Neuronal over-expression of ACE2 protects brain from ischemia-induced damage

Neuropharmacology

Volumn 79, Issue , 2014, Pages 550-558

  Chen, Ji ^a,b   Zhao, Yuhui ^a   Chen, Shuzhen ^a   Wang, Jinju ^a   Xiao, Xiang ^a   Ma, Xiaotang ^b   Penchikala, Madhuri ^a   Xia, Huijing ^c   Lazartigues, Eric ^c   Zhao, Bin ^b   Chen, Yanfang ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

^b GUANGDONG MEDICAL UNIVERSITY   (China)

^c LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiotensin II; Angiotensin converting enzyme type 2; Blood pressure; Ischemic stroke; Oxidative stress

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN[1-7]; ANGIOTENSIN[1-7][7 DEXTRO ALANINE]; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; 7-ALA-ANGIOTENSIN (1-7); ANGIOTENSIN II; ANGIOTENSINOGEN; DIPEPTIDYL CARBOXYPEPTIDASE; NEUROPROTECTIVE AGENT; PEPTIDE FRAGMENT; RENIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; BRAIN BLOOD FLOW; BRAIN DAMAGE; BRAIN FUNCTION; BRAIN ISCHEMIA; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; ENZYME REGULATION; ENZYME SYNTHESIS; GENE OVEREXPRESSION; MALE; MEAN ARTERIAL PRESSURE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION; TELEMETRY; ANALOGS AND DERIVATIVES; ANIMAL; ARTERIAL PRESSURE; BRAIN; BRAIN CIRCULATION; DRUG EFFECTS; GENETICS; HUMAN; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ANGIOTENSIN II; ANGIOTENSINOGEN; ANIMALS; ARTERIAL PRESSURE; BRAIN; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MICE; MICE, TRANSGENIC; NEURONS; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; PEPTIDYL-DIPEPTIDASE A; RENIN;

EID: 84893160147     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.01.004     Document Type: Article

References (39)

1. N.B. Beamer, B.M. Coull, W.M. Clark, J.S. Hazel, and J.R. Silberger Interleukin-6 and interleukin-1 receptor antagonist in acute stroke Ann. Neurol. 37 1995 800 805
2. L.K. Becker, G.M. Etelvino, T. Walther, R.A. Santos, and M.J. Campagnole-Santos Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain Am. J. Physiol. Heart Circ. Physiol. 293 2007 H1416 H1424
3. L.A. Cassis, M. Gupte, S. Thayer, X. Zhang, R. Charnigo, D.A. Howatt, D.L. Rateri, and A. Daugherty ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice Am. J. Physiol. Heart Circ. Physiol. 296 2009 H1660 H1665
4. J. Chen, S. Chen, Y. Chen, C. Zhang, J. Wang, W. Zhang, G. Liu, B. Zhao, and Y. Chen Circulating endothelial progenitor cells and cellular membrane microparticles in db/db diabetic mouse: possible implications in cerebral ischemic damage Am. J. Physiol. Endocrinol. Metab. 301 2011 E62 E71
5. J. Chen, X. Xiao, S. Chen, C. Zhang, J. Chen, D. Yi, V. Shenoy, M.K. Raizada, B. Zhao, and Y. Chen Angiotensin-converting enzyme 2 priming enhances the function of endothelial progenitor cells and their therapeutic efficacy Hypertension 61 2013 681 689
6. S. Chen, G. Li, W. Zhang, J. Wang, C.D. Sigmund, J.E. Olson, and Y. Chen Ischemia-induced brain damage is enhanced in human renin and angiotensinogen double-transgenic mice Am. J. Physiol. Regul. Integr. Comp. Physiol. 297 2009 R1526 R1531
7. Y. Chen, H. Chen, A. Hoffmann, D.R. Cool, D.I. Diz, M.C. Chappell, A.F. Chen, and M. Morris Adenovirus-mediated small-interference RNA for in vivo silencing of angiotensin AT1a receptors in mouse brain Hypertension 47 2006 230 237 (Pubitemid 43189768)
8. S.G. Chrysant Possible pathophysiologic mechanisms supporting the superior stroke protection of angiotensin receptor blockers compared to angiotensin-converting enzyme inhibitors: clinical and experimental evidence J. Hum. Hypertens. 19 2005 923 931 (Pubitemid 41823781)
9. B. Dahlöf, R.B. Devereux, S.E. Kjeldsen, S. Julius, G. Beevers, U. de Faire, F. Fyhrquist, H. Ibsen, K. Kristiansson, O. Lederballe-Pedersen, L.H. Lindholm, M.S. Nieminen, P. Omvik, S. Oparil, and H. Wedel Cardiovascular morbidity and mortality in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol Lancet 359 2002 995 1003 (Pubitemid 34286536)
10. D.I. Diz, M.A. Garcia-Espinosa, S. Gegick, E.N. Tommasi, C.M. Ferrario, T.E. Ann, M.C. Chappell, and P.E. Gallagher Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats Exp. Physiol. 93 2008 694 700 (Pubitemid 351595065)
11. M.F. Doobay, L.S. Talman, T.D. Obr, X. Tian, R.L. Davisson, and E. Lazartigues Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system Am. J. Physiol. Regul. Integr. Comp. Physiol. 292 2007 R373 R381
12. A.K. Doughan, D.G. Harrison, and S.I. Dikalov Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction Circ. Res. 102 2008 488 496 (Pubitemid 351651106)
13. Y. Feng, H. Xia, Y. Cai, C.M. Halabi, L.K. Becker, R.A. Santos, R.C. Speth, C.D. Sigmund, and E. Lazartigues Brain-selective overexpression of human angiotensin-converting enzyme type 2 attenuates neurogenic hypertension Circ. Res. 106 2010 373 382
14. H. Girouard, A. Lessard, C. Capone, T.A. Milner, and C. Iadecola The neurovascular dysfunction induced by angiotensin II in the mouse neocortex is sexually dimorphic Am. J. Physiol. Heart Circ. Physiol. 294 2008 H156 H163
15. K. Gora-Kupilas, and J. Josko The neuroprotective function of vascular endothelial growth factor (VEGF) Folia Neuropathol. 43 2005 31 39 (Pubitemid 40533190)
16. Y.J. Guo, W.H. Li, R. Wu, Q. Xie, and L.Q. Cui ACE2 overexpression inhibits angiotensin II-induced monocyte chemoattractant protein-1 expression in macrophages Arch. Med. Res. 39 2008 149 154 (Pubitemid 350299617)
17. S. Iida, G.L. Baumbach, J.L. Lavoie, F.M. Faraci, C.D. Sigmund, and D.D. Heistad Spontaneous stroke in a genetic model of hypertension in mice Stroke 36 2005 1253 1258 (Pubitemid 40798748)
18. J. Iwanami, M. Mogi, K. Tsukuda, L.J. Min, A. Sakata, F. Jing, M. Iwai, and M. Horiuchi Low dose of telmisartan prevents ischemic brain damage with peroxisome proliferator-activated receptor-gamma activation in diabetic mice J. Hypertens. 28 2010 1730 1737
19. S.N. Iyer, M.C. Chappell, D.B. Averill, D.I. Diz, and C.M. Ferrario Vasodepressor actions of angiotensin-(1-7) unmasked during combined treatment with lisinopril and losartan Hypertension 31 1998 699 705
20. T. Jiang, L. Gao, J. Guo, J. Lu, Y. Wang, and Y. Zhang Suppressing inflammation by inhibiting the NF-kappaB pathway contributes to the neuroprotective effect of angiotensin-(1-7) in rats with permanent cerebral ischaemia Br. J. Pharmacol. 167 2012 1520 1532
21. S.E. Kjeldsen, P.A. Lyle, J.R. Kizer, B. Dahlof, R.B. Devereux, S. Julius, G. Beevers, U. de Faire, F. Fyhrquist, H. Ibsen, K. Kristianson, O. Lederballe-Pedersen, L.H. Lindholm, M.S. Nieminen, P. Omvik, S. Oparil, S.M. Snapinn, K.E. Harris, and H. Wedel The effects of losartan compared to atenolol on stroke in patients with isolated systolic hypertension and left ventricular hypertrophy. The LIFE study J. Clin. Hypertens. 7 2005 152 158
22. H. Kojima, M. Hirata, Y. Kudo, K. Kikuchi, and T. Nagano Visualization of oxygen-concentration-dependent production of nitric oxide in rat hippocampal slices during aglycemia J. Neurochem. 76 2001 1404 1410 (Pubitemid 32198245)
23. S. Lecour, and R.W. James When are pro-inflammatory cytokines SAFE in heart failure? Eur. Heart J. 32 2011 680 685
24. A.P. Mecca, R.W. Regenhardt, T.E. O'Connor, J.P. Joseph, M.K. Raizada, M.J. Katovich, and C. Sumners Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke Exp. Physiol. 96 2011 1084 1096
25. Y. Nishimura, T. Ito, and J.M. Saavedra Angiotensin II AT(1) blockade normalizes cerebrovascular autoregulation and reduces cerebral ischemia in spontaneously hypertensive rats Stroke 31 2000 2478 2486
26. S. Ramasamy, G. Narayanan, S. Sankaran, Y.H. Yu, and S. Ahmed Neural stem cell survival factors Arch. Biochem. Biophys. 534 2013 71 87
27. J.M. Saavedra, J. Benicky, and J. Zhou Mechanisms of the anti-ischemic effect of angiotensin II AT(1) receptor antagonists in the brain Cell. Mol. Neurobiol. 26 2006 1099 1111 (Pubitemid 44924033)
28. H. Schunkert, J.R. Ingelfinger, A.T. Hirsch, Y. Pinto, W.J. Remme, H. Jacob, and V.J. Dzau Feedback regulation of angiotensin converting enzyme activity and mRNA levels by angiotensin II Circ. Res. 72 1993 312 318 (Pubitemid 23024519)
29. C. Sierra, A. Coca, and E.L. Schiffrin Vascular mechanisms in the pathogenesis of stroke Curr. Hypertens. Rep. 13 2011 200 207
30. A.Q. Silva, R.A. Santos, and M.A. Fontes Blockade of endogenous angiotensin-(1-7) in the hypothalamic paraventricular nucleus reduces renal sympathetic tone Hypertension 46 2005 341 348 (Pubitemid 41099167)
31. R. Veltkamp, N. Rajapakse, G. Robins, M. Puskar, K. Shimizu, and D. Busija Transient focal ischemia increases endothelial nitric oxide synthase in cerebral blood vessels Stroke 33 2002 2704 2710 (Pubitemid 35266445)
32. T. Walther, L. Olah, C. Harms, B. Maul, M. Bader, H. Hortnagl, H.P. Schultheiss, and G. Mies Ischemic injury in experimental stroke depends on angiotensin II FASEB J. 16 2002 169 176 (Pubitemid 34113010)
33. W.M. Williams, and Y.W. Chung Evidence for an age-related attenuation of cerebral microvascular antioxidant response to oxidative stress Life Sci. 79 2006 1638 1644 (Pubitemid 44344728)
34. W.M. Williams, M. Reichman, and T.H. McNeill Cerebral microvascular and parenchymal phospholipid composition in the mouse Neurochem. Res. 13 1988 743 747
35. H. Xia, Y. Feng, T.D. Obr, P.J. Hickman, and E. Lazartigues Angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice Hypertension 53 2009 210 216
36. H. Xia, S. Suda, S. Bindom, Y. Feng, S.B. Gurley, D. Seth, L.G. Navar, and E. Lazartigues ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function PLoS. One 6 2011 e22682
37. L. Xiao, L. Gao, E. Lazartigues, and I.H. Zucker Brain-selective overexpression of angiotensin-converting enzyme 2 attenuates sympathetic nerve activity and enhances baroreflex function in chronic heart failure Hypertension 58 2011 1057 1065
38. E. Yamamoto, N. Tamamaki, T. Nakamura, K. Kataoka, Y. Tokutomi, Y.F. Dong, M. Fukuda, S. Matsuba, H. Ogawa, and S. Kim-Mitsuyama Excess salt causes cerebral neuronal apoptosis and inflammation in stroke-prone hypertensive rats through angiotensin II-induced NADPH oxidase activation Stroke 39 2008 3049 3056
39. Y. Zhang, J. Lu, J. Shi, X. Lin, J. Dong, S. Zhang, Y. Liu, and Q. Tong Central administration of angiotensin-(1-7) stimulates nitric oxide release and upregulates the endothelial nitric oxide synthase expression following focal cerebral ischemia/reperfusion in rats Neuropeptides 42 2008 593 600