The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice

Xenobiotica

Volumn 44, Issue 2, 2014, Pages 146-153

  Higuchi, Yuichiro ^a   Kawai, Kenji ^a   Yamazaki, Hiroshi ^b   Nakamura, Masato ^c   Bree, Françoise ^d   Guguen Guillouzo, Christiane ^e   Suemizu, Hiroshi ^a  

^a CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^c TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d Saint Grégoire ^*  (France)

^e Biopredic International   (France)

Author keywords

HepaRG; Human hepatocytes; Humanized liver mice; TK NOG mouse

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450 3A4; GANCICLOVIR; HLA ANTIGEN; HUMAN ALBUMIN; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; THYMIDINE KINASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN HEPARG; CELL STRAIN HEPG2; CELL TRANSPLANTATION; CONTROLLED STUDY; CRYOPRESERVATION; DRUG METABOLISM; GENE EXPRESSION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; HUMANIZED LIVER; IMMUNE DEFICIENCY; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CELL; LIVER CELL CULTURE; LIVER FUNCTION TEST; LIVER METABOLISM; LIVER TOXICITY; MOUSE; MOUSE STRAIN; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TK NOG MOUSE; TRANSGENE;

ALBUMINS; ANIMALS; CARCINOGENICITY TESTS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CELL TRANSPLANTATION; FEMALE; HEPATOCYTES; HUMANS; LIVER; MALE; METABOLIC DETOXICATION, DRUG; MICE; MICE, TRANSGENIC; TRANSPLANTATION CHIMERA;

EID: 84893117698     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2013.836257     Document Type: Article

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