Association of morphine-induced antinociception with variations in the 5′ flanking and 3′ untranslated regions of the μ opioid receptor gene in 10 inbred mouse strains

Pharmacogenetics and Genomics

Volumn 18, Issue 11, 2008, Pages 927-936

  Shigeta, Yoshihiro ^a,b   Kasai, Shinya ^a   Han, Wenhua ^a   Hata, Harumi ^a,d   Nishi, Akinori ^a,c,f   Takamatsu, Yukio ^a   Hagino, Yoko ^a   Yamamoto, Hideko ^a   Koide, Tsuyoshi ^c   Shiroishi, Toshihiko ^c   Kasai, Kiyoto ^b   Tsunashima, Koichi ^c,e   Kato, Nobumasa ^b,d   Ikeda, Kazutaka ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL INSTITUTE OF GENETICS   (Japan)

^d SHOWA UNIVERSITY   (Japan)

^e JUNTENDO UNIVERSITY   (Japan)

^f BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Opioid receptor gene; Antinociception; Inbred mice; Interindividual differences; Morphine

Indexed keywords

AMINO ACID; MORPHINE; MU OPIATE RECEPTOR; NUCLEOTIDE;

3' UNTRANSLATED REGION; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; DRUG EFFECT; EXON; GENE; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; INBRED STRAIN; LOCOMOTION; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; OPRM1 GENE; PRIORITY JOURNAL; SHORT TANDEM REPEAT;

3' UNTRANSLATED REGIONS; 5' UNTRANSLATED REGIONS; AMINO ACID SUBSTITUTION; ANIMALS; BASE SEQUENCE; GENETIC VARIATION; HAPLOTYPES; MICE; MICE, INBRED STRAINS; MICROSATELLITE REPEATS; MORPHINE; OPEN READING FRAMES; PAIN; RECEPTORS, OPIOID, MU;

MUS;

EID: 56149107778     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e32830d0b9e     Document Type: Article

References (52)

1. Aubrun F, Langeren O, Quesnel C, Coriat P, Riou B. Relationships between measurement of pain using visual analog score and morphine requirements during postoperative intravenous morphine titration. Anesthesiology 2003; 98:1415-1421.
2. Beck JA, Lloyd S, Hafezparast M, Lennon-Pierce M, Eppig JT, Festing F, et al. Genealogies of mouse inbred strains. Nat Genet 2000; 24:23-25.
3. Mogil JS, Kest B, Sadowski B, Belknap JK. Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay. J Pharmacol Exp Ther 1996; 276:532-544.
4. Elmer GI, Pieper JO, Negus SS, Woods JH. Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests. Pain 1998; 75:129-140.
5. Wilson SG, Smith SB, Chester EJ, Melton KA, Haas JJ, Mitton B, et al. The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics. J Pharmacol Exp Ther 2003; 304:547-559.
6. Wilson SG, Bryant CD, Lariviere WR, Olsen MS, Giles BE, Chesler EJ, et al. The heritability of antinociception: II. Pharmacogenetic mediation of three over-the-counter analgesics in mice. J Pharmacol Exp Ther 2003; 305:755-764.
7. Orsini C, Bonito-Oliva A, Conversi D, Cabib S. Susceptibility to conditioned place preference induced by addictive drugs in mice of the C57BL/6 and DBA/2 inbred strains. Psychopharmacology 2005; 181:327-336.
8. Kest B, Hopkins E, Palmese CA, Adler M, Mogil JS. Genetic variation in morphine analgesic tolerance: a survey of 11 inbred mouse strains. Pharmacol Biochem Behav 2002; 73:821-828.
9. Kest B, Palmese CA, Hopkins E, Adler M, Juni A, Mogil JS. Naloxone-precipitated withdrawal jumping in 11 inbred mouse strains: evidence for common genetic mechanisms in acute and chronic morphine physical dependence. Neuroscience 2002; 115:463-469.
10. Koide T, Moriwaki K, Uchida K, Mita A, Sagai T, Yonekawa H, et al. A new inbred strain JF1 established from Japanese fancy mouse carrying the classic piebald allele. Mamm Genome 1998; 9:15-19.
11. Koide T, Moriwaki K, Ikeda K, Niki H, Shiroishi T. Multi-phenotype behavioral characterization of inbred strains derived from wild stocks of Mus musculus. Mamm Genome 2000; 11:664-670.
12. Furuse T, Blizard DA, Moriwaki K, Miura Y, Yagasaki K, Shiroishi T, et al. Genetic diversity underlying capsaicin intake in the Mishima battery of mouse strains. Brain Res Bull 2002; 57:49-55.
13. Takahashi A, Kato K, Makino J, Shiroishi T, Koide T. Multivariate analysis of temporal descriptions of open-field behavior in wild-derived mouse strains. Behav Genet 2006; 36:763-774.
14. Waldhoer M, Bartlett SE, Whistler JL. Opioid receptors. Annu Rev Biochem 2004; 73:953-990.
15. Kieffer BL, Gavériaux-Ruff C. Exploring the opioid system by gene knockout. Prog Neurobiol 2002; 66:285-306.
16. Matthes HW, Maldonado R, Simonin F, Valverde O, Slowe S, Kitchen I, et al. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the μ-opioid-receptor gene. Nature 1996; 383:819-823.
17. Sora I, Takahashi N, Funada M, Ujike H, Revay RS, Donovan DM, et al. Opiate receptor knockout mice define μ receptor roles in endogenous nociceptive responses and morphine-induced analgesia. Proc Natl Acad Sci USA 1997; 94:1544-1549.
18. Loh HH, Liu HC, Cavalli A, Yang W, Chen YF, Wei LN. μ Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality. Brain Res Mol Brain Res 1998; 54:321-326.
19. Pan YX, Xu J, Mahurter L, Bolan E, Xu M, Pasternak GW. Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm gene. Proc Natl Acad Sci U S A 2001; 98:14084-14089.
20. Kaufman DL, Keith DE Jr, Anton B, Tian J, Magendzo K, Newman D, et al. Characterization of the murine μ opioid receptor gene. J Biol Chem 1995; 270:15877-15883.
21. Ikeda K, Kobayashi T, Ichikawa T, Kumanishi T, Niki H, Yano R. The untranslated region of μ-opioid receptor mRNA contributes to reduced opioid sensitivity in CXBK mice. J Neurosci 2001; 21:1334-1339.
22. Ikeda K, Ide S, Han W, Hayashida M, Uhl GR, Sora I. How individual sensitivity to opiates can be predicted by gene analyses. Trends Pharmacol Sci 2005; 26:311-317.
23. Mayer P, Höllt V. Pharmacogenetics of opioid receptors and addiction. Pharmacogenet Genomics 2006; 16:1-7.
24. Somogyi AA, Barratt DT, Coller JK. Pharmacogenetics of opioids. Clin Pharmacol Ther 2007; 81:429-444.
25. Bonhomme F, Guénet J-L. The laboratory mouse and its wild relatives. In: Lyon MF, Rastan S, Brown SDM, editors. Genetic variants and strains of the laboratory mouse. 3rd ed. Oxford: Oxford University Press; 1996. pp. 1577-1596.
26. Bonhomme F, Catalan J, Britton-Davidian J, Chapman VM, Moriwaki K, Nevo E, et al. Biochemical diversity and evolution in the genus Mus. Biochem Genet 1984; 22:275-303.
27. D'Amour F, Smith D. A method for determining loss of pain sensation. J Pharmacol Exp Ther 1941; 72:74-79.
28. Woolfe G, MacDonald A. The evaluation of the analgesic action of pethidine hydrochloride (demerol). J Pharmacol Exp Ther 1944; 80:300-307.
29. κ-agonists. Neurosci Res 1999; 34: 149-155.
30. Mogil JS, Wilson SG, Bon K, Lee SE, Chung K, Raber P, et al. Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception. Pain 1999; 80:67-82.
31. Liang Y, Mestek A, Yu L, Carr LG. Cloning and characterization of the promoter region of the mouse μ opioid receptor gene. Brain Res 1995; 679:82-88.
32. Ko JL, Minnerath SR, Loh HH. Dual promoters of mouse μ-opioid receptor gene. Biochem Biophys Res Commun 1997; 234:351-357.
33. Liang Y, Carr LG. Transcription of the mouse μ-opioid receptor gene is regulated by two promoters. Brain Res 1997; 769:372-374.
34. Law PY, Loh HH, Wei LN. Insights into the receptor transcription and signaling: implications in opioid tolerance and dependence. Neuropharmacology 2004; 47 (Suppl 1):300-311.
35. Min BH, Augustin LB, Felsheim RF, Fuchs JA, Loh HH. Genomic structure analysis of promoter sequence of a mouse μ opioid receptor gene. Proc Natl Acad Sci USA 1994; 91:9081-9085.
36. Kraus J, Horn G, Zimprich A, Simon T, Mayer P, Höllt V. Molecular cloning and functional analysis of the rat μ opioid receptor gene promoter. Biochem Biophys Res Commun 1995; 215:591-597.
37. Andria ML, Simon EJ. Localization of promoter elements in the human mu-opioid receptor gene and regulation by DNA methylation. Brain Res Mol Brain Res 1999; 70:54-65.
38. Andria ML, Simon EJ. Identification of a neurorestrictive suppressor element (NRSE) in the human μ-opioid receptor gene. Brain Res Mol Brain Res 2001; 91:73-80.
39. Kim CS, Hwang CK, Choi HS, Song KY, Law PY, Wei LN, Loh HH. Neuron-restrictive silencer factor (NRSF) functions as a represser in neuronal cells to regulate the μ opioid receptor gene. J Biol Chem 2004; 279:46464-46473.
40. 15 microsatellite in intron 2 of the HLA-DRB1*0401 gene. Gene 2000; 253:209-214.
41. n repeats mediates bithoraxoid polycomb group response element-dependent silencing. Mol Cell Biol 2001; 21:4528-4543.
42. Wang JB, Johnson PS, Persico AM, Hawkins AL, Griffin CA, Uhl GR. Human μ opiate receptor: cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. FEBS Lett 1994; 338: 217-222.
43. Ide S, Han W, Kasai S, Hata H, Sora I, Ikeda K. Characterization of the 3′ untranslated region of the human mu-opioid receptor (MOR-1) mRNA. Gene 2005; 364:139-145.
44. Han W, Kasai S, Hala H, Takahashi T, Takamatsu Y, Yamamolo H, et al. Intracistemal A-particle element in the 3′ noncoding region of the mu-opioid receptor gene in CXBK mice: a new genetic mechanism underlying differences in opioid sensitivity. Pharmacogenel Genomics 2006; 16:451-460.
45. Uhl GR, Sora I, Wang Z. The μ opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses. Proc Natl Acad Sci U S A 1999; 96:7752-7755.
46. Kranzler HR, Gelernter J, O'Malley S, Hernandez-Avila CA, Kaufman D. Association of alcohol or other drug dependence with alleles of the μ opioid receptor gene (OPRM1). Alcohol Clin Exp Res 1998; 22:1359-1362.
47. Shaw G, Kamen R. A conserved AU sequence from the 3′untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 1986; 46:659-667.
48. Caput D, Beutler B, Hartog K, Thayer R, Brown-Shimer S, Cerami A. Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators. Proc Natl Acad Sci U S A 1986; 83:1670-1674.
49. Kasai S, Han W, Ide S, Hata H, Takamatsu Y, Yamamoto H, et al. Involvement of the 3′ non-coding region of the mu opioid receptor gene in morphine-induced analgesia. Psychiatry Clin Neurosci 2006; 60 (Suppl 1):S11-S17.
50. Peng SS, Chen CY, Xu N, Shyu AB. RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein. EMBO J 1998; 17:3461-3470.
51. Brennan CM, Gallouzi IE, Steitz JA. Protein ligands to HuR modulate its interaction with target mRNAs in vivo. J Cell Biol 2000; 151:1-14.
52. Kasai S, Hayashida M, Sora I, Ikeda K. Candidate gene polymorphisms predicting individual sensitivity to opioids. Naunyn Schmiedebergs Arch Pharmacol 2008; 377:269-281.