Autophagy-dependent metabolic reprogramming sensitizes tsc2-deficient cells to the antimetabolite 6-aminonicotinamide

Molecular Cancer Research

Volumn 12, Issue 1, 2014, Pages 48-57

  Parkhitko, Andrey A ^a,b,f   Priolo, Carmen ^a,b   Coloff, Jonathan L ^b,c   Yun, Jihye ^b,d   Wu, Julia J ^e   Mizumura, Kenji ^a,b   Xu, Wenping ^a,b   Malinowska, Izabela A ^b   Yu, Jane ^a,b   Kwiatkowski, David J ^b   Locasale, Jason W ^g   Asara, John M ^b,d   Choi, Augustine M K ^a,b   Finkel, Toren ^e   Henske, Elizabeth P ^a,b  

^a Division of Pulmonary and Critical Care Medicine   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Department of Cell Biology ^*  (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^e NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^f PIROGOV RUSSIAN NATIONAL RESEARCH MEDICAL UNIVERSITY   (Russian Federation)

^g Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 AMINONICOTINAMIDE; CHLOROQUINE; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; LACTIC ACID; PROTEIN S6; REACTIVE OXYGEN METABOLITE; TUBERIN;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; MITOCHONDRION; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; OXYGEN CONSUMPTION; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL;

6-AMINONICOTINAMIDE; ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CASPASE 1; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CHLOROQUINE; ENZYME INHIBITORS; GLUCOSE; HYDROXYCHLOROQUINE; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; MICE; MICE, INBRED A; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; MULTIPROTEIN COMPLEXES; NF-KAPPA B; NUCLEAR REPROGRAMMING; OXYGEN CONSUMPTION; PENTOSE PHOSPHATE PATHWAY; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TERATOGENS; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

EID: 84893108714     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-13-0258-T     Document Type: Article

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