Fluorescent techniques for discovery and characterization of phosphopantetheinyl transferase inhibitors

Journal of Antibiotics

Volumn 67, Issue 1, 2014, Pages 113-120

  Kosa, Nicolas M ^a   Foley, Timothy L ^b   Burkart, Michael D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Antibiotics; Carrier protein; Drug discovery; Fluorescence polarization; High throughput screening; Pantetheine; PPTase

Indexed keywords

2' DEOXY 3,5 PHOSPHOADENOSINE; 3 (4 TERT BUTYLPHENYLSULFONYL) 2 PROPENENITRILE; 3,5 PHOSPHOADENOSINE; 6 NITROSO 1,2 BENZOPYRONE; BENSERAZIDE; CALMIDAZOLIUM CHLORIDE; COENZYME A; ENZYME INHIBITOR; EPHEDRINE HEMISULFATE; GUANIDINYL NALTRINDOLE DITRIFLUOROACETATE; MITOXANTRONE; N (2,3 DIPHENYL 1,2,4 THIADIAZOL 5(2H) YLIDENE)METHANAMINE; PANTETHEINE PHOSPHATE; PD 404182; PHOSPHOPANTETHEINYL TRANSFERASE; PHOSPHOPANTETHEINYL TRANSFERASE INHIBITOR; SANGUINARINE; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; FLUORESCENCE POLARIZATION; MOLECULAR WEIGHT; PRIORITY JOURNAL;

ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL PROTEINS; DRUG DISCOVERY; ENZYME INHIBITORS; FLUORESCENCE POLARIZATION; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MOLECULAR WEIGHT; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

EID: 84893123621     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2013.106     Document Type: Article

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