Anti-fibrotic effect of thalidomide through inhibiting TGF-β-induced ERK1/2 pathways in bleomycin-induced lung fibrosis in mice

Inflammation Research

Volumn 59, Issue 3, 2010, Pages 177-188

  Choe, Jung Yoon ^a   Jung, Hyun Joo ^a   Park, Ki Yeun ^a   Kum, Yoon Seup ^a   Song, Gwan Gyu ^b   Hyun, Dae Sung ^a   Park, Sung Hoon ^a   Kim, Seong Kyu ^a  

^a The Catholic University of Korea   (South Korea)

^b Korea University College of Medicine   (South Korea)

Author keywords

Bleomycin; ERK1 2; Fibrosis; Lung; TGF ; Thalidomide

Indexed keywords

ANTIFIBROTIC AGENT; BLEOMYCIN; COLLAGEN TYPE 1; FIBRONECTIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; THALIDOMIDE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; INFLAMMATORY CELL; LUNG FIBROSIS; LUNG LAVAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANGIOGENESIS INHIBITORS; ANIMALS; BLEOMYCIN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FIBROBLASTS; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PULMONARY FIBROSIS; SIGNAL TRANSDUCTION; THALIDOMIDE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77749340411     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-009-0084-9     Document Type: Article

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