Exposure to lipid-rich follicular fluid is associated with endoplasmic reticulum stress and impaired oocyte maturation in cumulus-oocyte complexes

Fertility and Sterility

Volumn 97, Issue 6, 2012, Pages 1438-1443

  Yang, Xing ^a,b   Wu, Linda L ^b   Chura, Lindsay R ^b   Liang, Xiaoyan ^a   Lane, Michelle ^b   Norman, Robert J ^b   Robker, Rebecca L ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

ATF4; ATF6; endoplasmic reticulum stress; free fatty acids; GRP78; lipotoxicity; obesity; triglyceride

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; FATTY ACID; GLUCOSE REGULATED PROTEIN 78; PERILIPIN; PERILIPIN 2; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BODY MASS; CELL ISOLATION; CONTROLLED STUDY; CUMULUS OOPHORUS; ENDOPLASMIC RETICULUM STRESS; FEMALE; FEMALE INFERTILITY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPID COMPOSITION; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; OOCYTE MATURATION; OUTCOME ASSESSMENT; OVARY FOLLICLE FLUID; PRIORITY JOURNAL;

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; ANIMALS; BODY MASS INDEX; CELL DIFFERENTIATION; CELL NUCLEUS; CUMULUS CELLS; ENDOPLASMIC RETICULUM STRESS; FEMALE; FOLLICULAR FLUID; GENE EXPRESSION; HEAT-SHOCK PROTEINS; HUMANS; HYPERLIPIDEMIAS; INFERTILITY, FEMALE; LIPIDS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; OOCYTES;

EID: 84862777013     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2012.02.034     Document Type: Article

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