MicroRNA-146a represses mycobacteria-induced inflammatory response and facilitates bacterial replication via targeting IRAK-1 and TRAF-6

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Li, Shuo ^a   Yue, Yan ^b   Xu, Wei ^b   Xiong, Sidong ^a,b  

^a FUDAN UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; MICRORNA 146A; MONOCYTE CHEMOTACTIC PROTEIN 1; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ANIMAL CELL; ARTICLE; BACTERIAL LOAD; BACTERIAL PHENOMENA AND FUNCTIONS; BACTERIUM REPLICATION; CONTROLLED STUDY; GENE EXPRESSION; INFLAMMATION; MACROPHAGE; MOUSE; MYCOBACTERIOSIS; MYCOBACTERIUM; NONHUMAN; PROTEIN TARGETING;

ANIMALS; INFLAMMATION; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICRORNAS; MYCOBACTERIUM; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6;

EID: 84892978342     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0081438     Document Type: Article

References (38)

1. Lawn SD, Zumla AI (2011) Tuberculosis. Lancet 378: 57-72.
2. Quinn EM, Wang JH, O'Callaghan G, Redmond HP (2013) MicroRNA-146a is upregulated by and negatively regulates TLR2 signaling. PLoS One 8: e62232.
3. Gammack D, Doering CR, Kirschner DE (2004) Macrophage response to Mycobacterium tuberculosis infection. J Math Biol 48: 218-242. (Pubitemid 40882749)
4. Liu PT, Modlin RL (2008) Human macrophage host defense against Mycobacterium tuberculosis. Curr Opin Immunol 20: 371-376.
5. Pieters J (2008) Mycobacterium tuberculosis and the macrophage: maintaining a balance. Cell Host Microbe 3: 399-407.
6. Macfarlane LA, Murphy PR (2010) MicroRNA: Biogenesis, Function and Role in Cancer. Curr Genomics 11: 537-561.
7. Buchan JR, Parker R (2007) Molecular biology. The two faces of miRNA. Science 318: 1877-1878.
8. Khan AA, Penny LA, Yuzefpolskiy Y, Sarkar S, Kalia V (2013) MicroRNA-17∼92 regulates effector and memory CD8 T-cell fates by modulating proliferation in response to infections. Blood 121: 4473-4483.
9. Escobar T, Yu CR, Muljo SA, Egwuagu CE (2013) STAT3 activates miR-155 in Th17 cells and acts in concert to promote experimental autoimmune uveitis. Invest Ophthalmol Vis Sci 54: 4017-4025.
10. Saba R, Gushue S, Huzarewich RL, Manguiat K, Medina S, et al. (2012) MicroRNA 146a (miR-146a) is over-expressed during prion disease and modulates the innate immune response and the microglial activation state. PLoS One 7: e30832.
11. Xia P, Fang X, Zhang ZH, Huang Q, Yan KX, et al. (2012) Dysregulation of miRNA146a versus IRAK1 induces IL-17 persistence in the psoriatic skin lesions. Immunol Lett 148: 151-162.
12. Liu Z, Xiao B, Tang B, Li B, Li N, et al. (2010) Up-regulated microRNA-146a negatively modulate Helicobacter pylori-induced inflammatory response in human gastric epithelial cells. Microbes Infect 12: 854-863.
13. Rom S, Rom I, Passiatore G, Pacifici M, Radhakrishnan S, et al. (2010) CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells. FASEB J 24: 2292-2300.
14. Rivero-Lezcano OM, Gonzalez-Cortes C, Reyes-Ruvalcaba D, Diez-Tascon C (2010) CCL20 is overexpressed in Mycobacterium tuberculosis-infected monocytes and inhibits the production of reactive oxygen species (ROS). Clin Exp Immunol 162: 289-297.
15. Shaler CR, Kugathasan K, McCormick S, Damjanovic D, Horvath C, et al. (2011) Pulmonary mycobacterial granuloma increased IL-10 production contributes to establishing a symbiotic host-microbe microenvironment. Am J Pathol 178: 1622-1634.
16. Hirsch CS, Yoneda T, Averill L, Ellner JJ, Toossi Z (1994) Enhancement of intracellular growth of Mycobacterium tuberculosis in human monocytes by transforming growth factor-beta 1. J Infect Dis 170: 1229-1237. (Pubitemid 24328628)
17. Wu Z, Lu H, Sheng J, Li L (2012) Inductive microRNA-21 impairs antimycobacterial responses by targeting IL-12 and Bcl-2. FEBS Lett 586: 2459-2467.
18. Ma F, Xu S, Liu X, Zhang Q, Xu X, et al. (2011) The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-gamma. Nat Immunol 12: 861-869.
19. Shen J, Ambrosone CB, DiCioccio RA, Odunsi K, Lele SB, et al. (2008) A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis. Carcinogenesis 29: 1963-1966.
20. El Gazzar M, Church A, Liu T, McCall CE (2011) MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-alpha during TLR4-induced gene reprogramming. J Leukoc Biol 90: 509-519.
21. Suzuki Y, Kim HW, Ashraf M, Haider H (2010) Diazoxide potentiates mesenchymal stem cell survival via NF-kappaB-dependent miR-146a expression by targeting Fas. Am J Physiol Heart Circ Physiol 299: H1077-1082.
22. Taganov KD, Boldin MP, Chang KJ, Baltimore D (2006) NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A 103: 12481-12486. (Pubitemid 44267285)
23. Hou J, Wang P, Lin L, Liu X, Ma F, et al. (2009) MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J Immunol 183: 2150-2158.
24. Nahid MA, Rivera M, Lucas A, Chan EK, Kesavalu L (2011) Polymicrobial infection with periodontal pathogens specifically enhances microRNA miR-146a in ApoE-/- mice during experimental periodontal disease. Infect Immun 79: 1597-1605.
25. Chatterjee S, Dwivedi VP, Singh Y, Siddiqui I, Sharma P, et al. (2011) Early secreted antigen ESAT-6 of Mycobacterium tuberculosis promotes protective T helper 17 cell responses in a toll-like receptor-2-dependent manner. PLoS Pathog 7: e1002378.
26. Rusca N, Monticelli S (2011) MiR-146a in Immunity and Disease. Mol Biol Int 2011: 437301.
27. Nahid MA, Satoh M, Chan EK (2011) MicroRNA in TLR signaling and endotoxin tolerance. Cell Mol Immunol 8: 388-403.
28. Means TK, Wang S, Lien E, Yoshimura A, Golenbock DT, et al. (1999) Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J Immunol 163: 3920-3927. (Pubitemid 29450920)
29. Chen XM, Splinter PL, O'Hara SP, LaRusso NF (2007) A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection. J Biol Chem 282: 28929-28938. (Pubitemid 47610421)
30. Benakanakere MR, Li Q, Eskan MA, Singh AV, Zhao J, et al. (2009) Modulation of TLR2 protein expression by miR-105 in human oral keratinocytes. J Biol Chem 284: 23107-23115.
31. Lai L, Song Y, Liu Y, Chen Q, Han Q, et al. (2013) MicroRNA-92a negatively regulates Toll-like receptor (TLR)-triggered inflammatory response in macrophages by targeting MKK4 kinase. J Biol Chem 288: 7956-7967.
32. Nahid MA, Pauley KM, Satoh M, Chan EK (2009) miR-146a is critical for endotoxin-induced tolerance: IMPLICATION IN INNATE IMMUNITY. J Biol Chem 284: 34590-34599.
33. Zeng Z, Gong H, Li Y, Jie K, Ding C, et al. (2013) Upregulation of miR-146a contributes to the suppression of inflammatory responses in LPS-induced acute lung injury. Exp Lung Res 39: 275-282.
34. Esquivel-Solis H, Vallecillo AJ, Benitez-Guzman A, Adams LG, Lopez-Vidal Y, et al. (2013) Nitric oxide not apoptosis mediates differential killing of Mycobacterium bovis in bovine macrophages. PLoS One 8: e63464.
35. L'Abbate C, Cipriano I, Perez-Hurtado EC, Leao SC, Carneiro CR, et al. (2011) TGF-beta-mediated sustained ERK1/2 activity promotes the inhibition of intracellular growth of Mycobacterium avium in epithelioid cells surrogates. PLoS One 6: e21465.
36. Klink M, Brzezinska M, Szulc I, Brzostek A, Kielbik M, et al. (2013) Cholesterol Oxidase Is Indispensable in the Pathogenesis of Mycobacterium tuberculosis. PLoS One 8: e73333.
37. Wang YP, Li XY, Song CQ, Hu ZB (2002) Effect of astragaloside IV on T, B lymphocyte proliferation and peritoneal macrophage function in mice. Acta Pharmacol Sin 23: 263-266.
38. Zhang W, Xu W, Xiong S (2010) Blockade of Notch1 signaling alleviates murine lupus via blunting macrophage activation and M2b polarization. J Immunol 184: 6465-6478.