Thrombocytopenia in liver transplant recipients: Predictors, impact on fungal infections, and role of endogenous thrombopoietin

Transplantation

Volumn 69, Issue 1, 2000, Pages 70-75

  Chang, Feng Yee ^a,b   Singh, Nina ^a,c   Gayowski, Timothy ^a   Wagener, Marilyn M ^a   Mietzner, Sue M ^a   Stout, Janet E ^a   Marino, Ignazio R ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THROMBOPOIETIN;

ADULT; ARTICLE; CLINICAL ARTICLE; HUMAN; LIVER TRANSPLANTATION; MYCOSIS; OUTCOMES RESEARCH; PATHOGENESIS; PRIORITY JOURNAL; THROMBOCYTE COUNT; THROMBOCYTE FUNCTION; THROMBOCYTOPENIA;

EID: 0343938877     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200001150-00014     Document Type: Article

References (27)

1. Munoz SJ, Carabasi AR, Moritz MJ, Jarrell BE, Maddrey WC. Postoperative thrombocytopenia in liver transplant recipients: prognostic implications and treatment with high dose of y-globulin. Transplant Proc 1989; 21(3): 3545.
2. Miyata T, Todo S, Selby R, Yokoyama I, Tzakis A, Starzl TA. Endotoxaemia, pulmonary complications and thrombocytopenia in liver transplantation. Lancet 1989; ii: 189.
3. Herrero JI, Sangro B, Quiroga J, et al. Partial splenic embolization in the treatment of thrombocytopenia after liver transplantation. Transplantation 1997; 63: 482.
4. Himmelreich G, Hundt K, Isenberg C, Bechstein WO, Neuhaus P, Riess H. Thrombocytopenia and platelet dysfunction in orthotopic liver transplantation. Semin Thromb Hemost 1993; 19(3): 209.
5. Porte RJ, Blauw E, Knot EAR, et al. Role of the donor liver in the origin of platelet disorders and hyperfibrinolysis in liver transplantation. J Hepatol 1994; 21: 592.
6. Plevak DJ, Halma GA, Forstrom LA. Thrombocytopenia after liver transplantation. Transplant Proc 1988; 10 (1 (Suppl 1): 630.
7. McCaughan GW, Herkes R, Powers B, et al. Thrombocytopenia post liver transplantation. J Hepatol 1998; 16: 16.
8. Nachman RL, Weksler B. The platelet as an inflammatory cell. Ann NY Acad Sci 1972; 201: 131.
9. Yeaman MR, Ibrahim A, Edwards JE Jr., Bayer AS, Ghannoum MA. Thrombin-induced rabbit platelet microbicidal protein is fungicidal in vitro. Antimicrob Agents Chemother 1993; 37: 546.
10. 9 complex of human complement. J Clin Invest 1976;57: 203.
11. Christin L, Wysong D, Meshulam T, et al. Human platelets damage Aspergillus fumigatus hyphae and potentiate killing by neutrophils. Abstract 214. Program and Abstracts of the 34th Annual Meeting of the Infectious Diseases Society of America (New Orleans). Alexandria, Virginia. 1996.
12. Kahn RA, Flinton LJ. The relationship between platelets and bacteria. Blood 1974; 44: 715.
13. Viscoli C, Bruzzi P, Castagnola E, et.al. Factors associated with bacteremia in febrile, granulocytopenic cancer patients. The International Antimicrobial Therapy Cooperative Group (IATCG) of the European Organization for Research and Treatment of Cancer (EORTC) Eur J Cancer 1994; 30A: 430.
14. Nash R, Kurzrock R, DiPersio J, et al. Safety and activity of recombinant human thrombopoietin (rhTPO) in patients (pts) with delayed platelet recovery (DPR) [Abstract]. Blood 1997; 90 (suppl 1): 262a
15. Geissler K, Kabrna E, Stengg S et al. Recombinant human megakaryocyte growth and development factor augments mobilization of hematopoietic progenitor cells post chemotherapy in patients with acute myeloid leukemia [Abstract]. Blood 1997; 90 (Suppl): 98a
16. Singh N, Yu VL, Mieles L, Wagener MM, Miner RC, Gayowski T. High-dose ayclovir compared with short-course preemptive ganciclovir therapy to prevent cytomegalovirus disease in liver transplant recipients: a randomized trial. Ann Intern Med 1994; 120: 375..
17. Drake WT, Lopes MN, Fenton JW, II, Sekutz AC. Thrombin enhancement of interleukin-1 and tumor necrosis factor-α induced polymorphonuclear leukocyte migration. Lab Invest 1992; 67: 617.
18. Deuel TF, Senior RM, Chang D, Griffin GL, Heinrikson RL, Kaiser ET. Platelet factor-4 is chemotactic for neutrophils and monocytes. Proc Natl Acad Sci USA 1981; 78: 458.
19. Yeamen MR. The role of platelets in antimicrobial host defense. Clin Infect Dis 1997; 25: 951.
20. Briegel J, Forst H, Spill B, et al. Risk factors for systemic fungal infections in liver transplant recipients. Eur J Clin Microbiol Infect Dis 1995; 14: 375.
21. Paterson DL, Singh N. Invasive aspergillosis in transplant recipients. Medicine 1999; 78: 123.
22. Singh N, Arnow PM, Bonham A, et al. Invasive aspergillosis in liver transplant recipients in the 1990s. Transplantation 1997; 64: 716.
23. Collins LA, Samore MH, Roberts MS, et al. Risk factors for invasive fungal infections complicating orthotopic liver transplantation. J Infect Dis 1994; 170: 644.
24. Marino IR, Weber T, Esquirel CO, Kang YG, Starzl TE, Duquesnoy RJ. Intraoperative blood transfusion requirements and deficient hemostasis in highly alloimmunized patients undergoing liver transplantation. Transplant Proc 1988; 10: 1087..
25. Kaushansky K. Thrombopoietin. N Engl J Med 1998; 339: 746.
26. Nichol JL, Hokom MM, Hornkohl A, et al. Megakaryocite growth and development factor: analysis of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia. J Clin Invest 1995; 95: 2973.
27. Martin TG III, Somberg KA, Meng YG, et al. Thrombopoietin levels in patients with cirrhosis before and after orthotopic liever transplantation. Ann Intern Med 1997; 127: 285.