Rictor encounters RhoGDI2: The second pilot is taking a lead

Small GTPases

Volumn 4, Issue 2, 2013, Pages 102-105

  Agarwal, Nitin K ^a   Kazyken, Dubek ^a,b   Sarbassov, Dos D ^a,c  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b L N GUMILYOV EURASIAN NATIONAL UNIVERSITY   (Kazakhstan)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

Cell migration; Rac1; Rho GTPases; RhoGDI2; Rictor

Indexed keywords

CELL PROTEIN; GUANOSINE TRIPHOSPHATASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PROTEIN CDC42; RAC1 PROTEIN; RHO FACTOR; RHOGDI1 PROTEIN; RHOGDI2 PROTEIN; RICTOR; UNCLASSIFIED DRUG; CARRIER PROTEIN; RHO GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR 2;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CANCER STAGING; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELL MIGRATION; DISEASE MARKER; HUMAN; MALIGNANT NEOPLASTIC DISEASE; METASTASIS; NONHUMAN; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REGULATORY SEQUENCE; SUMOYLATION; TISSUE DISTRIBUTION; UPREGULATION; ANIMAL; CELL MOTION; METABOLISM; NOTE; PHYSIOLOGY; RAC1; RHO GTPASES; RHOGDI2; RICTOR;

CELL MIGRATION; RAC1; RHO GTPASES; RHOGDI2; RICTOR;

ANIMALS; CARRIER PROTEINS; CELL MOVEMENT; HUMANS; RHO GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR BETA;

EID: 84893178571     PISSN: 21541248     EISSN: 21541256     Source Type: Journal    
DOI: 10.4161/sgtp.23346     Document Type: Article

References (31)

1. Lauffenburger DA, Horwitz AF. Cell migration: a physically integrated molecular process. Cell 1996; 84:359-369; PMID:8608589; http://dx.doi. org/10.1016/S0092-8674(00)81280-5.
2. Dovas A, Couchman JR. RhoGDI: multiple functions in the regulation of Rho family GTPase activities. Biochem J 2005; 390:1-9; PMID:16083425; http://dx.doi.org/10.1042/BJ20050104.
3. Nomanbhoy TK, Cerione R. Characterization of the interaction between RhoGDI and Cdc42Hs using fluorescence spectroscopy. J Biol Chem 1996; 271:10004-10009; PMID:8626553; http://dx.doi. org/10.1074/jbc.271.17.10004.
4. Titus B, Frierson HF Jr., Conaway M, Ching K, Guise T, Chirgwin J, et al. Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2. Cancer Res 2005; 65:7320-7327; PMID:16103083; http://dx.doi.org/10.1158/0008-5472.CAN-05-14 03.
5. Theodorescu D, Sapinoso LM, Conaway MR, Oxford G, Hampton GM, Frierson HF Jr. Reduced expression of metastasis suppressor RhoGDI2 is associated with decreased survival for patients with bladder cancer. Clin Cancer Res 2004; 10:3800-3806; PMID:15173088; http://dx.doi.org/10.1158/1078-0432.CCR-03-0653.
6. Hu LD, Zou HF, Zhan SX, Cao KM. Biphasic expression of RhoGDI2 in the progression of breast cancer and its negative relation with lymph node metastasis. Oncol Rep 2007; 17:1383-1389; PMID:17487395.
7. Gildea JJ, Seraj MJ, Oxford G, Harding MA, Hampton GM, Moskaluk CA, et al. RhoGDI2 is an invasion and metastasis suppressor gene in human cancer. Cancer Res 2002; 62:6418-6423; PMID:12438227.
8. Abiatari I, DeOliveira T, Kerkadze V, Schwager C, Esposito I, Giese NA, et al. Consensus transcrip-tome signature of perineural invasion in pancreatic carcinoma. Mol Cancer Ther 2009; 8:1494-1504; PM I D:1950 9238; http: //dx.doi.org /10.1158 /1535 -7163.MCT-08-0755.
9. Jiang WG, Watkins G, Lane J, Cunnick GH, Douglas-Jones A, Mokbel K, et al. Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers. Clin Cancer Res 2003; 9:6432-6440; PMID:14695145.
10. Ma L, Xu G, Sotnikova A, Szczepanowski M, Giefing M, Krause K, et al. Loss of expression of LyGDI (ARHGDIB), a rho GDP-dissociation inhibitor, in Hodgkin lymphoma. Br J Haematol 2007; 139:217-223; PMID:17897297; http://dx.doi.o r g/10.1111/j.13 65 -2141. 2007. 0678 2. x.
11. Dransart E, Morin A, Cherfils J, Olofsson B. RhoGDI-3, a promising system to investigate the regulatory function of rhoGDIs: uncoupling of inhibitory and shuttling functions of rhoGDIs. Biochem Soc Trans 2005; 33:623-626; PMID:16042558; http://dx.doi.org/10.1042/BST0330623.
12. Garcia-Mata R, Boulter E, Burridge K. The 'invisible hand': regulation of RHO GTPases by RHOGDIs. Nat Rev Mol Cell Biol 2011; 12:493-504; PMID:21779026; http://dx.doi.org/10.1038/nrm3153.
13. Longenecker K, Read P, Derewenda U, Dauter Z, Liu X, Garrard S, et al. How RhoGDI binds Rho. Acta Crystallogr D Biol Crystallogr 1999; 55:1503-1515; PMID:10489445; http://dx.doi.org/10.1107/ S090744499900801X.
14. Scheffzek K, Stephan I, Jensen ON, Illenberger D, Gierschik P. The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI. Nat Struct Biol 2000; 7:122-126; PMID:10655614; http://dx.doi.org/10.1038/72392.
15. Tnimov Z, Guo Z, Gambin Y, Nguyen UT, Wu Y W, Abankwa D, et al. Quantitative analysis of prenyl-ated RhoA interaction with its chaperone, RhoGDI. J Biol Chem 2012; 287:26549-26562; PMID:22628549; http://dx.doi.org/10.1074/jbc.M112.371294.
16. Agarwal NK, Chen CH, Cho H, Boulbès DR, Spooner E, Sarbassov DD. Rictor regulates cell migration by suppressing RhoGDI2. Oncogene 2012; In press; PMID:22777355; http://dx.doi. org/10.1038/onc.2012.287.
17. Chen MY, Long Y, Devreotes PN. A novel cyto-solic regulator, Pianissimo, is required for chemoat-tractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium. Genes Dev 1997; 11:3218-3231; PMID:9389653; http://dx.doi.org/10.1101/gad.11.23.3218.
18. Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004; 14:1296-1302; PMID:15268862; http://dx.doi.org/10.1016/j. cub.2004.06.054.
19. Jacinto E, Loewith R, Schmidt A, Lin S, Rüegg MA, Hall A, et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 2004; 6:1122-1128; PMID:15467718; http://dx.doi.org/10.1038/ncb1183.
20. Sarbassov DD, Ali SM, Sabatini DM. Growing roles for the mTOR pathway. Curr Opin Cell Biol 2005; 17:596-603; PMID:16226444; http://dx.doi. org/10.1016/j.ceb.2005.09.009.
21. Schmidt A, Bickle M, Beck T, Hall MN. The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell 1997; 88:531-542; PMID:9038344; http:// dx.doi.org/10.1016/S0092-8674(00)81893-0.
22. Hagan GN, Lin Y, Magnuson MA, Avruch J, Czech MPA. A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes. Mol Cell Biol 2008; 28:4215-4226; PMID:18426911; http://dx.doi.org/10.1128/MCB.00867-07.
23. McDonald PC, Oloumi A, Mills J, Dobreva I, Maidan M, Gray V, et al. Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer Res 2008; 68:1618-1624; PMID:18339839; http://dx.doi.org/10.1158/0008-5472.CAN-07-5869.
24. Gunst SJ, Zhang W. Actin cytoskeletal dynamics in smooth muscle: a new paradigm for the regulation of smooth muscle contraction. Am J Physiol Cell Physiol 2008; 295:C576-C587; PMID:18596210; http://dx.doi.org/10.1152/ajpcell.00253.2008.
25. Golovanov AP, Chuang TH, DerMardirossian C, Barsukov I, Hawkins D, Badii R, et al. Structure-activity relationships in flexible protein domains: regulation of rho GTPases by RhoGDI and D4 GDI. J Mol Biol 2001; 305:121-135; PMID:11114252; http://dx.doi.org/10.1006/jmbi.2000.4262.
26. DerMardirossian C, Rocklin G, Seo JY, Bokoch GM. Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling. Mol Biol Cell 2006; 17:4760-4768; PMID:16943322; http:// dx.doi.org/10.1091/mbc.E06-06-0533.
27. Wu Y, Moissoglu K, Wang H, Wang X, Frierson HF, Schwartz MA, et al. Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function. Proc Natl Acad Sci U S A 2009; 106:5807-5812; PMID:19321744; http://dx.doi.org/10.1073/ pnas.0810094106.
28. Dovas A, Choi Y, Yoneda A, Multhaupt HA, Kwon SH, Kang D, et al. Serine 34 phosphorylation of rho guanine dissociation inhibitor (RhoGDIalpha) links signaling from conventional protein kinase C to RhoGTPase in cell adhesion. J Biol Chem 2010; 285:23296-23308; PMID:20472934; http://dx.doi. org/10.1074/jbc.M109.098129.
29. Griner EM, Churchill ME, Brautigan DL, Theodorescu D. PKCα phosphorylation of RhoGDI2 at Ser31 disrupts interactions with Rac1 and decreases GDI activity. Oncogene 2012; In press; PMID:22469974; http://dx.doi.org/10.1038/onc.2012.124.
30. DerMardirossian C, Schnelzer A, Bokoch GM. Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase. Mol Cell 2004; 15:117-127; PMID:15225553; http://dx.doi.org/10.1016/j.mol-cel.2004.05.019.
31. Yu J, Zhang D, Liu J, Li J, Yu Y, Wu XR, et al. RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility. J Biol Chem 2012; 287:13752-13760; PMID:22393046; http://dx.doi.org/10.1074/ j b c. M111. 3374 69.