Platelets in liver transplantation: Friend or foe?

Liver Transplantation

Volumn 14, Issue 7, 2008, Pages 923-931

  Pereboom, Ilona T A ^a   Lisman, Ton ^a   Porte, Robert J ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; SEROTONIN; TISSUE PLASMINOGEN ACTIVATOR;

ANGIOGENESIS; BLEEDING; GASTROINTESTINAL HEMORRHAGE; HEMOSTASIS; HUMAN; INFLAMMATION; LIVER FAILURE; LIVER FUNCTION; LIVER GRAFT; LIVER ISCHEMIA; LIVER REGENERATION; LIVER TRANSPLANTATION; LOW DRUG DOSE; LUNG INJURY; MORTALITY; NONHUMAN; PERIOPERATIVE COMPLICATION; POSTOPERATIVE CARE; POSTOPERATIVE PERIOD; POSTOPERATIVE THROMBOSIS; PRIORITY JOURNAL; REPERFUSION INJURY; REVIEW; RISK FACTOR; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT; THROMBOCYTE FUNCTION; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; TISSUE REPAIR; TREATMENT CONTRAINDICATION;

BLOOD PLATELETS; HUMANS; LIVER DISEASES; LIVER REGENERATION; LIVER TRANSPLANTATION; PLATELET AGGREGATION INHIBITORS; PLATELET COUNT; PLATELET TRANSFUSION; REPERFUSION INJURY; THROMBOSIS;

EID: 48949120273     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.21510     Document Type: Review

References (66)

1. Lisman T, Leebeek FW, de Groot PG. Haemostatic abnormalities in patients with liver disease. J Hepatol 2002;37: 280-287.
2. Caldwell SH, Hoffman M, Lisman T, Macik BG, Northup PG, Reddy KR, et al. Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management. Hepatology 2006:44:1039-1046.
3. Porte RJ. Coagulation and fibrinolysis in orthotopic liver-transplantation - current views and insights. Semin Thromb Hemost 1993;19:191-196.
4. Hutchison DE, Genton E, Porter KA, Daloze PM, Huguet C, Brettschneider L, et al. Platelet changes following clinical and experimental hepatic homotransplantation. Arch Surg 1968;97:27-33.
5. Owen CA, Rettke SR, Bowie EJW, Cole TL, Jensen CC, Wiesner RH, et al. Hemostatic evaluation of patients undergoing liver transplantation. Mayo Clin Proc 1987;62: 761-772.
6. Lisman T, Adelmeijer J, de Groot PG, Janssen HL, Leebeek FW. No evidence for an intrinsic platelet defect in patients with liver cirrhosis - studies under flow conditions. J Thromb Haemost 2006;4:2070-2072.
7. Tripodi A, Salerno F, Chantarangkul V, Clerici M, Cazzaniga M, Primignani M, et al. Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests. Hepatology 2005;41:553-558.
8. Sindram D, Porte RJ, Hoffman MR, Bentley RC, Clavien PA. Platelets induce sinusoidal endothelial cell apoptosis upon reperfusion of the cold ischemic rat liver. Gastroenterology 2000;118:183-191.
9. Cywes R, Packham MA, Tietze L, Sanabria JR, Harvey PRC, Phillips MJ, et al. Role of platelets in hepatic allograft preservation injury in the rat. Hepatology 1993;18:635-647.
10. Porte RJ, Blauw E, Knot EA, de Maat MR de RC, Minke BC, et al. Role of the donor liver in the origin of platelet disorders and hyperfibrinolysis in liver transplantation. J Hepatol 1994;21:592-600.
11. Lesurtel M, Graf R, Aleil B, Walther DJ, Tian Y, Jochum W, et al. Platelet-derived serotonin mediates liver regeneration. Science 2006;312:104-107.
12. de Boer MT, Christensen MC, Asmussen M, van der Hilst CS, Hendriks HGD, Sloolf MJH, et al. Impact of intraoperative transfusion of platelets and red blood cells on survival after liver transplantation. Anesth Analg 2008;106:32-44.
13. Nocito A, Georgiev P, Dahm F, Jochum W, Bader M, Graf R, et al. Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice. Hepatology 2007 26;45:369-376.
14. Lisman T, Caldwell SH, Leebeek FWG, Porte RJ. Hemostasis in chronic liver disease. J Thromb Haemost 2006;4: 2059-2060.
15. Aster RH. Pooling of platelets in spleen - role in pathogenesis of hypersplenic thrombocytopenia. J Clin Invest 1966;45:645-657.
16. Goulis J, Chau TN, Jordan S, Mehta AB, Watkinson A, Rolles K, et al. Thrombopoietin concentrations are low in patients with cirrhosis and thrombocytopenia and are restored after orthotopic liver transplantation. Gut 1999; 44: 754-758.
17. Kajihara M, Kato S, Okazaki Y, Kawakami Y, Ishii H, Ikeda Y, et al. A role of autoantibody-mediated platelet destruction in thrombocytopenia in patients with cirrhosis. Hepatology 2003;37:1267-1276.
18. Levine RF, Spivak JL, Meagher RC, Sieber F. Effect of ethanol on thrombopoicsis. Br J Haematol 1986;62:345-354.
19. Ben-Ari Z, Osman E, Hutton RA, Burroughs AK. Disseminated intravascular coagulation in liver cirrhosis: fact or fiction? Am J Gastroenterol 1999;94:2977-2982.
20. Escolar G, Cases A, Vinas M, Pino M, Calls J, Cirera I, et al. Evaluation of acquired platelet dysfunctions in uremic and cirrhotic patients using the platelet function analyzer (PFA 100 (TM)): influence of hematocrit elevation. Haematologica 1999;84:614-619.
21. Laffi G, Marra F, Gresele P, Romagnoli P, Palermo A, Bartolini O, et al. Evidence for a storage pool defect in platelets from cirrhotic-patients with defective aggregation. Gastroenterology 1992;103:641-646.
22. Laffi G, Marra F, Failli P, Ruggiero M, Cecchi E, Carloni V, et al. Defective signal-transduction in platelets from cirrhotics is associated with increased cyclic-nucleotides. Gastroenterology 1993; 105:148-156.
23. Laffi G, Cominelli F, Ruggiero M, Fedi S, Chiarugi VP, Lavilla G, et al. Altered platelet-function in cirrhosis of the liver - impairment of inositol lipid and arachidonic-acid metabolism in response to agonists. Hepatology 1988;8: 1620-1626.
24. Pasche B, Ouimet H, Francis S, Loscalzo J. Structural-changes in platelet glycoprotein iib/iiia by plasmin - de-terminants and functional consequences. Blood 1994;83: 404-414.
25. Desai K, Mistry P, Bagget C, Burroughs AK, Bellamy MF, Owen JS. Inhibition of platelet-aggregation by abnormal high-density lipoprotein particles in plasma from patients with hepatic cirrhosis. Lancet 1989;1:693-695.
26. Turitto VT, Baumgartner HR. Platelet interaction with subendothelium in a perfusion system - physical role of red blood-cells. Microvasc Res 1975;9:335-344.
27. Cahill PA, Redmond EM, Sitzmann JV. Endothelial dysfunction in cirrhosis and portal hypertension. Pharmacol Ther 2001;89:273-293.
28. Tripodi A, Primignani M, Chantarangkul V, Clerici M, Dell'Era A, Fabris F, et al. Thrombin generation in patients with cirrhosis: the role of platelets. Hepatology 2006;44: 440-445.
29. Lisman T, Leebeek FW, Mosnier LO, Bouma BN, Meijers JC, Janssen HL, et al. Thrombin-activatable fibrinolysis inhibitor deficiency in cirrhosis is not associated with increased plasma fibrinolysis. Gastroenterology 2001;21:131-139.
30. Lisman T, Bongers TN, Adelmeijer J, Janssen HLA, de Maat MPM, de Groot PG, et al. Elevated levels of von Willebrand factor in cirrhosis support platelet adhesion despite reduced functional capacity. Hepatology 2006;44: 53-61.
31. Himmelreich G, Hundt K, Neuhaus P, Roissant R, Riess H. Decreased platelet aggregation after reperfusion in orthotopic liver transplantation. Transplantation 1992;53:582-586.
32. Himmelreich G, Hundt K, Isenberg C, Bechstein WO, Neuhaus P, Riess H. Thrombocytopenia and platelet dysfunction in orthotopic liver transplantation. Semin Thromb Hemost 1993; 19:209-212.
33. West KA, Anderson DR, McAlister VC, Hewlett TJ, Belitsky P, Smith JW, et al. Alloimmune thrombocytopenia after organ transplantation. N Engl J Med 1999;341:1504-1507.
34. Day JRS, Punjabi PP, Randi AM, Haskard DO, Landis RC, Taylor KM. Clinical inhibition of the seven-transmembrane thrombin receptor (PARI) by intravenous aprotinin during cardiothoracic surgery. Circulation 2004;110: 2597-2600.
35. Federici AB, Berkowitz SD, Lattuada A, Mannucci PM. Degradation of von Willebrand factor in patients with acquired clinical conditions in which there is heightened proteolysis. Blood 1993;81:720-725.
36. Porte RJ, Bontempo FA, Knot EA, Lewis JH, Kang YG, Starzi TE. Systemic effects of tissue plasminogen activator-associated fibrinolysis and its relation to thrombin generation in orthotopic liver transplantation. Transplantation 1989;47:978-984.
37. Porte RJ, Leebeek FW. Pharmacological strategies to decrease transfusion requirements in patients undergoing surgery. Drugs 2002;62:2193-2211.
38. Stricker RB, Wong D, Shiu DT, Reyes PT, Shuman MA. Activation of plasminogen by tissue plasminogen activator on normal and thrombasthenic platelets: effects on surface proteins and platelet aggregation. Blood 1986;68: 275-280.
39. Schalm SW, Terpstra JL, Achterberg JR, Noordhoek HV, Haverkate F, Popescu DT, et al. Orthotopic liver transplantation: an experimental study on mechanisms of hemorrhagic diathesis and thrombosis. Surgery 1975;78: 499-507.
40. Ben-Ari Z, Panagou M, Patch D, Bates S, Osman E, Pasi J, et al. Hypercoagulability in patients with primary biliary cirrhosis and primary sclerosing cholangitis evaluated by thromboelastography. J Hepatol 1997;26:554-559.
41. Sindram D, Porte RJ, Hoffman MR, Bentley RC, Clavien PA. Synergism between platelets and leukocytes in inducing endothelial cell apoptosis in the cold ischemic rat liver: a Kupffer cell-mediated injury. FASEB J 2001:15:1230-1232.
42. Seuwen K, Pouyssegur J. Serotonin as a growth factor. Biochem Pharmacol 1990;39:985-990.
43. Fanburg BL, Lee SL. A new role for an old molecule: serotonin as a mitogen. Am J Physiol 1997;272:L795-L806.
44. Balasubramanian S, Paulose CS. Induction of DNA synthesis in primary cultures of rat hepatocytes by serotonin: possible involvement of serotonin S2 receptor. Hepatology 1998;27:62-66.
45. George JN. Platelets. Lancet 2000;355:1531-1539.
46. Hendriks HG, Meijer K, de Wolf JT, Klompmaker IJ, Porte RJ, de Kam PJ, et al. Reduced transfusion requirements by recombinant factor VIIa in orthotopic liver transplantation: a pilot study, Transplantation 2001;71:402-405.
47. Richards EM, Alexander GJM, Calne RY, Baglin TP. Thrombocytopenia following liver transplantation is associated with platelet consumption and thrombin generation. Br J Haematol 1997; 98:315-321.
48. Marubashi S, Dono K, Miyamoto A, Takeda Y, Nagano H, Umeshita K, et al. Impact of graft size on postoperative thrombocytopenia in living donor liver transplant. Arch Surg 2007; 142:1054-1058.
49. Bonfiglio MF, Traeger SM, Kier KL, Martin BR, Hulisz DT, Verbeck SR. Thrombocytopenia in intensive-care patients - a comprehensive analysis of risk-factors in 314 patients. Ann Pharmacother 1995;29:835-842.
50. Bradbury AW, Bachoo P, Milne AA, Duncan JL. Platelet count and the outcome of operation for ruptured abdominal aortic-aneurysm. J Vasc Surg 1995;21:484-491.
51. Nijsten MW, ten Duis HJ, Zijlstra JG, Porte Rd, Zwaveling JH, Paling JC, et al. Blunted rise in platelet count in critically ill patients is associated with worse outcome. Crit Care Med 2000;28:3843-3846.
52. Seth AK, Gunson BK, Mirza BF, Haydon G. Thrombocytosis in liver transplant recipients: prevalence, natural history, and impact. Liver Transpl 2007;13:1598-1602.
53. Gando S, Kameue T, Nanzaki S, Nakanishi Y. Disseminated intravascular coagulation is a frequent complication of systemic inflammatory response syndrome. Thromb Haemost 1996;75:224-228.
54. Heffner JE, Sahn SA, Repine JE. The role of platelets in the adult respiratory-distress syndrome - culprits or by-standers. Am Rev Respir Dis 1987;135:482-492.
55. Sigurdsson GH, Christenson JT, Elrakshy MB, Sadek S. Intestinal platelet trapping after traumatic and septic shock - an early sign of sepsis and multiorgan failure in critically ill patients. Crit Care Med 1992;20:458-467.
56. Cacciarelli TV, Keeffe EB, Moore DH, Burns W, Busque S, Concepcion W, et al. Effect of intraoperative blood transfusion on patient outcome in hepatic transplantation. Arch Surg 1999;134:25-29.
57. Ramos E, Dalmau A, Sabate A, Lama C, Llado L, Figueras J, et al. Intraoperative red blood cell transfusion in liver transplantation: influence on patient outcome, prediction of requirements, and measures to reduce them. Liver Transpl 2003;9:1320-1327.
58. Spiess BD, Royston D, Levy JH, Fitch J, Dietrich W, Body S, et al. Platelet transfusions during coronary artery bypass graft surgery are associated with serious adverse outcomes. Transfusion 2004;44:1143-1148.
59. Markmann JF, Markmann JW, Desai NM, Baquerizo A, Singer J, Yersiz H, et al. Operative parameters that predict the outcomes of hepatic transplantation. J Am Coll Surg 2003;196:566-572.
60. Silva MA, Jambulingam PS, Gunson BK, Mayer D, Buckels, JAC, Mirza DF, et al. Hepatic artery thrombosis following orthotopic liver transplantation: a 10-year experience from a single centre in the United Kingdom. Liver Transpl 2006;12:146-151.
61. Quiroga S, Sebastia MC, Margarit C, Castells L, Boye R, Varez-Castells A. Complications of orthotopic liver transplantation: spectrum of findings with helical CT. Radiographics 2001;21:1085-1102.
62. Lisman T, Porte RJ. Antiplatelet medication after liver transplantation: does it affect outcome? Liver Transpl 2007;13:644-646.
63. Heffron TG, Welch D, Pillen T, Fasola C, Redd D, Smallwood GA, et al. Low incidence of hepatic artery thrombosis after pediatric liver transplantation without the use of intraoperative microscope or parenteral anticoagulation. Pediatr Transplant 2005;9:486-490.
64. Vivarelli M, La BG, Cucchetti A, Lauro A, Del GM, Ravaioli M, et al. Can antiplatelet prophylaxis reduce the incidence of hepatic artery thrombosis after liver transplantation? Liver Transpl 2007;13:651-654.
65. Wolf DC, Freni MA, Boccagni P, Mor E, Chodoff L, Birnbaum A, et al. Low-dose aspirin therapy is associated with few side effects but does not prevent hepatic artery thrombosis in liver transplant recipients. Liver Transpl Surg 1997;3:598-603.
66. Stroncek DF, Rebulla. P. Platelet transfusions. Lancet 2007;370:427-438.