012b) Regulation of let-7 and its target oncogenes (review). Oncol Lett 3:955-960
77. Wang X, Loram LC, Ramos K, de Jesus AJ, Thomas J, Cheng K, Reddy A, Somogyi AA, Hutchinson MR, Watkins LR, Yin H (2012c) Morphine activates neuroinflammation in a manner parallel to endotoxin. Proc Natl Acad Sci USA 109:6325-6330
78. Wang Y, Barker K, Shi S, Diaz M, Mo B, Gutstein HB (2012d) Blockade of PDGFR-[beta] activation eliminates morphine analgesic tolerance. Nat Med 18:385-387
79. Wuethrich PY, Hsu Schmitz SF, Kessler TM, Thalmann GN, Studer UE, Stueber F, Burkhard FC (2010) Potential influence of the anesthetic technique used during open radical prostatectomy on prostate cancer-related outcome: a retrospective study. Anesthesiology 113:570-576
80. Yeager MP, Colacchio TA (1991) Effect of morphine on growth of metastatic colon cancer in vivo. Arch Surg 126:454-456
81. Yoshida S, Ohta J, Yamasaki K, Kamei H, Harada Y, Yahara T, Kaibara A, Ozaki K, Tajiri T, Shirouzu K (2000) Effect of surgical stress on endogenous morphine and cytokine levels in the plasma after laparoscopic or open cholecystectomy. Surg Endosc 14:137-140
82. Yuan CS, Foss JF, O’Connor M, Toledano A, Roizen MF, Moss J (1996) Methylnaltrexone prevents morphine-induced delay in oral-cecal transit time without affecting analgesia: a doubleblind randomized placebo-controlled trial. Clin Pharmacol Ther 59:469-475
83. Zheng H, Zeng Y, Zhang X, Chu J, Loh HH, Law PY (2010) Mu-opioid receptor agonists differentially regulate the expression of miR-190 and NeuroD. Mol Pharmacol 77:102-109
84. Zhu W, Cadet P, Baggerman G, Mantione KJ, Stefano GB (2005) Human white blood cells synthesize morphine: CYP2D6 modulation. J Immunol 175:7357-7362