-
1
-
-
10744222390
-
Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats
-
Abe K, Shimokawa H, Morikawa K, Uwatoku T, Oi K, Matsumoto Y, Hattori T, Nakashima Y, Kaibuchi K, Sueishi K, Takeshit A (2004) Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ Res 94:385-393
-
(2004)
Circ Res
, vol.94
, pp. 385-393
-
-
Abe, K.1
Shimokawa, H.2
Morikawa, K.3
Uwatoku, T.4
Oi, K.5
Matsumoto, Y.6
Hattori, T.7
Nakashima, Y.8
Kaibuchi, K.9
Sueishi, K.10
Takeshit, A.11
-
2
-
-
19944432269
-
Prostacyclin does not inhibit Rho-kinase: An implication for the treatment of pulmonary hypertension
-
Abe K, Morikawa K, Hizume T, Uwatoku T, Oi K, Seto M, Ikegaki I, Asano T, Kaibuchi K, Shimokawa H (2005) Prostacyclin does not inhibit Rho-kinase: An implication for the treatment of pulmonary hypertension. J Cardiovasc Pharmacol 45:120-124
-
(2005)
J Cardiovasc Pharmacol
, vol.45
, pp. 120-124
-
-
Abe, K.1
Morikawa, K.2
Hizume, T.3
Uwatoku, T.4
Oi, K.5
Seto, M.6
Ikegaki, I.7
Asano, T.8
Kaibuchi, K.9
Shimokawa, H.10
-
3
-
-
33846110312
-
Long-term inhibition of rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice
-
Abe K, Tawara S, Oi K, Hizume T, Uwatoku T, Fukumoto Y, Kaibuchi K, Shimokawa H (2006) Long-term inhibition of rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice. J Cardiovasc Pharmacol 48:280-285
-
(2006)
J Cardiovasc Pharmacol
, vol.48
, pp. 280-285
-
-
Abe, K.1
Tawara, S.2
Oi, K.3
Hizume, T.4
Uwatoku, T.5
Fukumoto, Y.6
Kaibuchi, K.7
Shimokawa, H.8
-
4
-
-
0031048791
-
Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase
-
Amano M, Chihara K, Kimura K, Fukata Y, Nakamura N, Matsuura Y, Kaibuchi K (1997) Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science 275:1308-1311
-
(1997)
Science
, vol.275
, pp. 1308-1311
-
-
Amano, M.1
Chihara, K.2
Kimura, K.3
Fukata, Y.4
Nakamura, N.5
Matsuura, Y.6
Kaibuchi, K.7
-
5
-
-
77957828780
-
Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension
-
Dahal BK, Kosanovic D, Pamarthi PK, Sydykov A, Lai YJ, Kast R, Schirok H, Stasch JP, Ghofrani HA, Weissmann N, Grimminger F, Seeger W, Schermuly RT (2010) Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension. Eur Respir J 36:808-818
-
(2010)
Eur Respir J
, vol.36
, pp. 808-818
-
-
Dahal, B.K.1
Kosanovic, D.2
Pamarthi, P.K.3
Sydykov, A.4
Lai, Y.J.5
Kast, R.6
Schirok, H.7
Stasch, J.P.8
Ghofrani, H.A.9
Weissmann, N.10
Grimminger, F.11
Seeger, W.12
Schermuly, R.T.13
-
6
-
-
69549129206
-
Evidence for rho-kinase activation in patients with pulmonary arterial hypertension
-
Do e Z, Fukumoto Y, Takaki A, Tawara S, Ohashi J, Nakano M, Tada T, Saji K, Sugimura K, Fujita H, Hoshikawa Y, Nawata J, Kondo T, Shimokawa H (2009) Evidence for rho-kinase activation in patients with pulmonary arterial hypertension. Circ J 73:1731-1739
-
(2009)
Circ J
, vol.73
, pp. 1731-1739
-
-
Do, E.Z.1
Fukumoto, Y.2
Takaki, A.3
Tawara, S.4
Ohashi, J.5
Nakano, M.6
Tada, T.7
Saji, K.8
Sugimura, K.9
Fujita, H.10
Hoshikawa, Y.11
Nawata, J.12
Kondo, T.13
Shimokawa, H.14
-
8
-
-
77950921360
-
Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension
-
Fujita H, Fukumoto Y, Saji K, Sugimura K, Demachi J, Nawata J, Shimokawa H (2010) Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension. Heart Vessels 25:144-149
-
(2010)
Heart Vessels
, vol.25
, pp. 144-149
-
-
Fujita, H.1
Fukumoto, Y.2
Saji, K.3
Sugimura, K.4
Demachi, J.5
Nawata, J.6
Shimokawa, H.7
-
9
-
-
0035150402
-
Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells
-
Fukata Y, Amano M, Kaibuchi K (2001) Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells. Trends Pharmacol Sci 22:32-39
-
(2001)
Trends Pharmacol Sci
, vol.22
, pp. 32-39
-
-
Fukata, Y.1
Amano, M.2
Kaibuchi, K.3
-
10
-
-
79960792540
-
Recent progress in the management of pulmonary hypertension
-
Fukumoto Y, Shimokawa H (2011) Recent progress in the management of pulmonary hypertension. Circ J 75:1801-1810
-
(2011)
Circ J
, vol.75
, pp. 1801-1810
-
-
Fukumoto, Y.1
Shimokawa, H.2
-
11
-
-
14244260105
-
Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension
-
Fukumoto Y, Matoba T, Ito A, Tanaka H, Kishi T, Hayashidani S, Abe K, Takeshita A, Shimokawa H (2005) Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension. Heart 91:391-392
-
(2005)
Heart
, vol.91
, pp. 391-392
-
-
Fukumoto, Y.1
Matoba, T.2
Ito, A.3
Tanaka, H.4
Kishi, T.5
Hayashidani, S.6
Abe, K.7
Takeshita, A.8
Shimokawa, H.9
-
12
-
-
34247168120
-
Recent progress in the treatment of pulmonary arterial hypertension: Expectation for Rho-kinase inhibitors
-
Fukumoto Y, Tawara S, Shimokawa H (2007) Recent progress in the treatment of pulmonary arterial hypertension: Expectation for Rho-kinase inhibitors. Tohoku J Exp Med 211:309-320
-
(2007)
Tohoku J Exp Med
, vol.211
, pp. 309-320
-
-
Fukumoto, Y.1
Tawara, S.2
Shimokawa, H.3
-
13
-
-
84884603855
-
A double-blind, placebo-controlled clinical trial with a Rho-kinase inhibitor in pulmonary arterial hypertension; A pilot efficacy trial
-
Fukumoto Y, Yamada N, Matsubara H, Mizoguchi M, Uchino K, Yao A, Kihara Y, Kawano M, Watanabe H, Takeda Y, Adachi T, Osanai S, Tanabe N, Inoue T, Nakano T, Shimokawa H (2013) A double-blind, placebo-controlled clinical trial with a Rho-kinase inhibitor in pulmonary arterial hypertension; a pilot efficacy trial. http://dx.doi.org/10.1253/circj.CJ-13-0443. Circ J 77:2691-2625
-
(2013)
Circ J
, vol.77
, pp. 2691-2625
-
-
Fukumoto, Y.1
Yamada, N.2
Matsubara, H.3
Mizoguchi, M.4
Uchino, K.5
Yao, A.6
Kihara, Y.7
Kawano, M.8
Watanabe, H.9
Takeda, Y.10
Adachi, T.11
Osanai, S.12
Tanabe, N.13
Inoue, T.14
Nakano, T.15
Shimokawa, H.16
-
14
-
-
0029055964
-
Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension
-
Giaid A, Saleh D (1995) Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med 333:214-221
-
(1995)
N Engl J Med
, vol.333
, pp. 214-221
-
-
Giaid, A.1
Saleh, D.2
-
15
-
-
0142120102
-
Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: Effect on endothelial NAD(P)H oxidase system
-
Higashi M, Shimokawa H, Hattori T, Hiroki J, Mukai Y, Morikawa K, Ichiki T, Takahashi S, Takeshita A (2003) Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: Effect on endothelial NAD(P)H oxidase system. Circ Res 93:767-775
-
(2003)
Circ Res
, vol.93
, pp. 767-775
-
-
Higashi, M.1
Shimokawa, H.2
Hattori, T.3
Hiroki, J.4
Mukai, Y.5
Morikawa, K.6
Ichiki, T.7
Takahashi, S.8
Takeshita, A.9
-
16
-
-
0031854540
-
Endothelial dysfunction providing the basis for the treatment of pulmonary hypertension: Giles f. Filley lecture
-
Higenbottam TW, Laude EA (1998) Endothelial dysfunction providing the basis for the treatment of pulmonary hypertension: Giles f. Filley lecture. Chest 114:72S-79S
-
(1998)
Chest
, vol.114
, pp. 72-79
-
-
Higenbottam, T.W.1
Laude, E.A.2
-
17
-
-
3242730347
-
Inflammatory stimuli upregulate rho-kinase in human coronary vascular smooth muscle cells
-
Hiroki J, Shimokawa H, Higashi M, Morikawa K, Kandabashi T, Kawamura N, Kubota T, Ichiki T, Amano M, Kaibuchi K, Takeshita A (2004) Inflammatory stimuli upregulate rho-kinase in human coronary vascular smooth muscle cells. J Mol Cell Cardiol 37:537-546
-
(2004)
J Mol Cell Cardiol
, vol.37
, pp. 537-546
-
-
Hiroki, J.1
Shimokawa, H.2
Higashi, M.3
Morikawa, K.4
Kandabashi, T.5
Kawamura, N.6
Kubota, T.7
Ichiki, T.8
Amano, M.9
Kaibuchi, K.10
Takeshita, A.11
-
18
-
-
2942541475
-
Cellular and molecular pathobiology of pulmonary arterial hypertension
-
Humbert M, Morrell NW, Archer SL, Stenmark KR, MacLean MR, Lang IM, Christman BW, Weir EK, Eickelberg O, Voelkel NF, RabinovitchM(2004) Cellular and molecular pathobiology of pulmonary arterial hypertension. J Am Coll Cardiol 43:13S-24S
-
(2004)
J Am Coll Cardiol
, vol.43
, pp. 13-24
-
-
Humbert, M.1
Morrell, N.W.2
Archer, S.L.3
Stenmark, K.R.4
Maclean, M.R.5
Lang, I.M.6
Christman, B.W.7
Weir, E.K.8
Eickelberg, O.9
Voelkel, N.F.10
Rabinovitch, M.11
-
19
-
-
31644431508
-
Beneficial acute effects of Rho-kinase inhibitor in patients with pulmonary arterial hypertension
-
Ishikura K, Yamada N, Ito M, Ota S, Nakamura M, Isaka N, Nakano T (2006) Beneficial acute effects of Rho-kinase inhibitor in patients with pulmonary arterial hypertension. Circ J 70:174-178
-
(2006)
Circ J
, vol.70
, pp. 174-178
-
-
Ishikura, K.1
Yamada, N.2
Ito, M.3
Ota, S.4
Nakamura, M.5
Isaka, N.6
Nakano, T.7
-
20
-
-
9244220646
-
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase
-
Ishizaki T, Maekawa M, Fujisawa K, Okawa K, Iwamatsu A, Fujita A, Watanabe N, Saito Y, Kakizuka A, Morii N, Narumiya S (1996) The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J 15:1885-1893
-
(1996)
EMBO J
, vol.15
, pp. 1885-1893
-
-
Ishizaki, T.1
Maekawa, M.2
Fujisawa, K.3
Okawa, K.4
Iwamatsu, A.5
Fujita, A.6
Watanabe, N.7
Saito, Y.8
Kakizuka, A.9
Morii, N.10
Narumiya, S.11
-
21
-
-
33847191058
-
Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats
-
Jiang BH, Tawara S, Abe K, Takaki A, Fukumoto Y, Shimokawa H (2007) Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats. J Cardiovasc Pharmacol 49:85-89
-
(2007)
J Cardiovasc Pharmacol
, vol.49
, pp. 85-89
-
-
Jiang, B.H.1
Tawara, S.2
Abe, K.3
Takaki, A.4
Fukumoto, Y.5
Shimokawa, H.6
-
22
-
-
36448945847
-
Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase
-
Kast R, Schirok H, Figueroa-Perez S, Mittendorf J, Gnoth MJ, Apeler H, Lenz J, Franz JK, Knorr A, Hutter J, Lobell M, Zimmermann K, Munter K, Augstein KH, Ehmke H, Stasch JP (2007) Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase. Br J Pharmacol 152:1070-1080
-
(2007)
Br J Pharmacol
, vol.152
, pp. 1070-1080
-
-
Kast, R.1
Schirok, H.2
Figueroa-Perez, S.3
Mittendorf, J.4
Gnoth, M.J.5
Apeler, H.6
Lenz, J.7
Franz, J.K.8
Knorr, A.9
Hutter, J.10
Lobell, M.11
Zimmermann, K.12
Munter, K.13
Augstein, K.H.14
Ehmke, H.15
Stasch, J.P.16
-
23
-
-
0028863142
-
A novel serine/threonine kinase binding the Ras-related Rhoa GPTase which translocates the kinase to peripheral membranes
-
Leung T, Manser E, Tan L, Lim L (1995) A novel serine/threonine kinase binding the Ras-related Rhoa GPTase which translocates the kinase to peripheral membranes. J Biol Chem 270:29051-29054
-
(1995)
J Biol Chem
, vol.270
, pp. 29051-29054
-
-
Leung, T.1
Manser, E.2
Tan, L.3
Lim, L.4
-
25
-
-
70349235617
-
Pharmacological characterization of sar407899, a novel Rho-kinase inhibitor
-
Lohn M, Plettenburg O, Ivashchenko Y, Kannt A, Hofmeister A, Kadereit D, Schaefer M, Linz W, Kohlmann M, Herbert JM, Janiak P, O'Connor SE, Ruetten H (2009) Pharmacological characterization of sar407899, a novel Rho-kinase inhibitor. Hypertension 54:676-683
-
(2009)
Hypertension
, vol.54
, pp. 676-683
-
-
Lohn, M.1
Plettenburg, O.2
Ivashchenko, Y.3
Kannt, A.4
Hofmeister, A.5
Kadereit, D.6
Schaefer, M.7
Linz, W.8
Kohlmann, M.9
Herbert, J.M.10
Janiak, P.11
O'Connor, S.E.12
Ruetten, H.13
-
26
-
-
33646763902
-
Rho kinases in cardiovascular physiology and pathophysiology
-
Loirand G, Guerin P, Pacaud P (2006) Rho kinases in cardiovascular physiology and pathophysiology. Circ Res 98:322-334
-
(2006)
Circ Res
, vol.98
, pp. 322-334
-
-
Loirand, G.1
Guerin, P.2
Pacaud, P.3
-
27
-
-
0035679020
-
Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans
-
Masumoto A, Hirooka Y, Shimokawa H, Hironaga K, Setoguchi S, Takeshita A (2001) Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans. Hypertension 38:1307-1310
-
(2001)
Hypertension
, vol.38
, pp. 1307-1310
-
-
Masumoto, A.1
Hirooka, Y.2
Shimokawa, H.3
Hironaga, K.4
Setoguchi, S.5
Takeshita, A.6
-
28
-
-
0037007054
-
Suppression of coronary artery spasm by the rho-kinase inhibitor fasudil in patients with vasospastic angina
-
Masumoto A, Mohri M, Shimokawa H, Urakami L, Usui M, Takeshita A (2002) Suppression of coronary artery spasm by the rho-kinase inhibitor fasudil in patients with vasospastic angina. Circulation 105:1545-1547
-
(2002)
Circulation
, vol.105
, pp. 1545-1547
-
-
Masumoto, A.1
Mohri, M.2
Shimokawa, H.3
Urakami, L.4
Usui, M.5
Takeshita, A.6
-
29
-
-
33748998458
-
Pulmonary arterial hypertension
-
McLaughlin VV, McGoon MD (2006) Pulmonary arterial hypertension. Circulation 114:1417-1431
-
(2006)
Circulation
, vol.114
, pp. 1417-1431
-
-
McLaughlin, V.V.1
McGoon, M.D.2
-
30
-
-
0037223388
-
Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm
-
Mohri M, Shimokawa H, Hirakawa Y, Masumoto A, Takeshita A (2003) Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm. J Am Coll Cardiol 41:15-19
-
(2003)
J Am Coll Cardiol
, vol.41
, pp. 15-19
-
-
Mohri, M.1
Shimokawa, H.2
Hirakawa, Y.3
Masumoto, A.4
Takeshita, A.5
-
31
-
-
0035049575
-
Adenovirus-mediated transfer of dominant-negative Rho-kinase induces a regression of coronary arteriosclerosis in pigs in vivo
-
Morishige K, Shimokawa H, Eto Y, Kandabashi T, Miyata K, Matsumoto Y, Hoshijima M, Kaibuchi K, Takeshita A (2001) Adenovirus-mediated transfer of dominant-negative Rho-kinase induces a regression of coronary arteriosclerosis in pigs in vivo. Arterioscler Thromb Vasc Biol 21:548-554
-
(2001)
Arterioscler Thromb Vasc Biol
, vol.21
, pp. 548-554
-
-
Morishige, K.1
Shimokawa, H.2
Eto, Y.3
Kandabashi, T.4
Miyata, K.5
Matsumoto, Y.6
Hoshijima, M.7
Kaibuchi, K.8
Takeshita, A.9
-
32
-
-
15944403568
-
Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension
-
Nagaoka T, Fagan KA, Gebb SA, Morris KG, Suzuki T, Shimokawa H, McMurtry IF, Oka M (2005) Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am J Respir Crit Care Med 171:494-499
-
(2005)
Am J Respir Crit Care Med
, vol.171
, pp. 494-499
-
-
Nagaoka, T.1
Fagan, K.A.2
Gebb, S.A.3
Morris, K.G.4
Suzuki, T.5
Shimokawa, H.6
McMurtry, I.F.7
Oka, M.8
-
33
-
-
0029791373
-
The small GTPase Rho: Cellular functions and signal transduction
-
Narumiya S (1996) The small GTPase Rho: Cellular functions and signal transduction. J Biochem 120:215-228
-
(1996)
J Biochem
, vol.120
, pp. 215-228
-
-
Narumiya, S.1
-
34
-
-
53849089211
-
Therapeutic potential of Rhoa/Rho kinase inhibitors in pulmonary hypertension
-
Oka M, Fagan KA, Jones PL, McMurtry IF (2008) Therapeutic potential of Rhoa/Rho kinase inhibitors in pulmonary hypertension. Br J Pharmacol 155:444-454
-
(2008)
Br J Pharmacol
, vol.155
, pp. 444-454
-
-
Oka, M.1
Fagan, K.A.2
Jones, P.L.3
McMurtry, I.F.4
-
35
-
-
84863698886
-
The Rho kinase inhibitor azaindole-1 has long-acting vasodilator activity in the pulmonary vascular bed of the intact chest rat
-
Pankey EA, Byun RJ, Smith WB 2nd, Bhartiya M, Bueno FR, Badejo AM, Stasch JP, Murthy SN, Nossaman BD, Kadowitz PJ (2012) The Rho kinase inhibitor azaindole-1 has long-acting vasodilator activity in the pulmonary vascular bed of the intact chest rat. Can J Physiol Pharmacol 90:825-835
-
(2012)
Can J Physiol Pharmacol
, vol.90
, pp. 825-835
-
-
Pankey, E.A.1
Byun, R.J.2
Smith II, W.B.3
Bhartiya, M.4
Bueno, F.R.5
Badejo, A.M.6
Stasch, J.P.7
Murthy, S.N.8
Nossaman, B.D.9
Kadowitz, P.J.10
-
36
-
-
84862538718
-
Sustained therapeutic hypercapnia attenuates pulmonary arterial Rho-kinase activity and ameliorates chronic hypoxic pulmonary hypertension in juvenile rats
-
Peng G, Ivanovska J, Kantores C, Van Vliet T, Engelberts D, Kavanagh BP, Enomoto M, Belik J, Jain A, McNamara PJ, Jankov RP (2012) Sustained therapeutic hypercapnia attenuates pulmonary arterial Rho-kinase activity and ameliorates chronic hypoxic pulmonary hypertension in juvenile rats. Am J Physiol Heart Circ Physiol 302:H2599-H2611
-
(2012)
Am J Physiol Heart Circ Physiol
, vol.302
-
-
Peng, G.1
Ivanovska, J.2
Kantores, C.3
Van Vliet, T.4
Engelberts, D.5
Kavanagh, B.P.6
Enomoto, M.7
Belik, J.8
Jain, A.9
McNamara, P.J.10
Jankov, R.P.11
-
37
-
-
0033979414
-
Cellular and molecular mechanisms of coronary artery spasm: Lessons from animal models
-
Shimokawa H (2000) Cellular and molecular mechanisms of coronary artery spasm: Lessons from animal models. Jpn Circ J 64:1-12
-
(2000)
Jpn Circ J
, vol.64
, pp. 1-12
-
-
Shimokawa, H.1
-
38
-
-
0036182417
-
Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases
-
Shimokawa H (2002) Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases. J Cardiovasc Pharmacol 39:319-327
-
(2002)
J Cardiovasc Pharmacol
, vol.39
, pp. 319-327
-
-
Shimokawa, H.1
-
39
-
-
34249301303
-
Development of Rho-kinase inhibitors for cardiovascular medicine
-
Shimokawa H, Rashid M (2007a) Development of Rho-kinase inhibitors for cardiovascular medicine. Trends Pharmacol Sci 28:296-302
-
(2007)
Trends Pharmacol Sci
, vol.28
, pp. 296-302
-
-
Shimokawa, H.1
Rashid, M.2
-
40
-
-
34249301303
-
Rho-kinase inhibitors for cardiovascular medicine. Its rationale and current status
-
Shimokawa H, Rashid M (2007b) Rho-kinase inhibitors for cardiovascular medicine. Its rationale and current status. Trends Pharmacol Sci 28:296-302
-
(2007)
Trends Pharmacol Sci
, vol.28
, pp. 296-302
-
-
Shimokawa, H.1
Rashid, M.2
-
41
-
-
24144498411
-
Rho-kinase is an important therapeutic target in cardiovascular medicine
-
Shimokawa H, Takeshita A (2005) Rho-kinase is an important therapeutic target in cardiovascular medicine. Arterioscler Thromb Vasc Biol 25:1767-1775
-
(2005)
Arterioscler Thromb Vasc Biol
, vol.25
, pp. 1767-1775
-
-
Shimokawa, H.1
Takeshita, A.2
-
42
-
-
0032877847
-
Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm
-
Shimokawa H, Seto M, Katsumata N, Amano M, Kozai T, Yamawaki T, Kuwata K, Kandabashi T, Egashira K, Ikegaki I, Asano T, Kaibuchi K, Takeshita A (1999) Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc Res 43:1029-1039
-
(1999)
Cardiovasc Res
, vol.43
, pp. 1029-1039
-
-
Shimokawa, H.1
Seto, M.2
Katsumata, N.3
Amano, M.4
Kozai, T.5
Yamawaki, T.6
Kuwata, K.7
Kandabashi, T.8
Egashira, K.9
Ikegaki, I.10
Asano, T.11
Kaibuchi, K.12
Takeshita, A.13
-
43
-
-
0034650714
-
Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
-
Somlyo AP, Somlyo AV (2000) Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 522(Pt 2):177-185
-
(2000)
J Physiol
, vol.522
, Issue.PART 2
, pp. 177-185
-
-
Somlyo, A.P.1
Somlyo, A.V.2
-
45
-
-
0036645303
-
Rho-kinase mediates hypoxiainduced downregulation of endothelial nitric oxide synthase
-
Takemoto M, Sun J, Hiroki J, Shimokawa H, Liao JK (2002) Rho-kinase mediates hypoxiainduced downregulation of endothelial nitric oxide synthase. Circulation 106:57-62
-
(2002)
Circulation
, vol.106
, pp. 57-62
-
-
Takemoto, M.1
Sun, J.2
Hiroki, J.3
Shimokawa, H.4
Liao, J.K.5
-
46
-
-
34547941265
-
Effects of combined therapy with a Rho-kinase inhibitor and prostacyclin on monocrotaline-induced pulmonary hypertension in rats
-
Tawara S, Fukumoto Y, Shimokawa H (2007) Effects of combined therapy with a Rho-kinase inhibitor and prostacyclin on monocrotaline-induced pulmonary hypertension in rats. J Cardiovasc Pharmacol 50:195-200
-
(2007)
J Cardiovasc Pharmacol
, vol.50
, pp. 195-200
-
-
Tawara, S.1
Fukumoto, Y.2
Shimokawa, H.3
-
47
-
-
0030656619
-
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
-
Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, Narumiya S (1997) Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389:990-994
-
(1997)
Nature
, vol.389
, pp. 990-994
-
-
Uehata, M.1
Ishizaki, T.2
Satoh, H.3
Ono, T.4
Kawahara, T.5
Morishita, T.6
Tamakawa, H.7
Yamagami, K.8
Inui, J.9
Maekawa, M.10
Narumiya, S.11
-
48
-
-
80054998108
-
Ocular hypotensive effect of the rho kinase inhibitor ar-12286 in patients with glaucoma and ocular hypertension
-
Williams RD, Novack GD, van Haarlem T, Kopczynski C (2011) Ocular hypotensive effect of the rho kinase inhibitor ar-12286 in patients with glaucoma and ocular hypertension. Am J Ophthalmol 152:834-841
-
(2011)
Am J Ophthalmol
, vol.152
, pp. 834-841
-
-
Williams, R.D.1
Novack, G.D.2
Van Haarlem, T.3
Kopczynski, C.4
-
49
-
-
9444220218
-
Increased arginase II and decreased no synthesis in endothelial cells of patients with pulmonary arterial hypertension
-
Xu W, Kaneko FT, Zheng S, Comhair SA, Janocha AJ, Goggans T, Thunnissen FB, Farver C, Hazen SL, Jennings C, Dweik RA, Arroliga AC, Erzurum SC (2004) Increased arginase II and decreased no synthesis in endothelial cells of patients with pulmonary arterial hypertension. FASEB J 18:1746-1748
-
(2004)
FASEB J
, vol.18
, pp. 1746-1748
-
-
Xu, W.1
Kaneko, F.T.2
Zheng, S.3
Comhair, S.A.4
Janocha, A.J.5
Goggans, T.6
Thunnissen, F.B.7
Farver, C.8
Hazen, S.L.9
Jennings, C.10
Dweik, R.A.11
Arroliga, A.C.12
Erzurum, S.C.13
-
50
-
-
80055117501
-
Rho-kinase inhibition alleviates pulmonary hypertension in transgenic mice expressing a dominant-negative type II bone morphogenetic protein receptor gene
-
Yasuda T, Tada Y, Tanabe N, Tatsumi K, West J (2011) Rho-kinase inhibition alleviates pulmonary hypertension in transgenic mice expressing a dominant-negative type II bone morphogenetic protein receptor gene. Am J Physiol Lung Cell Mol Physiol 301:L667-L674
-
(2011)
Am J Physiol Lung Cell Mol Physiol
, vol.301
-
-
Yasuda, T.1
Tada, Y.2
Tanabe, N.3
Tatsumi, K.4
West, J.5
-
51
-
-
0032491187
-
Dysfunctional voltage-gated K+ channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension
-
Yuan JX, Aldinger AM, Juhaszova M, Wang J, Conte JV Jr, Gaine SP, Orens JB, Rubin LJ (1998) Dysfunctional voltage-gated K+ channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension. Circulation 98:1400-1406
-
(1998)
Circulation
, vol.98
, pp. 1400-1406
-
-
Yuan, J.X.1
Aldinger, A.M.2
Juhaszova, M.3
Wang, J.4
Conte Jr., J.V.5
Gaine, S.P.6
Orens, J.B.7
Rubin, L.J.8
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