Poor prognostic clinicopathologic features correlate with VEGF expression but not with PTEN expression in squamous cell carcinoma of the larynx

Diagnostic Pathology

Volumn 5, Issue 1, 2010, Pages

  Sullu, Yurdanur ^a   Gun, Seda ^b   Atmaca, Sinan ^a   Karagoz, Filiz ^a   Kandemir, Bedri ^a  

^a ONDOKUZ MAYIS UNIVERSITY   (Turkey)

^b Mehmet Aydin Education and Research Hospital   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, HUMAN; TUMOR MARKER; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER STAGING; CAPILLARY; CHEMISTRY; CHI SQUARE DISTRIBUTION; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; LARYNGECTOMY; LARYNX TUMOR; LYMPH NODE METASTASIS; MALE; MIDDLE AGED; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PROGNOSIS; SQUAMOUS CELL CARCINOMA; UPREGULATION; VASCULARIZATION;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD34; CAPILLARIES; CARCINOMA, SQUAMOUS CELL; CHI-SQUARE DISTRIBUTION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LARYNGEAL NEOPLASMS; LARYNGECTOMY; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; PROGNOSIS; PTEN PHOSPHOHYDROLASE; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79960376931     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-5-35     Document Type: Article

References (35)

1. Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003, 3:401-410. 10.1038/nrc1093, 12778130.
2. Ferrara N. Vascular endothelial growth factor. Eur J Cancer 1996, 32:2413-2422.
3. Jiang BH, Liu LZ. PI3K/PTEN signaling in tumorigenesis and angiogenesis. Biochim Biophys Acta 2008, 1784:150-158.
4. Byun DS, Cho K, Ryu BK, Lee MG, Park JI, Chae KS, Kim HJ, Chi SG. Frequent monoallelic deletion of PTEN and its reciprocal association with PIK3CA amplification in gastric carcinoma. Int J Cancer 2003, 104:318-327. 10.1002/ijc.10962, 12569555.
5. Lee JW, Soung YH, Kim SY, Lee HW, Park WS, Nam SW, Kim SH, Lee JY, Yoo NJ, Lee SH. PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas. Oncogene 2005, 24:1477-1480. 10.1038/sj.onc.1208304, 15608678.
6. Shayesteh L, Lu Y, Kuo WL, Baldocchi R, Godfrey T, Collins C, Pinkel D, Powell B, Mills GB, Grey JW. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 1999, 21:99-102. 10.1038/5042, 9916799.
7. Bandoh N, Hayashi T, Takahara M, Kishibe K, Ogino T, Katayama A, Imada M, Nonaka S, Harabuchi Y. VEGF and bFGF expression and microvessel density of maxillary sinus squamous cell carcinoma in relation to p53 status, spontaneous apoptosis and prognosis. Cancer Lett 2004, 208:215-225. 10.1016/j.canlet.2003.11.031, 15142681.
8. Tae K, El-Naggar AK, Yoo E, Feng L, Lee JJ, Hong WK, Hittelman WN, Shin DM. Expression of vascular endothelial growth factor and microvessel density in head and neck tumorigenesis. Clin Cancer Res 2000, 6:2821-2828.
9. Hlatky L, Hahnfeldt P, Folkman J. Clinical application of antiangiogenic therapy: Microvessel density, what it does and doesn't tell us. J Natl Cancer Inst 2002, 94:883-893.
10. Cardesa A, Gale N, Nadai A, Zidar N. Squamous cell carcinoma. World Health Organization Classification of Tumours Pathology and Genetics Head and Neck Tumours 2005, 118-123. Lyon: IARC Press, Barnes L, Eveson JW, Reichart P, Sidransky D.
11. Iwasaki A, Kuwahara M, Yoshinaga Y, Shirakusa T. Basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) levels, as prognostic indicators in NSCLC. Eur J Cardiothorac Surg 2004, 25:443-438. 10.1016/j.ejcts.2003.11.031, 15019676.
12. Li C, Shintani S, Terakado N, Klosek SK, Ishikawa T, Nakashiro K, Hamakawa H. Microvessel density and expression of vascular endothelial growth factor, basic fibroblast growth factor, and platelet-derived endothelial growth factor in oral squamous cell carcinomas. Int J Oral Maxillofac Surg 2005, 34:559-565. 10.1016/j.ijom.2004.10.016, 16053878.
13. Shang ZJ, Li ZB, Li JR. VEGF is up-regulated by hypoxic stimulation and related to tumor angiogenesis and severity of disease in oral squamous cell carcinoma: in vitro and in vivo studies. Int J Oral Maxillofac Surg 2006, 35:533-538. 10.1016/j.ijom.2005.09.006, 16388929.
14. Mukhopadhyay D, Datta K. Multiple regulatory pathways of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in tumors. Semin Cancer Biol 2004, 14:123-130. 10.1016/j.semcancer.2003.09.019, 15018896.
15. Weidner N, Folkman J, Pozza F, Bevilacqua P, Allred EN, Moore DH, Meli S, Gasparini G. Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J Nat Cancer Inst 1992, 84:1875-1887. 10.1093/jnci/84.24.1875, 1281237.
16. Zhou YJ, Xiong YX, Wu XT, Shi D, Fan W, Zhou T, Li YC, Huang X. Inactivation of PTEN is associated with increased angiogenesis and VEGF overexpression in gastric cancer. World J Gastroenterol 2004, 10:3225-3229.
17. Do NY, Lim SC, Im TS. Expression of c-erbB receptors, MMPs and VEGF in squamous cell carcinoma of the head and neck. Oncol Rep 2004, 12:229-237.
18. Kyzas PA, Stefanou D, Batistatou A, Agnantis NJ. Prognostic significance of VEGF immunohistochemical expression and tumor angiogenesis in head and neck squamous cell carcinoma. J Cancer Res Clin Oncol 2005, 131:624-630. 10.1007/s00432-005-0003-6, 16044346.
19. Tse GM, Chan AWH, Yu K-H, King AD, Wong K-T, Chen GG, Tsang RKY, Chan ABW. Strong immunohistochemical expression of vascular endothelial growth factor predicts overall survival in head and neck squamous cell carcinoma. Ann Surg Oncol 2007, 14:3558-3565. 10.1245/s10434-007-9632-0, 17929099.
20. Lentsch EJ, Goudy S, Sosnowski J, Major S, Bumpous JM. Microvessel density in head and neck squamous cell carcinoma primary tumors and its correlation with clinical staging parameters. Laryngoscope 2006, 116:397-400. 10.1097/01.MLG.0000195286.29613.E1, 16540897.
21. Pazouki S, Chisholm DM, Adi MM, Carmichael G, Farquharson M, Ogden GR, Schor SL, Schor AM. The association between tumour progression and vascularity in the oral mucosa. J Pathol 1997, 183:39-43. 10.1002/(SICI)1096-9896(199709)183:1<39::AID-PATH1088>3.0.CO;2-L, 9370945.
22. Shpitzer T, Chaimoff M, Gal R, Stern Y, Feinmesser R, Segal K. Tumor angiogenesis as a prognostic factor in early oral tongue cancer. Arch Otolaryngol Head Neck Surg 1996, 122:865-868.
23. Lalla RV, Boisoneau DS, Spiro JD, Kreutzer DL. Expression of vascular endothelial growth factor receptors on tumor cells in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2003, 129:882-888. 10.1001/archotol.129.8.882, 12925349.
24. Schimming R, Marme D. Endoglin (CD105) expression in squamous cell carcinoma of the oral cavity. Head Neck 2002, 24:151-156. 10.1002/hed.10040, 11891945.
25. Campbell IG, Russell SE, Choong DY, Montgomery KG, Ciavarella ML, Hooi CS, Cristiano BE, Pearson RB, Phillips WA. Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res 2004, 64:7678-7681. 10.1158/0008-5472.CAN-04-2933, 15520168.
26. Chu EC, Tarnawski AS. PTEN regulatory functions in tumor suppression and cell biology. Med Sci Monit 2004, 10:235-241.
27. Dahia PL, Marsh DJ, Zheng Z, Zedenius J, Komminoth P, Frisk T, Wallin G, Parsons R, Longy M, Larsson C, Eng C. Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors. Cancer Res 1997, 57:4710-4713.
28. Wang JY, Huang TJ, Chen FM, Hsieh MC, Lin SR, Hou MF, Hsieh JS. Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas. Virchows Arch 2003, 442:437-443.
29. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997, 275:1943-1947. 10.1126/science.275.5308.1943, 9072974.
30. Chen RW, Avizienyte E, Roth S, Leivo I, Makitie AA, Aaltonen LM, Aaltonen LA. PTEN and LKB1 genes in laryngeal tumours. J Med Genet 1999, 36:943-944. 1734284, 10636746.
31. Squarize CH, Castilho RM, Santos PD. Immunohistochemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the histological malignancy grading system. J Oral Pathol Med 2002, 31:379-384. 10.1034/j.1600-0714.2002.00142.x, 12224530.
32. Guney K, Ozbilim G, Derin AT, Cetin S. Expression of PTEN protein in patients with laryngeal squamous cell carcinoma. Auris Nasus Larynx 2007, 34:481-486. 10.1016/j.anl.2007.03.014, 17475427.
33. Jiang YA, Fan LF, Jiang CQ. Expression and significance of PTEN hypoxia-inducible factor-1 alpha in colorectal adenoma and adenocarcinoma. World J Gastroenterol 2003, 9:491-494.
34. Chung MJ, Jung SH, Lee BJ, Kang MJ, Lee DG. Inactivation of the PTEN gene product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer. Pathol Int 2004, 54:10-15. 10.1111/j.1440-1827.2004.01576.x, 14674989.
35. Matta A, Ralhan R. Overview of current and future biologically based targeted therapies in head and neck squamous cell carcinoma. Head Neck Oncol 2009, 1:6. 10.1186/1758-3284-1-6, 2660327, 19284526.