Proarrhythmic effect of blocking the small conductance calcium activated potassium channel in isolated canine left atrium

Heart Rhythm

Volumn 10, Issue 6, 2013, Pages 891-898

  Hsueh, Chia Hsiang ^a   Chang, Po Cheng ^a   Hsieh, Yu Cheng ^a   Reher, Thomas ^a   Chen, Peng Sheng ^a   Lin, Shien Fong ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Action potential duration; Atrial arrhythmia; Optical mapping; Repolarization

Indexed keywords

6,10 DIAZA 3(1,3)8,(1,4) DIBENZENA 1,5(1,4) DIQUINOLINACYCLODECAPHANE; APAMIN; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ARTICLE; GENETIC ASSOCIATION; HEART ATRIUM ARRHYTHMIA; HEART ELECTROPHYSIOLOGY; HEART LEFT ATRIUM; HEART MUSCLE POTENTIAL; MALE; MONGREL DOG; NONHUMAN; PRIORITY JOURNAL; WESTERN BLOTTING;

ANIMALS; ARRHYTHMIAS, CARDIAC; ATRIAL FIBRILLATION; BLOTTING, WESTERN; DOGS; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; GENOME-WIDE ASSOCIATION STUDY; HEART ATRIA; MALE; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; VOLTAGE-SENSITIVE DYE IMAGING;

EID: 84893148729     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2013.01.033     Document Type: Article

References (24)

1. Lloyd-Jones DM, Wang TJ, Leip EP, et al. Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation 2004;110: 1042-1046.
2. Chen LY, Shen WK. Epidemiology of atrial fibrillation: a current perspective. Heart Rhythm 2007;4:S1-S6.
3. Wakili R, Voigt N, Kääb S, Dobrev D, Nattel S. Recent advances in the molecular pathophysiology of atrial fibrillation. J Clin Invest 2011;121: 2955-2968.
4. Xia XM, Fakler B, Rivard A, et al. Mechanism of calcium gating in small-conductance calcium-activated potassium channels. Nature 1998;395: 503-507.
5. Kohler M, Hirschberg B, Bond CT, et al. Small-conductance, calcium-activated potassium channels from mammalian brain. Science 1996;273: 1709-1714.
6. Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. Pharmacol Rev 2005;57: 463-472.
7. Xu Y, Tuteja D, Zhang Z, et al. Molecular identification and functional roles of a Ca2+-activated K+ channel in human and mouse hearts. J Biol Chem 2003;278: 49085-49094.
8. Tuteja D, Xu D, Timofeyev V, et al. Differential expression of small-conductance Ca2+-activated K+ channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes. Am J Physiol Heart Circ Physiol 2005;289:H2714-H2723.
9. Chandler NJ, Greener ID, Tellez JO, et al. Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker. Circulation 2009;119: 1562-1575.
10. Ellinor PT, Lunetta KL, Glazer NL, et al. Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet 2010;42: 240-244.
11. Olesen MS, Jabbari J, Holst AG, et al. Screening of KCNN3 in patients with early-onset lone atrial fibrillation. Europace 2011;13: 963-967.
12. Ozgen N, Dun W, Sosunov EA, et al. Early electrical remodeling in rabbit pulmonary vein results from trafficking of intracellular SK2 channels to membrane sites. Cardiovasc Res 2007;75: 758-769.
13. Li N, Timofeyev V, Tuteja D, et al. Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation. J Physiol 2009;587: 1087-1100.
14. Chou CC, Nihei M, Zhou S, et al. Intracellular calcium dynamics and anisotropic reentry in isolated canine pulmonary veins and left atrium. Circulation 2005;111: 2889-2897.
15. Aslanidi OV, Boyett MR, Dobrzynski H, Li J, Zhang H. Mechanisms of transition from normal to reentrant electrical activity in a model of rabbit atrial tissue: interaction of tissue heterogeneity and anisotropy. Biophys J 2009;96: 798-817.
16. Lamy C, Goodchild SJ, Weatherall KL, et al. Allosteric block of KCa2 channels by apamin. J Biol Chem 2010;285: 27067-27077.
17. Weatherall KL, Seutin V, Liegeois JF, Marrion NV. Crucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channels. Proc Natl Acad Sci U S A 2011;108: 18494-18499.
18. Cherry EM, Evans SJ. Properties of two human atrial cell models in tissue: restitution, memory, propagation, and reentry. J Theor Biol 2008;254: 674-690.
19. Fenton FH, Cherry EM, Kornreich BG. Termination of equine atrial fibrillation by quinidine: an optical mapping study. J Vet Cardiol 2008;10: 87-103.
20. Ohara T, Qu Z, Lee MH, et al. Increased vulnerability to inducible atrial fibrillation caused by partial cellular uncoupling with heptanol. Am J Physiol Heart Circ Physiol 2002;283:H1116-H1122.
21. Weiss JN, Qu Z, Chen PS, et al. The dynamics of cardiac fibrillation. Circulation 2005;112: 1232-1240.
22. Hara M, Shvilkin A, Rosen MR, Danilo P Jr, Boyden PA. Steady-state and nonsteady-state action potentials in fibrillating canine atrium: abnormal rate adaptation and its possible mechanisms. Cardiovasc Res 1999;42: 455-469.
23. Chang P, Turker I, Lopshire JC, et al. Heterogeneous upregulation of apamin-sensitive potassium currents in failing human ventricles. J Am Heart Assoc 2013;42:e004713.
24. Diness JG, Sorensen US, Nissen JD, et al. Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation. Circ Arrhythm Electrophysiol 2010;3: 380-390.