Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Sommese, Ruth F ^a   Nag, Suman ^a   Sutton, Shirley ^a   Miller, Susan M ^b   Spudich, James A ^a   Ruppel, Kathleen M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; BETA CARDIAC MYOSIN; CARDIAC MYOSIN; MYOSIN ADENOSINE TRIPHOSPHATASE; TROPONIN T; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CALCIUM BINDING; CONFORMATIONAL TRANSITION; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; CROSS BRIDGE KINETICS; DISSOCIATION; GENE MUTATION; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; IN VITRO STUDY; KINETICS; PROTEIN SUBUNIT; THIN FILAMENT;

ACTIN CYTOSKELETON; ACTOMYOSIN; ADULT; CALCIUM; CARDIOMYOPATHIES; CARDIOMYOPATHY, DILATED; CARDIOMYOPATHY, HYPERTROPHIC; HUMANS; KINETICS; MODELS, MOLECULAR; MUTATION; MYOSIN SUBFRAGMENTS; PROTEIN STRUCTURE, SECONDARY; TROPOMYOSIN; TROPONIN T; VENTRICULAR MYOSINS;

EID: 84893160910     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083403     Document Type: Article

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