Low platelet counts after liver transplantation predict early posttransplant survival: The 60-5 criterion

Liver Transplantation

Volumn 20, Issue 2, 2014, Pages 147-155

  Lesurtel, Mickaël ^a   Raptis, Dimitri A ^a   Melloul, Emmanuel ^a   Schlegel, Andrea ^a   Oberkofler, Christian ^a   El Badry, Ashraf Mohammad ^a   Weber, Annina ^a   Mueller, Nicolas ^a   Dutkowski, Philipp ^a   Clavien, Pierre Alain ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD PLATELETS; FEMALE; FOLLOW-UP STUDIES; GRAFT SURVIVAL; HUMANS; ISCHEMIA; LIVER FAILURE; LIVER REGENERATION; LIVER TRANSPLANTATION; LIVING DONORS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; PLATELET COUNT; POSTOPERATIVE COMPLICATIONS; PREDICTIVE VALUE OF TESTS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RISK FACTORS; THROMBOCYTOPENIA; TREATMENT OUTCOME;

EID: 84893206600     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.23759     Document Type: Article

References (50)

1. Klinger MH,. Platelets and inflammation. Anat Embryol (Berl) 1997; 196: 1-11.
2. Wu KK,. Platelet activation mechanisms and markers in arterial thrombosis. J Intern Med 1996; 239: 17-34.
3. Tang YQ, Yeaman MR, Selsted ME,. Antimicrobial peptides from human platelets. Infect Immun 2002; 70: 6524-6533.
4. Sierko E, Wojtukiewicz MZ,. Platelets and angiogenesis in malignancy. Semin Thromb Hemost 2004; 30: 95-108.
5. Cywes R, Packham MA, Tietze L, Sanabria JR, Harvey PR, Phillips MJ, Strasberg SM,. Role of platelets in hepatic allograft preservation injury in the rat. Hepatology 1993; 18: 635-647.
6. Lesurtel M, Graf R, Aleil B, Walther DJ, Tian Y, Jochum W, et al. Platelet-derived serotonin mediates liver regeneration. Science 2006; 312: 104-107.
7. Nocito A, Georgiev P, Dahm F, Jochum W, Bader M, Graf R, Clavien PA,. Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice. Hepatology 2007; 45: 369-376.
8. Pereboom IT, Lisman T, Porte RJ,. Platelets in liver transplantation: friend or foe? Liver Transpl 2008; 14: 923-931.
9. Furrer K, Rickenbacher A, Tian Y, Jochum W, Bittermann AG, Käch A, et al. Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGF-dependent pathway. Proc Natl Acad Sci U S A 2011; 108: 2945-2950.
10. Sindram D, Porte RJ, Hoffman MR, Bentley RC, Clavien PA,. Platelets induce sinusoidal endothelial cell apoptosis upon reperfusion of the cold ischemic rat liver. Gastroenterology 2000; 118: 183-191.
11. Silva MA, Jambulingam PS, Gunson BK, Mayer D, Buckels JA, Mirza DF, Bramhall SR,. Hepatic artery thrombosis following orthotopic liver transplantation: a 10-year experience from a single centre in the United Kingdom. Liver Transpl 2006; 12: 146-151.
12. de Boer MT, Christensen MC, Asmussen M, van der Hilst CS, Hendriks HG, Slooff MJ, Porte RJ,. The impact of intraoperative transfusion of platelets and red blood cells on survival after liver transplantation. Anesth Analg 2008; 106: 32-44.
13. Witters P, Freson K, Verslype C, Peerlinck K, Hoylaerts M, Nevens F, et al. Review article: blood platelet number and function in chronic liver disease and cirrhosis. Aliment Pharmacol Ther 2008; 27: 1017-1029.
14. Escolar G, Cases A, Viñas M, Pino M, Calls J, Cirera I, Ordinas A,. Evaluation of acquired platelet dysfunctions in uremic and cirrhotic patients using the platelet function analyzer (PFA-100): influence of hematocrit elevation. Haematologica 1999; 84: 614-619.
15. Alkozai EM, Nijsten MW, de Jong KP, de Boer MT, Peeters PM, Slooff MJ, et al. Immediate postoperative low platelet count is associated with delayed liver function recovery after partial liver resection. Ann Surg 2010; 251: 300-306.
16. von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP,; for STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 2007; 370: 1453-1457.
17. Killenberg PG, Clavien PA, eds. Medical Care of the Liver Transplant Patient: Total Pre-, Intra- and Post-Operative Management. Oxford, England: Wiley-Blackwell; 2006.
18. Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, et al. The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg 2009; 250: 187-196.
19. Ploeg RJ, D'Alessandro AM, Knechtle SJ, Stegall MD, Pirsch JD, Hoffmann RM, et al. Risk factors for primary dysfunction after liver transplantation-a multivariate analysis. Transplantation 1993; 55: 807-813.
20. Dahm F, Georgiev P, Clavien PA,. Small-for-size syndrome after partial liver transplantation: definition, mechanisms of disease and clinical implications. Am J Transplant 2005; 5: 2605-2610.
21. Lo CM, Liu CL, Fan ST,. Portal hyperperfusion injury as the cause of primary nonfunction in a small-for-size liver graft-successful treatment with splenic artery ligation. Liver Transpl 2003; 9: 626-628.
22. Guarrera JV, Henry SD, Samstein B, Odeh-Ramadan R, Kinkhabwala M, Goldstein MJ, et al. Hypothermic machine preservation in human liver transplantation: the first clinical series. Am J Transplant 2010; 10: 372-381.
23. Rana A, Hardy MA, Halazun KJ, Woodland DC, Ratner LE, Samstein B, et al. Survival outcomes following liver transplantation (SOFT) score: a novel method to predict patient survival following liver transplantation. Am J Transplant 2008; 8: 2537-2546.
24. Fluss R, Faraggi D, Reiser B,. Estimation of the Youden index and its associated cutoff point. Biom J 2005; 47: 458-472.
25. Youden WJ,. Index for rating diagnostic tests. Cancer 1950; 3: 32-35.
26. Feng S, Goodrich NP, Bragg-Gresham JL, Dykstra DM, Punch JD, DebRoy MA, et al. Characteristics associated with liver graft failure: the concept of a donor risk index. Am J Transplant 2006; 6: 783-790.
27. Dutkowski P, Oberkofler CE, Béchir M, Müllhaupt B, Geier A, Raptis DA, Clavien PA,. The Model for End-Stage Liver Disease allocation system for liver transplantation saves lives, but increases morbidity and cost: a prospective outcome analysis. Liver Transpl 2011; 17: 674-684.
28. Organ Procurement and Transplantation Network. http://optn.transplant. hrsa.gov/data/annualreport.asp. Accessed January 2011.
29. European Liver Transplant Registry. http://www.eltr.org. Accessed January 2011.
30. Chang FY, Singh N, Gayowski T, Wagener MM, Mietzner SM, Stout JE, Marino IR,. Thrombocytopenia in liver transplant recipients: predictors, impact on fungal infections, and role of endogenous thrombopoietin. Transplantation 2000; 69: 70-75.
31. Chatzipetrou MA, Tsaroucha AK, Weppler D, Pappas PA, Kenyon NS, Nery JR, et al. Thrombocytopenia after liver transplantation. Transplantation 1999; 67: 702-706.
32. McCaughan GW, Herkes R, Powers B, Rickard K, Gallagher ND, Thompson JF, Sheil AG,. Thrombocytopenia post liver transplantation. Correlations with pre-operative platelet count, blood transfusion requirements, allograft function and outcome. J Hepatol 1992; 16: 16-22.
33. Eyraud D, Granger B, Ionescu C, Fratéa S, Darnat S, Vaillant JC, et al. Thrombocytopenia, splenomegaly, and portal blood flow in patients who have undergone liver transplantation for cirrhosis. Liver Transpl 2012; 18: 340-346.
34. Richards EM, Alexander GJ, Calne RY, Baglin TP,. Thrombocytopenia following liver transplantation is associated with platelet consumption and thrombin generation. Br J Haematol 1997; 98: 315-321.
35. Murata S, Matsuo R, Ikeda O, Myronovych A, Watanabe M, Hisakura K, et al. Platelets promote liver regeneration under conditions of Kupffer cell depletion after hepatectomy in mice. World J Surg 2008; 32: 1088-1096.
36. Murata S, Ohkohchi N, Matsuo R, Ikeda O, Myronovych A, Hoshi R,. Platelets promote liver regeneration in early period after hepatectomy in mice. World J Surg 2007; 31: 808-816.
37. Matsuo R, Nakano Y, Ohkohchi N,. Platelet administration via the portal vein promotes liver regeneration in rats after 70% hepatectomy. Ann Surg 2011; 253: 759-763.
38. Myronovych A, Murata S, Chiba M, Matsuo R, Ikeda O, Watanabe M, et al. Role of platelets on liver regeneration after 90% hepatectomy in mice. J Hepatol 2008; 49: 363-372.
39. Tian Y, Graf R, El-Badry AM, Lesurtel M, Furrer K, Moritz W, Clavien PA,. Activation of serotonin receptor-2B rescues small-for-size liver graft failure in mice. Hepatology 2011; 53: 253-262.
40. Jarnagin WR, Gonen M, Fong Y, DeMatteo RP, Ben-Porat L, Little S, et al. Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade. Ann Surg 2002; 236: 397-406.
41. Kaneko K, Shirai Y, Wakai T, Yokoyama N, Akazawa K, Hatakeyama K,. Low preoperative platelet counts predict a high mortality after partial hepatectomy in patients with hepatocellular carcinoma. World J Gastroenterol 2005; 11: 5888-5892.
42. Poon RT, Fan ST, Lo CM, Liu CL, Lam CM, Yuen WK, et al. Improving perioperative outcome expands the role of hepatectomy in management of benign and malignant hepatobiliary diseases: analysis of 1222 consecutive patients from a prospective database. Ann Surg 2004; 240: 698-708.
43. Taketomi A, Kitagawa D, Itoh S, Harimoto N, Yamashita Y, Gion T, et al. Trends in morbidity and mortality after hepatic resection for hepatocellular carcinoma: an institute's experience with 625 patients. J Am Coll Surg 2007; 204: 580-587.
44. Maithel SK, Kneuertz PJ, Kooby DA, Scoggins CR, Weber SM, Martin RC II, et al. Importance of low preoperative platelet count in selecting patients for resection of hepatocellular carcinoma: a multi-institutional analysis. J Am Coll Surg 2011; 212: 638-648.
45. Kim J, Yi NJ, Shin WY, Kim T, Lee KU, Suh KS,. Platelet transfusion can be related to liver regeneration after living donor liver transplantation. World J Surg 2010; 34: 1052-1058.
46. Nijsten MW, ten Duis HJ, Zijlstra JG, Porte RJ, Zwaveling JH, Paling JC, The TH,. Blunted rise in platelet count in critically ill patients is associated with worse outcome. Crit Care Med 2000; 28: 3843-3846.
47. Parker RI,. Etiology and significance of thrombocytopenia in critically ill patients. Crit Care Clin 2012; 28: 399-411.
48. Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ,. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 1995; 23: 1638-1652.
49. Vincent JL, de Mendonça A, Cantraine F, Moreno R, Takala J, Suter PM, et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. Crit Care Med 1998; 26: 1793-1800.
50. Vamvakas EC,. Platelet transfusion and adverse outcomes. Lancet 2004; 364: 1736-1738.