Morphine depresses macrophage numbers and function in mouse spleens

Advances in Experimental Medicine and Biology

Volumn 437, Issue , 1998, Pages 33-41

  Eisenstein, T K ^a   Rogers, T J ^a   Meissler Jr , J J ^a   Adler, M W ^a   Hilburger, M E ^a,b  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE; NALTREXONE;

ANIMAL TISSUE; ANTIGEN PRESENTATION; CELLULAR IMMUNITY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MACROPHAGE FUNCTION; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; SPLEEN;

ANIMALIA;

EID: 0031825077     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-5347-2_4     Document Type: Conference Paper

References (13)

1. Arora, P.K., Fride, E., Petitto, J., Waggie, K. and Skolnick, P. (1990) Morphine-induced immune alterations in vivo. Cell.Immunol. 126, 343-353.
2. Bryant, H.U., Bernton, E.W. and Holaday, J.W. (1988) Morphine pellet-induced immunomodulation in mice: temporal relationships. J.Pharmacol.Exp.Ther. 245, 913-920.
3. Bussiere, J.L., Adler, M.W., Rogers, T.J. and Eisenstein, T.K. (1992a) Differential effects of morphine and naltrexone on the antibody response in various mouse strains. Immunopharmacol.Immunotoxicol. 14, 657-673.
4. J (beige) mice. Life Sci. 52, PL43-PL48.
5. Bussiere, J.L., Adler, M.W., Rogers, T.J. and Eisenstein, T.K. (1993) Cytokine reversal of morphine-induced suppression of the antibody response. J.Pharmacol.Exp.Ther. 264, 591-597.
6. Eisenstein, T.K., Hilburger, M.E. and Lawrence, D.M.P. Immunomodulation by morphine and other opioids. In: Drugs of abuse, immunity and infections, edited by Friedman, H., Klein, T.W. and Specter, S. Boca Raton: CRC Press, Inc., 1996, p. 103-120.
7. Guan, L., Townsend, R., Eisenstein, T.K., Adler, M.W. and Rogers, T.J. (1994) Both T cells and macrophages are targets of k-opioid-induced immunosuppression. Brain Behav.Immun. 8, 229-240.
8. Portolés, J.M., Ojeda, G., Ronda, M., Leza, J.C. and Rojo, J.M. (1995) Suppression of immune parameters in animal models of morphine dependence. Immunol.Invest. 24, 643-652.
9. Rojavin, M., Szabo, I., Bussiere, J.L., Rogers, T.J., Adler, M.W. and Eisenstein, T.K. (1993) Morphine treatment in vitro or in vivo decreases phagocytic functions of murine macrophages. Life Sci. 53, 997-1006.
10. Roy, S., Ramakrishnan, S., Loh, H.H. and Lee, N.M. (1991) Chronic morphine treatment selectively suppresses macrophage colony formation in bone marrow. Eur.J.Pharmacol. 195, 359-363.
11. Siegel, S. and Castellan, N.J. Nonparametric Statistics, New York,NY:McGraw-Hill, 1988. Ed. 2
12. Szabo, I., Rojavin, M., Bussiere, J.L., Eisenstein, T.K., Adler, M.W. and Rogers, T.J. (1993) Suppression of peritoneal macrophage phagocytosis of Candida albicans by opioids. J.Pharmacol.Exp.Ther. 267, 703-706.
13. Taub, D.D., Eisenstein, T.K., Geller, E.B., Adler, M.W. and Rogers, T.J. (1991) Immunomodulatory activity of μ-and κ-selective opioid agonists. Proc.Natl.Acad.Sci.USA 88, 360-364.