메뉴 건너뛰기




Volumn 38, Issue 1, 2014, Pages 1-7

Effects of ginseol k-g3, an rg3-enriched fraction, on scopolamine-induced memory impairment and learning deficit in mice

Author keywords

Ginseol k g3; Memory; Panax ginseng; Rg3; Scopolamine

Indexed keywords

ACETYLCHOLINESTERASE; DONEPEZIL; GINSENG EXTRACT; GINSENOSIDE; GINSENOSIDE RG 3; GINSEOL K G3; SCOPOLAMINE; UNCLASSIFIED DRUG; WATER;

EID: 84892987305     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jgr.2013.11.003     Document Type: Article
Times cited : (24)

References (42)
  • 1
    • 0033621165 scopus 로고    scopus 로고
    • Amyloid diseases: Abnormal protein aggregation in neurodegeneration
    • Koo EH, Lansbury PT, Kelly JW. Amyloid diseases: abnormal protein aggregation in neurodegeneration. Proc Natl Acad Sci USA 1999;96:9989-90.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 9989-9990
    • Koo, E.H.1    Lansbury, P.T.2    Kelly, J.W.3
  • 2
    • 77957103117 scopus 로고
    • The fine structure of neurofibrillary tangles in Alzheimer's disease
    • Terry RD. The fine structure of neurofibrillary tangles in Alzheimer's disease. J Neuropathol Exp Neurol 1963;22:629-42.
    • (1963) J Neuropathol Exp Neurol , vol.22 , pp. 629-642
    • Terry, R.D.1
  • 3
    • 0030805991 scopus 로고    scopus 로고
    • Frequency of stages of Alzheimer-related lesions in different age categories
    • Braak H, Braak E. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging 1997;18:351-7.
    • (1997) Neurobiol Aging , vol.18 , pp. 351-357
    • Braak, H.1    Braak, E.2
  • 4
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus RT, Dean 3rd RL, Beer B, Lippa A. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982;217:408-17.
    • (1982) Science , vol.217 , pp. 408-417
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3    Lippa, A.4
  • 6
    • 55849111494 scopus 로고    scopus 로고
    • Cholinergic system during the progression of Alzheimer's disease: Therapeutic implications
    • Mufson EJ, Counts SE, Perez SE, Ginsberg SD. Cholinergic system during the progression of Alzheimer's disease: therapeutic implications. Expert Rev Neurother 2008;8:1703-18.
    • (2008) Expert Rev Neurother , vol.8 , pp. 1703-1718
    • Mufson, E.J.1    Counts, S.E.2    Perez, S.E.3    Ginsberg, S.D.4
  • 7
    • 0042433479 scopus 로고    scopus 로고
    • The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: Recent challenges and their implications for novel drug development
    • Terry Jr AV, Buccafusco JJ. The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development. J Pharmacol Exp Ther 2003;306:821-7.
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 821-827
    • Terry, A.V.1    Buccafusco, J.J.2
  • 8
    • 77951874698 scopus 로고    scopus 로고
    • Persistent treatment with cholinesterase inhibitors and/or memantine shows clinical progression of Alzheimer disease
    • Rountree SD, Chan W, Pavlik VN, Darby EJ, Siddiqui S, Doody RS. Persistent treatment with cholinesterase inhibitors and/or memantine shows clinical progression of Alzheimer disease. Alzheimers Res Ther 2009;1:7.
    • (2009) Alzheimers Res Ther , vol.1 , pp. 7
    • Rountree, S.D.1    Chan, W.2    Pavlik, V.N.3    Darby, E.J.4    Siddiqui, S.5    Doody, R.S.6
  • 9
    • 33646057761 scopus 로고    scopus 로고
    • Ginseng and ion channels: Are ginsensosides, active component of Panax ginseng, differential modulator of ion channels?
    • Jeong SM, Nah SY. Ginseng and ion channels: are ginsensosides, active component of Panax ginseng, differential modulator of ion channels? J Ginseng Res 2005;29:19-26.
    • (2005) J Ginseng Res , vol.29 , pp. 19-26
    • Jeong, S.M.1    Nah, S.Y.2
  • 12
    • 0001780741 scopus 로고
    • Effects of ginsenoside Rb1 and ginsenoside Rg1 on learning and memory
    • Shibata S, Ohtsuka Y, Saito H, editors, Tokyo: Hirokawa Publishing
    • Saito H. Effects of ginsenoside Rb1 and ginsenoside Rg1 on learning and memory. In: Shibata S, Ohtsuka Y, Saito H, editors. Recent advances in ginseng study. Tokyo: Hirokawa Publishing; 1990. p. 99.
    • (1990) Recent Advances In Ginseng Study , pp. 99
    • Saito, H.1
  • 13
    • 0028803581 scopus 로고
    • Effects of ginsenosides on impaired performance induced in the rat by scopolamine in a radial-arm maze
    • Yamaguchi Y, Haruta K, Kobayashi H. Effects of ginsenosides on impaired performance induced in the rat by scopolamine in a radial-arm maze. Psychoneuroendocrinology 1995;20:645-53.
    • (1995) Psychoneuroendocrinology , vol.20 , pp. 645-653
    • Yamaguchi, Y.1    Haruta, K.2    Kobayashi, H.3
  • 14
    • 1942420868 scopus 로고    scopus 로고
    • Ab(25-35)- induced memory impairment, axonal atrophy, and synaptic loss are ameliorated by M1, a metabolite of protopanaxadiol-type saponins
    • Tohda C, Matsumoto N, Zou K, Meselhy MR, Komatsu K. Ab(25-35)- induced memory impairment, axonal atrophy, and synaptic loss are ameliorated by M1, a metabolite of protopanaxadiol-type saponins. Neuropsychopharmacology 2004;29:860-8.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 860-868
    • Tohda, C.1    Matsumoto, N.2    Zou, K.3    Meselhy, M.R.4    Komatsu, K.5
  • 15
    • 0025518656 scopus 로고
    • Preliminary study on antiamnesic mechanism of Rg1 and Rb1
    • Zhang JT, Qu ZW, Liu Y, Deng HL. Preliminary study on antiamnesic mechanism of Rg1 and Rb1. Chin Med J 1990;103:932-8.
    • (1990) Chin Med J , vol.103 , pp. 932-938
    • Zhang, J.T.1    Qu, Z.W.2    Liu, Y.3    Deng, H.L.4
  • 16
    • 0036180097 scopus 로고    scopus 로고
    • Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro
    • Liao B, Newmark H, Zhou R. Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro. Experiment Neurol 2002;173:224-34.
    • (2002) Experiment Neurol , vol.173 , pp. 224-234
    • Liao, B.1    Newmark, H.2    Zhou, R.3
  • 17
    • 0028183354 scopus 로고
    • Malonyl-ginsenoside Rb1 potentiates nerve growth factor (NGF)-induced neurite outgrowth of cultured chick embryonic dorsal root ganglia
    • Nishiyama N, Cho SI, Kitagawa I, Saito H. Malonyl-ginsenoside Rb1 potentiates nerve growth factor (NGF)-induced neurite outgrowth of cultured chick embryonic dorsal root ganglia. Biol Pharmacol Bull 1994;17:509-13.
    • (1994) Biol Pharmacol Bull , vol.17 , pp. 509-513
    • Nishiyama, N.1    Cho, S.I.2    Kitagawa, I.3    Saito, H.4
  • 19
    • 83455245428 scopus 로고    scopus 로고
    • Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model
    • Fang F, Chen X, Huang T, Lue LF, Luddy JS, Yan SS. Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model. Biochim Biophys Acta 2012;1822:286-92.
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 286-292
    • Fang, F.1    Chen, X.2    Huang, T.3    Lue, L.F.4    Luddy, J.S.5    Yan, S.S.6
  • 20
    • 70349958198 scopus 로고    scopus 로고
    • Ginsenoside Rh2 ameliorates scopolamine-induced learning deficit in mice
    • Yang JH, Han SJ, Ryu JH, Kang IS, Kim DH. Ginsenoside Rh2 ameliorates scopolamine-induced learning deficit in mice. Biol Pharm Bull 2009;32: 1710-5.
    • (2009) Biol Pharm Bull , vol.32 , pp. 1710-1715
    • Yang, J.H.1    Han, S.J.2    Ryu, J.H.3    Kang, I.S.4    Kim, D.H.5
  • 21
    • 77954086949 scopus 로고    scopus 로고
    • The validity of scopolamine as a pharmacological model for cognitive impairment: A review of animal behavioral studies
    • Klinkenberg I, Blokland A. The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies. Neurosci Biobehav Rev 2010;34:1307-50.
    • (2010) Neurosci Biobehav Rev , vol.34 , pp. 1307-1350
    • Klinkenberg, I.1    Blokland, A.2
  • 22
    • 16544366501 scopus 로고    scopus 로고
    • Ginsenosides inhibit NMDA receptor-mediated epileptic discharges in cultured hippocampal neurons
    • Kim S, Rhim H. Ginsenosides inhibit NMDA receptor-mediated epileptic discharges in cultured hippocampal neurons. Arch Pharm Res 2004;27:524-30.
    • (2004) Arch Pharm Res , vol.27 , pp. 524-530
    • Kim, S.1    Rhim, H.2
  • 24
    • 79951804440 scopus 로고    scopus 로고
    • Neuroprotective effects of ginsenoside Rg3 against 24-OH-cholesterol-induced cytotoxicity in cortical neurons
    • Roh YS, Kim HB, Kang CW, Kim BS, Nah SY, Kim JH. Neuroprotective effects of ginsenoside Rg3 against 24-OH-cholesterol-induced cytotoxicity in cortical neurons. J Ginseng Res 2010;34:246-53.
    • (2010) J Ginseng Res , vol.34 , pp. 246-253
    • Roh, Y.S.1    Kim, H.B.2    Kang, C.W.3    Kim, B.S.4    Nah, S.Y.5    Kim, J.H.6
  • 26
    • 0036386954 scopus 로고    scopus 로고
    • Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons
    • Kim S, Ahn K, Oh TH, Nah SY, Rhim H. Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons. Biochem Biophys Res Commun 2002;296:247-54.
    • (2002) Biochem Biophys Res Commun , vol.296 , pp. 247-254
    • Kim, S.1    Ahn, K.2    Oh, T.H.3    Nah, S.Y.4    Rhim, H.5
  • 27
    • 33845672995 scopus 로고    scopus 로고
    • Reductions in levels of the Alzheimer's amyloid b peptide after oral administration of ginsenosides
    • Chen F, Eckman E, Eckman C. Reductions in levels of the Alzheimer's amyloid b peptide after oral administration of ginsenosides. FASEB J 2006;20:1269-71.
    • (2006) FASEB J , vol.20 , pp. 1269-1271
    • Chen, F.1    Eckman, E.2    Eckman, C.3
  • 28
    • 79951792885 scopus 로고    scopus 로고
    • Increase of functional saponin by acidic treatment and temperature of red ginseng extract
    • In JG, Lee BS, Kim EJ, Park MH, Yang DC. Increase of functional saponin by acidic treatment and temperature of red ginseng extract. Korea J Plant Res 2006;19:139-43.
    • (2006) Korea J Plant Res , vol.19 , pp. 139-143
    • In, J.G.1    Lee, B.S.2    Kim, E.J.3    Park, M.H.4    Yang, D.C.5
  • 30
    • 84862662586 scopus 로고    scopus 로고
    • A comparison between extract products of Magnolia officinalis on memory impairment and amyloidogenesis in a transgenic mouse model of Alzheimer's disease
    • Lee YJ, Choi DY, Han SB, Kim YH, Kim KH, Seong YH, Oh KW, Hong TJ. A comparison between extract products of Magnolia officinalis on memory impairment and amyloidogenesis in a transgenic mouse model of Alzheimer's disease. Biomol Ther 2012;20:332-9.
    • (2012) Biomol Ther , vol.20 , pp. 332-339
    • Lee, Y.J.1    Choi, D.Y.2    Han, S.B.3    Kim, Y.H.4    Kim, K.H.5    Seong, Y.H.6    Oh, K.W.7    Hong, T.J.8
  • 33
    • 84866005647 scopus 로고    scopus 로고
    • The memory ameliorating effects of INM-176, an ethanolic extract of Angelica gigas, against scopolamine- or Ab1-42-induced cognitive dysfunction in mice
    • Park SJ, Jung JM, Lee HE, Lee YW, Kim DH, Kim JM, Hong JG, Lee CH, Jung IH, Cho YB, et al. The memory ameliorating effects of INM-176, an ethanolic extract of Angelica gigas, against scopolamine- or Ab1-42-induced cognitive dysfunction in mice. J Ethnopharmacology 2012;143:611-20.
    • (2012) J Ethnopharmacology , vol.143 , pp. 611-620
    • Park, S.J.1    Jung, J.M.2    Lee, H.E.3    Lee, Y.W.4    Kim, D.H.5    Kim, J.M.6    Hong, J.G.7    Lee, C.H.8    Jung, I.H.9    Cho, Y.B.10
  • 34
    • 0018627150 scopus 로고
    • Spatial memory and hippocampal function
    • Olton DS, Papas BC. Spatial memory and hippocampal function. Neuropsychologia 1979;17:669-82.
    • (1979) Neuropsychologia , vol.17 , pp. 669-682
    • Olton, D.S.1    Papas, B.C.2
  • 35
    • 0030593636 scopus 로고    scopus 로고
    • Role of dorsal hippocampus in acquisition, consolidation and retrieval of rat's passive avoidance response: A tetrodotoxin functional inactivation study
    • Lorenzini CA, Baldi E, Bucherelli C, Sacchetti B, Tassoni G. Role of dorsal hippocampus in acquisition, consolidation and retrieval of rat's passive avoidance response: a tetrodotoxin functional inactivation study. Brain Res 1996;730: 32-9.
    • (1996) Brain Res , vol.730 , pp. 32-39
    • Lorenzini, C.A.1    Baldi, E.2    Bucherelli, C.3    Sacchetti, B.4    Tassoni, G.5
  • 36
    • 0029924670 scopus 로고    scopus 로고
    • Effects of the uncompetitive NMDA receptor antagonist memantine on hippocampal long-term potentiation, shortterm exploratory modulation and spatial memory in awake, freely moving rats
    • Barnes CA, Danysz W, Parsons CG. Effects of the uncompetitive NMDA receptor antagonist memantine on hippocampal long-term potentiation, shortterm exploratory modulation and spatial memory in awake, freely moving rats. Eur J Neurosci 1996;8:565-71.
    • (1996) Eur J Neurosci , vol.8 , pp. 565-571
    • Barnes, C.A.1    Danysz, W.2    Parsons, C.G.3
  • 37
    • 0021173996 scopus 로고
    • Development of a water maze procedure for studying spatial learning in the rat
    • Morris RG. Development of a water maze procedure for studying spatial learning in the rat. J Neurosci Methods 1984;11:47-60.
    • (1984) J Neurosci Methods , vol.11 , pp. 47-60
    • Morris, R.G.1
  • 38
    • 84872358224 scopus 로고    scopus 로고
    • The revival of scopolamine reversal for the assessment of cognition-enhancing drugs
    • Buccafusco JJ, editor, 2nd ed. Florida: CRC Press
    • Buccafusco JJ. The revival of scopolamine reversal for the assessment of cognition-enhancing drugs. In: Buccafusco JJ, editor. Methods of behavior analysis in neuroscience. 2nd ed. Florida: CRC Press; 2009. Ch. 17:329-43.
    • (2009) Methods of Behavior Analysis In Neuroscience , vol.17 , pp. 329-343
    • Buccafusco, J.J.1
  • 39
    • 0022643823 scopus 로고
    • Non-cholinergic neurotransmitter abnormalities in Alzheimer's disease
    • Rossor M, Iversen LL. Non-cholinergic neurotransmitter abnormalities in Alzheimer's disease. Brit Med Bull 1986;42:70-4.
    • (1986) Brit Med Bull , vol.42 , pp. 70-74
    • Rossor, M.1    Iversen, L.L.2
  • 40
    • 0037622682 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor-mediated neuroprotection by donezepil against glutamate neurotoxicity in rat cortical neurons
    • Takada Y, Yonezawa A, Kume T, Katsuki H, Kaneko S, Sugimoto H, et al. Nicotinic acetylcholine receptor-mediated neuroprotection by donezepil against glutamate neurotoxicity in rat cortical neurons. J Pharmacol Exp Ther 2003;306:772-7.
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 772-777
    • Takada, Y.1    Yonezawa, A.2    Kume, T.3    Katsuki, H.4    Kaneko, S.5    Sugimoto, H.6
  • 41
    • 12344319426 scopus 로고    scopus 로고
    • Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms
    • Fan Y, Hu J, Li J, Yang Z, Xin X, Wang J, Ding J, Geng M. Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms. Neurosci Lett 2005;374:222-6.
    • (2005) Neurosci Lett , vol.374 , pp. 222-226
    • Fan, Y.1    Hu, J.2    Li, J.3    Yang, Z.4    Xin, X.5    Wang, J.6    Ding, J.7    Geng, M.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.