메뉴 건너뛰기




Volumn , Issue , 2013, Pages 47-61

Opioid regulation of vascular integrity

Author keywords

Angiogenesis; Endothelial barrier; Inflammation; Opioid receptor antagonists; Opioids; Signaling; Vascular integrity

Indexed keywords


EID: 84893267142     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-94-007-5678-6_4     Document Type: Chapter
Times cited : (2)

References (60)
  • 3
    • 81855161676 scopus 로고    scopus 로고
    • Molecular mechanisms of opioid receptor-dependent signaling and behavior
    • Al-Hasani R, Bruchas MR (2011) Molecular mechanisms of opioid receptor-dependent signaling and behavior. Anesthesiology 115:1363-1381
    • (2011) Anesthesiology , vol.115 , pp. 1363-1381
    • Al-Hasani, R.1    Bruchas, M.R.2
  • 4
    • 0035823506 scopus 로고    scopus 로고
    • Mu-Opioid receptor-mediated ERK activation involves calmodulin-dependent epidermal growth factor receptor transactivation
    • Belcheva MM, Szucs M, Wang D, Sadee W, Coscia CJ (2001) Mu-Opioid receptor-mediated ERK activation involves calmodulin-dependent epidermal growth factor receptor transactivation. J Biol Chem 276:33847-33853
    • (2001) J Biol Chem , vol.276 , pp. 33847-33853
    • Belcheva, M.M.1    Szucs, M.2    Wang, D.3    Sadee, W.4    Coscia, C.J.5
  • 5
    • 71049174151 scopus 로고    scopus 로고
    • Lung endothelial barrier protection by iloprost in the 2-hit models of ventilator-induced lung injury (VILI) involves inhibition of Rho signaling
    • Birukova AA, Fu P, Xing J, Cokic I, Birukov KG (2010) Lung endothelial barrier protection by iloprost in the 2-hit models of ventilator-induced lung injury (VILI) involves inhibition of Rho signaling. Transl Res 155:44-54
    • (2010) Transl Res , vol.155 , pp. 44-54
    • Birukova, A.A.1    Fu, P.2    Xing, J.3    Cokic, I.4    Birukov, K.G.5
  • 7
    • 77954343077 scopus 로고    scopus 로고
    • Vascular permeability modulation at the cell, microvessel, or whole organ level: Towards closing gaps in our knowledge
    • Curry FR, Adamson RH (2010) Vascular permeability modulation at the cell, microvessel, or whole organ level: towards closing gaps in our knowledge. Cardiovasc Res 87:218-229
    • (2010) Cardiovasc Res , vol.87 , pp. 218-229
    • Curry, F.R.1    Adamson, R.H.2
  • 8
    • 37549038311 scopus 로고    scopus 로고
    • Endogenous opioid peptides, endomorphin-1 and -2 and deltorphin I, stimulate angiogenesis in the CAM assay
    • Dai X, Cui SG, Wang T, Liu Q, Song HJ, Wang R (2008) Endogenous opioid peptides, endomorphin-1 and -2 and deltorphin I, stimulate angiogenesis in the CAM assay. Eur J Pharmacol 579: 269-275
    • (2008) Eur J Pharmacol , vol.579 , pp. 269-275
    • Dai, X.1    Cui, S.G.2    Wang, T.3    Liu, Q.4    Song, H.J.5    Wang, R.6
  • 9
    • 73949143036 scopus 로고    scopus 로고
    • The stimulative effects of endogenous opioids on endothelial cell proliferation, migration and angiogenesis in vitro
    • Dai X, Song HJ, Cui SG, Wang T, Liu Q, Wang R (2010) The stimulative effects of endogenous opioids on endothelial cell proliferation, migration and angiogenesis in vitro. Eur J Pharmacol 628:42-50
    • (2010) Eur J Pharmacol , vol.628 , pp. 42-50
    • Dai, X.1    Song, H.J.2    Cui, S.G.3    Wang, T.4    Liu, Q.5    Wang, R.6
  • 10
    • 57749192473 scopus 로고    scopus 로고
    • Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees
    • Dejana E, Orsenigo F, Molendini C, Baluk P, McDonald DM (2009a) Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees. Cell Tissue Res 335:17-25
    • (2009) Cell Tissue Res , vol.335 , pp. 17-25
    • Dejana, E.1    Orsenigo, F.2    Molendini, C.3    Baluk, P.4    Mc Donald, D.M.5
  • 11
    • 59649092177 scopus 로고    scopus 로고
    • The control of vascular integrity by endothelial cell junctions: Molecular basis and pathological implications
    • Dejana E, Tournier-Lasserve E, Weinstein BM (2009b) The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications. Dev Cell 16:209-221
    • (2009) Dev Cell , vol.16 , pp. 209-221
    • Dejana, E.1    Tournier-Lasserve, E.2    Weinstein, B.M.3
  • 12
    • 70449727682 scopus 로고    scopus 로고
    • Methylnaltrexone: A novel approach for the management of opioid-induced constipation in patients with advanced illness
    • Diego L, Atayee R, Helmons P, von Gunten CF (2009) Methylnaltrexone: a novel approach for the management of opioid-induced constipation in patients with advanced illness. Expert Rev Gastroenterol Hepatol 3:473-485
    • (2009) Expert Rev Gastroenterol Hepatol , vol.3 , pp. 473-485
    • Diego, L.1    Atayee, R.2    Helmons, P.3    Von Gunten, C.F.4
  • 13
    • 0032520696 scopus 로고    scopus 로고
    • Opiates as potential cofactors in progression of HIV-1 infections to AIDS
    • Donahoe RM, Vlahov D (1998) Opiates as potential cofactors in progression of HIV-1 infections to AIDS. J Neuroimmunol 83:77-87
    • (1998) J Neuroimmunol , vol.83 , pp. 77-87
    • Donahoe, R.M.1    Vlahov, D.2
  • 15
    • 0036283315 scopus 로고    scopus 로고
    • Opioids causing peripheral edema
    • Gardner-Nix J (2002) Opioids causing peripheral edema. J Pain Symptom Manage 23:453-455
    • (2002) J Pain Symptom Manage , vol.23 , pp. 453-455
    • Gardner-Nix, J.1
  • 16
    • 33745669094 scopus 로고    scopus 로고
    • Post-opioid receptor adaptations to chronic morphine; altered functionality and associations of signaling molecules
    • Gintzler AR, Chakrabarti S (2006) Post-opioid receptor adaptations to chronic morphine; altered functionality and associations of signaling molecules. Life Sci 79:717-722
    • (2006) Life Sci , vol.79 , pp. 717-722
    • Gintzler, A.R.1    Chakrabarti, S.2
  • 18
    • 0036682055 scopus 로고    scopus 로고
    • Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth
    • Gupta K, Kshirsagar S, Chang L, Schwartz R, Law PY, Yee D, Hebbel RP (2002) Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth. Cancer Res 62:4491-4498
    • (2002) Cancer Res , vol.62 , pp. 4491-4498
    • Gupta, K.1    Kshirsagar, S.2    Chang, L.3    Schwartz, R.4    Law, P.Y.5    Yee, D.6    Hebbel, R.P.7
  • 19
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • Hawkins BT, Davis TP (2005) The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev 57:173-185
    • (2005) Pharmacol Rev , vol.57 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 20
    • 79955048932 scopus 로고    scopus 로고
    • Oxidative stress and endothelial dysfunction during sepsis
    • Huet O, Dupic L, Harrois A, Duranteau J (2011) Oxidative stress and endothelial dysfunction during sepsis. Front Biosci 16:1986-1995
    • (2011) Front Biosci , vol.16 , pp. 1986-1995
    • Huet, O.1    Dupic, L.2    Harrois, A.3    Duranteau, J.4
  • 21
    • 77957275033 scopus 로고    scopus 로고
    • Morphine suppresses tumor angiogenesis through a HIF-1alpha/p38MAPK pathway
    • Koodie L, Ramakrishnan S, Roy S (2010) Morphine suppresses tumor angiogenesis through a HIF-1alpha/p38MAPK pathway. Am J Pathol 177:984-997
    • (2010) Am J Pathol , vol.177 , pp. 984-997
    • Koodie, L.1    Ramakrishnan, S.2    Roy, S.3
  • 22
    • 49949094428 scopus 로고    scopus 로고
    • Prolonged use of high-dose morphine impairs angiogenesis and mobilization of endothelial progenitor cells in mice
    • Lam CF, Chang PJ, Huang YS, Sung YH, Huang CC, Lin MW, Liu YC, Tsai YC (2008) Prolonged use of high-dose morphine impairs angiogenesis and mobilization of endothelial progenitor cells in mice. Anesth Analg 107:686-692
    • (2008) Anesth Analg , vol.107 , pp. 686-692
    • Lam, C.F.1    Chang, P.J.2    Huang, Y.S.3    Sung, Y.H.4    Huang, C.C.5    Lin, M.W.6    Liu, Y.C.7    Tsai, Y.C.8
  • 23
    • 84856598797 scopus 로고    scopus 로고
    • Jumping the barrier: VE-cadherin, VEGF and other angiogenic modifiers in cancer
    • Le Guelte A, Dwyer J, Gavard J (2011) Jumping the barrier: VE-cadherin, VEGF and other angiogenic modifiers in cancer. Biol Cell 103:593-605
    • (2011) Biol Cell , vol.103 , pp. 593-605
    • Le Guelte, A.1    Dwyer, J.2    Gavard, J.3
  • 24
    • 79955017821 scopus 로고    scopus 로고
    • Endothelial activation, dysfunction and permeability during severe infections
    • Lee WL, Liles WC (2011) Endothelial activation, dysfunction and permeability during severe infections. Curr Opin Hematol 18:191-196
    • (2011) Curr Opin Hematol , vol.18 , pp. 191-196
    • Lee, W.L.1    Liles, W.C.2
  • 25
    • 77953451099 scopus 로고    scopus 로고
    • Opioid-induced proliferation of vascular endothelial cells
    • Leo S, Nuydens R, Meert TF (2009) Opioid-induced proliferation of vascular endothelial cells. J Pain Res 2:59-66
    • (2009) J Pain Res , vol.2 , pp. 59-66
    • Leo, S.1    Nuydens, R.2    Meert, T.F.3
  • 26
    • 79952116743 scopus 로고    scopus 로고
    • The role of opioid receptor antagonists in the treatment of opioid-induced constipation: A review
    • Leppert W (2010) The role of opioid receptor antagonists in the treatment of opioid-induced constipation: a review. Adv Ther 27:714-730
    • (2010) Adv Ther , vol.27 , pp. 714-730
    • Leppert, W.1
  • 27
    • 0346732389 scopus 로고    scopus 로고
    • Dual effects of morphine on permeability and apoptosis of vascular endothelial cells: Morphine potentiates lipopolysaccharide-induced permeability and apoptosis of vascular endothelial cells
    • Liu HC, Anday JK, House SD, Chang SL (2004) Dual effects of morphine on permeability and apoptosis of vascular endothelial cells: morphine potentiates lipopolysaccharide-induced permeability and apoptosis of vascular endothelial cells. J Neuroimmunol 146:13-21
    • (2004) J Neuroimmunol , vol.146 , pp. 13-21
    • Liu, H.C.1    Ay, J.K.2    House, S.D.3    Chang, S.L.4
  • 28
    • 77954908389 scopus 로고    scopus 로고
    • The pharmacological treatment of opioid addiction - a clinical perspective
    • Lobmaier P, Gossop M, Waal H, Bramness J (2010) The pharmacological treatment of opioid addiction - a clinical perspective. Eur J Clin Pharmacol 66:537-545
    • (2010) Eur J Clin Pharmacol , vol.66 , pp. 537-545
    • Lobmaier, P.1    Gossop, M.2    Waal, H.3    Bramness, J.4
  • 30
    • 63249115113 scopus 로고    scopus 로고
    • Loss of tight junction barrier function and its role in cancer metastasis
    • Martin TA, Jiang WG (2009) Loss of tight junction barrier function and its role in cancer metastasis. Biochim Biophys Acta 1788:872-891
    • (2009) Biochim Biophys Acta , vol.1788 , pp. 872-891
    • Martin, T.A.1    Jiang, W.G.2
  • 32
    • 33748472967 scopus 로고    scopus 로고
    • HDAC7 supports vascular integrity
    • Miano JM, Berk BC (2006) HDAC7 supports vascular integrity. Nat Med 12:997-998
    • (2006) Nat Med , vol.12 , pp. 997-998
    • Miano, J.M.1    Berk, B.C.2
  • 33
    • 24644469145 scopus 로고    scopus 로고
    • Opioid receptors and their interacting proteins
    • Milligan G (2005) Opioid receptors and their interacting proteins. Neuromolecular Med 7:51-59
    • (2005) Neuromolecular Med , vol.7 , pp. 51-59
    • Milligan, G.1
  • 34
    • 0031867637 scopus 로고    scopus 로고
    • Signal transduction and regulation of lung endothelial cell permeability: Interaction between calcium and cAMP
    • Moore TM, Chetham PM, Kelly JJ, Stevens T (1998) Signal transduction and regulation of lung endothelial cell permeability: interaction between calcium and cAMP. Am J Physiol 275: L203-L222
    • (1998) Am J Physiol , vol.275
    • Moore, T.M.1    Chetham, P.M.2    Kelly, J.J.3    Stevens, T.4
  • 35
    • 1542605624 scopus 로고    scopus 로고
    • Chronic morphine accelerates the progression of lipopolysaccharide-induced sepsis to septic shock
    • Ocasio FM, Jiang Y, House SD, Chang SL (2004) Chronic morphine accelerates the progression of lipopolysaccharide-induced sepsis to septic shock. J Neuroimmunol 149:90-100
    • (2004) J Neuroimmunol , vol.149 , pp. 90-100
    • Ocasio, F.M.1    Jiang, Y.2    House, S.D.3    Chang, S.L.4
  • 36
    • 79751525900 scopus 로고    scopus 로고
    • The molecular basis of the blood brain barrier differentiation and maintenance: Is it still a mystery?
    • Paolinelli R, Corada M, Orsenigo F, Dejana E (2011) The molecular basis of the blood brain barrier differentiation and maintenance: is it still a mystery? Pharmacol Res 63:165-171
    • (2011) Pharmacol Res , vol.63 , pp. 165-171
    • Paolinelli, R.1    Corada, M.2    Orsenigo, F.3    Dejana, E.4
  • 37
    • 38549138286 scopus 로고    scopus 로고
    • Morphine attenuates microvascular hyperpermeability via a protein kinase A-dependent pathway
    • Puana R, McAllister RK, Hunter FA, Warden J, Childs EW (2008) Morphine attenuates microvascular hyperpermeability via a protein kinase A-dependent pathway. Anesth Analg 106:480-485
    • (2008) Anesth Analg , vol.106 , pp. 480-485
    • Puana, R.1    Mc Allister, R.K.2    Hunter, F.A.3    Warden, J.4    Childs, E.W.5
  • 38
    • 46949090616 scopus 로고    scopus 로고
    • Severe peripheral edema during an outpatient continuous epidural morphine infusion trial in a patient with failed back surgery syndrome
    • Ruan X, Tadia R, Couch JP, Ruan J, Chiravuri S (2008) Severe peripheral edema during an outpatient continuous epidural morphine infusion trial in a patient with failed back surgery syndrome. Pain Physician 11:363-367
    • (2008) Pain Physician , vol.11 , pp. 363-367
    • Ruan, X.1    Tadia, R.2    Couch, J.P.3    Ruan, J.4    Chiravuri, S.5
  • 39
    • 33745053647 scopus 로고    scopus 로고
    • Opioids and the immune system
    • Sacerdote P (2006) Opioids and the immune system. Palliat Med 20(suppl 1):s9-15
    • (2006) Palliat Med , vol.20
    • Sacerdote, P.1
  • 40
    • 33646901336 scopus 로고    scopus 로고
    • Adenylyl cyclase type II activity is regulated by two different mechanisms: Implications for acute and chronic opioid exposure
    • Schallmach E, Steiner D, Vogel Z (2006) Adenylyl cyclase type II activity is regulated by two different mechanisms: implications for acute and chronic opioid exposure. Neuropharmacology 50:998-1005
    • (2006) Neuropharmacology , vol.50 , pp. 998-1005
    • Schallmach, E.1    Steiner, D.2    Vogel, Z.3
  • 41
    • 0006169580 scopus 로고
    • Morphine receptors as regulators of adenylate cyclase activity
    • Sharma SK, Nirenberg M, Klee WA (1975) Morphine receptors as regulators of adenylate cyclase activity. Proc Natl Acad Sci U S A 72:590-594
    • (1975) Proc Natl Acad Sci U S A , vol.72 , pp. 590-594
    • Sharma, S.K.1    Nirenberg, M.2    Klee, W.A.3
  • 42
    • 77956311003 scopus 로고    scopus 로고
    • Effect of perioperative opioids on cancer recurrence: A hypothesis
    • Singleton PA, Moss J (2010) Effect of perioperative opioids on cancer recurrence: a hypothesis. Future Oncol 6:1237-1242
    • (2010) Future Oncol , vol.6 , pp. 1237-1242
    • Singleton, P.A.1    Moss, J.2
  • 43
    • 26444551684 scopus 로고    scopus 로고
    • Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and alpha-actinin
    • Singleton PA, Dudek SM, Chiang ET, Garcia JG (2005) Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and alpha-actinin. Faseb J 19:1646-1656
    • (2005) Faseb J , vol.19 , pp. 1646-1656
    • Singleton, P.A.1    Dudek, S.M.2    Chiang, E.T.3    Garcia, J.G.4
  • 44
    • 33845949505 scopus 로고    scopus 로고
    • Transactivation of sphingosine 1-phosphate receptors is essential for vascular barrier regulation: Novel role for hyaluronan and CD44 receptor family
    • Singleton PA, Dudek SM, Ma SF, Garcia JG (2006a) Transactivation of sphingosine 1-phosphate receptors is essential for vascular barrier regulation: novel role for hyaluronan and CD44 receptor family. J Biol Chem 281:34381-34393
    • (2006) J Biol Chem , vol.281 , pp. 34381-34393
    • Singleton, P.A.1    Dudek, S.M.2    Ma, S.F.3    Garcia, J.G.4
  • 45
    • 33746336258 scopus 로고    scopus 로고
    • Methylnaltrexone inhibits opiate and VEGF-induced angiogenesis: Role of receptor transactivation
    • Singleton PA, Lingen MW, Fekete MJ, Garcia JG, Moss J (2006b) Methylnaltrexone inhibits opiate and VEGF-induced angiogenesis: role of receptor transactivation. Microvasc Res 72:3-11
    • (2006) Microvasc Res , vol.72 , pp. 3-11
    • Singleton, P.A.1    Lingen, M.W.2    Fekete, M.J.3    Garcia, J.G.4    Moss, J.5
  • 48
    • 81855185336 scopus 로고    scopus 로고
    • Advances in the management of sepsis and the understanding of key immunologic defects
    • Skrupky LP, Kerby PW, Hotchkiss RS (2011) Advances in the management of sepsis and the understanding of key immunologic defects. Anesthesiology 115:1349-1362
    • (2011) Anesthesiology , vol.115 , pp. 1349-1362
    • Skrupky, L.P.1    Kerby, P.W.2    Hotchkiss, R.S.3
  • 49
    • 77954843916 scopus 로고    scopus 로고
    • Effect of anaesthetic technique and other perioperative factors on cancer recurrence
    • Snyder GL, Greenberg S (2010) Effect of anaesthetic technique and other perioperative factors on cancer recurrence. Br J Anaesth 105:106-115
    • (2010) Br J Anaesth , vol.105 , pp. 106-115
    • Snyder, G.L.1    Greenberg, S.2
  • 50
    • 79960921683 scopus 로고    scopus 로고
    • Regulation of endothelial barrier function by cyclic nucleotides: The role of phosphodiesterases
    • Surapisitchat J, Beavo JA (2011) Regulation of endothelial barrier function by cyclic nucleotides: the role of phosphodiesterases. Handb Exp Pharmacol 204:193-210
    • (2011) Handb Exp Pharmacol , vol.204 , pp. 193-210
    • Surapisitchat, J.1    Beavo, J.A.2
  • 51
    • 4143066901 scopus 로고    scopus 로고
    • Opioids as modulators of cell death and survival - unraveling mechanisms and revealing new indications
    • Tegeder I, Geisslinger G (2004) Opioids as modulators of cell death and survival - unraveling mechanisms and revealing new indications. Pharmacol Rev 56:351-369
    • (2004) Pharmacol Rev , vol.56 , pp. 351-369
    • Tegeder, I.1    Geisslinger, G.2
  • 52
    • 80052365486 scopus 로고    scopus 로고
    • Evaluation of morphine effect on tumour angiogenesis in mouse breast tumour model, EATC
    • Ustun F, Durmus-Altun G, Altaner S, Tuncbilek N, Uzal C, Berkarda S (2011) Evaluation of morphine effect on tumour angiogenesis in mouse breast tumour model, EATC. Med Oncol 28:1264-1272
    • (2011) Med Oncol , vol.28 , pp. 1264-1272
    • Ustun, F.1    Durmus-Altun, G.2    Altaner, S.3    Tuncbilek, N.4    Uzal, C.5    Berkarda, S.6
  • 53
    • 33847735481 scopus 로고    scopus 로고
    • Naloxone treatment in opioid addiction: The risks and benefits
    • van Dorp EL, Yassen A, Dahan A (2007) Naloxone treatment in opioid addiction: the risks and benefits. Expert Opin Drug Saf 6:125-132
    • (2007) Expert Opin Drug Saf , vol.6 , pp. 125-132
    • Van Dorp, E.L.1    Yassen, A.2    Dahan, A.3
  • 55
    • 4644259224 scopus 로고    scopus 로고
    • Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors
    • Waeber C, Blondeau N, Salomone S (2004) Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors. Drug News Perspect 17:365-382
    • (2004) Drug News Perspect , vol.17 , pp. 365-382
    • Waeber, C.1    Blondeau, N.2    Salomone, S.3
  • 56
    • 2342509663 scopus 로고    scopus 로고
    • The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction
    • Waters C, Pyne S, Pyne NJ (2004) The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction. Semin Cell Dev Biol 15:309-323
    • (2004) Semin Cell Dev Biol , vol.15 , pp. 309-323
    • Waters, C.1    Pyne, S.2    Pyne, N.J.3
  • 57
    • 79959596087 scopus 로고    scopus 로고
    • Morphine induces expression of platelet-derived growth factor in human brain microvascular endothelial cells: Implication for vascular permeability
    • Wen H, Lu Y, Yao H, Buch S (2011) Morphine induces expression of platelet-derived growth factor in human brain microvascular endothelial cells: implication for vascular permeability. PLoS One 6:e21707
    • (2011) Plos One , vol.6
    • Wen, H.1    Lu, Y.2    Yao, H.3    Buch, S.4
  • 60
    • 59049089275 scopus 로고    scopus 로고
    • Src phosphorylation of micro-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal
    • Zhang L, Zhao H, Qiu Y, Loh HH, Law PY (2009) Src phosphorylation of micro-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal. J Biol Chem 284:1990-2000
    • (2009) J Biol Chem , vol.284 , pp. 1990-2000
    • Zhang, L.1    Zhao, H.2    Qiu, Y.3    Loh, H.H.4    Law, P.Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.