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Volumn 7, Issue 3, 2014, Pages 669-674

Function of the transforming growth factor-β1/c-Jun N-terminal kinase signaling pathway in the action of thalidomide on a rat model of pulmonary fibrosis

Author keywords

smooth muscle actin; c Jun N terminal kinase; Pulmonary fibrosis; Thalidomide

Indexed keywords


EID: 84892982995     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2013.1457     Document Type: Article
Times cited : (17)

References (23)
  • 2
    • 41549115946 scopus 로고    scopus 로고
    • Reactive oxygen species-mediated pancreatic beta-cell death is regulated by interactions between stress-activated protein kinases, p38 and c-Jun N-terminal kinase, and mitogen-activated protein kinase phosphatases
    • Hou N, Torii S, Saito N, Hosaka M and Takeuchi T: Reactive oxygen species-mediated pancreatic beta-cell death is regulated by interactions between stress-activated protein kinases, p38 and c-Jun N-terminal kinase, and mitogen-activated protein kinase phosphatases. Endocrinology 149: 1654-1665, 2008.
    • (2008) Endocrinology , vol.149 , pp. 1654-1665
    • Hou, N.1    Torii, S.2    Saito, N.3    Hosaka, M.4    Takeuchi, T.5
  • 3
    • 84868327008 scopus 로고    scopus 로고
    • Thalidomide for the treatment of cough in idiopathic pulmonary fibrosis: A randomized trial
    • Horton MR, Santopietro V, Mathew L, et al: Thalidomide for the treatment of cough in idiopathic pulmonary fibrosis: a randomized trial. Ann Intern Med 157: 398-406, 2012.
    • (2012) Ann Intern Med , vol.157 , pp. 398-406
    • Horton, M.R.1    Santopietro, V.2    Mathew, L.3
  • 4
    • 0033782189 scopus 로고    scopus 로고
    • Ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice
    • Smith JL, Schaffner AE, Hofmeister JK, et al: ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice. Mol Cell Biol 20: 8026-8034, 2000.
    • (2000) Mol Cell Biol , vol.20 , pp. 8026-8034
    • Smith, J.L.1    Schaffner, A.E.2    Hofmeister, J.K.3
  • 5
    • 77749340411 scopus 로고    scopus 로고
    • Anti-fibrotic effect of thalidomide through inhibiting TGF-beta-induced ERK1/2 pathways in bleomycin-induced lung fibrosis in mice
    • Choe JY, Jung HJ, Park KY, et al: Anti-fibrotic effect of thalidomide through inhibiting TGF-beta-induced ERK1/2 pathways in bleomycin-induced lung fibrosis in mice. Inflamm Res 59: 177-188, 2010.
    • (2010) Inflamm Res , vol.59 , pp. 177-188
    • Choe, J.Y.1    Jung, H.J.2    Park, K.Y.3
  • 7
    • 0027230553 scopus 로고
    • Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation
    • Moreira AL, Sampaio EP, Zmuidzinas A, Frindt P, Smith KA and Kaplan G: Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation. J Exp Med 177: 1675-1680, 1993.
    • (1993) J Exp Med , vol.177 , pp. 1675-1680
    • Moreira, A.L.1    Sampaio, E.P.2    Zmuidzinas, A.3    Frindt, P.4    Smith, K.A.5    Kaplan, G.6
  • 8
    • 0022230283 scopus 로고
    • Thalidomide and congeners as anti-inflammatory agents
    • Koch HP: Thalidomide and congeners as anti-inflammatory agents. Prog Med Chem 22: 165-242, 1985.
    • (1985) Prog Med Chem , vol.22 , pp. 165-242
    • Koch, H.P.1
  • 9
    • 0035149573 scopus 로고    scopus 로고
    • Transforming growth Factor-betal induces phenotypic modulation of human lung fibroblasts to myofibroblast through a c-Jun-NH2-terminal kinase-dependent pathway
    • Hashimoto S, Gon Y, Takeshita I, Matsumoto K, Maruoka S and Horie T: Transforming growth Factor-betal induces phenotypic modulation of human lung fibroblasts to myofibroblast through a c-Jun-NH2-terminal kinase-dependent pathway. Am J Respir Crit Care Med 163: 152-157, 2001.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 152-157
    • Hashimoto, S.1    Gon, Y.2    Takeshita, I.3    Matsumoto, K.4    Maruoka, S.5    Horie, T.6
  • 10
    • 43149111275 scopus 로고    scopus 로고
    • Jun N-terminal kinase1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1
    • Alcorn JF, Guala AS, van der Velden J, et al: Jun N-terminal kinase1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1. J Cell Sci 121: 1036-1045, 2008.
    • (2008) J Cell Sci , vol.121 , pp. 1036-1045
    • Alcorn, J.F.1    Guala, A.S.2    van der Velden, J.3
  • 11
    • 33746265817 scopus 로고    scopus 로고
    • Transforming growth factor-beta receptor type 1 (TGFbetaRI) kinase activity but not p38 activation is required for TGF betaRI-induced myofibroblast differentiation and profibrotic gene expression
    • Kapoun AM, Gaspar NJ, Wang Y, et al: Transforming growth factor-beta receptor type 1 (TGFbetaRI) kinase activity but not p38 activation is required for TGF betaRI-induced myofibroblast differentiation and profibrotic gene expression. Mol Pharmacol 70: 518-531, 2006.
    • (2006) Mol Pharmacol , vol.70 , pp. 518-531
    • Kapoun, A.M.1    Gaspar, N.J.2    Wang, Y.3
  • 12
  • 13
    • 16844387124 scopus 로고    scopus 로고
    • Role of JNK activation apoptosis: A double-edged sword
    • Liu J and Lin A: Role of JNK activation apoptosis: a double-edged sword. Cell Res 15: 36-42, 2005.
    • (2005) Cell Res , vol.15 , pp. 36-42
    • Liu, J.1    Lin, A.2
  • 14
    • 0035923665 scopus 로고    scopus 로고
    • SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
    • Bennett BL, Sasaki DT, Murray BW, et al: SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 98: 13681-13686, 2001.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 13681-13686
    • Bennett, B.L.1    Sasaki, D.T.2    Murray, B.W.3
  • 15
    • 84892968241 scopus 로고    scopus 로고
    • The expression and significance of p-JNK protein and α-SMA in rats with pulmonary fibrosis
    • (In Chinese)
    • Zhang C-X and Liu X-J: The expression and significance of p-JNK protein and α-SMA in rats with pulmonary fibrosis. Chinese Remedies & Clinics 12: 36-38, 2012 (In Chinese).
    • (2012) Chinese Remedies & Clinics , vol.12 , pp. 36-38
    • Zhang, C.-X.1    Liu, X.-J.2
  • 16
    • 2342647946 scopus 로고    scopus 로고
    • The promise of thalidomide: Evolving indications
    • Joglekar S and Levin M: The promise of thalidomide: evolving indications. Drugs Today (Barc) 40: 197-204, 2004.
    • (2004) Drugs Today (Barc) , vol.40 , pp. 197-204
    • Joglekar, S.1    Levin, M.2
  • 17
    • 79955756312 scopus 로고    scopus 로고
    • Thalidomide prevents the progression of peritoneal fibrosis in mice
    • Arai H, Furusu A, Nishino T, et al: Thalidomide prevents the progression of peritoneal fibrosis in mice. Acta Histochem Cytochem 44: 51-60, 2011.
    • (2011) Acta Histochem Cytochem , vol.44 , pp. 51-60
    • Arai, H.1    Furusu, A.2    Nishino, T.3
  • 18
    • 33646579586 scopus 로고    scopus 로고
    • Anti-fibrotic effects of thalidomide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats
    • Chong LW, Hsu YC, Chiu YT, Yang KC and Huang YT: Anti-fibrotic effects of thalidomide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats. J Biomed Sci 13: 403-418, 2006.
    • (2006) J Biomed Sci , vol.13 , pp. 403-418
    • Chong, L.W.1    Hsu, Y.C.2    Chiu, Y.T.3    Yang, K.C.4    Huang, Y.T.5
  • 19
    • 33847402332 scopus 로고    scopus 로고
    • Thalidomide reduces IL-18, IL-8 and TNF-alpha release from alveolar macrophages in interstitial lung disease
    • Ye Q, Chen B, Tong Z, et al: Thalidomide reduces IL-18, IL-8 and TNF-alpha release from alveolar macrophages in interstitial lung disease. Eur Respir J 28: 824-831, 2006.
    • (2006) Eur Respir J , vol.28 , pp. 824-831
    • Ye, Q.1    Chen, B.2    Tong, Z.3
  • 20
    • 84892990623 scopus 로고    scopus 로고
    • Thalidomide inhibits the over-expression of type I collagen in pulmonary fibrosis rats via inhibition the JNK signaling pathway
    • (In Press)
    • Liu X, Qian L, Nan H, et al: Thalidomide inhibits the over-expression of type I collagen in pulmonary fibrosis rats via inhibition the JNK signaling pathway. Chinese Journal of Geriatrics (In Press).
    • Chinese Journal of Geriatrics
    • Liu, X.1    Qian, L.2    Nan, H.3
  • 21
    • 84892983845 scopus 로고    scopus 로고
    • Thalidomide suppresses bleomycin-induced pulmonary fibrosis by down-regulating expressions of TGF-β1 and TNF-α in rats
    • (In Chinese)
    • Luo X and Liu X-J: Thalidomide suppresses bleomycin-induced pulmonary fibrosis by down-regulating expressions of TGF-β1 and TNF-α in rats. Chinese Remedies & Clinics 10: 1346-1349, 2010 (In Chinese).
    • (2010) Chinese Remedies & Clinics , vol.10 , pp. 1346-1349
    • Luo, X.1    Liu, X.-J.2
  • 22
    • 84869232678 scopus 로고    scopus 로고
    • Revisiting thalidomide: Fighting with caution against idiopathic pulmonary fibrosis
    • Horton MR and Hallowell RW: Revisiting thalidomide: fighting with caution against idiopathic pulmonary fibrosis. Drugs Today (Barc) 48: 661-671, 2012.
    • (2012) Drugs Today (Barc) , vol.48 , pp. 661-671
    • Horton, M.R.1    Hallowell, R.W.2
  • 23
    • 84868327008 scopus 로고    scopus 로고
    • Thalidomide for the treatment of cough in idiopathic pulmonary fibrosis: A randomized trial
    • Horton MR, Santopietro V, Mathew L, et al: Thalidomide for the treatment of cough in idiopathic pulmonary fibrosis: a randomized trial. Ann Intern Med 157: 398-406, 2012.
    • (2012) Ann Intern Med , vol.157 , pp. 398-406
    • Horton, M.R.1    Santopietro, V.2    Mathew, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.